Non-Cochrane · intervention · PM42740455
Emerging, personalized, and minimally invasive technologies for periodontal and peri-implant soft and hard tissue regenerative therapy.
Barootchi Shayan, Tavelli Lorenzo, Sabri Hamoun, et al. · Journal of periodontology · 2026 · PubMed · doi:10.1002/jper.70108
Findings
31 findings
| Population | ||||
|---|---|---|---|---|
| Adults with natural teeth needing soft tissue thickness augmentation | CTG (bilaminar approach) | Flap therapy alone (no soft tissue augmentation) | gingival thickness (GT) change 12 months minimum (6 to 144 months reported; data beyond 72 months not analyzed) · Randomized clinical trials, mostly university settings | MD 0.62 [0.47, 0.77] High 54 studies · 2972 participants |
| Adults with gingival soft tissue defects around natural teeth | VCMX with flap | Flap alone | Gingival thickness gain (mm) | MD 0.57 [0.21, 0.93] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | hADM with flap | Flap alone | Gingival thickness gain (mm) | MD 0.48 [0.28, 0.67] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | pADM with flap | Flap alone | Gingival thickness gain (mm) | MD 0.47 [0.15, 0.81] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | CMX with flap | Flap alone | Gingival thickness gain (mm) | MD 0.33 [0.17, 0.49] GRADE not reported Studies not reported |
| Adults with natural teeth needing soft tissue thickness augmentation | Flap therapy alone | CTG (connective tissue graft), bilaminar approach | gingival thickness (GT) change 12 months minimum (6 to 144 months reported; data beyond 72 months not analyzed) · Randomized clinical trials, mostly university settings Unresolved: the two extractors disagree on this row. | MD -0.62 [-0.77, -0.48] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | CMX with flap | CTG with flap | Gingival thickness gain (mm) | MD -0.28 [-0.43, -0.14] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | hADM with flap | CTG with flap | Gingival thickness gain (mm) | MD -0.14 [-0.34, 0.05] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | VCMX with flap | CTG with flap | Gingival thickness gain (mm) | MD -0.05 [-0.71, 0.61] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | pADM with flap | CTG with flap | Gingival thickness gain (mm) | MD -0.14 [-0.43, 0.14] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | CMX | No soft tissue augmentation | Mucosal thickness gain (mm) | MD 0.68 [0.42, 0.95] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | pADM | No soft tissue augmentation | Mucosal thickness gain (mm) | MD 0.71 [0.12, 1.29] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | VCMX | No soft tissue augmentation | Mucosal thickness gain (mm) | MD 0.88 [0.21, 1.54] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | hADM | No soft tissue augmentation | Mucosal thickness gain (mm) | MD 0.98 [0.62, 1.33] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | CMX | CTG | Mucosal thickness gain (mm) | MD -0.44 [-0.62, -0.26] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | ADM | CTG | Mucosal thickness gain (mm) | MD -0.14 [-0.17, 0.46] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | XCM | CTG | Mucosal thickness gain (mm) | MD -0.24 [-0.56, 0.08] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | Baseline gingival thickness | None | Gingival thickness gain (mm) | Regression coefficient 0.49 [0.22, 0.76] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | Baseline keratinized tissue width | None | Gingival thickness gain (mm) | Regression coefficient 0.019 [-0.08, 0.12] GRADE not reported Studies not reported |
| Adults with dental implants needing peri-implant mucosal thickness augmentation | CTG (bilaminar approach) | No soft tissue augmentation (untreated sites) | mucosal thickness (MT) change 6 months minimum (6 to 48 months) · Randomized clinical trials, mostly university settings | MD 1.12 [0.91, 1.33] High 24 studies · 851 participants |
| Adults with gingival soft tissue defects around natural teeth | Baseline gingival recession | None | Gingival thickness gain (mm) | Regression coefficient 0.05 [-0.05, 0.16] GRADE not reported Studies not reported |
