Non-Cochrane · intervention · PM42016156

Effectiveness of arthrocentesis versus other therapeutic modalities in patients with temporomandibular disorders. Systematic review and meta-analysis.

Valenzuela-Fuenzalida Juan José, Araya-Gonzalez Florencia, Katz-Figols Ursula, et al. · The Japanese dental science review · 2026 · PubMed · doi:10.1016/j.jdsr.2026.04.001

Findings

32 findings

Population
Patients with intra-articular temporomandibular disorders (all diagnoses)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Ipsilateral movement
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified
MD -0.14 [-1.02, 0.75]
GRADE not reported
2 studies · 116 participants
Patients with intra-articular temporomandibular disorders (all diagnoses)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Right lateral movement
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified
MD -1.54 [-3.64, 0.55]
GRADE not reported
3 studies · 96 participants
Patients with intra-articular temporomandibular disorders (all diagnoses)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Maximum mouth opening (MMO)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified
SMD -0.67 [-1.14, -0.20]
Low
Downgraded: risk of bias, inconsistency
14 studies · 549 participants
Patients with intra-articular temporomandibular disorders (all diagnoses)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Contralateral movement
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified
MD 0.04 [-0.50, 0.58]
GRADE not reported
3 studies · 153 participants
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsMandibular movement: lateral only
Oral and maxillofacial clinics · Meta-regression moderator: Proportion of women
Meta-regression coefficient (beta) -37.690 [-117.923, 42.706]
GRADE not reported
Studies not reported
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsMaximum incisal opening (MIO)
Oral and maxillofacial clinics · Meta-regression moderator: Proportion of women
Meta-regression coefficient (beta) -1.640 [-24.881, 21.602]
GRADE not reported
Studies not reported
Patients with intra-articular temporomandibular disorders (all diagnoses)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Pain intensity (VAS)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified
MD -0.25 [-1.09, 0.59]
Very low
Downgraded: risk of bias, imprecision, inconsistency
26 studies · 947 participants
Patients with intra-articular temporomandibular disorders (all diagnoses)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Lateral movement (only lateral)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified
MD -0.52 [-1.13, 0.09]
GRADE not reported
5 studies · 145 participants
Patients with intra-articular temporomandibular disorders (all diagnoses)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Maximum incisal opening (MIO)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified
SMD -2.93 [-4.54, -1.32]
Very low
Downgraded: risk of bias, inconsistency
11 studies · 325 participants
Patients with intra-articular temporomandibular disorders (all diagnoses)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Overall mandibular movement
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified
MD -0.40 [-0.93, 0.14]
Very low
Downgraded: risk of bias, imprecision, inconsistency
22 studies · 796 participants
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsPain intensity (VAS)
Oral and maxillofacial clinics · Meta-regression moderator: Proportion of women
Meta-regression coefficient (beta) -1.609 [-5.033, 1.816]
GRADE not reported
Studies not reported
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsMandibular movement: contralateral
Oral and maxillofacial clinics · Meta-regression moderator: Age (years)
Meta-regression coefficient (beta) 0.074 [-0.187, 0.336]
GRADE not reported
Studies not reported
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsMandibular movement: protrusive
Oral and maxillofacial clinics · Meta-regression moderator: Age (years)
Meta-regression coefficient (beta) -0.021 [-0.501, 0.460]
GRADE not reported
Studies not reported
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsMandibular movement: protrusive
Oral and maxillofacial clinics · Meta-regression moderator: Proportion of women
Meta-regression coefficient (beta) -15.246 [-134.135, 103.644]
GRADE not reported
Studies not reported
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsMandibular movement: contralateral
Oral and maxillofacial clinics · Meta-regression moderator: Proportion of women
Meta-regression coefficient (beta) -14.225 [-29.918, 0.469]
GRADE not reported
Studies not reported
Patients with intra-articular temporomandibular disorders (all diagnoses)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Left lateral movement
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified
MD -0.42 [-3.10, 2.26]
GRADE not reported
3 studies · 96 participants
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsMandibular movement: lateral only
Oral and maxillofacial clinics · Meta-regression moderator: Age (years)
Meta-regression coefficient (beta) 0.160 [0.056, 0.263]
GRADE not reported
Studies not reported
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsMaximum mouth opening (MMO)
Oral and maxillofacial clinics · Meta-regression moderator: Age (years)
Meta-regression coefficient (beta) -0.067 [-0.156, 0.021]
GRADE not reported
Studies not reported
Patients with intra-articular temporomandibular disorders (all diagnoses)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Masticatory efficiency
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified
MD 1.15 [0.22, 2.08]
Very low
Downgraded: risk of bias, imprecision, inconsistency
2 studies · 55 participants
Patients with intra-articular temporomandibular disorders (all diagnoses)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Protrusive movement
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified
MD 0.01 [-0.99, 1.02]
GRADE not reported
6 studies · 190 participants
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsMaximum incisal opening (MIO)
Oral and maxillofacial clinics · Meta-regression moderator: Age (years)
Meta-regression coefficient (beta) 0.302 [-0.231, 0.836]
GRADE not reported
Studies not reported
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsMaximum mouth opening (MMO)
Oral and maxillofacial clinics · Meta-regression moderator: Proportion of women
Meta-regression coefficient (beta) -0.681 [-3.831, 2.470]
GRADE not reported
Studies not reported
Patients with intra-articular temporomandibular disorders (all diagnoses)Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsOther treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsPain intensity (VAS)
Oral and maxillofacial clinics · Meta-regression moderator: Age (years)
Meta-regression coefficient (beta) -0.028 [-0.125, 0.069]
GRADE not reported
Studies not reported
Patients with TMJ disc displacementTMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Maximum mouth opening (MMO)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified · Disc displacement
SMD -0.48 [-1.10, 0.14]
GRADE not reported
7 studies · 272 participants
Patients with TMJ disc displacementTMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Maximum incisal opening (MIO)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified · Disc displacement
SMD -5.07 [-7.38, -2.75]
GRADE not reported
6 studies · 173 participants
Patients with TMJ disc displacementTMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Pain intensity (VAS)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified · Disc displacement
MD -0.79 [-2.10, 0.51]
GRADE not reported
13 studies · 488 participants
Patients with TMJ osteoarthritisTMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Maximum incisal opening (MIO)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified · Osteoarthritis
SMD -1.33 [-3.42, 0.76]
GRADE not reported
4 studies · 108 participants
Patients with TMJ osteoarthritisTMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Maximum mouth opening (MMO)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified · Osteoarthritis
SMD -1.27 [-2.87, 0.33]
GRADE not reported
4 studies · 113 participants
Patients with TMJ osteoarthritisTMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Pain intensity (VAS)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified · Osteoarthritis
MD 0.39 [-0.97, 1.74]
GRADE not reported
7 studies · 190 participants
Patients with TMJ arthralgiaTMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Maximum mouth opening (MMO)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified · Arthralgia
SMD -0.30 [-0.76, 0.17]
GRADE not reported
2 studies · 104 participants
Patients with TMJ arthralgiaTMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Pain intensity (VAS)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified · Arthralgia
MD -0.22 [-1.53, 1.09]
GRADE not reported
2 studies · 97 participants
Patients with other TMJ pathologies (juvenile idiopathic arthritis, condylar fracture, TMJ dysfunction syndrome, internal derangement)TMJ arthrocentesis, alone or with adjunctive intra-articular agentsOther therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols)Pain intensity (VAS)
Follow-up from 1 month to 5 years across trials (mean 53 weeks) · Not specified · Other pathologies
MD 0.60 [-0.27, 1.48]
GRADE not reported
4 studies · 172 participants

