Non-Cochrane · aetiology · PM38477801
Overweight/obesity and dental caries in Brazilian children and adolescents: a systematic review and meta-analysis.
Pizzi Julia Faria, Carrada Camila Faria, Zeferino Maria Vitória de Sá, et al. · Brazilian oral research · 2024 · PubMed · doi:10.1590/1807-3107bor-2024.vol38.0015
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
16
current version
GRADE rated
16
No studies
0
Included studies
51
linked below
No studies 0 · 0%Ungraded 0 · 0%Very low 12 · 75%Low 3 · 18.8%Moderate 1 · 6.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Children and adolescents <=19 years, both sexes, any race/SES/region in Brazil | Brazilian children and adolescents aged 12 months to 19 years (n=41 studies; primary and permanent dentition) |
| Intervention | Overweight and/or obesity defined using BMI (Body Mass Index) | Overweight, obesity, and combined overweight/obesity by BMI using multiple reference curves (CDC 2000, WHO 2006, WHO 2007, IOTF/Cole, NCHS, Conde & Monteiro, Hammer) |
| Comparison | Normal weight (eutrophic) | Normal weight (eutrophic) |
| Outcomes | Dental caries experience diagnosed by standardized visual indices (DMFT/dmft, dft, dmfs, ECC, ICDAS, decayed component) | Dental caries by DMFT/dmft (experience and prevalence) and untreated caries (d component); continuous (MD) and dichotomous (OR) |
| Study designs | Observational studies (cross-sectional, case-control, cohort) and clinical trials | 37 cross-sectional, 3 cohort, 1 case-control (n=41) |
| Timing | No restriction on publication year or language | Included studies published 2008-2021 |
Search date: July 2023 (Methods); abstract states up to June 2022. Databases: Cochrane Library, LILACS, PubMed, Embase, Scopus, Web of Science, SciELO; grey literature: Open Grey, Google Scholar
Questions and results
Overweight vs Normal weight (eutrophic)
Population: Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries experience (dmft), continuous Overweight may make little or no difference to caries experience (dmft) in the primary dentition of Brazilian children (very low certainty). Source: Figure 2; Table 8 (CDC 2000_Overweight_dmft_Mean) · same question in other reviews | MD 0.31 [-0.10, 0.73] | 2 studies · 734 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Dental caries prevalence (any dmft), dichotomous Overweight may make little or no difference to the odds of dental caries in the primary dentition (very low certainty). Source: Figure 4; Table 8 (CDC 2000_Overweight_dmft_Dichotomous) · same question in other reviews | OR 1.02 [0.69, 1.53] 5 [-89, 106] per 1,000 | 2 studies · 734 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Overweight vs Normal weight (eutrophic)
Population: Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries experience (DMFT), continuous Overweight may make little or no difference to caries experience (DMFT) in the permanent dentition (very low certainty). Source: Figure 3; Table 8 (CDC 2000_Overweight_DMFT_Mean) · same question in other reviews | MD -0.06 [-1.03, 0.91] | 2 studies · 446 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Dental caries prevalence (any DMFT), dichotomous Overweight may make little or no difference to the odds of caries in the permanent dentition (very low certainty). Source: Figure 5; Table 8 (CDC 2000_Overweight_DMFT_Dichotomous) · same question in other reviews | OR 1.01 [0.43, 2.35] 2 [-208, 175] per 1,000 | 2 studies · 706 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Obesity vs Normal weight (eutrophic)
Population: Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries experience (dmft), continuous Obesity may make little or no difference to caries experience (dmft) in the primary dentition (very low certainty). Source: Figure 7; Table 8 (CDC 2000_Obesity_dmft_Mean) · same question in other reviews | MD -0.34 [-0.96, 0.27] | 2 studies · 710 participants | Very low Downgraded: risk of bias, indirectness |
Dental caries prevalence (any dmft), dichotomous The evidence is very uncertain about the effect of obesity on caries odds in the primary dentition (very low certainty). Source: Figure 9; Table 8 (CDC 2000_Obesity_dmft_Dichotomous) · same question in other reviews | OR 0.44 [0.08, 2.61] -183 [-382, 232] per 1,000 | 2 studies · 709 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Obesity vs Normal weight (eutrophic)
Population: Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries prevalence (any DMFT), dichotomous Normal-weight adolescents in the permanent dentition probably have greater odds of dental caries than obese peers (OR 2.53; moderate certainty). Source: Figure 10; Table 8 (CDC 2000_Obesity_DMFT_Dichotomous) · same question in other reviews | OR 2.53 [1.49, 4.29] 187 [89, 259] per 1,000 | 2 studies · 659 participants | Moderate Downgraded: risk of bias, indirectness |
Dental caries experience (DMFT), continuous Normal-weight adolescents may have higher caries experience (DMFT) than obese peers in the permanent dentition, but the evidence is very uncertain (very low certainty). Source: Figure 8; Table 8 (CDC 2000_Obesity_DMFT_Mean) · same question in other reviews | MD 0.61 [0.08, 1.15] | 2 studies · 659 participants | Very low Downgraded: risk of bias, indirectness |
Overweight/obesity (combined) vs Normal weight (eutrophic)
Population: Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries prevalence (any dmft), dichotomous The evidence is very uncertain about the effect of overweight/obesity on caries odds in the primary dentition (very low certainty). Source: Figure 12; Table 8 (CDC 2000_Overweight and Obesity_dmft_Dichotomous) · same question in other reviews | OR 0.83 [0.45, 1.54] -45 [-179, 108] per 1,000 | 2 studies · 826 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Overweight/obesity (combined) vs Normal weight (eutrophic)
Population: Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries prevalence (any DMFT), dichotomous The evidence is very uncertain about the effect of overweight/obesity on caries odds in the permanent dentition (very low certainty). Source: Figure 13; Table 8 (CDC 2000_Overweight and Obesity_DMFT_Dichotomous) · same question in other reviews | OR 1.18 [0.71, 1.95] 36 [-81, 132] per 1,000 | 3 studies · 1377 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |
Overweight vs Normal weight (eutrophic)
Population: Brazilian children/adolescents (BMI classified by WHO 2007 Z-score)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Untreated dental caries (d component), continuous Overweight may make little or no difference to untreated dental caries (low certainty). Source: Figure 6; Table 5 (WHO 2007 Z Score_Overweight_D_Mean) · same question in other reviews | MD 0.03 [-0.24, 0.30] | 2 studies · 515 participants | Low Downgraded: risk of bias |
Obesity vs Normal weight (eutrophic)