| Adults with dental implants needing peri-implant mucosal thickness augmentation | No soft tissue augmentation | CTG (connective tissue graft), bilaminar approach | mucosal thickness (MT) change 6 months minimum (6 to 48 months) · Randomized clinical trials, mostly university settings Unresolved: the two extractors disagree on this row. | MD -1.12 [-1.33, -0.91] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | Time | None | Gingival thickness gain (mm) | Regression coefficient -0.0009 [-0.001, 0.00009] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | Increase in gingival thickness | None | Gingival recession over time | Regression coefficient -0.16 [-0.31, -0.01] GRADE not reported Studies not reported |
| Adults with gingival soft tissue defects around natural teeth | Increase in gingival thickness | None | Plaque index over time | Regression coefficient -0.39 [-0.64, -0.13] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | Baseline mucosal thickness | None | Mucosal thickness gain (mm) | Regression coefficient 1.04 [0.75, 1.33] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | Baseline keratinized tissue | None | Mucosal thickness gain (mm) | Regression coefficient -0.12 [-0.54, 0.28] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | Time | None | Mucosal thickness gain (mm) | Regression coefficient -0.01 [-0.02, 0.0006] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | Mucosal thickness augmentation | None | Probing depth | Regression coefficient -0.81 [-1.25, -0.35] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | Mucosal thickness augmentation | None | Bleeding on probing | Regression coefficient -0.52 [-3.26, 2.21] GRADE not reported Studies not reported |
| Adults requiring peri-implant soft tissue augmentation | Mucosal thickness augmentation | None | Plaque index | Regression coefficient -1.4 [-7.87, 5.07] GRADE not reported Studies not reported |
Included primary studies 170
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Ferrarotti 2018 Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial. PMID:29779220 | 2018 | 4 other reviews | not stated | not extracted yet |
| Chen 2016 Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial. PMID:26895633 | 2016 | 3 other reviews | not stated | not extracted yet |
| Sanchez 2020 Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A… PMID:32946590 | 2020 | 3 other reviews | not stated | not extracted yet |
| Aroca 2013 Treatment of multiple adjacent Miller class I and II gingival recessions with a Modified Coronally Advanced Tunnel (MCAT) technique and a… PMID:23627374 | 2013 | 2 other reviews | not stated | not extracted yet |
| Bajestan 2017 Stem cell therapy for reconstruction of alveolar cleft and trauma defects in adults: A randomized controlled, clinical trial. PMID:28656723 | 2017 | 2 other reviews | not stated | not extracted yet |
| Cairo 2017 Xenogeneic collagen matrix versus connective tissue graft for buccal soft tissue augmentation at implant site. A randomized, controlled… DOI:10.1111/jcpe.12750 | 2017 | 2 other reviews | not stated | not extracted yet |
| Clem 2024 Harvest graft substitute for soft tissue volume augmentation around existing implants: A randomized, controlled and blinded multicenter… DOI:10.1002/jper.23-0305 | 2023 | 2 other reviews | not stated | not extracted yet |
| Fatale 2022 Histomorphometric Comparison of New Bone Formed After Maxillary Sinus Lift With Lateral and Crestal Approaches Using Periostal Mesenchymal… PMID:36041126 | 2022 | 2 other reviews | not stated | not extracted yet |
| Gjerde 2018 Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. PMID:30092840 | 2018 | 2 other reviews | not stated | not extracted yet |
| Gupta 2021 A comparative evaluation of bone regeneration using mesenchymal stem cells versus blood coagulum in sinus augmentation procedures. PMID:35153430 | 2021 | 2 other reviews | not stated | not extracted yet |
| Hamdy 2024 Volumetric assessment of volume stable collagen matrix in maxillary single implant site development: A randomized controlled clinical trial DOI:10.1111/cid.13353 | 2024 | 2 other reviews | not stated | not extracted yet |
| Kaigler 2013 Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial. PMID:22776413 | 2013 | 2 other reviews | not stated | not extracted yet |