Included primary studies 33

Open in Studies
StudyYearAlso included byOutcomes it informs hereTrial data
Karadayi 2021
Randomised controlled trial of arthrocentesis with or without PRF for internal derangement of the TMJ.
PMID:33581954
20214 other reviewsPain intensity (VAS); Maximum incisal opening (MIO)not extracted yet
Comert Kilic 2016 A
Is arthrocentesis plus platelet-rich plasma superior to arthrocentesis plus hyaluronic acid for the treatment of temporomandibular joint…
PMID:27364372
20163 other reviewsProtrusive movement; Maximum incisal opening (MIO); Masticatory efficiency; Overall mandibular movement; Mandibular movement: lateral onlynot extracted yet
Isik 2022
Injectable platelet-rich fibrin as treatment for temporomandibular joint osteoarthritis: A randomized controlled clinical trial.
PMID:35798596
20223 other reviewsPain intensity (VAS); Mandibular movement: contralateral; Protrusive movement; Maximum mouth opening (MMO); Overall mandibular movement; Ipsilateral movementnot extracted yet
Abbadi 2022
Arthrocentesis, Injectable Platelet-Rich Plasma and Combination of Both Protocols of Temporomandibular Joint Disorders Management: A…
PMID:36523721
20222 other reviewsPain intensity (VAS); Maximum mouth opening (MMO)not extracted yet
Bayramoglu 2023
Does intra-articular injection of tenoxicam after arthrocentesis heal outcomes of temporomandibular joint osteoarthritis? A randomized…
PMID:36890529
20232 other reviewsPain intensity (VAS); Maximum mouth opening (MMO)not extracted yet
Bergstrand 2019
Long-term effectiveness of arthrocentesis with and without hyaluronic acid injection for treatment of temporomandibular joint…
PMID:30814387
20192 other reviewsPain intensity (VAS); Mandibular movement: contralateral; Protrusive movement; Maximum incisal opening (MIO); Overall mandibular movement; Mandibular movement: lateral onlynot extracted yet
Dasukil 2022
Intra-articular injection of hyaluronic acid versus platelet-rich plasma following single puncture arthrocentesis for the management of…
PMID:36372680
20222 other reviewsPain intensity (VAS); Maximum mouth opening (MMO)not extracted yet
Ghoneim 2021
Treatment of temporomandibular joint disc displacement using arthrocentesis combined with injectable platelet rich fibrin versus…
PMID:35028072
20222 other reviewsPain intensity (VAS); Maximum incisal opening (MIO); Overall mandibular movement; Right lateral movement; Left lateral movementnot extracted yet
Yapici-Yavuz 2018
A comparison of the effects of Methylprednisolone Acetate, Sodium Hyaluronate and Tenoxicam in the treatment of non-reducing disc…
PMID:29680845
20182 other reviewsPain intensity (VAS); Maximum mouth opening (MMO)not extracted yet
Chandra 2021
Minimally invasive intraarticular platelet rich plasma injection for refractory temporomandibular joint dysfunction syndrome in comparison…
PMID:34017736
20211 other reviewPain intensity (VAS); Maximum incisal opening (MIO)not extracted yet
Olsen-Bergem 2014
A cohort study of patients with juvenile idiopathic arthritis and arthritis of the temporomandibular joint: outcome of arthrocentesis with…
PMID:24794763
20141 other reviewPain intensity (VAS)not extracted yet
Yilmaz 2019
Comparison of treatment efficacy between hyaluronic acid and arthrocentesis plus hyaluronic acid in internal derangements of…
PMID:31451342
20191 other reviewPain intensity (VAS)not extracted yet
Alpaslan 2001
Efficacy of temporomandibular joint arthrocentesis with and without injection of sodium hyaluronate in treatment of internal derangements.
PMID:11381380
2001this review onlyOverall mandibular movement; Mandibular movement: lateral onlynot extracted yet
Ansar 2022
Prognostic criteria for the management of temporomandibular disorders using arthrocentesis with normal saline and arthrocentesis with…
PMID:35815075
2022this review onlyPain intensity (VAS); Maximum mouth opening (MMO)not extracted yet
Bayramoglu 2019
Comparison of single- and double-puncture arthrocentesis for the treatment of temporomandibular joint disorders: A six-month, prospective…
PMID:31021311
2021this review onlyMaximum mouth opening (MMO)not extracted yet
Bhargava 2019
Ultrasound-guided arthrocentesis using single-puncture, double-lumen, single-barrel needle for patients with temporomandibular joint acute…
PMID:30923970
2019this review onlyPain intensity (VAS)not extracted yet
