Non-Cochrane · intervention · PM42740456
Use of cells and/or biologics combined with scaffolds in alveolar bone augmentation for implant site development.
Monje Alberto, Soldini Maria Costanza, Fahimipour Farahnaz, et al. · Journal of periodontology · 2026 · PubMed · doi:10.1002/jper.70105
Findings
15 findings
| Population | ||||
|---|---|---|---|---|
| Patients undergoing ridge augmentation for implant site development | Biologics combined with scaffolds | Scaffold or guided bone regeneration without biologics | Ridge width gain (mm) | WMD 0.30 [0.19, 0.40] GRADE not reported 5 studies |
| Patients undergoing ridge augmentation for implant site development | Biologics combined with scaffolds | Scaffold or guided bone regeneration without biologics | Ridge height gain (mm) | WMD 0.39 [-0.15, 0.92] GRADE not reported 2 studies |
| Patients undergoing ridge augmentation for implant site development | Platelet-rich plasma combined with scaffolds | Scaffold or guided bone regeneration without biologics | Ridge width gain (mm) | WMD 0.52 GRADE not reported 2 studies |
| Patients undergoing alveolar ridge preservation for implant site development | Biologics combined with scaffolds | Scaffold or guided bone regeneration without biologics | Ridge height change (mm) | WMD 0.40 [0.16, 0.63] GRADE not reported 6 studies |
| Patients undergoing alveolar ridge preservation for implant site development | Biologics combined with scaffolds | Scaffold or guided bone regeneration without biologics | Residual graft (%) | WMD -5.01 [-12.19, 2.17] GRADE not reported 5 studies |
| Patients undergoing alveolar ridge preservation for implant site development | Biologics combined with scaffolds | Scaffold or guided bone regeneration without biologics | Mineralized tissue (%) | WMD 7.46 [-10.94, 25.86] GRADE not reported 5 studies |
| Patients undergoing alveolar ridge preservation for implant site development | Biologics combined with scaffolds | Scaffold or guided bone regeneration without biologics | Ridge width change (mm) | WMD 0.48 [0.03, 0.93] GRADE not reported 7 studies |
| Patients undergoing alveolar ridge preservation for implant site development | Biologics combined with scaffolds | Scaffold or guided bone regeneration without biologics | Non-mineralized tissue (%) | WMD -14.87 [-26.05, -3.68] GRADE not reported 2 studies |
| Patients undergoing alveolar ridge preservation for implant site development | Recombinant human bone morphogenetic protein-2 combined with scaffolds | Scaffold or guided bone regeneration without biologics | Ridge width change (mm) | WMD 1.08 GRADE not reported 3 studies |
| Patients undergoing alveolar ridge preservation for implant site development | Recombinant human bone morphogenetic protein-2 combined with scaffolds | Scaffold or guided bone regeneration without biologics | Ridge height change (mm) | WMD 0.42 GRADE not reported 3 studies |
| Patients undergoing maxillary sinus floor elevation for implant site development | Biologics combined with scaffolds | Scaffold or guided bone regeneration without biologics | Non-mineralized tissue (%) | WMD 4.36 [-2.23, 10.94] GRADE not reported 5 studies |
| Patients undergoing maxillary sinus floor elevation for implant site development | Biologics combined with scaffolds | Scaffold or guided bone regeneration without biologics | Residual graft (%) | WMD -5.54 [-8.80, -2.29] GRADE not reported 5 studies |
| Patients undergoing maxillary sinus floor elevation for implant site development | Biologics combined with scaffolds | Scaffold or guided bone regeneration without biologics | Mineralized tissue (%) | WMD 3.08 [-3.17, 9.32] GRADE not reported 6 studies |
| Patients undergoing maxillary sinus floor elevation for implant site development | Biologics combined with scaffolds | Scaffold or guided bone regeneration without biologics | Ridge height gain (mm) | WMD 0.32 [-3.78, 4.42] GRADE not reported 2 studies |
| Patients receiving implants after bone augmentation for implant site development | Cell therapy combined with a scaffold | Scaffold with or without barrier membrane, without biologics | Implant stability, peri-implant tissue stability, adverse events and patient-reported outcomes | no estimate extracted No studies found 0 studies |
Included primary studies 125
