Cochrane · systematic review · CD009672
Hormone therapy for sexual function in perimenopausal and postmenopausal women
Lara, LA, Cartagena-Ramos, D, Figueiredo, JBP, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
9
No studies
1
Included studies
NR
No studies 1 · 10%Ungraded 0 · 0%Very low 6 · 60%Low 1 · 10%Moderate 2 · 20%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsHormonal therapy compared with placebo or no intervention for sexual function in symptomatic or early postmenopausal women
Population: symptomatic or early postmenopausal womena
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Estrogen aloneSexual function score measured by MENQoL sexual subscore (higher score = better sexual functioning); GCS sexual subscore (higher score = worse sexual functioning and for analysis, the scoring direction was reversed); and MSQ (higher ... Hormonal therapy vs placebo or no intervention | no estimate extracted | 3 studies · 699 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Estrogen + progestogens Hormonal therapy vs placebo or no intervention | no estimate extracted | NR | No studies |
Synthetic steroids Sexual function score measured by WHQ sexual subscore (higher score = better sexual functioning) Hormonal therapy vs placebo or no intervention | no estimate extracted | 1 study · 883 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
SERMs Composite sexual function score measured by AESEX scale (higher score = worse sexual functioning and for analysis, the scoring direction was reversed) Hormonal therapy vs placebo or no intervention | no estimate extracted | 1 study · 215 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
SERMs + estrogen Composite sexual function score measured by ASEX scale (higher score = worse sexual functioning and for analysis, the scoring direction was reversed) Hormonal therapy vs placebo or no intervention | no estimate extracted | 1 study · 542 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Hormonal therapy compared with placebo or no intervention for sexual function in unselected postmenopausal women
Population: unselected postmenopausal womena
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Estrogen alone Sexual function score measured by FSFI (higher score = better sexual functioning); WHQ sexual subscore (higher score = better sexual functioning); MENQoL sexual subscore (higher score = better sexual functioning) Hormonal therapy vs placebo or no intervention | no estimate extracted | 6 studies · 608 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Estrogen + progestogens Sexual function score measured by WHQ sexual subscore (higher score = better sexual functioning) Hormonal therapy vs placebo or no intervention | no estimate extracted | 1 study · 104 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Synthetic steroids Sexual function score measured by FSFI; WHQ sexual subscore (higher score = better sexual functioning) Hormonal therapy vs placebo or no intervention | no estimate extracted | 1 study · 105 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
SERMs Sexual function score measured by FSFI (higher score = better sexual functioning) Hormonal therapy vs placebo or no intervention | no estimate extracted | 2 studies · 1525 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
SERMs + estrogen Sexual function score measured by MENQoL sexual subscore (higher score = better sexual functioning) Hormonal therapy vs placebo or no intervention | no estimate extracted | 1 study · 272 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |