Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Use of cells and/or biologics combined with scaffolds in alveolar bone augmentation for implant site development.. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Effect of different platelet-rich fibrin matrices for ridge preservation in multiple tooth extractions: A split-mouth randomized controlled clinical… et al. (2021) · Castro Ana B, Van Dessel Jeroen, et al. · Journal of clinical periodontology PMID:33847018 | 2021 | 4 | 3 | not extracted yet |
| Tomographic and histomorphometric evaluation of socket healing after tooth extraction using leukocyte- and platelet-rich fibrin: A randomized,… et al. (2020) · Canellas João Vitor Dos Santos, da Costa Rafael Cabral, et al. · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery PMID:31810848 | 2020 | 4 | 3 | not extracted yet |
| Comparison of histologic and radiographic changes of sockets grafted with LPRF and sockets without intervention after tooth extraction. et al. (2024) · Mousavi Yousof, Paknejad M, et al. · Oral and maxillofacial surgery PMID:37940776 | 2024 | 3 | 2 | not extracted yet |
| Histomorphometric Comparison of New Bone Formed After Maxillary Sinus Lift With Lateral and Crestal Approaches Using Periostal Mesenchymal Stem… Fatale 2022 · Fatale Valentina, Pagnoni Stefano, et al. · The Journal of craniofacial surgery PMID:36041126 | 2022 | 3 | none stated | not extracted yet |
| Buccal fat pad-derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: An exploratory… Khojasteh 2019 · Khojasteh Arash, Hosseinpour Sepanta, et al. · Clinical implant dentistry and related research PMID:30821120 | 2019 | 3 | none stated | not extracted yet |
| Platelet-rich fibrin to preserve alveolar bone sockets following tooth extraction: A randomized controlled trial. et al. (2019) · Areewong Kanokporn, Chantaramungkorn Montri, et al. · Clinical implant dentistry and related research PMID:31647177 | 2019 | 3 | 1 | not extracted yet |
| To assess the efficacy of socket plug technique using platelet rich fibrin with or without the use of bone substitute in alveolar ridge… et al. (2018) · Girish Kumar N, Chaudhary Rupanzal, et al. · Oral and maxillofacial surgery PMID:29411166 | 2018 | 3 | 2 | not extracted yet |
| Advanced platelet-rich fibrin and freeze-dried bone allograft for ridge preservation: A randomized controlled clinical trial. et al. (2018) · Clark Daniel, Rajendran Yogalakshmi, et al. · Journal of periodontology PMID:29683498 | 2018 | 3 | 3 | not extracted yet |
| Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. Gjerde 2018 · Gjerde Cecilie, Mustafa Kamal, et al. · Stem cell research & therapy PMID:30092840 | 2018 | 3 | none stated | not extracted yet |
| The use of leucocyte and platelet-rich fibrin in socket management and ridge preservation: a split-mouth, randomized, controlled clinical trial. et al. (2016) · Temmerman Andy, Vandessel Jeroen, et al. · Journal of clinical periodontology PMID:27509214 | 2016 | 3 | 2 | not extracted yet |
| Bone Engineering of Maxillary Sinus Bone Deficiencies Using Enriched CD90+ Stem Cell Therapy: A Randomized Clinical Trial. Kaigler 2015 · Kaigler Darnell, Avila-Ortiz Gustavo, et al. · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research PMID:25652112 | 2015 | 3 | none stated | not extracted yet |
| Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial. Kaigler 2013 · Kaigler Darnell, Pagni Giorgio, et al. · Cell transplantation PMID:22776413 | 2013 | 3 | none stated | not extracted yet |
| Bone Augmentation of Atrophic Alveolar Ridges Using a Synthetic Bone Substitute With Mesenchymal Stem Cells: A Randomized, Controlled Clinical Trial. Sanz 2025 · Sanz Mariano, Gjerde Cecilie, et al. · Clinical oral implants research PMID:40844304 | 2025 | 2 | none stated | not extracted yet |
| Flapless osteotome-mediated sinus floor elevation using platelet-rich fibrin versus lateral approach using deproteinised bovine bone mineral for… et al. (2022) · Lv Huixin, Sun Xiaolin, et al. · Clinical oral implants research PMID:35488479 | 2022 | 2 | none stated | not extracted yet |