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| et al. (2020) Tomographic and histomorphometric evaluation of socket healing after tooth extraction using leukocyte- and platelet-rich fibrin: A… PMID:31810848 | 2020 | 3 other reviews | not stated | not extracted yet |
| et al. (2021) Effect of different platelet-rich fibrin matrices for ridge preservation in multiple tooth extractions: A split-mouth randomized… PMID:33847018 | 2021 | 3 other reviews | not stated | not extracted yet |
| et al. (2013) Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial. PMID:22776413 | 2013 | 2 other reviews | not stated | not extracted yet |
| et al. (2015) Bone Engineering of Maxillary Sinus Bone Deficiencies Using Enriched CD90+ Stem Cell Therapy: A Randomized Clinical Trial. PMID:25652112 | 2015 | 2 other reviews | not stated | not extracted yet |
| et al. (2016) The use of leucocyte and platelet-rich fibrin in socket management and ridge preservation: a split-mouth, randomized, controlled clinical… PMID:27509214 | 2016 | 2 other reviews | not stated | not extracted yet |
| et al. (2018) To assess the efficacy of socket plug technique using platelet rich fibrin with or without the use of bone substitute in alveolar ridge… PMID:29411166 | 2018 | 2 other reviews | not stated | not extracted yet |
| et al. (2018) Advanced platelet-rich fibrin and freeze-dried bone allograft for ridge preservation: A randomized controlled clinical trial. PMID:29683498 | 2018 | 2 other reviews | not stated | not extracted yet |
| et al. (2018) Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. PMID:30092840 | 2018 | 2 other reviews | not stated | not extracted yet |
| et al. (2019) Buccal fat pad-derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: An… PMID:30821120 | 2019 | 2 other reviews | not stated | not extracted yet |
| et al. (2019) Platelet-rich fibrin to preserve alveolar bone sockets following tooth extraction: A randomized controlled trial. PMID:31647177 | 2019 | 2 other reviews | not stated | not extracted yet |
| et al. (2022) Histomorphometric Comparison of New Bone Formed After Maxillary Sinus Lift With Lateral and Crestal Approaches Using Periostal Mesenchymal… PMID:36041126 | 2022 | 2 other reviews | not stated | not extracted yet |
| et al. (2024) Comparison of histologic and radiographic changes of sockets grafted with LPRF and sockets without intervention after tooth extraction. PMID:37940776 | 2024 | 2 other reviews | not stated | not extracted yet |
| Castro 2021 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Clark 2018 matched by author and year (probable) | NR | 1 other review | Ridge width change (mm); Ridge height change (mm); Mineralized tissue (%); Residual graft (%) | not extracted yet |
| et al. (2005) Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation. PMID:15857102 | 2005 | 1 other review | not stated | not extracted yet |
| et al. (2005) De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. PMID:16297689 | 2005 | 1 other review | not stated | not extracted yet |
| et al. (2009) A randomized-controlled clinical trial evaluating clinical and radiological outcomes after 3 and 5 years of dental implants placed in bone… PMID:19489935 | 2009 | 1 other review | not stated | not extracted yet |
| et al. (2009) Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone… PMID:19686934 | 2009 | 1 other review | not stated | not extracted yet |
| et al. (2011) Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective… PMID:20831758 | 2011 | 1 other review | not stated | not extracted yet |
| et al. (2013) Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP-2/ACS or autogenous bone grafts: a proof-of-concept randomized… PMID:23998375 | 2013 | 1 other review | not stated | not extracted yet |
| et al. (2014) Buccal bone formation after flapless extraction: a randomized, controlled clinical trial comparing recombinant human bone morphogenetic… PMID:23826643 | 2014 | 1 other review | not stated | not extracted yet |
| et al. (2015) Efficacy of rhBMP-2/Hydroxyapatite on Sinus Floor Augmentation: A Multicenter, Randomized Controlled Clinical Trial. PMID:26185033 | 2015 | 1 other review | not stated | not extracted yet |
