Search review questions

Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Dental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania, Study design: cohort

Untreated dental caries (d component), continuous · Brazilian children/adolescents (BMI classified by WHO 2007 Z-score) · Brazil

Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) · 5 to 10 weeks

Child oral health behaviours · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Countries with highest life expectancy, Life expectancy: highest (>80 years)

Adverse events for mother or child · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,…

Muscle pain at rest · People with temporomandibular disorders (TMD) · Short term (mean 4.4 weeks), Myofascial pain TMD

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months

Rotation of the mandibular second permanent molar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), University clinics and hospitals in 8 countries (children/adolescents <18 years), Mandible

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · GNI $5000-$9999, GNI $5000-$9999

Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… · Children assessed at 2-3 yrs

Overall success (composite of clinical and radiographic success) · Mature permanent teeth with irreversible pulpitis and carious pulp exposure (treated with full pulpotomy) · >=12 months

Aesthetics · Children and adults (with or without carious lesions)

Early childhood caries (ECC) · Children aged <6 years · Community/population-based; multiple countries, Sample size: ≥300

dmft index score · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 6 yrs

Streptococcus mutans count (CFU/mL) · Children and/or adolescents (<18 years) without background systemic disease · follow-up: mean 4.4 months, Healthy children and/or adolescents (<18 years) without systemic disease; RCTs from multiple countries (India, Thailand, Spain, Australia, New Zealand, Sweden, Poland, Colombia, Saudi Arabia); mostly school/community and clinic settings, Overall (all presentations pooled)

Bacterial growth inhibition (MIC/MBC) · Streptococcus mutans (in vitro cultures and biofilms) · in vitro (laboratory)

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India), Primary dentition

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), University clinics and hospitals in 8 countries (children/adolescents <18 years), Mandible

Pocket closure · Adults (> 18 years) with peri-implant mucositis, receiving active treatment

Dental caries (meta of mixed phenotypes: present-study self-report + GLIDE clinical DMFS + UKB self-report/dentures) · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK… · Lifelong (germline genotype), Population-based genetic association study (Japanese direct-to-consumer cohort + European GLIDE/UKB cohorts), Meta-analysis: present study + GLIDE + UKB

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings, Study design: cross-sectional

Change in probing pocket depth (PPD) · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care · 6 months (change from baseline)

Patient satisfaction · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care

Severity of joint noise · People with temporomandibular disorders (TMD)

Spontaneous space closure · Children and adolescents (<18 years) after extraction of a permanent first molar before eruption of the permanent… · Until eruption of the permanent second molar (median follow-up 4.0 years), University clinics and hospitals in 8 countries (children/adolescents <18 years), Overall

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India), Real-time quantitative PCR genotyping

Difficulty in mouth opening (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Dental pain or sensitivity · Children and adults (with or without carious lesions)

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

Serum 25-hydroxyvitamin D level · Preschool children ≤6 years

Dental caries prevalence (DMF/dmf score > 0) · Institutionalized orphan children (roughly 3 to 18 years) · Orphanages/childcare institutions in low- and middle-income countries (India, Iran, China, Yemen, Egypt, Lithuania, Malaysia), Overall (pooled)

Caries arrest · Children and adults (with or without carious lesions) · Permanent dentition

Gingival bleeding index · Children and/or adolescents (<18 years) without background systemic disease · 1.5 months, Healthy children and/or adolescents (<18 years) without systemic disease; RCTs from multiple countries (India, Thailand, Spain, Australia, New Zealand, Sweden, Poland, Colombia, Saudi Arabia); mostly school/community and clinic settings, Single study (Borrell 2021); not pooled

Frequency of joint noise · People with temporomandibular disorders (TMD)

Salivary TNF-α level (pg/mL) · Children and young adults (3-25 years) · Observational studies in children and young adults across nine countries (saliva-based cytokine comparison)

Discomfort · People with temporomandibular disorders (TMD)

Early childhood caries (ECC) · Preschool children ≤6 years, North America · North America

Dental caries (ECC) · Preschool children under 6 years of age · First dental examination before age 6 years, Clinical, field, or unclear dental examination settings, Cohort studies; sensitivity analysis excluding studies 35, 42, and 48

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months

Bacterial adhesion or initial colonization · Streptococcus mutans cultures and biofilms · In vitro laboratory studies

Dental caries experience (DMFT), continuous · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts) · Brazil

Difficulty in swallowing (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Self-reported joint pain when chewing · People with temporomandibular disorders (TMD) · Short term (10 weeks), Mixed TMD

Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) · 8 to 12 weeks

Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms) · in vitro (laboratory)

High salivary S. mutans (over 10^4 CFU/ml) · Adults · Salivary/plaque microbiology samples from case-control studies, Overall

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment