Cochrane · systematic review · CD008189
Preconception lifestyle advice for people with infertility
Boedt, T, Vanhove, A-C, Vercoe, MA, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
26
current version
GRADE rated
18
No studies
8
Included studies
NR
No studies 8 · 30.8%Ungraded 0 · 0%Very low 13 · 50%Low 5 · 19.2%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Preconception lifestyle advice on a combination of topics compared to routine care or attention control for people with infertility
Population: people with infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Preconception lifestyle advice on a combination of topics vs routine care or attention control | RR 0.93 [0.79, 1.1] | 1 study · 626 participants | Low Downgraded: risk of bias |
Adverse events Preconception lifestyle advice on a combination of topics vs routine care or attention control | no estimate extracted | NR | No studies |
Miscarriage Preconception lifestyle advice on a combination of topics vs routine care or attention control | no estimate extracted | NR | No studies |
Reported behavioural changes in weight: BMI (measured "at study end" ‐ 3 months) Preconception lifestyle advice on a combination of topics vs routine care or attention control | no estimate extracted | 1 study · 180 participants | Very low Downgraded: risk of bias |
Reported behavioural changes in diet: vegetable intake Preconception lifestyle advice on a combination of topics vs routine care or attention control | no estimate extracted | 1 study · 264 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Reported behavioural changes on vitamin or mineral supplement intake: number of women with adequate use of folic acid supplement Preconception lifestyle advice on a combination of topics vs routine care or attention control | RR 0.98 [0.95, 1.01] | 2 studies · 850 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Reported behavioural changes in alcohol intake (measured at 6 months) Preconception lifestyle advice on a combination of topics vs routine care or attention control | RR 1.07 [0.99, 1.17] | 1 study · 607 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Reported behavioural changes in smoking (measured at 6 months): Preconception lifestyle advice on a combination of topics vs routine care or attention control | RR 1.01 [0.98, 1.04] | 1 study · 606 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Preconception lifestyle advice on weight compared to routine care or attention control for people with infertility and obesity
Population: women with infertility and obesity
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Preconception lifestyle advice on weight vs routine care or attention control | RR 0.94 [0.62, 1.43] | 2 studies · 707 participants | Very low Downgraded: risk of bias |
Adverse events ‐ Hypertension Preconception lifestyle advice on weight vs routine care or attention control | RR 1.07 [0.66, 1.75] | 1 study · 317 participants | Very low Downgraded: risk of bias |
Adverse events ‐ Gestational diabetes Preconception lifestyle advice on weight vs routine care or attention control | RR 0.78 [0.48, 1.26] | 1 study · 317 participants | Very low Downgraded: risk of bias |
Miscarriage Preconception lifestyle advice on weight vs routine care or attention control | RR 1.5 [0.95, 2.37] | 1 study · 577 participants | Very low Downgraded: risk of bias |
Reported behavioural changes in weight: BMI (measured at 6 months) Preconception lifestyle advice on weight vs routine care or attention control | no estimate extracted | 1 study · 574 participants | Low Downgraded: risk of bias |
Reported behavioural changes in weight: percentage of weight loss (measured at 6 months) Preconception lifestyle advice on weight vs routine care or attention control | no estimate extracted | 2 studies · 380 participants | Very low Downgraded: risk of bias |
Reported behavioural changes in diet: vegetable intake Preconception lifestyle advice on weight vs routine care or attention control | no estimate extracted | 1 study · 250 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Reported behavioural changes in diet: fruit intake Preconception lifestyle advice on weight vs routine care or attention control | no estimate extracted | 1 study · 258 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Reported behavioural changes in alcohol intake Preconception lifestyle advice on weight vs routine care or attention control | no estimate extracted | 1 study · 239 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Reported behavioural changes in physical activity Preconception lifestyle advice on weight vs routine care or attention control | no estimate extracted | 1 study · 254 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Preconception lifestyle advice on alcohol intake compared to routine care or attention control for at‐risk drinking women with infertility
Population: women with infertility and at‐risk drinking
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth Preconception lifestyle advice on alcohol intake vs routine care or attention control | RR 1.15 [0.53, 2.5] | 1 study · 37 participants | Very low Downgraded: risk of bias |
Adverse events Preconception lifestyle advice on alcohol intake vs routine care or attention control | no estimate extracted | NR | No studies |
Miscarriage Preconception lifestyle advice on alcohol intake vs routine care or attention control | RR 1.31 [0.21, 8.34] | 1 study · 37 participants | Very low Downgraded: risk of bias |
Reported behavioural changes Preconception lifestyle advice on alcohol intake vs routine care or attention control | no estimate extracted | NR | No studies |
Preconception lifestyle advice on smoking compared to routine care or attention control for people with infertility
Population: smoking people with infertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth or ongoing pregnancy Preconception lifestyle advice on smoking vs routine care or attention control | no estimate extracted | NR | No studies |
Adverse events Preconception lifestyle advice on smoking vs routine care or attention control | no estimate extracted | NR | No studies |
Miscarriage Preconception lifestyle advice on smoking vs routine care or attention control | no estimate extracted | NR | No studies |
Reported behavioural changes: smoking Preconception lifestyle advice on smoking vs routine care or attention control | no estimate extracted | NR | No studies |