| et al. (2016) Application of buccal fat pad-derived stem cells in combination with autogenous iliac bone graft in the treatment of maxillomandibular… PMID:26846793 | 2016 | 1 other review | not stated | not extracted yet |
| et al. (2017) Randomised controlled clinical trial of augmentation of the alveolar ridge using recombinant human bone morphogenetic protein 2 with… PMID:28864147 | 2017 | 1 other review | not stated | not extracted yet |
| et al. (2017) Influence of platelet rich fibrin on post-extraction socket healing: A clinical and radiographic study. PMID:29033524 | 2017 | 1 other review | not stated | not extracted yet |
| et al. (2018) Randomized, controlled clinical two-centre study using xenogeneic block grafts loaded with recombinant human bone morphogenetic protein-2… PMID:29150957 | 2018 | 1 other review | not stated | not extracted yet |
| et al. (2019) Evaluation of L-PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A… PMID:30690860 | 2019 | 1 other review | not stated | not extracted yet |
| et al. (2020) Randomized and Controlled Clinical Trial of Bone Healing After Alveolar Ridge Preservation Using Xenografts and Allografts Versus Plasma… PMID:32315435 | 2020 | 1 other review | not stated | not extracted yet |
| et al. (2021) Safety and Efficacy Results of BonoFill First-in-Human, Phase I/IIa Clinical Trial for the Maxillofacial Indication of Sinus Augmentation… PMID:33434518 | 2021 | 1 other review | not stated | not extracted yet |
| et al. (2021) Clinical applications of concentrated growth factors combined with bone substitutes for alveolar ridge preservation in maxillary molar… PMID:34842993 | 2021 | 1 other review | not stated | not extracted yet |
| et al. (2022) Flapless osteotome-mediated sinus floor elevation using platelet-rich fibrin versus lateral approach using deproteinised bovine bone… PMID:35488479 | 2022 | 1 other review | not stated | not extracted yet |
| et al. (2022) Increased local concentrations of growth factors from leucocyte- and platelet-rich fibrin do not translate into improved alveolar ridge… PMID:35734895 | 2022 | 1 other review | not stated | not extracted yet |
| et al. (2025) Bone Augmentation of Atrophic Alveolar Ridges Using a Synthetic Bone Substitute With Mesenchymal Stem Cells: A Randomized, Controlled… PMID:40844304 | 2025 | 1 other review | not stated | not extracted yet |
| Fatale 2022 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Gjerde 2018 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Kaigler 2015 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Kumar 2018 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Rickert 2014 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Tzur 2021 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Wang 2022 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Abaza 2024 matched by author and year (probable) | NR | this review only | Ridge width change (mm); Mineralized tissue (%); Residual graft (%) | not extracted yet |
| Aboelela 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Al Nashar 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Alzahrani 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Areewong 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Azangookhiavi 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Barros-Mourao 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bettega 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Boyne 2005 matched by author and year (probable) | NR | this review only | Ridge height gain (mm) | not extracted yet |
| Canellas 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Coomes 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Darestani 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| de Freitas 2013 matched by author and year (probable) | NR | this review only | Ridge width gain (mm) | not extracted yet |
| Del Fabbro 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Elsheikh 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Eskan 2014 matched by author and year (probable) | NR | this review only | Ridge width gain (mm) | not extracted yet |
| et al. (2003) Sinus floor augmentation with beta-tricalciumphosphate (beta-TCP): does platelet-rich plasma promote its osseous integration and… PMID:12656882 | 2003 | this review only | not stated | not extracted yet |
