evidencegaps
Primary study · included by 2 reviews

Adult patients' adjustability to orthodontic appliances. Part I: a comparison between Labial, Lingual, and Invisalign™.

Shalish 2012 · Shalish Miri, Cooper-Kazaz Rena, Ivgi Inbal, et al. · European journal of orthodontics · 2012

Included by

Oral Health-Related Quality of Life (OHRQoL), Pain and Side Effects in Adults Undergoing Different Orthodontic Treatment Modalities: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2025 · cited as Shalish et al. 2012 · Table 1; Figures 3-8

The review does not say which of its outcomes this study informs.

Comparative impact of clear aligners versus fixed orthodontic appliances on periodontal health, pain, and quality of life: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Shalish 2012 · Table 2 row 24; Fig. 4
Outcome this study informsPooled effectEvidenceCertainty
Pain intensity
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · All follow-up time points (1 week to 6 months)
SMD -0.419 [-0.536, -0.302]18 studies · 892 participantsModerate

2 including reviews in total.