Non-Cochrane · intervention · PM42371457
Adjunctive Autologous Platelet Concentrates for Periodontal Regeneration in Intrabony Defects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Charrouf Abou Zeid Chadi, Tamayo Flavia P, Jaramillo Arturo P, et al. · Cureus · 2026 · PubMed · doi:10.7759/cureus.109878
Findings
Population Adults with periodontal intrabony defects requiring regenerative therapy
3 findings
| Regenerative periodontal therapy with autologous platelet-concentrate adjunct (PRF, CGF, i-PRF, A-PRF, T-PRF) | Regenerative periodontal therapy without platelet concentrate (graft only, OFD or other) | Radiographic bone fill or defect-depth reduction (mm) Follow-up 6 to 12 months (varied across studies) · Periodontal surgery | MD 0.57 [-0.06, 1.20] GRADE not reported 5 studies · 123 participants |
| Regenerative periodontal therapy with autologous platelet-concentrate adjunct (PRF, CGF, i-PRF, A-PRF, T-PRF) | Regenerative periodontal therapy without platelet concentrate (graft only, OFD or other) | Clinical attachment level or relative attachment level gain (mm) Follow-up 6 to 12 months (varied across studies) · Periodontal surgery | MD 0.64 [0.38, 0.90] GRADE not reported 10 studies · 259 participants |
| Regenerative periodontal therapy with autologous platelet-concentrate adjunct (PRF, CGF, i-PRF, A-PRF, T-PRF) | Regenerative periodontal therapy without platelet concentrate (graft only, OFD or other) | Clinical attachment level or relative attachment level gain (mm) Follow-up 6 to 12 months (varied across studies) · Periodontal surgery · Sensitivity analysis: reduced set of 8 RCTs | MD 0.35 [0.08, 0.61] GRADE not reported 8 studies · 200 participants |
Included primary studies 10
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Bahammam 2021 Expression of Vascular Endothelial Growth Factor Using Platelet Rich Fibrin (PRF) and Nanohydroxyapatite (nano-HA) in Treatment of… PMID:33424378 | 2021 | 3 other reviews | Clinical attachment level or relative attachment level gain (mm) | not extracted yet |
| Mallappa 2022 Clinicoradiographic evaluation of advanced-platelet rich fibrin block (A PRF + i PRF + nanohydroxyapatite) compared to nanohydroxyapatite… PMID:35959304 | 2022 | 1 other review | Clinical attachment level or relative attachment level gain (mm); Radiographic bone fill or defect-depth reduction (mm) | not extracted yet |
| Ozkal Eminoglu 2024 The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study. PMID:38843242 | 2024 | 1 other review | Clinical attachment level or relative attachment level gain (mm) | not extracted yet |
| Qiao 2016 The effect of concentrated growth factors in the treatment of periodontal intrabony defects. PMID:28642822 | 2016 | 1 other review | Clinical attachment level or relative attachment level gain (mm); Radiographic bone fill or defect-depth reduction (mm) | not extracted yet |
| Alshoiby 2023 Injectable platelet-rich fibrin with demineralized freeze-dried bone allograft compared to demineralized freeze-dried bone allograft in… PMID:37002441 | 2023 | this review only | Clinical attachment level or relative attachment level gain (mm) | not extracted yet |
| Atchuta 2020 Clinical and radiographic evaluation of platelet-rich fibrin as an adjunct to bone grafting demineralized freeze-dried bone allograft in… PMID:31983847 | 2020 | this review only | Clinical attachment level or relative attachment level gain (mm) | not extracted yet |
| Goyal 2020 Comparative assessment of periodontal regeneration in periodontal intraosseous defects treated with PepGen P-15 unaided or in blend with… PMID:32189844 | 2020 | this review only | Clinical attachment level or relative attachment level gain (mm); Radiographic bone fill or defect-depth reduction (mm) | not extracted yet |
| Hazari 2021 Clinical and Radiographic Analysis of Novabone Putty with Platelet-Rich Fibrin in the Treatment of Periodontal Intrabony Defects: A… PMID:34220155 | 2021 | this review only | Clinical attachment level or relative attachment level gain (mm) | not extracted yet |
| Naqvi 2017 Comparative Evaluation of Bioactive Glass Putty and Platelet Rich Fibrin in the Treatment of Human Periodontal Intrabony Defects: A… PMID:28893033 | 2017 | this review only | Clinical attachment level or relative attachment level gain (mm); Radiographic bone fill or defect-depth reduction (mm) | not extracted yet |
| Pavani 2021 Evaluation of platelet-rich fibrin and tricalcium phosphate bone graft in bone fill of intrabony defects using cone-beam computed… PMID:33888946 | 2021 | this review only | Clinical attachment level or relative attachment level gain (mm); Radiographic bone fill or defect-depth reduction (mm) | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adult patients with periodontal intrabony defects requiring regenerative periodontal therapy | Patients with periodontal intrabony defects (n=10 RCTs) |
| Intervention | Autologous platelet-concentrate adjuncts (PRF, CGF, i-PRF, A-PRF, T-PRF or related) used alone or with grafting materials | PRF, CGF, i-PRF, A-PRF or T-PRF with or without graft (n=10) |
| Comparison | Regenerative periodontal therapy without platelet-concentrate adjunct (OFD, graft only, GTR or other) | Graft-only, OFD or other regeneration without platelet concentrate (n=10) |
| Outcomes | Primary: CAL or RAL gain (mm). Secondary: PPD reduction, radiographic bone fill or defect-depth reduction, gingival recession, CBCT bone measures, biologic markers | CAL or RAL gain (n=10 and n=8 sensitivity); radiographic bone fill or defect-depth reduction (n=5) |
| Study designs | Randomized controlled trials (parallel and split-mouth), human, English, last 10 years | RCTs (n=10), including parallel-arm and split-mouth designs |
| Timing | Not specified | Follow-up 3 to 12 months across trials |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | No | No | yes |
| 3Choice of study designs explained | No | No | yes |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | No | No | yes |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | NRSI: N/A · RCT: Yes | NRSI: N/A · RCT: Yes | yes |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: No · NRSI: N/A | NRSI: N/A · RCT: No | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | Yes | Yes | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |