Cochrane · systematic review · CD004034
Pharmacological treatment of hypertension in people without prior cerebrovascular disease for the prevention of cognitive impairment and dementia
Cunningham, EL, Todd, SA, Passmore, P, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antihypertensive therapy compared to placebo for patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia
Population: participants without prior cerebrovascular disease for prevention of cognitive impairment and dementia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of cases of dementia Range of Antihypertensive therapy vs placebo | OR 0.89 [0.72, 1.07] | 4 studies · 15427 participants | Very low Downgraded: risk of bias, indirectness |
Change in cognitive score (MMSE) Range of Antihypertensive therapy vs placebo | no estimate extracted | 4 studies · 9435 participants | Very low Downgraded: imprecision, indirectness |
Change in systolic blood pressure level (mmHg) Range of Antihypertensive therapy vs placebo | no estimate extracted | 6 studies · 17793 participants | Low Downgraded: risk of bias, inconsistency |
Change in diastolic blood pressure level (mmHg) Range of Antihypertensive therapy vs placebo | no estimate extracted | 5 studies · 15209 participants | Low Downgraded: risk of bias, inconsistency |
Adverse effects Range of Antihypertensive therapy vs placebo | no estimate extracted | 6 studies · 16830 participants | Very low Downgraded: risk of bias, inconsistency |
Quality of life measured via Sickness Impact Profile, PGWB Positive well‐being, and EuroQoL Current Health Range of Antihypertensive therapy vs placebo | no estimate extracted | 5 studies · 15795 participants | Very low Downgraded: risk of bias, inconsistency |