Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Comparative impact of clear aligners versus fixed orthodontic appliances on periodontal health, pain, and quality of life: a systematic…. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| The impact of non-extraction orthodontic treatment on oral health-related quality of life: clear aligners versus fixed appliances-a randomized… Alfawal 2022 · Alfawal Alaa M H, Burhan Ahmad S, et al. · European journal of orthodontics PMID:35395075 | 2022 | 4 | 4 | not extracted yet |
| Periodontal health status in patients treated with the Invisalign(®) system and fixed orthodontic appliances: A 3 months clinical and… Levrini et al. 2015 · Levrini Luca, Mangano Alessandro, et al. · European journal of dentistry PMID:26430371 | 2015 | 4 | 3 | not extracted yet |
| Periodontal status of adult patients treated with fixed buccal appliances and removable aligners over one year of active orthodontic therapy. Karkhanechi et al. 2013 · Karkhanechi Marzieh, Chow Denise, et al. · The Angle orthodontist PMID:22725616 | 2013 | 4 | 5 | not extracted yet |
| Comparison of anxiety, pain, and quality of life in individuals with mild or moderate malocclusion between conventional fixed orthodontic treatment… Tunca 2024 · Tunca Yasemin, Kaya Yesim, et al. · BMC oral health PMID:38760747 | 2024 | 3 | 3 | not extracted yet |
| Comparison of pain perception, anxiety, and impacts on oral health-related quality of life between patients receiving clear aligners and fixed… Gao 2021 · Gao Meiya, Yan Xinyu, et al. · European journal of orthodontics PMID:32613250 | 2021 | 3 | 4 | not extracted yet |
| Pain and Oral-Health-Related Quality of Life in Orthodontic Patients During Initial Therapy with Conventional, Low-Friction, and Lingual Brackets… Antonio-Zancajo 2020a · Antonio-Zancajo Laura, Montero Javier, et al. · Journal of clinical medicine PMID:32635196 | 2020 | 3 | 2 | not extracted yet |
| A comparison of treatment impacts between Invisalign aligner and fixed appliance therapy during the first week of treatment. Miller 2007 · Miller Kevin B, McGorray Susan P, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:17346581 | 2007 | 3 | 4 | not extracted yet |
| A comparison of the periodontal health of patients during treatment with the Invisalign system and with fixed orthodontic appliances. Miethke 2005 · Miethke Rainer-Reginald, Vogt Silke · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie PMID:15959635 | 2005 | 3 | 4 | not extracted yet |
| Impact of orthodontic treatment with aligners and fixed appliances on OHRQoL: a randomized clinical trial. Borsato 2025 · Borsato Thais Teixeira, Bittencourt Jéssica Madeira, et al. · Brazilian oral research PMID:39936711 | 2025 | 2 | 1 | not extracted yet |
| Root resorption during maxillary molar intrusion with clear aligners: a randomized controlled trial. Withayanukonkij 2023 · Withayanukonkij Wisama, Chanmanee Pannapat, et al. · The Angle orthodontist PMID:37922387 | 2023 | 2 | none stated | not extracted yet |
| Comparative Study of Oral Health-Related Quality of Life (OHRQL) between Different Types of Orthodontic Treatment. Zamora-Martinez 2021 · Zamora-Martínez Natalia, Paredes-Gallardo Vanessa, et al. · Medicina (Kaunas, Lithuania) PMID:34356964 | 2021 | 2 | 1 | not extracted yet |
| Which orthodontic appliance is best for oral hygiene? A randomized clinical trial. Chhibber 2018 · Chhibber Aditya, Agarwal Sachin, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:29407494 | 2018 | 2 | 3 | not extracted yet |
| Pain perception among patients treated with passive self-ligating fixed appliances and Invisalign® aligners during the first week of orthodontic… Almasoud 2018 · Almasoud Naif N · Korean journal of orthodontics PMID:30206531 | 2018 | 2 | 1 | not extracted yet |
| Patient satisfaction and quality of life status after 2 treatment modalities: Invisalign and conventional fixed appliances. Flores-Mir 2018 · Flores-Mir Carlos, Brandelli Jeremy, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:30384934 | 2018 | 2 | 1 | not extracted yet |
| Discomfort associated with Invisalign and traditional brackets: A randomized, prospective trial. White 2017 · White David W, Julien Katie C, et al. · The Angle orthodontist PMID:28753032 | 2017 | 2 | 1 | not extracted yet |
