Cochrane · systematic review · CD005356
Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility
Cantineau, AEP, Rutten, AGH, Cohlen, BJ · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
36
current version
GRADE rated
36
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 11 · 30.6%Low 21 · 58.3%Moderate 4 · 11.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Gonadotropins versus anti‐oestrogens for intrauterine insemination in women with infertility
Population: intrauterine insemination (IUI) in women with infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple ‐ all types of infertility Gonadotropins vs anti‐oestrogens | OR 1.37 [1.05, 1.79] | 5 studies · 1924 participants | Moderate Downgraded: imprecision |
Multiple pregnancy rate per couple Gonadotropins vs anti‐oestrogens | OR 1.58 [0.6, 4.17] | 7 studies · 2139 participants | Low Downgraded: imprecision, inconsistency |
Clinical pregnancy rate per couple Gonadotropins vs anti‐oestrogens | OR 1.34 [1.12, 1.61] | 12 studies · 2576 participants | Moderate Downgraded: imprecision |
Miscarriage rate per couple Gonadotropins vs anti‐oestrogens | OR 1.25 [0.88, 1.77] | 6 studies · 2002 participants | Low Downgraded: imprecision |
OHSS rate per couple Gonadotropins vs anti‐oestrogens | OR 0.77 [0.19, 3.14] | 6 studies · 1482 participants | Low Downgraded: imprecision |
Ectopic pregnancy rate per couple Gonadotropins vs anti‐oestrogens | OR 1.64 [0.67, 3.98] | 2 studies · 1339 participants | Low Downgraded: imprecision |
Aromatase inhibitors versus anti‐oestrogens for intrauterine insemination in women with infertility
Population: intrauterine insemination (IUI) in women with infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple Aromatase inhibitors vs anti‐oestrogens | OR 0.75 [0.51, 1.11] | 1 study · 599 participants | Low Downgraded: imprecision |
Multiple pregnancy rate per couple Aromatase inhibitors vs anti‐oestrogens | OR 1.28 [0.61, 2.68] | 4 studies · 1000 participants | Low Downgraded: imprecision |
Clinical pregnancy rate per couple Aromatase inhibitors vs anti‐oestrogens | OR 1.21 [0.75, 1.94] | 8 studies · 1160 participants | Low Downgraded: imprecision, inconsistency |
Miscarriage rate per couple Aromatase inhibitors vs anti‐oestrogens | OR 0.91 [0.47, 1.77] | 3 studies · 967 participants | Low Downgraded: imprecision |
OHSS rate per couple Aromatase inhibitors vs anti‐oestrogens | no estimate extracted | 2 studies · 813 participants | Moderate Downgraded: imprecision |
Ectopic pregnancy rate per couple Aromatase inhibitors vs anti‐oestrogens | OR 1 [0.29, 3.5] | 2 studies · 813 participants | Low Downgraded: imprecision |
Gonadotropins with GnRH agonists versus gonadotropins alone for intrauterine insemination in women with infertility
Population: intrauterine insemination (IUI) in women with infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Multiple pregnancy rate per couple Gonadotropins with GnRH agonists vs gonadotropins alone | OR 2.53 [0.82, 7.86] | 2 studies · 264 participants | Very low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate per couple Gonadotropins with GnRH agonists vs gonadotropins alone | OR 0.55 [0.32, 0.95] | 3 studies · 355 participants | Very low Downgraded: risk of bias, imprecision |
Miscarriage rate per couple Gonadotropins with GnRH agonists vs gonadotropins alone | OR 2.07 [0.18, 24.15] | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
OHSS rate per couple Gonadotropins with GnRH agonists vs gonadotropins alone | OR 1.8 [0.39, 8.32] | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
Gonadotropins with GnRH antagonist versus gonadotropins alone for intrauterine insemination in women with infertility
Population: intrauterine insemination (IUI) in women with infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple Gonadotropins with GnRH antagonist vs gonadotropins alone | OR 1.5 [0.52, 4.39] | 3 studies · 419 participants | Very low Downgraded: imprecision, inconsistency |
