Non-Cochrane · aetiology · PM38519922
Investigation of the presence of Non-carious cervical lesions (NCCLs) in ancient adult skulls: analyzing data from prehistoric and historical samples through a systematic review and meta-analysis.
Dioguardi Mario, Spirito Francesca, Lo Muzio Eleonora, et al. · BMC oral health · 2024 · PubMed · doi:10.1186/s12903-024-04154-4
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
2
current version
GRADE rated
0
No studies
0
Included studies
8
linked below
No studies 0 · 0%Ungraded 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Ancient or prehistoric human skulls (excavated/archaeological skeletal remains) with teeth assessable for cervical lesions | 6 studies of ancient skulls (805 skulls; 11,578 teeth in the 4-study teeth analysis); France, USA (x2), Chile, Italy (Mehrgarh, Pakistan site), New Zealand |
| Intervention | Presence of non-carious cervical lesions (NCCLs) (single-group; no intervention) | NCCL presence; NCCLs identified in only 2 of 6 studies (Bondioli 2012; Ritter 2009) |
| Comparison | None per protocol PICO; modern-era skulls used only as descriptive reference | Modern-era comparison samples reported in 2 studies (Aubry 2003; Aaron 2004): 81/436 modern skulls with NCCLs (descriptive, not pooled) |
| Outcomes | Proportion of teeth with NCCLs relative to total teeth in ancient skulls (and proportion of skulls with NCCLs) | Pooled proportion of teeth with NCCLs 0.004 (95% CI 0.001-0.006; 4 studies; crude 123/11,578); pooled proportion of skulls with NCCLs 0.014 (95% CI 0.001-0.027; 6 studies; crude 17/805, 2.11%) |
| Study designs | Studies reporting NCCL data on excavated ancient/prehistoric human skulls, distinguishing NCCLs from occlusal wear and caries (observational) | 6 observational studies of excavated skulls (publication years 2001-2015) |
| Timing | Ancient/prehistoric and historical, pre-industrial periods (before widespread toothbrush use) | Samples spanning Neolithic to late 19th century |
Search date: 16 August 2023 (PubMed keyword update 15 January 2024). Databases: PubMed, Scopus, Cochrane Library; grey literature: Google Scholar, Science Direct, OpenGrey
Questions and results
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)
Population: Ancient/prehistoric human skulls (excavated/archaeological skeletal remains)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of ancient skulls with at least one non-carious cervical lesion (NCCL) Overall (all included studies) About 1.4% of ancient skulls (pooled) had at least one NCCL; crude 17/805 (2.11%) across 6 studies (ungraded, substantial heterogeneity I2=69%). Source: Results 'Meta-analysis' (second meta-analysis); Fig. 3 caption; Table 1 (N ancient skulls / N with NCCL) · same question in other reviews | Proportion 0.014 [0.001, 0.027] | 6 studies · 805 participants | Ungraded |
Proportion of teeth with non-carious cervical lesions (NCCLs) in ancient skulls Overall (all included studies) Non-carious cervical lesions affected a pooled proportion of about 0.4% of teeth in ancient skulls (4 studies; ungraded, very high heterogeneity I2=97.6%). Source: Results 'Meta-analysis' (first meta-analysis); Fig. 2 caption; Table 1 (N teeth examined / N of NCCL) · same question in other reviews | Proportion 0.004 [0.001, 0.006] | 4 studies · 11578 participants | Ungraded |
Included primary studies 8
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Aaron 2004 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Aaron 2004 Radiochemical purity of a 99mTc-labeled pyrophosphate technescan PYP. PMID:200430 | this review only | not stated | not extracted yet | not extracted yet |
| Aubry et al. 2003 Brief communication: Study of noncarious cervical tooth lesions in samples of prehistoric, historic, and modern populations from the South… DOI:10.1002/ajpa.10210 | this review only | not stated | not extracted yet | not extracted yet |
| Bondioli 2012 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Bondioli et al. 2012 Hallervorden-Spatz syndrome. PMID:201232 | this review only | not stated | not extracted yet | not extracted yet |
| Kieser et al. 2001 Patterns of dental wear in the early Maori dentition DOI:10.1002/oa.534 | this review only | Proportion of ancient skulls with at least one non-carious cervical lesion (NCCL) | not extracted yet | not extracted yet |
| Ritter et al. 2009 Prevalence of Carious and Non‐carious Cervical Lesions in Archaeological Populations from North America and Europe DOI:10.1111/j.1708-8240.2009.00285.x | this review only | Proportion of ancient skulls with at least one non-carious cervical lesion (NCCL) | not extracted yet | not extracted yet |
| Urzua et al. 2015 Absence of Non-Carious Cervical Lesions (NCCLs) in a Chilean Pre-Columbian Sample with Severe Occlusal Tooth Wear DOI:10.4067/s0718-381x2015000100009 | this review only | not stated | not extracted yet | not extracted yet |