Cochrane · systematic review · CD011110

Anti‐adhesion therapy following operative hysteroscopy for treatment of female subfertility

Bosteels, J, Weyers, S, D'Hooghe, TM, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library

Gynaecology and Fertility2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 25%Low 3 · 75%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Show all 2 versions

Any anti‐adhesion therapy versus placebo or no treatment following operative hysteroscopy

Population: women treated by operative hysteroscopy for uterine pathology associated with subfertility or adverse pregnancy outcome

2 questions

Outcome	Effect	Evidence	Status / GRADE
Live birth a Any anti‐adhesion therapy vs placebo or no treatment following operative hysteroscopy	OR 0.94 [0.42, 2.12]	2 studies · 107 participants	Very low Downgraded: risk of bias, imprecision, indirectness
Presence of intrauterine adhesions at second‐look hysteroscopy (second‐look hysteroscopy at 4‐12 weeks after operative hysteroscopy) Any anti‐adhesion therapy vs placebo or no treatment following operative hysteroscopy	OR 0.35 [0.21, 0.6]	8 studies · 560 participants	Low Downgraded: risk of bias, imprecision, indirectness

Any anti‐adhesion therapy A versus anti‐adhesion therapy B following operative hysteroscopy

Population: women treated by operative hysteroscopy for uterine pathology

2 questions

Outcome	Effect	Evidence	Status / GRADE
Live birth a Any anti‐adhesion therapy A vs anti‐adhesion therapy B following operative hysteroscopy	OR 1.48 [0.57, 3.83]	3 studies · 180 participants	Low Downgraded: risk of bias, imprecision, indirectness
Presence of intrauterine adhesions at second‐look hysteroscopy (6‐12 weeks) Any anti‐adhesion therapy A vs anti‐adhesion therapy B following operative hysteroscopy	OR 0.55 [0.36, 0.83]	5 studies · 451 participants	Low Downgraded: risk of bias, imprecision, indirectness