| Kaigler 2015 Bone Engineering of Maxillary Sinus Bone Deficiencies Using Enriched CD90+ Stem Cell Therapy: A Randomized Clinical Trial. PMID:25652112 | 2015 | 2 other reviews | not stated | not extracted yet |
| Khojasteh 2019 Buccal fat pad-derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: An… PMID:30821120 | 2019 | 2 other reviews | not stated | not extracted yet |
| Meza‐Mauricio 2021 Comparison between a xenogeneic dermal matrix and connective tissue graft for the treatment of multiple adjacent gingival recessions: a… PMID:34021404 | 2021 | 2 other reviews | not stated | not extracted yet |
| Payer 2014 Effects of directly autotransplanted tibial bone marrow aspirates on bone regeneration and osseointegration of dental implants. PMID:23701676 | 2014 | 2 other reviews | not stated | not extracted yet |
| Pietruska 2019 Clinical evaluation of Miller class I and II recessions treatment with the use of modified coronally advanced tunnel technique with either… PMID:30362599 | 2019 | 2 other reviews | not stated | not extracted yet |
| Rakasevic 2020 The use of collagen porcine dermal matrix and connective tissue graft with modified coronally advanced tunnel technique in the treatment… PMID:32706184 | 2020 | 2 other reviews | not stated | not extracted yet |
| Whitt 2020 Efficacy of stem cell allograft in maxillary sinus bone regeneration: a randomized controlled clinical and blinded histomorphometric study. PMID:32596764 | 2020 | 2 other reviews | not stated | not extracted yet |
| Abdelwahab 2023 Soft tissue esthetics around immediately provisionalized delayed implants with and without connective tissue graft: A randomized clinical… DOI:10.1111/cid.13168 | 2022 | 1 other review | not stated | not extracted yet |
| Ahmedbeyli 2014 Clinical evaluation of coronally advanced flap with or without acellular dermal matrix graft on complete defect coverage for the treatment… PMID:24304099 | 2014 | 1 other review | not stated | not extracted yet |
| Ahmedbeyli 2019 Coronally advanced flap and envelope type of flap plus acellular dermal matrix graft for the treatment of thin phenotype multiple… PMID:31350924 | 2019 | 1 other review | not stated | not extracted yet |
| Aimetti 2018 Regenerative Treatment of Periodontal Intrabony Defects Using Autologous Dental Pulp Stem Cells: A 1-Year Follow-Up Case Series. PMID:29240205 | 2018 | 1 other review | not stated | not extracted yet |
| Asahina 2021 Clinical Outcome and 8-Year Follow-Up of Alveolar Bone Tissue Engineering for Severely Atrophic Alveolar Bone Using Autologous Bone Marrow… PMID:34830513 | 2021 | 1 other review | not stated | not extracted yet |
| Baba 2016 Phase I/II Trial of Autologous Bone Marrow Stem Cell Transplantation with a Three-Dimensional Woven-Fabric Scaffold for Periodontitis. PMID:27990164 | 2016 | 1 other review | not stated | not extracted yet |
| Cairo 2016 Clinical efficacy of coronally advanced flap with or without connective tissue graft for the treatment of multiple adjacent gingival… PMID:27329829 | 2016 | 1 other review | not stated | not extracted yet |
| Cairo 2017 Xenogeneic collagen matrix versus connective tissue graft for buccal soft tissue augmentation at implant site. A randomized, controlled… PMID:28548210 | 2017 | 1 other review | not stated | not extracted yet |
| Carrera 2023 Root coverage with platelet-rich fibrin or connective tissue graft: a split-mouth randomized trial. PMID:37672418 | 2023 | 1 other review | not stated | not extracted yet |
| Chen 2023 Does vestibular incision improve the outcomes of vestibular incision subperiosteal tunnel technique: A randomized clinical trial for… PMID:37078417 | 2023 | 1 other review | not stated | not extracted yet |
| Clem 2024 Harvest graft substitute for soft tissue volume augmentation around existing implants: A randomized, controlled and blinded multicenter… PMID:38071454 | 2024 | 1 other review | not stated | not extracted yet |
| D'Elia 2017 Peri-implant Soft Tissue Stability After Single Implant Restorations Using Either Guided Bone Regeneration or a Connective Tissue Graft: A… DOI:10.11607/prd.2747 | 2017 | 1 other review | not stated | not extracted yet |
