evidencegaps
Primary study · included by 4 reviews

Expression of Vascular Endothelial Growth Factor Using Platelet Rich Fibrin (PRF) and Nanohydroxyapatite (nano-HA) in Treatment of Periodontal Intra-Bony Defects - A Randomized Controlled Trial.

Bahammam 2021 · Bahammam Maha A, Attia Mai S · Saudi journal of biological sciences · 2021

Included by

Scaffold-Based Biomaterials for Periodontal Regeneration in Periodontitis: A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Bahammam 2021 · Table 1; reference 41

The review does not say which of its outcomes this study informs.

Adjunctive Autologous Platelet Concentrates for Periodontal Regeneration in Intrabony Defects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Non-Cochrane · intervention · 2026 · cited as Bahammam 2021 · Table 2; Figure 2; reference list
Outcome this study informsPooled effectEvidenceCertainty
Clinical attachment level or relative attachment level gain (mm)
Regenerative periodontal therapy with autologous platelet-concentrate adjunct (PRF, CGF, i-PRF, A-PRF, T-PRF) vs Regenerative periodontal therapy without platelet concentrate (graft only, OFD or other) · Follow-up 6 to 12 months (varied across studies)
MD 0.64 [0.38, 0.90]10 studies · 259 participantsGRADE not reported
Clinical attachment level or relative attachment level gain (mm)
Regenerative periodontal therapy with autologous platelet-concentrate adjunct (PRF, CGF, i-PRF, A-PRF, T-PRF) vs Regenerative periodontal therapy without platelet concentrate (graft only, OFD or other) · Follow-up 6 to 12 months (varied across studies)
MD 0.35 [0.08, 0.61]8 studies · 200 participantsGRADE not reported
Effects of platelet-rich fibrin combined with hydroxyapatite in the treatment of patients with periodontal intrabony defects: a meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Bahammam 2021 · Table 1; reference 18

The review does not say which of its outcomes this study informs.

Efficacy of Leukocyte and Platelet-Rich Fibrin (L-PRF) as an adjunct to Open Flap Debridement (OFD) in periodontal intrabony defects: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Bahammam & Attia 2021 · Table 1; References 15-37

The review does not say which of its outcomes this study informs.

4 including reviews in total.