Primary study · included by 2 reviews

Patient satisfaction and quality of life status after 2 treatment modalities: Invisalign and conventional fixed appliances.

Flores-Mir 2018 · Flores-Mir Carlos, Brandelli Jeremy, Pacheco-Pereira Camila · American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2018

Included by

Non-Cochrane · intervention · 2025 · cited as Flores-Mir et al. 2018 · Table 1; Figures 3-8

The review does not say which of its outcomes this study informs.

Comparative impact of clear aligners versus fixed orthodontic appliances on periodontal health, pain, and quality of life: a systematic review and meta-analysis.

Non-Cochrane · intervention · 2026 · cited as Flores-Mir 2018 · Table 2 row 11; Fig. 8

Outcome this study informs	Pooled effect	Evidence	Certainty
Quality of life Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 10 days	SMD -0.895 [-1.426, -0.364]	1 study	GRADE not reported
Quality of life Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · All follow-up durations (1 week to end of treatment)	SMD -0.850 [-0.973, -0.727]	16 studies · 856 participants	Moderate
Quality of life Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 3 months	SMD -0.590 [-1.194, 0.013]	1 study	GRADE not reported
Quality of life Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 2 weeks	SMD -0.734 [-1.172, -0.397]	2 studies	GRADE not reported
Quality of life Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · End of treatment	SMD -0.970 [-1.412, -0.528]	2 studies	GRADE not reported
Quality of life Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 20 days	SMD -0.895 [-1.426, -0.364]	1 study	GRADE not reported
Quality of life Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 1 week	SMD -0.985 [-1.272, -0.699]	3 studies	GRADE not reported
Quality of life Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 6 months	SMD -0.850 [-1.144, -0.557]	4 studies	GRADE not reported
Quality of life Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 1 month	SMD -0.829 [-1.081, -0.577]	4 studies	GRADE not reported
Quality of life Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 12 months	SMD -0.531 [-1.178, 0.116]	1 study	GRADE not reported

2 including reviews in total.