| Elena 2024 Analysis of the treatment of RT2 recessions with a xenogeneic collagen matrix vs. connective tissue graft combined with a coronally… PMID:38489063 | 2024 | 1 other review | not stated | not extracted yet |
| Feng 2021 Small blood stem cells for enhancing early osseointegration formation on dental implants: a human phase I safety study. PMID:34215319 | 2021 | 1 other review | not stated | not extracted yet |
| Górski 2022 Effect of 24% EDTA root conditioning on the outcome of modified coronally advanced tunnel technique with subepithelial connective tissue… PMID:34431001 | 2022 | 1 other review | not stated | not extracted yet |
| Hamdy 2024 Volumetric assessment of volume stable collagen matrix in maxillary single implant site development: A randomized controlled clinical trial. PMID:38938060 | 2024 | 1 other review | not stated | not extracted yet |
| Kassis 2024 The Effect of Connective Tissue Graft Compared to Concentrated Growth Factor Graft on Buccal Peri-Implant Gingival Thickness: A 12-month… DOI:10.1016/j.joms.2024.02.005 | 2024 | 1 other review | not stated | not extracted yet |
| Kuka 2018 Clinical evaluation of coronally advanced flap with or without platelet-rich fibrin for the treatment of multiple gingival recessions. PMID:29058084 | 2018 | 1 other review | not stated | not extracted yet |
| Lazzari 2022 Single implant placement in the maxillary aesthetic area with or without connective tissue grafting: A 1-year follow-up randomised… PMID:35266669 | 2022 | 1 other review | not stated | not extracted yet |
| Lee 2023 Clinical efficacy of soft‐tissue augmentation on tissue preservation at immediate implant sites: A randomized controlled trial DOI:10.1111/jcpe.13816 | 2023 | 1 other review | not stated | not extracted yet |
| Menezes 2024 Efficacy of xenogeneic collagen matrix in the treatment of gingival recessions: a controlled clinical trial. PMID:39536202 | 2024 | 1 other review | not stated | not extracted yet |
| Puzio 2018 Ultrasound assessment of soft tissue augmentation around implants in the aesthetic zone using a connective tissue graft and xenogeneic… DOI:10.1016/j.aanat.2017.11.003 | 2018 | 1 other review | not stated | not extracted yet |
| Puzio 2018 Ultrasound assessment of soft tissue augmentation around implants in the aesthetic zone using a connective tissue graft and xenogeneic… PMID:29248711 | 2018 | 1 other review | not stated | not extracted yet |
| Rotundo 2019 Adjunctive benefit of a xenogenic collagen matrix associated with coronally advanced flap for the treatment of multiple gingival… PMID:31292987 | 2019 | 1 other review | not stated | not extracted yet |
| Sanz 2025 Bone Augmentation of Atrophic Alveolar Ridges Using a Synthetic Bone Substitute With Mesenchymal Stem Cells: A Randomized, Controlled… PMID:40844304 | 2025 | 1 other review | not stated | not extracted yet |
| Shabaan 2023 Alveolar cleft reconstruction using bone marrow aspirate concentrate and iliac cancellous bone: A 12-month randomized clinical study. PMID:37794139 | 2023 | 1 other review | not stated | not extracted yet |
| Skierska 2024 Tunnel technique and subepithelial connective tissue graft, with or without cross-linked hyaluronic acid, in the treatment of multiple… PMID:38808976 | 2024 | 1 other review | not stated | not extracted yet |
| Surdiacourt 2025 A multi‐centre randomized controlled trial comparing connective tissue graft with collagen matrix to increase soft tissue thickness at the… DOI:10.1111/jcpe.13975 | 2024 | 1 other review | not stated | not extracted yet |
| Tavelli 2022 Recombinant human platelet-derived growth factor improves root coverage of a collagen matrix for multiple adjacent gingival recessions: A… PMID:35871600 | 2022 | 1 other review | not stated | not extracted yet |
| Tavelli 2023 Coronally advanced flap versus tunnel technique for the treatment of peri‐implant soft tissue dehiscences with the connective tissue… DOI:10.1111/jcpe.13806 | 2023 | 1 other review | not stated | not extracted yet |
| Trivedi 2024 Comparative evaluation of pinhole surgical technique with and without A-PRF in the treatment of multiple adjacent recession defects: A… PMID:37466087 | 2024 | 1 other review | not stated | not extracted yet |
