Cochrane · systematic review · CD011184
Fresh versus frozen embryo transfers in assisted reproduction
Zaat, T, Zagers, M, Mol, F, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
13
No studies
1
Included studies
NR
No studies 1 · 7.1%Ungraded 0 · 0%Very low 3 · 21.4%Low 7 · 50%Moderate 3 · 21.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsFresh compared to frozen embryo transfer (cumulatively) in assisted reproduction
Population: women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate: cumulatively Fresh vs frozen embryo transfer (cumulatively) | OR 1.08 [0.95, 1.22] | 8 studies · 4712 participants | Moderate Downgraded: risk of bias |
OHSS: per cycle with ovarian hyperstimulation Fresh vs frozen embryo transfer (cumulatively) | OR 0.26 [0.17, 0.39] | 6 studies · 4478 participants | Low Downgraded: risk of bias, imprecision |
Ongoing pregnancy rate: cumulatively Fresh vs frozen embryo transfer (cumulatively) | OR 0.95 [0.75, 1.19] | 4 studies · 1245 participants | Moderate Downgraded: risk of bias |
Miscarriage rate: cumulatively Fresh vs frozen embryo transfer (cumulatively) | OR 1.06 [0.72, 1.55] | 2 studies · 986 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Multiple pregnancy rate: cumulatively Fresh vs frozen embryo transfer (cumulatively) | OR 0.88 [0.61, 1.25] | 2 studies · 986 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Time to pregnancy Fresh vs frozen embryo transfer (cumulatively) | no estimate extracted | NR | No studies |
Fresh compared to frozen embryo transfers in assisted reproduction regarding pregnancy and neonatal outcomes
Population: women undergoing assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hypertensive disorders of pregnancy: cumulatively Fresh vs frozen embryo transfers | OR 0.7 [0.27, 1.82] | 1 study · 782 participants | Low Downgraded: risk of bias, imprecision |
Hypertensive disorders of pregnancy: after first ET Fresh vs frozen embryo transfers | OR 2.15 [1.42, 3.25] | 3 studies · 3940 participants | Low Downgraded: risk of bias, imprecision |
Large for gestational age (birth weight above 90th percentile): cumulatively Fresh vs frozen embryo transfers | OR 1.97 [0.63, 6.15] | 1 study · 782 participants | Low Downgraded: risk of bias, imprecision |
Large for gestational age (birth weight above 90th percentile): after first ET Fresh vs frozen embryo transfers | OR 1.96 [1.51, 2.55] | 3 studies · 3940 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Small for gestational age (birth weight below 10th percentile): cumulatively Fresh vs frozen embryo transfers | OR 0.36 [0.16, 0.8] | 1 study · 782 participants | Low Downgraded: risk of bias, imprecision |
Small for gestational age (birth weight below 10th percentile): after first ET Fresh vs frozen embryo transfers | OR 0.82 [0.65, 1.05] | 3 studies · 3940 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Birth weight of babies born: singletons Fresh vs frozen embryo transfers | no estimate extracted | 5 studies · 1607 participants | Moderate Downgraded: risk of bias |
Birth weight of babies born: multiples Fresh vs frozen embryo transfers | no estimate extracted | 4 studies · 804 participants | Low Downgraded: risk of bias, inconsistency |