| et al. (2005) Reconstruction of the severely resorbed maxilla with autogenous bone, platelet-rich plasma, and implants: 1-year results of a controlled… PMID:16336912 | 2005 | this review only | not stated | not extracted yet |
| et al. (2009) Autologous platelet concentrates for bone graft enhancement in sinus lift procedure. PMID:19171004 | 2009 | this review only | not stated | not extracted yet |
| et al. (2009) Effect of platelet-rich plasma on sinus lifting: a randomized-controlled clinical trial. PMID:19563329 | 2009 | this review only | not stated | not extracted yet |
| et al. (2009) Sinus grafting with a natural fluorohydroxyapatite for immediate load: a study with histologic analysis and histomorphometry. PMID:19813420 | 2009 | this review only | not stated | not extracted yet |
| et al. (2009) Immediate implant placement into fresh extraction sites with chronic periapical pathologic features combined with plasma rich in growth… PMID:19837321 | 2009 | this review only | not stated | not extracted yet |
| et al. (2010) Platelet-rich plasma may prevent titanium-mesh exposure in alveolar ridge augmentation with anorganic bovine bone. PMID:20796106 | 2010 | this review only | not stated | not extracted yet |
| et al. (2011) Alveolar ridge augmentation using anodized implants coated with Escherichia coli-derived recombinant human bone morphogenetic protein 2. PMID:21194992 | 2011 | this review only | not stated | not extracted yet |
| et al. (2011) Bone marrow concentrate and bovine bone mineral for sinus floor augmentation: a controlled, randomized, single-blinded clinical and… PMID:21529247 | 2011 | this review only | not stated | not extracted yet |
| et al. (2013) Effect of platelet rich plasma on bone regeneration in maxillary sinus augmentation (randomized clinical trial). PMID:23078753 | 2013 | this review only | not stated | not extracted yet |
| et al. (2013) A histomorphometric comparison of Bio-Oss alone versus Bio-Oss and platelet-derived growth factor for sinus augmentation: a postsurgical… PMID:23593620 | 2013 | this review only | not stated | not extracted yet |
| et al. (2013) Histomorphometric comparison of different concentrations of recombinant human bone morphogenetic protein with allogeneic bone compared to… PMID:24116356 | 2013 | this review only | not stated | not extracted yet |
| et al. (2014) Platelet-rich plasma-assisted guided bone regeneration for ridge augmentation: a randomized, controlled clinical trial. PMID:23895252 | 2014 | this review only | not stated | not extracted yet |
| et al. (2014) Ridge preservation using demineralized bone matrix gel with recombinant human bone morphogenetic protein-2 after tooth extraction: a… PMID:24709512 | 2014 | this review only | not stated | not extracted yet |
| et al. (2015) Evaluation of the use of plasma rich in growth factors with immediate implant placement in periodontally compromised extraction sites: a… PMID:25541015 | 2015 | this review only | not stated | not extracted yet |
| et al. (2015) A clinical comparison of guided bone regeneration with platelet-derived growth factor-enhanced bone ceramic versus autogenous bone block… PMID:26009922 | 2015 | this review only | not stated | not extracted yet |
| et al. (2016) Maxillary Sinus Floor Elevation Using Platelet-Rich Plasma Combined With Either Biphasic Calcium Phosphate or Deproteinized Bovine Bone. PMID:27046471 | 2016 | this review only | not stated | not extracted yet |
| et al. (2018) Maxillary sinus augmentation with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral: A split-mouth histological and… PMID:28786494 | 2018 | this review only | not stated | not extracted yet |
| et al. (2019) Does the association of blood-derived growth factors to nanostructured carbonated hydroxyapatite contributes to the maxillary sinus floor… PMID:29730707 | 2019 | this review only | not stated | not extracted yet |
| et al. (2019) Short implants and platelet-rich fibrin for transcrestal sinus floor elevation: a prospective multicenter clinical study. PMID:32425033 | 2019 | this review only | not stated | not extracted yet |
| et al. (2020) Maxillary Sinus Floor Elevation Surgery With BioOss Mixed With Enamel Matrix Derivative: A Human Randomized Controlled Clinical and… PMID:32299097 | 2020 | this review only | not stated | not extracted yet |