| Wiesner 2010 Connective tissue grafts for thickening peri-implant tissues at implant placement. One-year results from an explanatory split-mouth… PMID:20467596 | 2010 | 1 other review | not stated | not extracted yet |
| Yilmaz 2022 Modified coronally advanced tunnel versus epithelialized free gingival graft technique in gingival phenotype modification: a comparative… PMID:35708779 | 2022 | 1 other review | not stated | not extracted yet |
| Zucchelli 2010 Patient morbidity and root coverage outcome after subepithelial connective tissue and de-epithelialized grafts: a comparative… PMID:20590963 | 2010 | 1 other review | not stated | not extracted yet |
| Abdelwahab 2023 Soft tissue esthetics around immediately provisionalized delayed implants with and without connective tissue graft: A randomized clinical… PMID:36579756 | 2023 | this review only | not stated | not extracted yet |
| Ahmedbeyli 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ahmedbeyli 2019 Coronally advanced flap and envelope type of flap plus acellular dermal matrix graft for the treatment of thin phenotype multiple… DOI:10.1111/jcpe.13174 | 2019 | this review only | not stated | not extracted yet |
| Ahmedbeyli 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Ahmedbeyli 2019 Laterally positioned flap along with acellular dermal matrix graft in the management of maxillary localized recessions. PMID:29725851 | 2019 | this review only | not stated | not extracted yet |
| Anderson 2014 Implant Associated Soft Tissue Defects in the Anterior Maxilla DOI:10.1097/id.0000000000000122 | 2014 | this review only | not stated | not extracted yet |
| Anderson 2014 Implant associated soft tissue defects in the anterior maxilla: a randomized control trial comparing subepithelial connective tissue graft… PMID:25033346 | 2014 | this review only | not stated | not extracted yet |
| Andrade 2008 Comparison between two surgical techniques for root coverage with an acellular dermal matrix graft DOI:10.1111/j.1600-051x.2007.01193.x | 2008 | this review only | not stated | not extracted yet |
| Andrade 2008 Comparison between two surgical techniques for root coverage with an acellular dermal matrix graft. PMID:18269666 | 2008 | this review only | not stated | not extracted yet |
| Aroca 2013 Treatment of multiple adjacent Miller class I and <scp>II</scp> gingival recessions with a Modified Coronally Advanced Tunnel… DOI:10.1111/jcpe.12112 | 2013 | this review only | not stated | not extracted yet |
| Ayub 2014 A Modified Surgical Technique for Root Coverage With an Allograft: A 12‐Month Randomized Clinical Trial DOI:10.1902/jop.2014.140111 | 2014 | this review only | not stated | not extracted yet |
| Ayub 2014 A modified surgical technique for root coverage with an allograft: a 12-month randomized clinical trial. PMID:24878327 | 2014 | this review only | not stated | not extracted yet |
| Barootchi 2019 Long term assessment of root coverage stability using connective tissue graft with or without an epithelial collar for gingival recession… DOI:10.1111/jcpe.13187 | 2019 | this review only | not stated | not extracted yet |
| Barootchi 2019 Long term assessment of root coverage stability using connective tissue graft with or without an epithelial collar for gingival recession… PMID:31446625 | 2019 | this review only | not stated | not extracted yet |
| Bittencourt 2009 Semilunar Coronally Positioned Flap or Subepithelial Connective Tissue Graft for the Treatment of Gingival Recession: A 30‐Month Follow‐Up… DOI:10.1902/jop.2009.080498 | 2009 | this review only | not stated | not extracted yet |
| Bittencourt 2009 Semilunar coronally positioned flap or subepithelial connective tissue graft for the treatment of gingival recession: a 30-month follow-up… PMID:19563287 | 2009 | this review only | not stated | not extracted yet |
| Bittencourt 2012 Surgical Microscope May Enhance Root Coverage With Subepithelial Connective Tissue Graft: A Randomized‐Controlled Clinical Trial DOI:10.1902/jop.2011.110202 | 2012 | this review only | not stated | not extracted yet |