Comert Kilic 2016 B
Does Injection of Corticosteroid After Arthrocentesis Improve Outcomes of Temporomandibular Joint Osteoarthritis? A Randomized Clinical…
PMID:27376184
2016this review onlyPain intensity (VAS); Protrusive movement; Maximum incisal opening (MIO); Masticatory efficiency; Overall mandibular movement; Mandibular movement: lateral onlynot extracted yet
Folle 2018
Double puncture versus single puncture arthrocentesis for the management of unilateral temporomandibular joint disc displacement without…
PMID:30446325
2018this review onlyPain intensity (VAS)not extracted yet
Fridrich 1996
Prospective comparison of arthroscopy and arthrocentesis for temporomandibular joint disorders.
PMID:8676225
1996this review onlyMaximum incisal opening (MIO)not extracted yet
Gorrela 2017
Efficacy of Temporomandibular Joint Arthrocentesis with Sodium Hyaluronate in the Management of Temporomandibular Joint Disorders: A…
PMID:29038631
2017this review onlyPain intensity (VAS); Maximum mouth opening (MMO)not extracted yet
Goudot 2000
Improvement of pain and function after arthroscopy and arthrocentesis of the temporomandibular joint: a comparative study.
PMID:10851672
2000this review onlynot statednot extracted yet
Grossmann 2020
Comparison of two needles arthrocentesis versus double needle cannula arthrocentesis in the treatment of temporomandibular disc…
PMID:32475229
2022this review onlyPain intensity (VAS); Maximum incisal opening (MIO)not extracted yet
Grossmann 2021
Comparison between TMJ arthrocentesis techniques with different needle positions: A randomized single-blind controlled clinical trial.
PMID:33642116
2021this review onlyProtrusive movement; Maximum incisal opening (MIO); Overall mandibular movement; Right lateral movement; Left lateral movementnot extracted yet
Gupta 2023
Role of Intra-articular Piroxicam in the Temporomandibular Joint After Arthrocentesis for Anterior Disc Displacement Without Reduction.
PMID:36891013
2023this review onlyProtrusive movement; Maximum mouth opening (MMO); Overall mandibular movement; Mandibular movement: lateral onlynot extracted yet
Marzook 2019
Intra-articular injection of a mixture of hyaluronic acid and corticosteroid versus arthrocentesis in TMJ internal derangement.
PMID:31121331
2020this review onlyPain intensity (VAS); Maximum incisal opening (MIO); Overall mandibular movement; Right lateral movement; Left lateral movementnot extracted yet
Nogami 2014
Clinical comparison between arthrocentesis and conventional conservative treatment with maxillomandibular fixation for unilateral high…
PMID:24372314
2014this review onlyPain intensity (VAS)not extracted yet
Ohrnell Malekzadeh 2019
Conservative therapy versus arthrocentesis for the treatment of symptomatic disk displacement without reduction: a prospective randomized…
PMID:31027963
2019this review onlyPain intensity (VAS); Maximum mouth opening (MMO)not extracted yet
Onder 2009
Long-term results of arthrocentesis in degenerative temporomandibular disorders.
PMID:18996032
2009this review onlyPain intensity (VAS); Maximum mouth opening (MMO)not extracted yet
Rajput 2020
A Comparative Analysis of Intra-articular Injection of Platelet-Rich Plasma and Arthrocentesis in Temporomandibular Joint Disorders.
PMID:35400915
2022this review onlyPain intensity (VAS); Maximum mouth opening (MMO)not extracted yet
Sivri 2016
Comparison of ultrasound-guided and conventional arthrocentesis of the temporomandibular joint.
PMID:27118616
2016this review onlyPain intensity (VAS); Maximum incisal opening (MIO)not extracted yet
Tang 2023
Arthrocentesis versus non-surgical intervention as initial treatment for temporomandibular joint arthralgia: a randomized controlled trial…
PMID:36117007
2023this review onlyPain intensity (VAS)not extracted yet
Tatli 2017
Comparison of the effectiveness of three different treatment methods for temporomandibular joint disc displacement without reduction.
PMID:28222947
2017this review onlyPain intensity (VAS); Mandibular movement: contralateral; Maximum mouth opening (MMO); Overall mandibular movement; Ipsilateral movementnot extracted yet
Vos 2014
Arthrocentesis as initial treatment for temporomandibular joint arthropathy: a randomized controlled trial.
PMID:23994055
2014this review onlyPain intensity (VAS); Maximum mouth opening (MMO)not extracted yet

