Cochrane · systematic review · CD001750
Gonadotrophin‐releasing hormone antagonists for assisted reproductive technology
Al‐Inany, HG, Youssef, MA, Ayeleke, RO, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 6 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyGnRH antagonist compared to long‐course GnRH agonist for assisted reproductive technology (ART)
Population: women undergoing assisted reproductive technology (ART)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per woman randomised GnRH antagonist vs long‐course GnRH agonist | OR 1.02 [0.85, 1.23] | 12 studies · 2303 participants | Moderate Downgraded: publication bias |
OHSS per woman randomised (any grade) GnRH antagonist vs long‐course GnRH agonist | OR 0.61 [0.51, 0.72] | 36 studies · 7944 participants | Moderate Downgraded: risk of bias |
Ongoing pregnancy rate per woman randomised GnRH antagonist vs long‐course GnRH agonist | OR 0.92 [0.83, 1.01] | 37 studies · 8311 participants | Moderate Downgraded: risk of bias |
Clinical pregnancy rate per woman randomised GnRH antagonist vs long‐course GnRH agonist | OR 0.91 [0.83, 1] | 54 studies · 9959 participants | Moderate Downgraded: risk of bias |
Miscarriage rate per woman randomised GnRH antagonist vs long‐course GnRH agonist | OR 1.03 [0.82, 1.29] | 34 studies · 7082 participants | Moderate Downgraded: risk of bias |
Cycle cancellation due to poor ovarian response GnRH antagonist vs long‐course GnRH agonist | OR 1.32 [1.06, 1.65] | 25 studies · 5230 participants | Moderate Downgraded: imprecision, inconsistency |
Pregnancy outcomes related to GnRH antagonists for infertility treated with assisted reproductive technology.
Population: patients with infertility treated with assisted reproductive technology
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per women randomised ‐ All women | OR 0.86 [0.69, 1.08] | 9 studies · 1515 participants | Moderate Downgraded: risk of bias |
Ongoing pregnancy rate per women randomised ‐ All women | OR 0.88 [0.77, 1] | 28 studies · 5014 participants | Moderate Downgraded: risk of bias |
Clinical pregnancy rate per women randomised ‐ All women | OR 0.84 [0.75, 0.94] | 41 studies · 6571 participants | Moderate Downgraded: risk of bias |
OHSS incidence per women randomised ‐ All women | OR 0.43 [0.33, 0.57] | 29 studies · 5417 participants | Low Downgraded: risk of bias |
Miscarriage rate per clinical pregnancy rate | OR 0.96 [0.7, 1.31] | 27 studies · 1647 participants | Low Downgraded: risk of bias |