| Increased local concentrations of growth factors from leucocyte- and platelet-rich fibrin do not translate into improved alveolar ridge… et al. (2022) · Wang Xuzhu, Fok Melissa R, et al. · Journal of clinical periodontology PMID:35734895 | 2022 | 2 | none stated | not extracted yet |
| Safety and Efficacy Results of BonoFill First-in-Human, Phase I/IIa Clinical Trial for the Maxillofacial Indication of Sinus Augmentation and… et al. (2021) · Tzur Ephraim, Ben-David Dror, et al. · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons PMID:33434518 | 2021 | 2 | none stated | not extracted yet |
| Clinical applications of concentrated growth factors combined with bone substitutes for alveolar ridge preservation in maxillary molar area: a… et al. (2021) · Lin Shi-Chen, Li Xin, et al. · International journal of implant dentistry PMID:34842993 | 2021 | 2 | none stated | not extracted yet |
| Randomized and Controlled Clinical Trial of Bone Healing After Alveolar Ridge Preservation Using Xenografts and Allografts Versus Plasma Rich in… et al. (2020) · Stumbras Arturas, Januzis Gintaras, et al. · The Journal of oral implantology PMID:32315435 | 2020 | 2 | none stated | not extracted yet |
| Evaluation of L-PRF combined with deproteinized bovine bone mineral for early implant placement after maxillary sinus augmentation: A randomized… et al. (2019) · Pichotano Elton Carlos, de Molon Rafael Scaf, et al. · Clinical implant dentistry and related research PMID:30690860 | 2019 | 2 | none stated | not extracted yet |
| Randomized, controlled clinical two-centre study using xenogeneic block grafts loaded with recombinant human bone morphogenetic protein-2 or… et al. (2018) · Thoma Daniel S, Payer Michael, et al. · Journal of clinical periodontology PMID:29150957 | 2018 | 2 | none stated | not extracted yet |
| Randomised controlled clinical trial of augmentation of the alveolar ridge using recombinant human bone morphogenetic protein 2 with hydroxyapatite… et al. (2017) · Nam J W, Khureltogtokh S, et al. · The British journal of oral & maxillofacial surgery PMID:28864147 | 2017 | 2 | none stated | not extracted yet |
| Influence of platelet rich fibrin on post-extraction socket healing: A clinical and radiographic study. et al. (2017) · Alzahrani Ahmed Abdullah, Murriky Afraa, et al. · The Saudi dental journal PMID:29033524 | 2017 | 2 | 1 | not extracted yet |
| Application of buccal fat pad-derived stem cells in combination with autogenous iliac bone graft in the treatment of maxillomandibular atrophy: a… et al. (2016) · Khojasteh A, Sadeghi N · International journal of oral and maxillofacial surgery PMID:26846793 | 2016 | 2 | none stated | not extracted yet |
| Efficacy of rhBMP-2/Hydroxyapatite on Sinus Floor Augmentation: A Multicenter, Randomized Controlled Clinical Trial. et al. (2015) · Kim H J, Chung J H, et al. · Journal of dental research PMID:26185033 | 2015 | 2 | none stated | not extracted yet |
| Buccal bone formation after flapless extraction: a randomized, controlled clinical trial comparing recombinant human bone morphogenetic protein… et al. (2014) · Coomes Angela M, Mealey Brian L, et al. · Journal of periodontology PMID:23826643 | 2014 | 2 | none stated | not extracted yet |
| Horizontal ridge augmentation of the atrophic anterior maxilla using rhBMP-2/ACS or autogenous bone grafts: a proof-of-concept randomized clinical… et al. (2013) · de Freitas Rubens Moreno, Susin Cristiano, et al. · Journal of clinical periodontology PMID:23998375 | 2013 | 2 | none stated | not extracted yet |
| Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized… et al. (2011) · Rickert D, Sauerbier S, et al. · Clinical oral implants research PMID:20831758 | 2011 | 2 | none stated | not extracted yet |
| A randomized-controlled clinical trial evaluating clinical and radiological outcomes after 3 and 5 years of dental implants placed in bone… et al. (2009) · Jung Ronald E, Windisch Simone I, et al. · Clinical oral implants research PMID:19489935 | 2009 | 2 | none stated | not extracted yet |
| Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for… et al. (2009) · Triplett R Gilbert, Nevins Myron, et al. · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons PMID:19686934 | 2009 | 2 | none stated | not extracted yet |
| Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation. et al. (2005) · Fiorellini Joseph P, Howell T Howard, et al. · Journal of periodontology PMID:15857102 | 2005 | 2 | none stated | not extracted yet |
| De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. et al. (2005) · Boyne Philip J, Lilly Leslie C, et al. · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons PMID:16297689 | 2005 | 2 | none stated | not extracted yet |
| Castro 2021 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Clark 2018 matched by author and year (probable) | NR | 2 | 4 | not extracted yet |
| Fatale 2022 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Gjerde 2018 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Kaigler 2015 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Kumar 2018 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Rickert 2014 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Tzur 2021 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Wang et al. 2022 matched by author and year (probable) | NR | 2 | none stated | not extracted yet |
| Injectable platelet rich fibrin versus hyaluronic acid with bovine derived xenograft for alveolar ridge preservation. A randomized controlled… et al. (2024) · Abaza Gehad, Abdel Gaber Hala Kamal, et al. · Clinical implant dentistry and related research PMID:37905704 | 2024 | 1 | none stated | not extracted yet |
| Application of sticky bone combined with concentrated growth factor (CGF) for horizontal alveolar ridge augmentation of anterior teeth: a randomized… et al. (2024) · Xie Yu, Qin Yanyan, et al. · BMC oral health PMID:38589825 | 2024 | 1 | none stated | not extracted yet |
| The Evaluation of Enamel Matrix Derivative on the Bone Regenerative Potential of the Dental Implant with the Transcrestal Sinus Floor Elevation… et al. (2024) · Ozbay Deniz, Tunc Samet, et al. · The International journal of oral & maxillofacial implants PMID:38788135 | 2024 | 1 | none stated | not extracted yet |
| The effect of platelet-rich fibrin (PRF) versus freeze-dried bone allograft (FDBA) used in alveolar ridge preservation on the peri-implant soft and… et al. (2024) · Azangookhiavi Hassan, Habibzadeh Sareh, et al. · BMC oral health PMID:38877446 | 2024 | 1 | none stated | not extracted yet |
| The effect of leukocyte- and platelet-rich fibrin on the bone loss and primary stability of implants placed in posterior maxilla: a randomized… et al. (2023) · Naeimi Darestani Meshkat, Asl Roosta Hoori, et al. · International journal of implant dentistry PMID:37555894 | 2023 | 1 | none stated | not extracted yet |
| The effect of recurrent application of concentrated platelet-rich fibrin inside the extraction socket on the hard and soft tissues. a randomized… et al. (2023) · Lahham Cezar, Ta'a Mahmoud Abu, et al. · BMC oral health PMID:37726689 | 2023 | 1 | none stated | not extracted yet |
| Comparison between platelet rich fibrin as space filling material versus xenograft and alloplastic bone grafting materials in immediate implant… et al. (2023) · Elsheikh Heba Abo-Elfetouh, Abdelsameaa Sally Elsayed, et al. · BMC oral health PMID:38066454 | 2023 | 1 | none stated | not extracted yet |
| Lateral Sinus Floor Elevation in the Severely Atrophied Maxilla: Concentrated Growth Factors Versus Bone Substitutes. A Controlled Clinical Trial. et al. (2022) · Merli Mauro, Moscatelli Marco, et al. · The International journal of periodontics & restorative dentistry PMID:35060969 | 2022 | 1 | none stated | not extracted yet |
| Ridge augmentation using autologous concentrated growth factors enriched bone graft matrix versus guided bone regeneration using native collagen… et al. (2022) · Aboelela Sarah Abd Allah, Atef Mohammed, et al. · Clinical implant dentistry and related research PMID:35811435 | 2022 | 1 | none stated | not extracted yet |
| Effect of Sinus Floor Augmentation with Platelet-Rich Fibrin Versus Allogeneic Bone Graft on Stability of One-Stage Dental Implants: A Split-Mouth… et al. (2022) · Karagah Aida, Tabrizi Reza, et al. · International journal of environmental research and public health PMID:35954926 | 2022 | 1 | none stated | not extracted yet |