Cochrane · systematic review · CD011110
Anti‐adhesion therapy following operative hysteroscopy for treatment of female subfertility
Bosteels, J, Weyers, S, D'Hooghe, TM, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 25%Low 3 · 75%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyAny anti‐adhesion therapy versus placebo or no treatment following operative hysteroscopy
Population: women treated by operative hysteroscopy for uterine pathology associated with subfertility or adverse pregnancy outcome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth a Any anti‐adhesion therapy vs placebo or no treatment following operative hysteroscopy | OR 0.94 [0.42, 2.12] | 2 studies · 107 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Presence of intrauterine adhesions at second‐look hysteroscopy (second‐look hysteroscopy at 4‐12 weeks after operative hysteroscopy) Any anti‐adhesion therapy vs placebo or no treatment following operative hysteroscopy | OR 0.35 [0.21, 0.6] | 8 studies · 560 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Any anti‐adhesion therapy A versus anti‐adhesion therapy B following operative hysteroscopy
Population: women treated by operative hysteroscopy for uterine pathology
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth a Any anti‐adhesion therapy A vs anti‐adhesion therapy B following operative hysteroscopy | OR 1.48 [0.57, 3.83] | 3 studies · 180 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Presence of intrauterine adhesions at second‐look hysteroscopy (6‐12 weeks) Any anti‐adhesion therapy A vs anti‐adhesion therapy B following operative hysteroscopy | OR 0.55 [0.36, 0.83] | 5 studies · 451 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Comparison
Population: women treated by operative hysteroscopy for uterine pathology associated with subfertility or adverse pregnancy outcome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth | OR 0.99 [0.46, 2.13] | 3 studies · 150 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Presence of intrauterine adhesions at any second‐look hysteroscopy ‐ anti‐adhesion barrier gels (second‐look hysteroscopy at 4 to 12 weeks after operative hysteroscopy) | OR 0.37 [0.2, 0.67] | 5 studies · 383 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Presence of intrauterine adhesions at any second‐look hysteroscopy ‐ other anti‐adhesion therapy (second‐look hysteroscopy at 4 to 8 weeks after operative hysteroscopy) | OR 0.14 [0.01, 2.72] | 2 studies · 145 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Comparison
Population: women treated by operative hysteroscopy for uterine pathology associated with subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Presence of intrauterine adhesions at second‐look hysteroscopy (4 to 8 weeks) | OR 1.23 [0.64, 2.37] | 1 study · 162 participants | Very low Downgraded: risk of bias, indirectness |