| et al. (2020) Radiologic comparative analysis between saline and platelet-rich fibrin filling after hydraulic transcrestal sinus lifting without… PMID:32871620 | 2020 | this review only | not stated | not extracted yet |
| et al. (2021) Three-dimensional analysis of dimensional changes after alveolar ridge preservation with bone substitutes or plasma rich in growth… PMID:33084205 | 2021 | this review only | not stated | not extracted yet |
| et al. (2021) A clinical and radiographic study of implants placed in autogenous bone grafts covered by either a platelet-rich fibrin membrane or… PMID:33554323 | 2021 | this review only | not stated | not extracted yet |
| et al. (2021) Enamel matrix derivative promotes new bone formation in xenograft assisted maxillary anterior ridge preservation-A randomized controlled… PMID:33715279 | 2021 | this review only | not stated | not extracted yet |
| et al. (2021) Guided bone regeneration simultaneous with implant placement using bovine-derived xenograft with and without liquid platelet-rich fibrin:… PMID:34047835 | 2021 | this review only | not stated | not extracted yet |
| et al. (2022) Lateral Sinus Floor Elevation in the Severely Atrophied Maxilla: Concentrated Growth Factors Versus Bone Substitutes. A Controlled… PMID:35060969 | 2022 | this review only | not stated | not extracted yet |
| et al. (2022) Ridge augmentation using autologous concentrated growth factors enriched bone graft matrix versus guided bone regeneration using native… PMID:35811435 | 2022 | this review only | not stated | not extracted yet |
| et al. (2022) Effect of Sinus Floor Augmentation with Platelet-Rich Fibrin Versus Allogeneic Bone Graft on Stability of One-Stage Dental Implants: A… PMID:35954926 | 2022 | this review only | not stated | not extracted yet |
| et al. (2023) The effect of leukocyte- and platelet-rich fibrin on the bone loss and primary stability of implants placed in posterior maxilla: a… PMID:37555894 | 2023 | this review only | not stated | not extracted yet |
| et al. (2023) The effect of recurrent application of concentrated platelet-rich fibrin inside the extraction socket on the hard and soft tissues. a… PMID:37726689 | 2023 | this review only | not stated | not extracted yet |
| et al. (2023) Comparison between platelet rich fibrin as space filling material versus xenograft and alloplastic bone grafting materials in immediate… PMID:38066454 | 2023 | this review only | not stated | not extracted yet |
| et al. (2024) Injectable platelet rich fibrin versus hyaluronic acid with bovine derived xenograft for alveolar ridge preservation. A randomized… PMID:37905704 | 2024 | this review only | not stated | not extracted yet |
| et al. (2024) Application of sticky bone combined with concentrated growth factor (CGF) for horizontal alveolar ridge augmentation of anterior teeth: a… PMID:38589825 | 2024 | this review only | not stated | not extracted yet |
| et al. (2024) The Evaluation of Enamel Matrix Derivative on the Bone Regenerative Potential of the Dental Implant with the Transcrestal Sinus Floor… PMID:38788135 | 2024 | this review only | not stated | not extracted yet |
| et al. (2024) The effect of platelet-rich fibrin (PRF) versus freeze-dried bone allograft (FDBA) used in alveolar ridge preservation on the peri-implant… PMID:38877446 | 2024 | this review only | not stated | not extracted yet |
| Fiorellini 2005 matched by author and year (probable) | NR | this review only | Ridge width change (mm); Ridge height change (mm) | not extracted yet |
| Froum 2013 (rhBMP-2) matched by author and year (probable) | NR | this review only | Mineralized tissue (%); Non-mineralized tissue (%); Residual graft (%) | not extracted yet |
| Froum 2013 (rhPDGF-BB) matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Hartlev 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Isik 2021 matched by author and year (probable) | NR | this review only | Ridge width gain (mm) | not extracted yet |
