Search review questions

Adverse events · haemodialysis patients

Duration of hospital stay ‐ not reported · haemodialysis patients

Dialysis dysequilibrium syndrome · haemodialysis patients

Severe dialysis dysequilibrium syndrome · haemodialysis patients

Death · haemodialysis patients

Adverse events · haemodialysis patients

All‐cause death median · people with CKD and diabetes

3P‐MACE median · people with CKD and diabetes

4P‐MACE median · people with CKD and diabetes

Kidney composite outcome median · people with CKD and diabetes

Kidney failure median · people with CKD and diabetes

Hypoglycaemia requiring third‐party assistance median · people with CKD and diabetes

Diabetic ketoacidosis median · people with CKD and diabetes

Virologically confirmed dengue case incidence (any severity, any phenotype) · children and adults at risk of dengue infection

Prevalence of DENV infection (any severity, any phenotype)a · children and adults at risk of dengue infection

Prevalence of dengue RNA in the mosquito population · children and adults at risk of dengue infection

Mosquito density (for population suppression strategy) · children and adults at risk of dengue infection

Prevalence of Wolbachia‐carrying mosquitoes (for population replacement strategy) · children and adults at risk of dengue infection

Adverse events potentially related to Wolbachia‐carrying Aedes deployments · children and adults at risk of dengue infection

Difference between effect estimates from RCTs and observational studies [for RCTs vs OBSs] · systematic reviews and overviews of systematic reviews

Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Dental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania, Adjustment for sex: yes

Sensitivity · Children and adults with primary or permanent dentition undergoing dental caries assessment · Cross-sectional diagnostic accuracy (index test vs reference standard, in-vivo), In-vivo: dental clinics/hospitals, schools, and a juvenile detention facility (11 countries), Overall (studies reporting sensitivity; narrative synthesis)

Association between orthodontic treatment duration and ICLs incidence · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new… · During or after fixed orthodontic treatment, International (16 countries; studies published 2005-2022); orthodontic clinical settings, By orthodontic treatment duration (subgroup meta-analysis; positive association, P<.01)

Number of dental caries (carious pieces) · Children and/or adolescents (<18 years) without background systemic disease · follow-up: mean 26 months, Healthy children and/or adolescents (<18 years) without systemic disease; RCTs from multiple countries (India, Thailand, Spain, Australia, New Zealand, Sweden, Poland, Colombia, Saudi Arabia); mostly school/community and clinic settings, Overall (all presentations pooled)

defs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6…

Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · 3 weeks to 12 months, Children/adults with dental caries; multiple countries; community/clinic care setting not clearly specified, SDF vs placebo

Caries arrest · Children and adults (with or without carious lesions) · 6 months, Primary dentition (coronal)

Secondary prevention of caries · Children and adults (with or without carious lesions) · 30 months, Primary dentition

Dental caries (early childhood caries) · Preschool children (<6 years) · Preschool children in high- and middle-income countries; caries assessed in clinical or field/community settings, Cohort studies

Change in Mutans streptococci (MS) count in dental plaque · Generally healthy individuals across all age groups (infants to elderly) · Post-consumption endpoint (trial durations 2 wk to 6 mo), All age groups, generally healthy; multiple countries; sugar substitutes delivered as chewing gum, milk, candy, or tablets, Xylitol gum vs no treatment (5 studies, mixed ages)

Poor (inadequate) oral hygiene (prevalence) · Children (<18 years) with intellectual and developmental disabilities (IDD) in India · India (Karnataka, Tamil Nadu, Rajasthan, Maharashtra); schools/institutions and community, Overall

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India)

Restoration/treatment success rate · Patients with deep carious lesions in permanent (mainly posterior) teeth · 1 to 5 years (follow-up varied by study)

Range of mandibular motion · People with temporomandibular disorders (TMD) · Short term (12 weeks), Mixed TMD

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India), Primary dentition

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India), Asian ethnicity

Ion release (fluoride, calcium, phosphate) · Human enamel specimens around orthodontic brackets (in vitro) · 14 days [31] and 20 days [27,28] (per Discussion); ion-release durations for [23,24] not reported, In vitro (laboratory), Overall

Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… · Children assessed at 18-24 months

Streptococcus mutans count · Patients undergoing fixed orthodontic treatment · 1, 3, and 6 months after bonding, Fixed orthodontic treatment

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · 3-year follow-up

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Participant satisfaction · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Biofilm formation (reduction) · Streptococcus mutans (in vitro cultures and biofilms) · in vitro (laboratory)

Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch) · 4 to 16 weeks

dmft index score (decayed, missing, filled primary teeth; range 0-20) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes,… · Children assessed at 4 yrs

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India), Asian ethnicity

Biofilm formation · Streptococcus mutans cultures and biofilms · In vitro laboratory studies

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months

Noticeable impact of gene sequencing on diagnosing/managing oral conditions · Human patients (any age) with oral-cavity related disorders (e.g. dental caries, periodontitis, gingivitis,… · Various countries; clinical trials of the oral microbiome/genetics, Overall