| Periodontal health in teenagers treated with removable aligners and fixed orthodontic appliances. Abbate 2015 · Abbate Gian Marco, Caria Maria Paola, et al. · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie PMID:25929710 | 2015 | 2 | 3 | not extracted yet |
| Braces versus Invisalign®: gingival parameters and patients' satisfaction during treatment: a cross-sectional study. Azaripour et al. 2015 · Azaripour A, Weusmann J, et al. · BMC oral health PMID:26104387 | 2015 | 2 | 1 | not extracted yet |
| Analysis of pain level in cases treated with Invisalign aligner: comparison with fixed edgewise appliance therapy. Fujiyama 2014 · Fujiyama Koji, Honjo Tadashi, et al. · Progress in orthodontics PMID:25416143 | 2014 | 2 | 1 | not extracted yet |
| Adult patients' adjustability to orthodontic appliances. Part I: a comparison between Labial, Lingual, and Invisalign™. Shalish 2012 · Shalish Miri, Cooper-Kazaz Rena, et al. · European journal of orthodontics PMID:21750242 | 2012 | 2 | 1 | not extracted yet |
| Alcon 2021 matched by author and year (probable) | NR | 2 | 1 | not extracted yet |
| Comparison between clear aligners and 2 × 4 mechanics in the mixed dentition: a randomized clinical trial. da Silva 2023 · da Silva Vinicius Merino, Ayub Priscila Vaz, et al. · The Angle orthodontist PMID:36066265 | 2023 | 1 | 1 | not extracted yet |
| Orthognathic surgery and aligners. A comparative assessment of periodontal health and quality of life in postsurgical orthodontic treatment with… Leyva 2023 · de Leyva P, Eslava J-M, et al. · Medicina oral, patologia oral y cirugia bucal PMID:37026606 | 2023 | 1 | 4 | not extracted yet |
| Differences in finished case quality between Invisalign and traditional fixed appliances. Lin 2022 · Lin Eric, Julien Katie, et al. · The Angle orthodontist PMID:35168256 | 2022 | 1 | 1 | not extracted yet |
| Evaluation of pain intensity in patients treated with aligners and conventional fixed appliances: Randomized clinical trial. Casteluci 2021 · Casteluci Cleomária Evelyn Vieira Freire, Oltramari Paula Vanessa Pedron, et al. · Orthodontics & craniofacial research PMID:33058419 | 2021 | 1 | 1 | not extracted yet |
| Frequency of awake bruxism behaviour in orthodontic patients: Randomised clinical trial: Awake bruxism behaviour in orthodontic patients. Pereira 2021 · Pereira Nayara C, Oltramari Paula V P, et al. · Journal of oral rehabilitation PMID:33278836 | 2021 | 1 | none stated | not extracted yet |
| Effects of orthodontic treatment with aligners and fixed appliances on speech. Melo 2021 · Damasceno Melo Paulo Eduardo, Bocato Jéssica Rico, et al. · The Angle orthodontist PMID:34037699 | 2021 | 1 | none stated | not extracted yet |
| A randomized clinical trial comparing mandibular incisor proclination produced by fixed labial appliances and clear aligners. Hennessy 2016 · Hennessy Joe, Garvey Thérèse, et al. · The Angle orthodontist PMID:27571371 | 2016 | 1 | none stated | not extracted yet |
| Clinical and microbiological studies of children and adolescents receiving orthodontic treatment. Rego 2010 · Rego Rodrigo O, Oliveira Cristiane A, et al. · American journal of dentistry PMID:21344829 | 2010 | 1 | 3 | not extracted yet |
| A Comparison of the periodontal health of patients during treatment with the Invisalign system and with fixed lingual appliances. Miethke and Brauner 2007 · Miethke Rainer-Reginald, Brauner Klaudia · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie PMID:17522806 | 2007 | 1 | 3 | not extracted yet |
| Activation time and material stiffness of sequential removable orthodontic appliances. Part 1: Ability to complete treatment. Bollen 2003 · Bollen Anne-Marie, Huang Greg, et al. · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics PMID:14614415 | 2003 | 1 | none stated | not extracted yet |
| Effect of orthodontic therapy with fixed and removable appliances on oral microbiota: a six-month longitudinal study. Petti 1997 · Petti S, Barbato E, et al. · The new microbiologica PMID:9037669 | 1997 | 1 | 2 | not extracted yet |
| Oral hygiene and gingival status in orthodontic patients. Dubey 1993 · Dubey R, Jalili V P, et al. · Journal of Pierre Fauchard Academy (Pierre Fauchard Academy. India Section) PMID:9791270 | 1993 | 1 | 2 | not extracted yet |