Multiple pregnancy rate per couple Gonadotropins with GnRH antagonist vs gonadotropins alone | OR 1.3 [0.74, 2.28] | 10 studies · 2095 participants | Moderate Downgraded: imprecision |
Clinical pregnancy rate per couple Gonadotropins with GnRH antagonist vs gonadotropins alone | OR 1.35 [1, 1.84] | 14 studies · 2525 participants | Low Downgraded: imprecision, inconsistency |
Miscarriage rate per couple Gonadotropins with GnRH antagonist vs gonadotropins alone | OR 1.37 [0.84, 2.22] | 9 studies · 2054 participants | Low Downgraded: imprecision |
OHSS rate per couple Gonadotropins with GnRH antagonist vs gonadotropins alone | OR 0.98 [0.12, 8.32] | 5 studies · 1348 participants | Very low Downgraded: imprecision, inconsistency |
Ectopic pregnancy rate per couple Gonadotropins with GnRH antagonist vs gonadotropins alone | OR 0.33 [0.01, 8.23] | 1 study · 407 participants | Low Downgraded: imprecision |
Gonadotrophins with anti‐oestrogens versus gonadotropins alone for intrauterine insemination in women with infertility
Population: intrauterine insemination (IUI) in women with infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Multiple pregnancy rate per couple Gonadotrophins with anti‐oestrogens vs gonadotropins alone | OR 3.03 [0.12, 75.06] | 1 study · 230 participants | Low Downgraded: imprecision |
Clinical pregnancy rate per couple Gonadotrophins with anti‐oestrogens vs gonadotropins alone | OR 1.99 [0.81, 4.9] | 2 studies · 328 participants | Very low Downgraded: imprecision, inconsistency |
OHSS rate per couple Gonadotrophins with anti‐oestrogens vs gonadotropins alone | OR 0.5 [0.04, 5.54] | 1 study · 230 participants | Low Downgraded: imprecision |
Aromatase inhibitors versus gonadotropins for intrauterine insemination in women with infertility
Population: intrauterine insemination (IUI) in women with infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple Aromatase inhibitors vs gonadotropins | OR 0.49 [0.34, 0.71] | 2 studies · 651 participants | Low Downgraded: imprecision |
Multiple pregnancy rate per couple Aromatase inhibitors vs gonadotropins | OR 0.69 [0.06, 8.17] | 3 studies · 731 participants | Very low Downgraded: imprecision, inconsistency |
Clinical pregnancy rate per couple Aromatase inhibitors vs gonadotropins | OR 0.61 [0.46, 0.82] | 6 studies · 1085 participants | Low Downgraded: risk of bias, imprecision |
Miscarriage rate per couple Aromatase inhibitors vs gonadotropins | OR 0.53 [0.3, 0.92] | 2 studies · 650 participants | Low Downgraded: imprecision |
OHSS rate per couple Aromatase inhibitors vs gonadotropins | OR 1 [0.14, 7.2] | 2 studies · 680 participants | Low Downgraded: imprecision |
Ectopic pregnancy per couple Aromatase inhibitors vs gonadotropins | OR 0.56 [0.21, 1.48] | 2 studies · 650 participants | Low Downgraded: imprecision |
Aromatase inhibitors with gonadotropins versus anti‐oestrogens with gonadotropins for intrauterine insemination in women with infertility
Population: intrauterine insemination (IUI) in women with infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple Aromatase inhibitors with gonadotropins vs anti‐oestrogens with gonadotropins | OR 0.99 [0.38, 2.54] | 3 studies · 708 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Multiple pregnancy rate per couple Aromatase inhibitors with gonadotropins vs anti‐oestrogens with gonadotropins | OR 1.31 [0.39, 4.37] | 4 studies · 901 participants | Low Downgraded: imprecision |
Clinical pregnancy rate per couple Aromatase inhibitors with gonadotropins vs anti‐oestrogens with gonadotropins | OR 0.78 [0.57, 1.07] | 8 studies · 1244 participants | Very low Downgraded: risk of bias, imprecision |
Miscarriage rate per couple Aromatase inhibitors with gonadotropins vs anti‐oestrogens with gonadotropins | OR 1.44 [0.75, 2.77] | 7 studies · 1164 participants | Very low Downgraded: risk of bias, imprecision |
OHSS rate per couple Aromatase inhibitors with gonadotropins vs anti‐oestrogens with gonadotropins | OR 4.45 [0.75, 26.43] | 4 studies · 901 participants | Low Downgraded: imprecision |