Cochrane · systematic review · CD008565
Statins for women with polycystic ovary syndrome not actively trying to conceive
Xiong, T, Fraison, E, Kolibianaki, E, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
30
current version
GRADE rated
12
No studies
5
Included studies
NR
No studies 5 · 16.7%Ungraded 13 · 43.3%Very low 12 · 40%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Statin compared to placebo for women with polycystic ovary syndrome not actively trying to conceive
Population: women with polycystic ovary syndrome not actively trying to conceive
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resumption of menstrual regularity (menstrual cycle length in days) Statin vs placebo | no estimate extracted | 1 study · 37 participants | Very low Downgraded: risk of bias, imprecision |
Resumption of spontaneous ovulation Statin vs placebo | no estimate extracted | NR | No studies |
Improvement in hirsutism Statin vs placebo | no estimate extracted | NR | No studies |
Improvement in acne severity Statin vs placebo | no estimate extracted | NR | No studies |
Improvement in testosterone level (nmol/L) Statin vs placebo | no estimate extracted | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects Statin vs placebo | no estimate extracted | 2 studies · 2 participants | Ungraded |
Statin plus metformin compared to metformin alone for women with polycystic ovary syndrome not actively trying to conceive
Population: women with polycystic ovary syndrome not actively trying to conceive
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resumption of menstrual regularity (spontaneous menses per 6 months) Statin plus metformin vs metformin alone | no estimate extracted | 1 study · 69 participants | Very low Downgraded: risk of bias, imprecision |
Resumption of spontaneous ovulation Statin plus metformin vs metformin alone | no estimate extracted | 2011 participants | Ungraded |
Improvement in hirsutism (Ferriman‐Gallwey score) after 6 months' treatment Statin plus metformin vs metformin alone | no estimate extracted | 1 study · 69 participants | Very low Downgraded: risk of bias, imprecision |
Improvement in acne severity (scale of 0–3) after 6 months' treatment Statin plus metformin vs metformin alone | no estimate extracted | 1 study · 69 participants | Very low Downgraded: risk of bias, imprecision |
Improvement in testosterone level (nmol/L) after 6 months' treatment Statin plus metformin vs metformin alone | no estimate extracted | 1 study · 69 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects Statin plus metformin vs metformin alone | no estimate extracted | 2011 participants | Ungraded |
Statin plus oral contraceptive pill compared to oral contraceptive pill alone for women with polycystic ovary syndrome not actively trying to conceive
Population: women with polycystic ovary syndrome not actively trying to conceive
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resumption of menstrual regularity Statin plus oral contraceptive pill vs oral contraceptive pill alone | no estimate extracted | 2006 participants | Ungraded |
Resumption of spontaneous ovulation Statin plus oral contraceptive pill vs oral contraceptive pill alone | no estimate extracted | 2006 participants | Ungraded |
Improvement in hirsutism (Ferriman‐Gallwey score) Statin plus oral contraceptive pill vs oral contraceptive pill alone | no estimate extracted | 1 study · 48 participants | Very low Downgraded: risk of bias, imprecision |
Improvement in acne severity Statin plus oral contraceptive pill vs oral contraceptive pill alone | no estimate extracted | 2006 participants | Ungraded |
Testosterone level (change from baseline in nmol/L) Statin plus oral contraceptive pill vs oral contraceptive pill alone | no estimate extracted | 1 study · 48 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects Statin plus oral contraceptive pill vs oral contraceptive pill alone | no estimate extracted | 2006 participants | Ungraded |
Statin compared to metformin for women with polycystic ovary syndrome not actively trying to conceive
Population: women with polycystic ovary syndrome not actively trying to conceive
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resumption of menstrual regularity (number of spontaneous menses per 6 months) after 6 months' treatment Statin vs metformin | no estimate extracted | 1 study · 61 participants | Very low Downgraded: risk of bias, imprecision |
Resumption of spontaneous ovulation Statin vs metformin | no estimate extracted | NR | No studies |
Improvement in hirsutism (Ferriman‐Gallwey score) after 6 months' treatment Statin vs metformin | no estimate extracted | 1 study · 61 participants | Very low Downgraded: risk of bias, imprecision |
Improvement in acne severity (scale of 0–3) after 6 months' treatment Statin vs metformin | no estimate extracted | 1 study · 61 participants | Very low Downgraded: risk of bias, imprecision |
Improvement in testosterone level (nmol/L) after 6 months' treatment Statin vs metformin | no estimate extracted | 1 study · 61 participants | Very low Downgraded: risk of bias, imprecision |
Adverse effects Statin vs metformin | no estimate extracted | NR | No studies |
Statin compared to oral contraceptive pill plus flutamide for women with polycystic ovary syndrome not actively trying to conceive
Population: women with polycystic ovary syndrome not actively trying to conceive
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resumption of menstrual regularity Statin vs oral contraceptive pill plus flutamide | no estimate extracted | 2016 participants | Ungraded |
Resumption of spontaneous ovulation Statin vs oral contraceptive pill plus flutamide | no estimate extracted | 2016 participants | Ungraded |
Improvement in hirsutism Statin vs oral contraceptive pill plus flutamide | no estimate extracted | 2016 participants | Ungraded |
Improvement in acne severity Statin vs oral contraceptive pill plus flutamide | no estimate extracted | 2016 participants | Ungraded |
Improvement in testosterone level. Statin vs oral contraceptive pill plus flutamide | no estimate extracted | 2016 participants | Ungraded |
Adverse effects Statin vs oral contraceptive pill plus flutamide | no estimate extracted | 2016 participants | Ungraded |