Cochrane · systematic review · CD004378
Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection
Brown, J, Daya, S, Matson, P · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 50%Low 1 · 16.7%Moderate 2 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Day 3 versus Day 2 embryo transfer following IVF or ICSI
Population: Women undergoing in vitro fertilisation or intracytoplasmic sperm injection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per woman Day 3 vs Day 2 embryo transfer following IVF or ICSI | RR 1.05 [0.89, 1.23] | 3 studies · 1200 participants | Very low Downgraded: risk of bias, imprecision |
Ongoing pregnancy rate per woman Day 3 vs Day 2 embryo transfer following IVF or ICSI | RR 0.98 [0.85, 1.12] | 6 studies · 1740 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Clinical pregnancy rate per woman Day 3 vs Day 2 embryo transfer following IVF or ICSI | RR 1.08 [0.98, 1.19] | 12 studies · 2461 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Multiple pregnancy rate per woman Day 3 vs Day 2 embryo transfer following IVF or ICSI | RR 1.12 [0.86, 1.44] | 8 studies · 1837 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Miscarriage rate per woman Day 3 vs Day 2 embryo transfer following IVF or ICSI | RR 1.16 [0.84, 1.6] | 9 studies · 2153 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Ectopic pregnancy rate per woman Day 3 vs Day 2 embryo transfer following IVF or ICSI | RR 0.99 [0.29, 3.4] | 6 studies · 1531 participants | Low Downgraded: risk of bias, imprecision, inconsistency |