Non-Cochrane · intervention · PM40265704
Effect of Autologous Concentrated Growth Factor in Regenerative Dentistry: A Systematic Review and Meta-Analysis.
Alshirah A A, Elnaem M H, Al-Ani Z, et al. · JDR clinical and translational research · 2026 · PubMed · doi:10.1177/23800844251325532
Findings
12 findings
| Population | ||||
|---|---|---|---|---|
| Adults with periodontal intrabony defects | CGF plus bone graft | Bone graft alone | Clinical attachment level (CAL) gain 12 months | MD 0.55 [0.19, 0.9] GRADE not reported 3 studies · 151 participants |
| Adults with periodontal intrabony defects | CGF plus bone graft | Bone graft alone | Intrabony defect depth (IDD) reduction 12 months | MD 1.41 [1.02, 1.8] GRADE not reported 2 studies · 91 participants |
| Adults with periodontal intrabony defects | CGF plus bone graft | Bone graft alone | Probing pocket depth (PPD) reduction 12 months | MD 0.49 [-0.17, 1.15] GRADE not reported 3 studies · 151 participants |
| Adults with gingival recession | CAF plus CGF | CAF alone | Clinical attachment level (CAL) gain 6 months | MD 0.23 [0.02, 0.45] GRADE not reported 2 studies · 149 participants |
| Adults with gingival recession | CAF plus CGF | CAF alone | Keratinized gingival width (KGW) 6 months | MD 0.41 [0.21, 0.61] GRADE not reported 2 studies · 149 participants |
| Adults with gingival recession | CAF plus CGF | CAF alone | Gingival thickness (GT) 6 months | MD 0.26 [0.23, 0.3] GRADE not reported 2 studies · 149 participants |
| Adults with gingival recession | CAF plus CGF | CAF alone | Probing pocket depth (PPD) 6 months | MD 0.11 [-0.05, 0.26] GRADE not reported 2 studies · 149 participants |
| Adults with gingival recession | CGF with CAF or tunnel technique | CTG with CAF or tunnel technique | Clinical attachment level (CAL) gain 6 months | MD -0.38 [-0.58, -0.18] GRADE not reported 2 studies · 182 participants |
| Adults with gingival recession | CGF with CAF or tunnel technique | CTG with CAF or tunnel technique | Mean root coverage (MRC) 6 months | MD -15.09 [-20.15, -10.02] GRADE not reported 3 studies · 252 participants |
| Adults with gingival recession | CGF with CAF or tunnel technique | CTG with CAF or tunnel technique | Probing pocket depth (PPD) 6 months | MD 0.07 [-0.03, 0.17] GRADE not reported 3 studies · 252 participants |
| Adults with gingival recession | CGF with CAF or tunnel technique | CTG with CAF or tunnel technique | Gingival thickness (GT) 6 months | MD -0.5 [-0.76, -0.25] GRADE not reported 3 studies · 252 participants |
| Adults with gingival recession | CGF with CAF or tunnel technique | CTG with CAF or tunnel technique | Keratinized gingival width (KGW) 6 months | MD -0.89 [-2.53, 0.76] GRADE not reported 3 studies · 252 participants |
Included primary studies 38
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Elayah 2022 Effect of concentrated growth factor (CGF) on postoperative sequel of completely impacted lower third molar extraction: a randomized… PMID:36042448 | 2022 | 1 other review | not stated | not extracted yet |
| Fang 2022 Efficacy and Safety of Concentrated Growth Factor Fibrin on the Extraction of Mandibular Third Molars: A Prospective, Randomized,… PMID:34801470 | 2022 | 1 other review | not stated | not extracted yet |
| Lin 2021 Clinical applications of concentrated growth factors combined with bone substitutes for alveolar ridge preservation in maxillary molar… PMID:34842993 | 2021 | 1 other review | not stated | not extracted yet |
| Ma 2021 The impact of autologous concentrated growth factors on the alveolar ridge preservation after posterior tooth extraction: A prospective,… PMID:34159704 | 2021 | 1 other review | not stated | not extracted yet |
| Ozveri Koyuncu 2020a Effect of concentrated growth factor (CGF) on short-term clinical outcomes after partially impacted mandibular third molar surgery: A… PMID:31299343 | 2020 | 1 other review | not stated | not extracted yet |
| Qiao 2016 The effect of concentrated growth factors in the treatment of periodontal intrabony defects. PMID:28642822 | 2016 | 1 other review | Probing pocket depth (PPD) reduction; Clinical attachment level (CAL) gain; Intrabony defect depth (IDD) reduction | not extracted yet |
| Samarth 2023 Comparative evaluation of demineralized freeze-dried bone allograft with and without concentrated growth factor membrane in the treatment… DOI:10.1007/s00784-022-04791-5 | 2022 | 1 other review | Probing pocket depth (PPD) reduction; Clinical attachment level (CAL) gain; Intrabony defect depth (IDD) reduction | not extracted yet |
| Aboelela 2021 Ridge augmentation using autologous concentrated growth factors enriched bone graft matrix versus guided bone regeneration using native… DOI:10.1111/cid.13121 | 2022 | this review only | not stated | not extracted yet |
| Aboelela 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Adali 2021 Does Concentrated Growth Factor Used With Allografts in Maxillary Sinus Lifting Have Adjunctive Benefits? PMID:32866488 | 2021 | this review only | not stated | not extracted yet |
| Akcan 2020 Gingival recession treatment with concentrated growth factor membrane: a comparative clinical trial DOI:10.1590/1678-7757-2019-0236 | 2020 | this review only | Probing pocket depth (PPD); Clinical attachment level (CAL) gain; Keratinized gingival width (KGW); Gingival thickness (GT); Mean root coverage (MRC) | not extracted yet |
| Akcan 2020 Gingival recession treatment with concentrated growth factor membrane: a comparative clinical trial. PMID:32236353 | 2020 | this review only | Probing pocket depth (PPD); Clinical attachment level (CAL) gain; Keratinized gingival width (KGW); Gingival thickness (GT); Mean root coverage (MRC) | not extracted yet |
| Bozkurt Dogan 2015 Concentrated growth factor in the treatment of adjacent multiple gingival recessions: a split‐mouth randomized clinical trial DOI:10.1111/jcpe.12444 | 2015 | this review only | Probing pocket depth (PPD); Clinical attachment level (CAL) gain; Keratinized gingival width (KGW); Gingival thickness (GT) | not extracted yet |
| Bozkurt Dogan 2015 Concentrated growth factor in the treatment of adjacent multiple gingival recessions: a split-mouth randomized clinical trial. PMID:26269089 | 2015 | this review only | Probing pocket depth (PPD); Clinical attachment level (CAL) gain; Keratinized gingival width (KGW); Gingival thickness (GT) | not extracted yet |
| Elayah 2022 Effect of concentrated growth factor (CGF) on postoperative sequel of completely impacted lower third molar extraction: a randomized… DOI:10.1186/s12903-022-02408-7 | 2022 | this review only | not stated | not extracted yet |
| Forabosco 2018 rT3 metabolism in patients with nephrotic syndrome and normal GFR compared with normal subjects. PMID:2018127 | 1991 | this review only | not stated | not extracted yet |
| Gaur 2022 Efficacy and Safety of Concentrated Growth Factors and Platelet- Rich Fibrin on Stability and Bone Regeneration in Patients with Immediate… PMID:35904836 | 2022 | this review only | not stated | not extracted yet |
| Ghasemirad 2023 Histological examination of the effect of concentrated growth factor (CGF) on healing outcomes after maxillary sinus floor augmentation… PMID:36937478 | 2023 | this review only | not stated | not extracted yet |
| Inchingolo 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Isler 2018 Regenerative surgical treatment of peri-implantitis using either a collagen membrane or concentrated growth factor: A 12-month randomized… PMID:30118569 | 2018 | this review only | not stated | not extracted yet |
| Isler 2022 Efficacy of concentrated growth factor versus collagen membrane in reconstructive surgical therapy of peri-implantitis: 3-year results of… DOI:10.1007/s00784-022-04493-y | 2022 | this review only | not stated | not extracted yet |
| Karthik 2022 Randomized Controlled Study on Effect of Concentrated Growth Factors on Crestal Bone Levels and Peri-implant Bone Density in Dental… PMID:36110820 | 2022 | this review only | not stated | not extracted yet |
| Keranmu 2022 Clinical application of concentrate growth factors combined with bone substitute in Alveolar ridge preservation of anterior teeth DOI:10.1186/s12903-022-02091-8 | 2022 | this review only | not stated | not extracted yet |
| Keranmu 2022 Clinical application of concentrate growth factors combined with bone substitute in Alveolar ridge preservation of anterior teeth. PMID:35241047 | 2022 | this review only | not stated | not extracted yet |
| Korkmaz 2021 Clinical evaluation of the treatment of multiple gingival recessions with connective tissue graft or concentrated growth factor using… DOI:10.1007/s00784-021-03935-3 | 2021 | this review only | Probing pocket depth (PPD); Clinical attachment level (CAL) gain; Keratinized gingival width (KGW); Gingival thickness (GT); Mean root coverage (MRC) | not extracted yet |
| Lin 2021 Clinical applications of concentrated growth factors combined with bone substitutes for alveolar ridge preservation in maxillary molar… DOI:10.1186/s40729-021-00396-x | 2021 | this review only | not stated | not extracted yet |
