Cochrane · systematic review · CD001750
Gonadotrophin‐releasing hormone antagonists for assisted reproductive technology
Al‐Inany, HG, Youssef, MA, Ayeleke, RO, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 6 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsGnRH antagonist compared to long‐course GnRH agonist for assisted reproductive technology (ART)
Population: women undergoing assisted reproductive technology (ART)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per woman randomised GnRH antagonist vs long‐course GnRH agonist | OR 1.02 [0.85, 1.23] | 12 studies · 2303 participants | Moderate Downgraded: publication bias |
OHSS per woman randomised (any grade) GnRH antagonist vs long‐course GnRH agonist | OR 0.61 [0.51, 0.72] | 36 studies · 7944 participants | Moderate Downgraded: risk of bias |
Ongoing pregnancy rate per woman randomised GnRH antagonist vs long‐course GnRH agonist | OR 0.92 [0.83, 1.01] | 37 studies · 8311 participants | Moderate Downgraded: risk of bias |
Clinical pregnancy rate per woman randomised GnRH antagonist vs long‐course GnRH agonist | OR 0.91 [0.83, 1] | 54 studies · 9959 participants | Moderate Downgraded: risk of bias |
Miscarriage rate per woman randomised GnRH antagonist vs long‐course GnRH agonist | OR 1.03 [0.82, 1.29] | 34 studies · 7082 participants | Moderate Downgraded: risk of bias |
Cycle cancellation due to poor ovarian response GnRH antagonist vs long‐course GnRH agonist | OR 1.32 [1.06, 1.65] | 25 studies · 5230 participants | Moderate Downgraded: imprecision, inconsistency |