Cochrane · systematic review · CD006919
Gonadotrophin‐releasing hormone agonist protocols for pituitary suppression in assisted reproduction
Siristatidis, CS, Gibreel, A, Basios, G, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
15
No studies
3
Included studies
NR
No studies 3 · 16.7%Ungraded 0 · 0%Very low 1 · 5.6%Low 13 · 72.2%Moderate 1 · 5.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Long protocol compared with short protocol for pituitary suppression in assisted reproduction
Population: women undergoing pituitary suppression in assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth or ongoing pregnancies per woman randomised Long protocol vs short protocol | OR 1.3 [0.94, 1.81] | 12 studies · 976 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancies per woman randomised Long protocol vs short protocol | OR 1.5 [1.18, 1.9] | 20 studies · 1643 participants | Moderate Downgraded: risk of bias, imprecision |
Long protocol compared with ultrashort protocol for pituitary suppression in assisted reproduction
Population: women undergoing pituitary suppression in assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth and ongoing pregnancies per woman randomised Long protocol vs ultrashort protocol | OR 1.78 [0.72, 4.36] | 1 study · 150 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancies per woman randomised Long protocol vs ultrashort protocol | OR 1.56 [0.8, 3.06] | 2 studies · 230 participants | Low Downgraded: risk of bias, imprecision |
Short compared with ultrashort protocol for pituitary suppression in assisted reproduction
Population: women undergoing pituitary suppression in assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth and ongoing pregnancies per woman randomised Short vs ultrashort protocol | no estimate extracted | NR | No studies |
Clinical pregnancies per woman randomised Short vs ultrashort protocol | OR 1.33 [0.47, 3.81] | 1 study · 82 participants | Very low Downgraded: imprecision, indirectness |
Long luteal phase protocol compared with long follicular phase protocol for pituitary suppression in assisted reproduction
Population: women undergoing pituitary suppression in assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth and ongoing pregnancies per woman randomised Long luteal phase protocol vs long follicular phase protocol | OR 1.89 [0.87, 4.1] | 1 study · 223 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancies per woman randomised Long luteal phase protocol vs long follicular phase protocol | OR 1.06 [0.76, 1.47] | 5 studies · 750 participants | Low Downgraded: risk of bias, imprecision |
Long protocol continued GnRH agonist compared with long protocol stop GnRH agonist for pituitary suppression in assisted reproduction
Population: women undergoing pituitary suppression in assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth and ongoing pregnancies Number of live births or ongoing pregnancies per woman randomised Long protocol continued GnRH agonist vs long protocol stop GnRH agonist | OR 0.75 [0.42, 1.33] | 3 studies · 290 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancies Number of clinical pregnancies per woman randomised Long protocol continued GnRH agonist vs long protocol stop GnRH agonist | OR 0.85 [0.51, 1.41] | 4 studies · 360 participants | Low Downgraded: risk of bias, imprecision |
Long protocol (continued same versus reduced dose GnRHa) for pituitary suppression in assisted reproduction
Population: women undergoing pituitary suppression in assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth and ongoing pregnancies per woman randomised Long protocol (continued same vs reduced dose GnRHa) | no estimate extracted | NR | No studies |
Clinical pregnancies per woman randomised Long protocol (continued same vs reduced dose GnRHa) | OR 1.02 [0.68, 1.52] | 4 studies · 407 participants | Low Downgraded: risk of bias, imprecision |
Long protocol (GnRHa until HCG) compared with long protocol (extend GnRHa 12 days after HCG) for pituitary suppression in assisted reproduction
Population: women undergoing pituitary suppression in assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth and ongoing pregnancies per woman randomised Long protocol (GnRHa until HCG) vs long protocol (extend GnRHa 12 days after HCG) | OR 0.89 [0.49, 1.64] | 1 study · 181 participants | Low Downgraded: imprecision |
Clinical pregnancies per woman randomised Long protocol (GnRHa until HCG) vs long protocol (extend GnRHa 12 days after HCG) | OR 1.02 [0.57, 1.83] | 1 study · 181 participants | Low Downgraded: imprecision |
Long protocol: administration of GnRHa for two versus three weeks before stimulation for pituitary suppression in assisted reproduction
Population: women undergoing pituitary suppression in assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth and ongoing pregnancies per woman randomised Long protocol: administration of GnRHa for two vs three weeks before stimulation | OR 0.88 [0.37, 2.05] | 1 study · 85 participants | Low Downgraded: risk of bias |
Clinical pregnancies per woman randomised Long protocol: administration of GnRHa for two vs three weeks before stimulation | OR 0.93 [0.39, 2.21] | 1 study · 85 participants | Low Downgraded: risk of bias |
Short protocol compared with stop short protocol for pituitary suppression in assisted reproduction
Population: women undergoing pituitary suppression in assisted reproduction
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth and ongoing pregnancies per woman randomised Short protocol vs stop short protocol | no estimate extracted | NR | No studies |
Clinical pregnancies per woman randomised Short protocol vs stop short protocol | OR 0.59 [0.3, 1.17] | 1 study · 230 participants | Low Downgraded: risk of bias |