Cochrane · systematic review · CD015636
Wolbachia ‐carrying Aedes mosquitoes for preventing dengue infection
Fox, T, Sguassero, Y, Chaplin, M, et al. · Cochrane Database of Systematic Reviews · 2024 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
1
No studies
5
Included studies
NR
No studies 5 · 83.3%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
wMel‐Wolbachia infected Aedes aegypti deployments compared to no deployments for preventing dengue virus infection
Population: children and adults at risk of dengue infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Virologically confirmed dengue case incidence (any severity, any phenotype) wMel‐Wolbachia infected Aedes aegypti deployments vs no deployments | no estimate extracted | NR | No studies |
Prevalence of DENV infection (any severity, any phenotype)a wMel‐Wolbachia infected Aedes aegypti deployments vs no deployments | OR 0.23 [0.15, 0.35] | 6306 participants | Moderate Downgraded: indirectness |
Prevalence of dengue RNA in the mosquito population wMel‐Wolbachia infected Aedes aegypti deployments vs no deployments | no estimate extracted | NR | No studies |
Mosquito density (for population suppression strategy) wMel‐Wolbachia infected Aedes aegypti deployments vs no deployments | no estimate extracted | NR | No studies |
Prevalence of Wolbachia‐carrying mosquitoes (for population replacement strategy) wMel‐Wolbachia infected Aedes aegypti deployments vs no deployments | no estimate extracted | NR | No studies |
Adverse events potentially related to Wolbachia‐carrying Aedes deployments wMel‐Wolbachia infected Aedes aegypti deployments vs no deployments | no estimate extracted | NR | No studies |