Cochrane Review Group

Gynaecology and Fertility

194 systematic reviews in Gynaecology and Fertility ask 2,653 questions. 20% have no studies to answer them, 31.1% rest on very low certainty evidence and 13.8% reach moderate or high certainty.

Reviews

194

Questions

2,653

current versions

No studies

20%

Moderate or high

13.8%

No studies 531 · 20%Ungraded 76 · 2.9%Very low 826 · 31.1%Low 855 · 32.2%Moderate 341 · 12.9%High 24 · 0.9%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Search questions in Gynaecology and Fertility

Thinnest evidence

All no studies and very low questions

Question	Effect	Evidence	Status / GRADE
Transvaginal biological graft vs native tissue repair Bladder function · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	RR 12.64 [1.6, 100.06]	2 studies · 143 participants	Very low
Transvaginal biological graft vs native tissue repair Quality of life · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	no estimate extracted	3 studies · 112 participants	Very low
Transvaginal permanent mesh vs native tissue repair Recurrent prolapse on examination (any compartment) · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	RR 0.42 [0.32, 0.55]	25 studies · 3680 participants	Very low
Transvaginal permanent mesh vs native tissue repair Quality of life · vaginal prolapse Transvaginal mesh or grafts or native tissue repair for vaginal prolapse (2024) · Cochrane	no estimate extracted	9 studies · 1365 participants	Very low
Summary of findings table ‐ Metformin vs megestrol Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 4.89 [1.56, 15.32]	2 studies · 83 participants	Very low
Summary of findings table ‐ Metformin + megestrol vs megestrol Progression of endometrial hyperplasia to endometrial cancer · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 7.96 [0.16, 402.02]	3 studies · 156 participants	Very low
Summary of findings table ‐ Metformin + megestrol vs megestrol Hysterectomy rate · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 7.39 [0.15, 372.38]	2 studies · 72 participants	Very low
Summary of findings table ‐ Metformin + megestrol vs megestrol Abnormal uterine bleeding ‐ not measured · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Metformin + megestrol vs megestrol Health‐related quality of life (HRQoL) ‐ not measured · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	NR	No studies
Summary of findings table ‐ Metformin + megestrol vs megestrol Adverse effects during treatment · endometrial hyerplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	1 study · 8 participants	Very low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system Regression of endometrial hyperplasia (with or without atypia) to proliferative, secretory, or atrophic endometrium · endometrial hyperplasia Metformin for endometrial hyperplasia (2024) · Cochrane	OR 3.42 [0.13, 88.4]	1 study · 46 participants	Very low
Summary of findings table ‐ Metformin + levonorgestrel (intrauterine system) vs levonorgestrel intrauterine system Recurrence of endometrial hyperplasia ‐ not reported · endometrial hyperplasia Metformin for endometrial hyperplasia (2024) · Cochrane	no estimate extracted	NR	No studies

Reviews 194

Selective progesterone receptor modulators (SPRMs) for uterine fibroids

Murji, A, Whitaker, L, et al. · Cochrane Database of Systematic Reviews · 2017

Gynaecology and Fertility

Thinnest evidence

Reviews 194

Selective progesterone receptor modulators (SPRMs) for uterine fibroids

Anti‐adhesion therapy following operative hysteroscopy for treatment of female subfertility

Assisted reproductive technologies for male subfertility

Volume expanders for the prevention of ovarian hyperstimulation syndrome

Local oestrogen for vaginal atrophy in postmenopausal women

Gonadotrophin‐releasing hormone antagonists for assisted reproductive technology

Dietary supplements for dysmenorrhoea

Clomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles

Surgery versus medical therapy for heavy menstrual bleeding

Surgery for women with anterior compartment prolapse

Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection

Aspirin for in vitro fertilisation

Ultrasound versus 'clinical touch' for catheter guidance during embryo transfer in women

Acupuncture for dysmenorrhoea

Short‐term and long‐term effects of tibolone in postmenopausal women

Human chorionic gonadotrophin priming for fertility treatment with in vitro maturation

Chinese herbal medicine for menopausal symptoms

Bioidentical hormones for women with vasomotor symptoms

Psychological and educational interventions for subfertile men and women

Nonsteroidal anti‐inflammatory drugs for dysmenorrhoea

Preoperative ripening of the cervix before operative hysteroscopy

Pain relief in hysterosalpingography

Gonadotrophin‐releasing hormone agonist protocols for pituitary suppression in assisted reproduction

Culture media for human pre‐implantation embryos in assisted reproductive technology cycles