Non-Cochrane · aetiology · PM39026257
Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and meta-analysis.
Alarcón-Sánchez Mario Alberto, Becerra-Ruiz Julieta Sarai, Avetisyan Anna, et al. · BMC oral health · 2024 · PubMed · doi:10.1186/s12903-024-04560-8
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
3
current version
GRADE rated
0
No studies
0
Included studies
15
linked below
No studies 0 · 0%Ungraded 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Children and young adults up to 25 years assessed for dental caries with a predefined caries index (individuals with physical/intellectual disabilities excluded) | 1,148 children and young adults aged 3-25 years (743 exposure, 405 control) across 15 studies |
| Intervention | Moderate-severe active dental caries (exposure group) | Moderate-severe active dental caries (n=743) |
| Comparison | Caries-free or mild dental caries (control group) | Caries-free or mild caries (n=405) |
| Outcomes | Salivary levels of TNF-α, IL-6 and IL-8 (pg/mL) | Salivary TNF-α (7 studies), IL-6 (11 studies), IL-8 (7 studies) |
| Study designs | Observational human studies (cross-sectional, cohort); case reports/series, reviews and animal studies excluded | 14 cross-sectional studies and 1 cohort study (n=15) |
| Timing | Not specified | Not specified |
Search date: 15 February 2012 to 13 January 2024. Databases: PubMed/MEDLINE; Cochrane; Scopus; Google Scholar; hand search of selected dental journals
Questions and results
Moderate-severe active dental caries (exposure) vs Caries-free or mild dental caries (control)
Population: Children and young adults (3-25 years)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Salivary IL-6 level (pg/mL) Salivary IL-6 levels are significantly higher in children and young adults with active dental caries than in caries-free or mild-caries controls (SMD 11.60 pg/mL, 95% CI 6.27 to 16.94; 11 studies); ungraded. Source: Results, meta-analysis paragraph (IL-6); Fig. 3 (forest plot) · same question in other reviews | SMD 11.60 [6.27, 16.94] | 11 studies · 879 participants | Ungraded |
Salivary IL-8 level (pg/mL) Salivary IL-8 levels are higher in children and young adults with active dental caries than in controls but the difference is not statistically significant (SMD 57.20 pg/mL, 95% CI -18.60 to 133.00; 7 studies); ungraded. Source: Results, meta-analysis paragraph (IL-8); Fig. 4 (forest plot) · same question in other reviews | SMD 57.20 [-18.60, 133.00] | 7 studies · 522 participants | Ungraded |
Salivary TNF-α level (pg/mL) Salivary TNF-α levels are significantly higher in children and young adults with active dental caries than in caries-free or mild-caries controls (SMD 14.81 pg/mL, 95% CI 4.76 to 24.86; 7 studies); ungraded. Source: Results, meta-analysis paragraph (TNF-α); Fig. 2 (forest plot) · same question in other reviews | SMD 14.81 [4.76, 24.86] | 7 studies · 348 participants | Ungraded |
Included primary studies 15
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Mohammed 2021 matched by author and year (probable) | 1 other review | not stated | not extracted yet | not extracted yet |
| AL-Dahhan 2021 Assessment of Some Pro-Inflammatory Cytokines in Saliva of Dental Caries DOI:10.37506/ijfmt.v15i3.15765 | this review only | not stated | not extracted yet | not extracted yet |
| Biria 2023 Relationship between the salivary concentrations of proteinase-3 and interleukin-8 and severe early childhood caries. PMID:38108476 | this review only | not stated | not extracted yet | not extracted yet |
| Børsting 2022 Systematic assessment of salivary inflammatory markers and dental caries in children: an exploratory study. PMID:34875210 | this review only | not stated | not extracted yet | not extracted yet |
| Gornowicz 2012 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Leme 2022 Exploring the Relationship between Salivary Levels of TNF-α, Lactobacillus acidophilus, Lactobacillus gasseri, Obesity, and Caries in… PMID:35631100 | this review only | not stated | not extracted yet | not extracted yet |
| Lo Giudice 2019 Correlation of s-IgA and IL-6 Salivary with Caries Disease and Oral Hygiene Parameters in Children. PMID:31892186 | this review only | not stated | not extracted yet | not extracted yet |
| Nazemisalman 2018 Melaena with Peutz-Jeghers syndrome: a case report. PMID:20181116 | this review only | not stated | not extracted yet | not extracted yet |
| Nireeksha 2024 Potential role of salivary vitamin D antimicrobial peptide LL-37 and interleukins in severity of dental caries: an exvivo study. PMID:38218769 | this review only | not stated | not extracted yet | not extracted yet |
| Prasanna 2022 The effect of Caries, Periodontitis and Substance abuse on Salivary Interleukin - 6 levels DOI:10.33882/jida.15.30307 | this review only | not stated | not extracted yet | not extracted yet |
| Ramírez-De los Santos 2020 Alteration of cytokines in saliva of children with caries and obesity DOI:10.1007/s10266-020-00515-x | this review only | not stated | not extracted yet | not extracted yet |
| Ribeiro 2017 Proinflammatory cytokines in early childhood caries: Salivary analysis in the mother/children pair. PMID:29246654 | this review only | not stated | not extracted yet | not extracted yet |
| Rinderknecht 2022 Associations between salivary cytokines and oral health, age, and sex in healthy children. PMID:36163488 | this review only | not stated | not extracted yet | not extracted yet |
| Seyedmajidi 2015 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Sharma 2017 Diagnostic potential of inflammatory biomarkers in early childhood caries - A case control study. PMID:28579141 | this review only | not stated | not extracted yet | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match).
| Review | Shared studies | Jaccard |
|---|---|---|
| Distribution of initial caries lesions in relation to fixed orthodontic therapy. A systematic review and meta-analysis. (2024) | 1 | 0.02 |