Overlap with other reviews

Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.

Review question

ElementPlanned (methods)Found (results)
PopulationPatients diagnosed with intra-articular temporomandibular disordersTMD patients: disc displacement, osteoarthritis, arthralgia, other pathologies; 1247 patients (640 arthrocentesis, 607 comparators) in 32 trials
InterventionTemporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agentsArthrocentesis alone or with hyaluronic acid, PRP, i-PRF, corticosteroids or NSAIDs (n=32)
ComparisonConservative therapies (occlusal splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocolsSplints and conservative care, intra-articular injections, arthroscopy, other arthrocentesis protocols (n=32)
OutcomesPain intensity (VAS); maximum mouth opening, maximum incisal opening, mandibular movements, masticatory efficiencyVAS (n=26), MMO (n=14), MIO (n=11), masticatory efficiency (n=2), mandibular movements (n=22)
Study designsRandomized controlled trials32 RCTs (Table 1 lists 33 trials)
TimingNot specifiedFollow-up 1 to 24 months; mean 53 weeks

AMSTAR 2 items

Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.

ItemExtractor AExtractor BAgree
1Research question includes PICO componentsYesYesyes
2Protocol established before the reviewcriticalPartial YesYesno
3Choice of study designs explainedNoNoyes
4Comprehensive literature searchcriticalNoPartial Yesno
5Study selection in duplicateYesYesyes
6Data extraction in duplicateYesYesyes
7List of excluded studies with reasonscriticalYesYesyes
8Included studies described in detailYesYesyes
9Risk of bias assessed satisfactorilycriticalRCT: Yes · NRSI: N/ANRSI: N/A · RCT: Yesno
10Funding of included studies reportedNoNoyes
11Appropriate meta-analysis methodscriticalRCT: No · NRSI: N/ANRSI: N/A · RCT: Nono
12Impact of risk of bias on the pooled resultsNoNoyes
13Risk of bias accounted for in interpretationcriticalYesYesyes
14Heterogeneity explainedYesYesyes
15Publication bias investigatedcriticalNoNoyes
16Conflicts of interest reportedYesYesyes
OverallCritically LowCritically Lowyes