| Bittencourt 2012 Surgical microscope may enhance root coverage with subepithelial connective tissue graft: a randomized-controlled clinical trial. PMID:21870975 | 2012 | this review only | not stated | not extracted yet |
| Cairo 2016 Clinical efficacy of coronally advanced flap with or without connective tissue graft for the treatment of multiple adjacent gingival… DOI:10.1111/jcpe.12590 | 2016 | this review only | not stated | not extracted yet |
| Cardaropoli 2012 Treatment of Gingival Recession Defects Using Coronally Advanced Flap With a Porcine Collagen Matrix Compared to Coronally Advanced Flap… DOI:10.1902/jop.2011.110215 | 2012 | this review only | not stated | not extracted yet |
| Cardaropoli 2012 Treatment of gingival recession defects using coronally advanced flap with a porcine collagen matrix compared to coronally advanced flap… PMID:21721988 | 2012 | this review only | not stated | not extracted yet |
| Cardaropoli 2014 Analysis of Buccolingual Dimensional Changes of the Extraction Socket Using the “Ice Cream Cone” Flapless Grafting Technique DOI:10.11607/prd.1605 | 2014 | this review only | not stated | not extracted yet |
| Cardaropoli 2014 Coronally advanced flap with and without a xenogenic collagen matrix in the treatment of multiple recessions: a randomized controlled… PMID:24956099 | 2014 | this review only | not stated | not extracted yet |
| Carrera 2023 Root coverage with platelet-rich fibrin or connective tissue graft: a split-mouth randomized trial DOI:10.1590/1807-3107bor-2023.vol37.0084 | 2023 | this review only | not stated | not extracted yet |
| Chen 2023 Does vestibular incision improve the outcomes of vestibular incision subperiosteal tunnel technique: A randomized clinical trial for… DOI:10.1111/jerd.13051 | 2023 | this review only | not stated | not extracted yet |
| Clementini 2018 Biologically guided flap stability: the role of flap thickness including periosteum retention on the performance of the coronally advanced… DOI:10.1111/jcpe.12998 | 2018 | this review only | not stated | not extracted yet |
| Clementini 2018 Biologically guided flap stability: the role of flap thickness including periosteum retention on the performance of the coronally advanced… PMID:30099762 | 2018 | this review only | not stated | not extracted yet |
| Cosyn 2022 A multi‐centre randomized controlled trial comparing connective tissue graft with collagen matrix to increase soft tissue thickness at the… DOI:10.1111/jcpe.13691 | 2022 | this review only | not stated | not extracted yet |
| Cosyn 2022 A multi-centre randomized controlled trial comparing connective tissue graft with collagen matrix to increase soft tissue thickness at the… PMID:35781692 | 2022 | this review only | not stated | not extracted yet |
| D'Elia 2017 Peri-implant Soft Tissue Stability After Single Implant Restorations Using Either Guided Bone Regeneration or a Connective Tissue Graft: A… PMID:28402353 | 2017 | this review only | not stated | not extracted yet |
| De Bruyckere 2018 A randomized controlled study comparing guided bone regeneration with connective tissue graft to re‐establish convexity at the buccal… DOI:10.1111/jcpe.13006 | 2018 | this review only | not stated | not extracted yet |
| De Bruyckere 2018 A randomized controlled study comparing guided bone regeneration with connective tissue graft to re-establish convexity at the buccal… PMID:30133718 | 2018 | this review only | not stated | not extracted yet |
| de Queiroz Cortes 2006 A two‐year prospective study of coronally positioned flap with or without acellular dermal matrix graft DOI:10.1111/j.1600-051x.2006.00969.x | 2006 | this review only | not stated | not extracted yet |
| de Queiroz Cortes 2006 A two-year prospective study of coronally positioned flap with or without acellular dermal matrix graft. PMID:16856894 | 2006 | this review only | not stated | not extracted yet |
| Di Domenico 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Di Domenico 2024 Treatment of Multiple Adjacent Gingival Recessions with a Coronally Advanced Flap vs a Modified Coronally Advanced Tunnel with a… PMID:37471160 | 2024 | this review only | not stated | not extracted yet |
