Search review questions

Dental caries experience in permanent dentition · Nigerian individuals with permanent dentition (approximately 12 years and older) · Community and school-based observational studies in Nigeria (12 of 14 in Southwest Nigeria), Permanent dentition

Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy · Prenatal exposure; dental caries assessed in children aged 2 to 8 years, Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey), Overall (all studies pooled)

Dental caries / early childhood caries (ECC) · Children (approx. 4-18 years) · Dental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania, Adjustment for sex: no

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Irreversible pulpitis

Proportion of teeth with non-carious cervical lesions (NCCLs) in ancient skulls · Ancient/prehistoric human skulls (excavated/archaeological skeletal remains) · Archaeological/museum skeletal (skull) collections; multiple countries and pre-industrial historical periods, Overall (all included studies)

Dental caries (prevalence) · Adults · Population-based and clinical dental study samples; multiple countries (1994-2022), Crude OR

Dental caries prevalence (any DMFT), dichotomous · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts) · Brazil

Factors associated with oral diseases · Adult residents of slums and non-slum urban settings of LMICs · Cross-sectional, Urban slums and non-slum/general-urban settings, LMICs

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years · Fluorosis assessed when most permanent teeth of interest had erupted (6 to 18 years)

Change in bleeding on probing (BOP) · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment · 3 months (change from baseline)

Muscle pain at rest · People with temporomandibular disorders (TMD)

Intra-examiner reliability · Children and adults with primary or permanent dentition · Schools, juvenile detention facility, dental clinics, and hospitals, Overall

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Cell damage or cytotoxicity · Streptococcus mutans cultures and biofilms · In vitro laboratory studies

Early childhood caries (ECC) · Children aged ≤6 years (early childhood) · Exposure and outcome assessed concurrently (observational); children aged ≤6 years, Children aged ≤6 years; multiple countries (Asia, Europe, Americas); dental/clinical and community settings, Sample size: <100 (Table 6; abstract text erroneously states '<1000')

Inter-examiner reliability · Children and adults with primary or permanent dentition undergoing dental caries assessment · Cross-sectional diagnostic accuracy (index test vs reference standard, in-vivo), In-vivo: dental clinics/hospitals, schools, and a juvenile detention facility (11 countries), Overall (studies reporting inter-examiner reliability; narrative synthesis)

Change in Mutans streptococci (MS) count in dental plaque · Generally healthy individuals across all age groups (infants to elderly) · Post-consumption endpoint (varied durations across trials), All age groups, generally healthy; multiple countries; sugar substitutes delivered as chewing gum, milk, candy, or tablets, Xylitol vs sorbitol (4 studies)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months

White spot lesion formation measured by QLF · Patients undergoing fixed orthodontic treatment · Before and after treatment, Fixed orthodontic treatment

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+GG vs TG), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India)

Antioxidant capacity · Streptococcus mutans (in vitro cultures and biofilms) · in vitro (laboratory)

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Pain at 72 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement) · 72 hours

Caries arrestment at the surface level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition) · 12 to 18 months, Children/adults with dental caries; multiple countries; community/clinic care setting not clearly specified, Overall (all comparators pooled)

Dental caries risk · Institutionalized orphan children · Orphanages/childcare institutions in low- and middle-income countries (India, Iran, China, Yemen, Egypt, Lithuania, Malaysia), Overall (pooled)

dmfs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6…

Range of mandibular motion · People with temporomandibular disorders (TMD) · Short term, Disc displacement (with/without reduction)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Unspecified/mixed diagnosis

Caries arrest · Children and adults (with or without carious lesions) · Permanent dentition (root)

Outcome NR · Adults with symptomatic apical periodontitis or acute apical abscess

Dental caries prevalence (any dmft), dichotomous · Brazilian children under 5 years in primary dentition (BMI classified by WHO 2006 Z-score) · Brazil

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months

Early childhood caries (ECC) · Children aged <6 years · Community/population-based; multiple countries, Time period: After 2018

Dental caries (prevalence) · Adults · Population-based and clinical dental study samples; multiple countries (1994-2022), Female

Dental caries - SNP-based heritability · Japanese adults (present-study cohort) · Lifelong (germline genotype), Population-based genetic association study (Japanese direct-to-consumer genetic testing cohort), LDSC heritability (present study)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure · >=12 months, Partial pulpotomy

Overall success (composite of clinical and radiographic success) · Full pulpotomy, unspecified/mixed diagnosis

Dental caries · Children aged 2 to 8 years · Maternal pregnancy to child age 2 to 8 years, Mostly developed countries (Europe and America), Meta-regression adjusted for gestational age, child age, and maternal vitamin D level

Caries arrestment at the tooth level · Children and adults without systemic diseases affecting dental health · 6 months to 12 months

Improvement in range of jaw movement · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (CC vs CT+TT), Children under 18 years; case-control and cross-sectional studies (China, Czech Republic, Turkey, Brazil, India)

Time to alignment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Dental caries prevalence (any dmft), dichotomous · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts) · Brazil

Caries arrest · Children and adults (with or without carious lesions) · Permanent dentition (coronal)

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF) · Less than 3 months

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion) · End of treatment

Caries arrest · Children and adults (with or without carious lesions) · 18 months, Primary dentition (coronal)

Time to alignment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Frequency of joint noise · People with temporomandibular disorders (TMD) · Short term (3 months), Myofascial pain TMD