Cochrane · systematic review · CD000360
Assisted reproductive technologies for male subfertility
Cissen, M, Bensdorp, A, Cohlen, BJ, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
15
No studies
5
Included studies
NR
No studies 5 · 25%Ungraded 0 · 0%Very low 10 · 50%Low 5 · 25%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
IUI in natural cycles compared to TI in natural cycles for male subfertility
Population: couples with male subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate IUI in natural cycles vs TI | no estimate extracted | NR | No studies |
OHSS IUI in natural cycles vs TI | no estimate extracted | NR | No studies |
Pregnancy rate per couple (all cycles) IUI in natural cycles vs TI | OR 4.57 [0.21, 101.61] | NR | Very low Downgraded: risk of bias, imprecision |
IUI in stimulated cycles compared to TI in stimulated cycles for male subfertility
Population: couples with male subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple (all cycles) IUI in stimulated cycles vs TI | OR 0.89 [0.3, 2.59] | NR | Low Downgraded: imprecision |
OHSS per couple IUI in stimulated cycles vs TI | no estimate extracted | NR | Low Downgraded: imprecision |
Pregnancy rate per couple (all cycles) IUI in stimulated cycles vs TI | OR 1.51 [0.74, 3.07] | NR | Very low Downgraded: imprecision, inconsistency |
Multiple pregnancy rate per couple IUI in stimulated cycles vs TI | OR 3.15 [0.12, 79.69] | NR | Low Downgraded: imprecision |
Miscarriage rate per couple IUI in stimulated cycles vs TI | OR 1.03 [0.19, 5.42] | NR | Low Downgraded: imprecision |
IUI in stimulated cycles compared to TI in natural cycles for male subfertility
Population: couples with male subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple (all cycles) IUI in stimulated cycles vs TI | OR 3.14 [0.12, 81.35] | NR | Very low Downgraded: risk of bias, imprecision |
OHSS IUI in stimulated cycles vs TI | no estimate extracted | NR | No studies |
Pregnancy rate per couple (all cycles) IUI in stimulated cycles vs TI | OR 3.14 [0.12, 81.35] | NR | Very low Downgraded: risk of bias, imprecision |
IUI in stimulated cycles compared to IUI in natural cycles for male subfertility
Population: couples with male subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple (all cycles) IUI in stimulated cycles vs IUI | OR 1.34 [0.77, 2.33] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
OHSS IUI in stimulated cycles vs IUI | no estimate extracted | NR | No studies |
Pregnancy rate per couple (all cycles) IUI in stimulated cycles vs IUI | OR 1.68 [1, 2.82] | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Miscarriage rate per couple IUI in stimulated cycles vs IUI | OR 1.06 [0.2, 5.63] | NR | Very low Downgraded: risk of bias, imprecision |
IVF compared to IUI in natural cycles for male subfertility
Population: couples with male subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple (all cycles) IVF vs IUI | OR 0.77 [0.25, 2.35] | NR | Low Downgraded: imprecision |
OHSS IVF vs IUI | no estimate extracted | NR | No studies |
IVF compared to IUI in stimulated cycles for male subfertility
Population: couples with male subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate per couple (all cycles) IVF vs IUI | OR 1.03 [0.43, 2.45] | NR | Very low Downgraded: risk of bias, imprecision |
OHSS per couple IVF vs IUI | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
Pregnancy rate per couple (all cycles) IVF vs IUI | OR 1.27 [0.33, 4.97] | NR | Very low Downgraded: risk of bias, imprecision |