Population: Brazilian children/adolescents (BMI classified by WHO 2007 Z-score)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Untreated dental caries (d component), continuous Obesity may make little or no difference to untreated dental caries (low certainty). Source: Figure 11; Table 5 (WHO 2007 Z Score_Obesity_D_Mean) · same question in other reviews | MD 0.28 [-0.03, 0.59] | 2 studies · 456 participants | Low Downgraded: risk of bias |
Overweight/obesity (combined) vs Normal weight (eutrophic)
Population: Brazilian children/adolescents in permanent dentition (BMI classified by WHO 2007 Z-score)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries prevalence (any DMFT), dichotomous Overweight/obesity may make little or no difference to the odds of caries in the permanent dentition (low certainty). Source: Figure 14; Table 5 (WHO 2007 Z Score_Overweight and Obesity_DMFT_Dichotomous) · same question in other reviews | OR 0.93 [0.78, 1.12] | 2 studies | Low |
Overweight/obesity (combined) vs Normal weight (eutrophic)
Population: Brazilian children/adolescents (BMI classified by WHO 2007 percentile)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries prevalence (any DMFT), dichotomous The evidence is very uncertain about the effect of overweight/obesity on caries odds (WHO 2007 percentile; very low certainty). Source: Figure 15; Table 6 (WHO 2007 Percentile_Overweight and Obesity_DMFT_Dichotomous) · same question in other reviews | OR 0.83 [0.35, 1.94] -46 [-255, 147] per 1,000 | 2 studies · 355 participants | Very low Downgraded: imprecision, inconsistency |
Overweight/obesity (combined) vs Normal weight (eutrophic)
Population: Brazilian children under 5 years in primary dentition (BMI classified by WHO 2006 Z-score)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries prevalence (any dmft), dichotomous The evidence is very uncertain about the effect of overweight/obesity on caries odds in the primary dentition (WHO 2006 Z-score; very low certainty). Source: Figure 16; Table 7 (WHO 2006 Z Score_Overweight and Obesity_dmft_Dichotomous) · same question in other reviews | OR 0.86 [0.60, 1.22] | 3 studies | Very low Downgraded: risk of bias, inconsistency, indirectness |
Overweight/obesity (combined) vs Normal weight (eutrophic)
Population: Brazilian children/adolescents in permanent dentition (BMI classified by WHO 2006 Z-score)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries prevalence (any DMFT), dichotomous A meta-analysis of 2 studies (permanent dentition, WHO 2006 Z-score) was rated very low certainty; the pooled effect was not shown in the article. Source: Table 7 (WHO 2006 Z Score_Overweight and Obesity_DMFT_Dichotomous) · same question in other reviews | Pooled effect not estimable (not shown in article); I2=85%; Very low | 2 studies | Very low Downgraded: inconsistency |
Included primary studies 51
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Jamelli et al. 2010 matched by author and year (probable) | 2 other reviews | not stated | not extracted yet | not extracted yet |
| Costa et al. 2013 matched by author and year (probable) | 1 other review | not stated | not extracted yet | not extracted yet |
| Freitas et al., 2014 matched by author and year (probable) | 1 other review | not stated | not extracted yet | not extracted yet |
| Lima 2016 matched by author and year (probable) | 1 other review | not stated | not extracted yet | not extracted yet |
| Oliveira et al. 2008 matched by author and year (probable) | 1 other review | not stated | not extracted yet | not extracted yet |
| Alves et al., 2013 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Antunes et al., 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Aragão et al. 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Aragao et al., 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Aranha et al., 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Araujo et al., 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Araujo et al., 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Assi et al., 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Aznar, 2015 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Barbosa et al., 2021 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Borges et al., 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Campos et al., 2011 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Carvalho et al., 2009 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Costa; Daher; Queiroz, 2013 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Crispim et al., 2010 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Fernández et al. 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Fernandez et al., 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Fraiz et al., 2019 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Frazão et al. 2014 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Frazao et al., 2014 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Gonçalves et al. 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Goncalves et al., 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Guaré et al. 2019 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Guare et al., 2019 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Jamelli; Rodrigues; Lira, 2010 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Lima et al., 2014 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Lima, 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Lock et al., 2019 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Martins et al., 2014 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Oliveira; Sheiham; Bonecker, 2008 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Pinto-Sarmento et al., 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Porcelli et al., 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Porcelli et al., 2019 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Rego et al., 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Ribeiro et al., 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Santos Junior et al., 2014 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Shqair et al., 2021 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Silva et al., 2013 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Silva et al., 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Silva, 2014 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Soares et al., 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Tambelini et al., 2010 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Tureli et al. 2010 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Tureli; Barbosa; Gaviao, 2010 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Vasconcelos et al., 2019 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Xavier et al., 2013 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match).