Primary study · included by 4 reviews

Injectable platelet-rich fibrin as treatment for temporomandibular joint osteoarthritis: A randomized controlled clinical trial.

Isik 2022 · Işık Gözde, Kenç Selin, Özveri Koyuncu Banu, et al. · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery · 2022

Included by

Effectiveness of Platelet-Rich Fibrin for Temporomandibular Disorders Management: A Systematic and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Isik 2022 · Fig. 3 and Fig. 4 forest plots; Supplementary Table 2; reference list

The review does not say which of its outcomes this study informs.

Efficacy and Safety of Intra-Articular Therapies for Temporomandibular Disorders: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Isik 2022 · Supplement S2; reference list

The review does not say which of its outcomes this study informs.

Outcome this study informsPooled effectEvidenceCertainty
Mandibular movement: protrusive
Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agents vs Other treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocols
Meta-regression coefficient (beta) -0.021 [-0.501, 0.460]NRGRADE not reported
Mandibular movement: protrusive
Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agents vs Other treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocols
Meta-regression coefficient (beta) -15.246 [-134.135, 103.644]NRGRADE not reported
Pain intensity (VAS)
Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agents vs Other treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocols
Meta-regression coefficient (beta) -1.609 [-5.033, 1.816]NRGRADE not reported
Ipsilateral movement
TMJ arthrocentesis, alone or with adjunctive intra-articular agents vs Other therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols) · Follow-up from 1 month to 5 years across trials (mean 53 weeks)
MD -0.14 [-1.02, 0.75]2 studies · 116 participantsGRADE not reported
Mandibular movement: contralateral
Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agents vs Other treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocols
Meta-regression coefficient (beta) -14.225 [-29.918, 0.469]NRGRADE not reported
Mandibular movement: contralateral
Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agents vs Other treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocols
Meta-regression coefficient (beta) 0.074 [-0.187, 0.336]NRGRADE not reported
Overall mandibular movement
TMJ arthrocentesis, alone or with adjunctive intra-articular agents vs Other therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols) · Follow-up from 1 month to 5 years across trials (mean 53 weeks)
MD -0.40 [-0.93, 0.14]22 studies · 796 participantsVery low
Maximum mouth opening (MMO)
TMJ arthrocentesis, alone or with adjunctive intra-articular agents vs Other therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols) · Follow-up from 1 month to 5 years across trials (mean 53 weeks)
SMD -0.67 [-1.14, -0.20]14 studies · 549 participantsLow
Contralateral movement
TMJ arthrocentesis, alone or with adjunctive intra-articular agents vs Other therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols) · Follow-up from 1 month to 5 years across trials (mean 53 weeks)
MD 0.04 [-0.50, 0.58]3 studies · 153 participantsGRADE not reported
Pain intensity (VAS)
TMJ arthrocentesis, alone or with adjunctive intra-articular agents vs Other therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols) · Follow-up from 1 month to 5 years across trials (mean 53 weeks)
MD -0.25 [-1.09, 0.59]26 studies · 947 participantsVery low
Maximum mouth opening (MMO)
Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agents vs Other treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocols
Meta-regression coefficient (beta) -0.067 [-0.156, 0.021]NRGRADE not reported
Protrusive movement
TMJ arthrocentesis, alone or with adjunctive intra-articular agents vs Other therapeutic modalities (conservative therapy, intra-articular injections, arthroscopy, alternative arthrocentesis protocols) · Follow-up from 1 month to 5 years across trials (mean 53 weeks)
MD 0.01 [-0.99, 1.02]6 studies · 190 participantsGRADE not reported
Pain intensity (VAS)
Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agents vs Other treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocols
Meta-regression coefficient (beta) -0.028 [-0.125, 0.069]NRGRADE not reported
Maximum mouth opening (MMO)
Temporomandibular joint arthrocentesis, alone or with adjunctive intra-articular agents vs Other treatments: conservative therapy (splints, physiotherapy, drugs), intra-articular injections, arthroscopy, or alternative arthrocentesis protocols
Meta-regression coefficient (beta) -0.681 [-3.831, 2.470]NRGRADE not reported

The review does not say which of its outcomes this study informs.

4 including reviews in total.