What do systematic reviews say?

Acupuncture vs sham

• Acupuncture for treatment of irritable bowel syndrome 2012 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 253 participants
  Moderate

Palliative care vs usual care

• Palliative care interventions for people with multiple sclerosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 58 participants
  Very low

Exercise vs no exercise

• Physical exercise for people with cirrhosis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 81 participants
  Low

Chinese herbal medicines vs HT

• Chinese herbal medicine for menopausal symptoms 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 127 participants
  Very low

ANY FORM OF BRIEF PSYCHOEDUCATION vs CBT

• Psychoeducation (brief) for people with serious mental illness 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 63 participants
  Very low

Hospital‐based specialist palliative care vs usual care

• The effectiveness and cost‐effectiveness of hospital‐based specialist palliative care for adults with advanced illness… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 1344 participants
  Low

Intervention not reported

• High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 214 participants
  Very low

Dental caries vs Caries-free controls

OHRQoL was worse in individuals with dental caries on OHIP-14/ECOHIS/Michigan scales (pooled SMD 0.87; 6 studies); this estimate was not GRADE-rated.

• Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and Meta-analysis. 2023 All outcomes

  India; community-based and institutional settings across multiple states
  SMD 0.87 [0.34, 1.40]
  6 studies · 4511 participants
  Moderate

Bipolar hemiarthroplasty vs unipolar hemiarthroplasty

• Arthroplasties for hip fracture in adults 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 115 participants
  Very low

Individual TF‐CBT vs Brief PTSD psychoeducation

• Psychological interventions for post‐traumatic stress disorder (PTSD) in people with severe mental illness 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Botulinum toxin vs placebo

• Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Low

Primary health professionals and lay health workers vs usual care

• Primary‐level worker interventions for the care of people living with mental disorders and distress in low‐ and… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 53 participants
  Very low

Transurethral radiofrequency collagen denaturation vs no treatment/sham

Transurethral radiofrequency collagen denaturation showed no clear difference in disease‐specific quality of life: number of women with an I‐QOL… compared with no treatment/sham treatment (low certainty).

• Transurethral radiofrequency collagen denaturation for the treatment of women with urinary incontinence 2015 · Cochrane Headline outcomes only
  RR 1.11 [0.77, 1.62]
  1 study · 142 participants
  Low

Intervention not reported

It is very uncertain whether the intervention changes HRQoL Using EQ‐5D (range 0 to 1) and HOOS (range 0 to 100). A higher… (very low certainty).

• Interventions for improving mobility after hip fracture surgery in adults 2022 · Cochrane Headline outcomes only
  SMD 0.39
  4 studies · 314 participants
  Very low

Summary of findings table ‐ Platinum‐sensitive recurrent EOC: PARPi monotherapy vs placebo (maintenance therapy)

• Poly(ADP‐ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 339 participants
  Moderate

Primary health professionals and lay health workers vs usual care

• Primary‐level worker interventions for the care of people living with mental disorders and distress in low‐ and… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 53 participants
  Very low

Total hip arthroplasty vs hemiarthroplasty

• Arthroplasties for hip fracture in adults 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 279 participants
  Very low

Antidepressants vs placebo

Antidepressant probably leads to higher quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0… compared with placebo (moderate certainty).

• Antidepressants for hip and knee osteoarthritis 2022 · Cochrane Headline outcomes only
  MD 0.04 [0.01, 0.07]
  3 studies · 815 participants
  Moderate

Self‐management interventions vs usual care

Self management programmes showed no clear difference in quality of life Change scores/post intervention SF‐12 or ‐36:… compared with usual care (low certainty).

• Self management programmes for quality of life in people with stroke 2016 · Cochrane Headline outcomes only
  SMD 0.2 [0, 0.41]
  6 studies · 469 participants
  Low

Antihypertensive drug therapy vs placebo

• Pharmacological treatment of hypertension in people without prior cerebrovascular disease for the prevention of… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 15795 participants
  Very low