| Jung 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kaigler 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Karagah 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Khairy 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Khojasteh 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Khojasteh 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lahham 2023 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mercado 2021 matched by author and year (probable) | NR | this review only | Ridge width change (mm); Ridge height change (mm); Mineralized tissue (%); Non-mineralized tissue (%); Residual graft (%) | not extracted yet |
| Merli 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mousavi 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Nizam 2017 matched by author and year (probable) | NR | this review only | Mineralized tissue (%); Non-mineralized tissue (%); Residual graft (%) | not extracted yet |
| Ozbay 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pichotano 2019 matched by author and year (probable) | NR | this review only | Mineralized tissue (%); Non-mineralized tissue (%); Residual graft (%) | not extracted yet |
| Santana 2015 matched by author and year (probable) | NR | this review only | Ridge width gain (mm) | not extracted yet |
| Sanz 2025 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Sauerbier 2010 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Stumbras 2020 matched by author and year (probable) | NR | this review only | Mineralized tissue (%); Non-mineralized tissue (%); Residual graft (%) | not extracted yet |
| Stumbras 2021 matched by author and year (probable) | NR | this review only | Ridge width change (mm); Ridge height change (mm) | not extracted yet |
| Taschieri 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Temmerman 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Testori 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Thoma 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Thor 2005 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Torres 2009 matched by author and year (probable) | NR | this review only | Mineralized tissue (%) | not extracted yet |
| Torres 2010 matched by author and year (probable) | NR | this review only | Ridge width gain (mm); Ridge height gain (mm) | not extracted yet |
| Triplett 2009 matched by author and year (probable) | NR | this review only | Ridge height gain (mm) | not extracted yet |
| Vincent-Bugnas 2020 matched by author and year (probable) | NR | this review only | Mineralized tissue (%); Non-mineralized tissue (%); Residual graft (%) | not extracted yet |
| Wiltfang 2003 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Systemically healthy patients with jaw bone defects requiring bone augmentation before or with implant placement | Ridge augmentation (6 RCTs, n=172), ridge preservation (9 RCTs, n=455), sinus floor elevation (8 RCTs, n=451) in the meta-analysis; 23 RCTs (n=1078) |
| Intervention | Biologics (enamel matrix derivative, BMPs, autologous blood-derived products, PDGF) or cell therapy combined with a scaffold, with or without barrier membrane | Biologics (PRP, PRF, CGF, rhBMP-2, rhPDGF-BB, EMD, PRGF) with scaffolds; cell therapy studied qualitatively only |
| Comparison | Scaffold with or without barrier membrane without biologics or cell therapy | Scaffold or GBR without biologics |
| Outcomes | Primary: vertical and horizontal bone gain; secondary: implant placement feasibility, implant stability, survival, complications, adverse effects, PROs, CROs, healing time, histomorphometry, bone quality | Ridge width and height, % mineralized tissue, % non-mineralized tissue, % residual graft; complications and PROs narrative |
| Study designs | RCTs, non-randomized trials (parallel or split-mouth) and prospective single-arm series with >=10 subjects per arm | 23 RCTs pooled; 56 studies in qualitative synthesis |
| Timing | No follow-up limitation | Not specified |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | No | Yes | no |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Yes | Partial Yes | no |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: Yes | NRSI: Yes · RCT: Yes | no |
| 10Funding of included studies reported | No | Yes | no |
| 11Appropriate meta-analysis methodscritical | RCT: No · NRSI: N/A | NRSI: N/A · RCT: No | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | No | Yes | no |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | Yes | Yes | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |