Search review questions

Time to alignment (alignment rate ratio) · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) · 6 months

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), University clinics and hospitals in 8 countries (children/adolescents <18 years), Mandible

GtfB/C and F-ATPase activity · Streptococcus mutans (in vitro cultures and biofilms) · in vitro (laboratory)

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · 3 to 6 months

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · Central/South America, Region: Central/South America

Range of mandibular motion · People with temporomandibular disorders (TMD) · Short term (6 weeks), Myofascial pain TMD

Adverse effects · Children and adults (with or without carious lesions) · 12 to 30 months, Adults

Pocket closure · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care · 3 months (change from baseline)

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · 49 countries worldwide; urban and rural communities, Overall (all regions)

Pain at 7 days · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 7 days

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (CC+AA vs CA), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment (9 to 15 months)

Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, North America · North America

Adverse effects (temporomandibular joint signs and symptoms) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment / follow-up

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months

Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), University clinics and hospitals in 8 countries (children/adolescents <18 years), Mandible

Joint pain at rest · People with temporomandibular disorders (TMD) · Short term, Osteoarthritis / mixed TMD

Oral disease prevalence · Adult residents of slum and non-slum urban settings in LMICs · LMIC slum and non-slum urban settings

Quality of life · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Bacterial growth inhibition · Streptococcus mutans cultures and biofilms · In vitro laboratory studies

Dental caries in children · Children (approx. 4-18 years) · Dental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings, Time period: 2018 and later

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (GG vs GA+AA), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India)

Quality of life · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care

Pain day 1 · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) · 7 to 14 days

Enamel demineralization / white spot lesions (DIAGNOdent, QLF) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35) · 1 to 6 months (to debonding), Orthodontic clinical practice (in-vivo human clinical trials); adolescents and adults

Dental pain or sensitivity · Children and adults (with or without carious lesions)

Recurrence rate · People with temporomandibular disorders (TMD)

Adverse effects (tooth staining; soft-tissue and systemic events) · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · up to 30 months, Children/adults with dental caries; multiple countries; community/clinic care setting not clearly specified

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India), PCR-RFLP genotyping

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India), Caucasian ethnicity

Swelling at 72 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement) · 72 hours

Negative predictive value · Children and adults with primary or permanent dentition undergoing dental caries assessment · Cross-sectional diagnostic accuracy (index test vs reference standard, in-vivo), In-vivo: dental clinics/hospitals, schools, and a juvenile detention facility (11 countries), Overall (studies reporting NPV; narrative synthesis)

Decayed surfaces (DS) · Periodontal disease severity (CDC-AAP); single study (Robert 2019); adjusted

Change in probing pocket depth (PPD) · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care · 3 months (change from baseline)

Percussion pain at 48 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or… · 48 hours

Early childhood caries experience (mean dmft) · Children younger than 71 months (under 6 years) · GNI $20000-$39999, GNI $20000-$39999

Change in gingival recession (REC) · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment · 6 months (change from baseline)

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Adverse effects · Children and adults (with or without carious lesions) · 24 hours to 30 months, Children

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · GNI $10000-$19999, GNI $10000-$19999

Early childhood caries (ECC) prevalence (%, dmft>0) · Children younger than 71 months (under 6 years) · Countries with low income inequality (Gini), Gini index: low inequality

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Severity of joint noise · People with temporomandibular disorders (TMD)

Untreated dental caries (d component), continuous · Brazilian children/adolescents (BMI classified by WHO 2007 Z-score) · Brazil

Early childhood caries (ECC) · Preschool children ≤6 years

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months

Self-perceived (self-rated) oral health status · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional, Urban slums and non-slum/general-urban settings, LMICs, By age, sex, socioeconomic class, employment