| Liu 2022 Clinical applications of concentrated growth factors membrane for sealing the socket in alveolar ridge preservation: a randomized… DOI:10.1186/s40729-022-00448-w | 2022 | this review only | not stated | not extracted yet |
| Liu 2022 Clinical applications of concentrated growth factors membrane for sealing the socket in alveolar ridge preservation: a randomized… PMID:36316617 | 2022 | this review only | not stated | not extracted yet |
| Ongoz Dede 2023 Comparison of the clinical efficacy of concentrated growth factor and advanced platelet-rich fibrin in the treatment of type I multiple… DOI:10.1007/s00784-022-04775-5 | 2022 | this review only | Probing pocket depth (PPD); Clinical attachment level (CAL) gain; Keratinized gingival width (KGW); Gingival thickness (GT) | not extracted yet |
| Ozveri Koyuncu 2020b Effect of concentrated growth factors on frequency of alveolar Osteitis following partially-erupted mandibular third molar surgery: a… DOI:10.1186/s12903-020-01210-7 | 2020 | this review only | not stated | not extracted yet |
| Ozveri Koyuncu 2020b Effect of concentrated growth factors on frequency of alveolar Osteitis following partially-erupted mandibular third molar surgery: a… PMID:32807173 | 2020 | this review only | not stated | not extracted yet |
| Pirpir 2017 Evaluation of effectiveness of concentrated growth factor on osseointegration DOI:10.1186/s40729-017-0069-3 | 2017 | this review only | not stated | not extracted yet |
| Pirpir 2017 Evaluation of effectiveness of concentrated growth factor on osseointegration. PMID:28258471 | 2017 | this review only | not stated | not extracted yet |
| Torul 2020 Evaluation of the effects of concentrated growth factors or advanced platelet rich-fibrin on postoperative pain, edema, and trismus… PMID:32068167 | 2020 | this review only | not stated | not extracted yet |
| Torul 2023 Investigation of the clinical efficacy of CGF and ozone in the management of alveolar osteitis: a randomized controlled trial DOI:10.1007/s00784-023-05074-3 | 2023 | this review only | not stated | not extracted yet |
| Vaid 2021 Clinical and radiographic evaluation of demineralized freeze-dried bone allograft with concentrated growth factor versus concentrated… PMID:34013194 | 2021 | this review only | not stated | not extracted yet |
| Xu 2019 One-Year Results Evaluating the Effects of Concentrated Growth Factors on the Healing of Intrabony Defects Treated with or without Bone… PMID:31188801 | 2019 | this review only | Probing pocket depth (PPD) reduction; Clinical attachment level (CAL) gain | not extracted yet |
| Xue 2022 Treatment of multiple gingival recessions with concentrated growth factor membrane and coronally advanced tunnel technique via digital… DOI:10.1016/j.jds.2021.10.012 | 2022 | this review only | Probing pocket depth (PPD); Keratinized gingival width (KGW); Gingival thickness (GT); Mean root coverage (MRC) | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients in good health with surgically manageable oral conditions needing improvement of bone, cementum, soft tissue and/or PDL; adults aged 18 or older | Periodontal intrabony defects (n=4 RCTs); gingival recession (n=5); alveolar ridge preservation (n=4); guided bone regeneration (n=1); sinus lifting (n=3); dental implants (n=7); third molar extraction and alveolar osteitis (n=6) |
| Intervention | Dental surgical treatments using concentrated growth factor (CGF) alone or with other biomaterials | CGF with bone graft (DFDBA or Bio-Oss), CAF or tunnel technique with CGF, CGF membrane, CGF in implants, sinus lift and extraction sockets |
| Comparison | Regenerative or reparative approaches without CGF | Bone graft alone, CAF alone, CTG with CAF or tunnel technique, collagen membrane, self-healing, no CGF |
| Outcomes | Restoration of soft and/or hard tissues of the periodontium, tooth structure, alveolar bone or peri-implant tissues, clinical and radiographic | PPD, CAL, intrabony defect depth, keratinized gingiva width, gingival thickness, mean root coverage (meta-analysed); other outcomes narrative |
| Study designs | Randomized controlled trials in humans (parallel or split-mouth), English only | 30 RCTs (8 in meta-analysis) |
| Timing | Publications from July 1, 2013 to July 1, 2023 | 3 to 36 months of follow-up (meta-analysed studies: 12 months for intrabony defects, 6 months for gingival recession) |