Primary study · included by 3 reviews

Comparison of pain perception, anxiety, and impacts on oral health-related quality of life between patients receiving clear aligners and fixed appliances during the initial stage of orthodontic treatment.

Gao 2021 · Gao Meiya, Yan Xinyu, Zhao Rui, et al. · European journal of orthodontics · 2021

Included by

Outcome this study informsPooled effectEvidenceCertainty
Pain (VAS)
Aligners and fixed labial appliances (combined) vs Within-group change, 7 days versus 24 hours after appliance fit · 24 hours to 7 days
SMD -7.45 [-11.28, -3.62]5 studies · 264 participantsGRADE not reported
Pain (VAS)
Fixed labial appliances vs Within-group change, 7 days versus 24 hours after appliance fit · 24 hours to 7 days
SMD -6.40 [-10.42, -2.38]5 studies · 176 participantsGRADE not reported

The review does not say which of its outcomes this study informs.

Outcome this study informsPooled effectEvidenceCertainty
Quality of life
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 10 days
SMD -0.895 [-1.426, -0.364]1 studyGRADE not reported
Quality of life
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · All follow-up durations (1 week to end of treatment)
SMD -0.850 [-0.973, -0.727]16 studies · 856 participantsModerate
Pain intensity
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · All follow-up time points (1 week to 6 months)
SMD -0.419 [-0.536, -0.302]18 studies · 892 participantsModerate
Quality of life
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 3 months
SMD -0.590 [-1.194, 0.013]1 studyGRADE not reported
Quality of life
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 2 weeks
SMD -0.734 [-1.172, -0.397]2 studiesGRADE not reported
Quality of life
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · End of treatment
SMD -0.970 [-1.412, -0.528]2 studiesGRADE not reported
Quality of life
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 20 days
SMD -0.895 [-1.426, -0.364]1 studyGRADE not reported
Quality of life
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 1 week
SMD -0.985 [-1.272, -0.699]3 studiesGRADE not reported
Quality of life
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 6 months
SMD -0.850 [-1.144, -0.557]4 studiesGRADE not reported
Quality of life
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 1 month
SMD -0.829 [-1.081, -0.577]4 studiesGRADE not reported
Quality of life
Clear aligners (Invisalign and similar removable aligners) vs Fixed orthodontic appliances (metal, self-ligating, ceramic, lingual brackets) · 12 months
SMD -0.531 [-1.178, 0.116]1 studyGRADE not reported

3 including reviews in total.