| Elena 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Franca‐Grohmann 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Franca‐Grohmann 2019 Does enamel matrix derivative application improve clinical outcomes after semilunar flap surgery? A randomized clinical trial. PMID:29948276 | 2019 | this review only | not stated | not extracted yet |
| Górski 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Happe 2022 Immediate Implant Placement in Conjunction with Acellular Dermal Matrix or Connective Tissue Graft: A Randomized Controlled Clinical… DOI:10.11607/prd.5632 | 2022 | this review only | not stated | not extracted yet |
| Happe 2022 Immediate Implant Placement in Conjunction with Acellular Dermal Matrix or Connective Tissue Graft: A Randomized Controlled Clinical… PMID:35472115 | 2022 | this review only | not stated | not extracted yet |
| Huber 2018 Non‐interventional 1‐year follow‐up study of peri‐implant soft tissues following previous soft tissue augmentation and crown insertion in… DOI:10.1111/jcpe.12865 | 2018 | this review only | not stated | not extracted yet |
| Huber 2018 Non-interventional 1-year follow-up study of peri-implant soft tissues following previous soft tissue augmentation and crown insertion in… PMID:29290089 | 2018 | this review only | not stated | not extracted yet |
| Jepsen 2017 Long‐Term Stability of Root Coverage by Coronally Advanced Flap Procedures DOI:10.1902/jop.2017.160767 | 2017 | this review only | not stated | not extracted yet |
| Jepsen 2017 Long-Term Stability of Root Coverage by Coronally Advanced Flap Procedures. PMID:28304210 | 2017 | this review only | not stated | not extracted yet |
| Kassis 2024 The Effect of Connective Tissue Graft Compared to Concentrated Growth Factor Graft on Buccal Peri-Implant Gingival Thickness: A 12-month… PMID:38432641 | 2024 | this review only | not stated | not extracted yet |
| Koseoglu 2013 Efficacy of Collagen Membrane Seeded With Autologous Gingival Fibroblasts in Gingival Recession Treatment: A Randomized, Controlled Pilot… DOI:10.1902/jop.2012.120529 | 2013 | this review only | not stated | not extracted yet |
| Koseoglu 2013 Efficacy of collagen membrane seeded with autologous gingival fibroblasts in gingival recession treatment: a randomized, controlled pilot… PMID:23259414 | 2013 | this review only | not stated | not extracted yet |
| Kuka 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lavareda Correa 2017 Use of Bone Allograft With or Without Bone Marrow Aspirate Concentrate in Appositional Reconstructions: A Tomographic and… PMID:29095784 | 2017 | this review only | not stated | not extracted yet |
| Lazzari 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Lee 2023 Clinical efficacy of soft-tissue augmentation on tissue preservation at immediate implant sites: A randomized controlled trial. PMID:37052357 | 2023 | this review only | not stated | not extracted yet |
| Leknes 2005 Coronally positioned flap procedures with or without a biodegradable membrane in the treatment of human gingival recession. A 6‐year… DOI:10.1111/j.1600-051x.2005.00706.x | 2005 | this review only | not stated | not extracted yet |
| Leknes 2005 Coronally positioned flap procedures with or without a biodegradable membrane in the treatment of human gingival recession. A 6-year… PMID:15842269 | 2005 | this review only | not stated | not extracted yet |
| Menezes 2024 DOI:10.1590/1807-3107bor-2024.vol38.0111pmc11552456 | NR | this review only | not stated | not extracted yet |
| Meza‐Mauricio 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Migliorati 2015 Clinical and Aesthetic Outcome with Post‐Extractive Implants with or without Soft Tissue Augmentation: A 2‐Year Randomized Clinical Trial DOI:10.1111/cid.12194 | 2013 | this review only | not stated | not extracted yet |
| Migliorati 2015 Clinical and Aesthetic Outcome with Post-Extractive Implants with or without Soft Tissue Augmentation: A 2-Year Randomized Clinical Trial. PMID:24373419 | 2015 | this review only | not stated | not extracted yet |
| Molnar 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Molnar 2022 Treatment of multiple adjacent RT 1 gingival recessions with the modified coronally advanced tunnel (MCAT) technique and a collagen matrix… PMID:35994126 | 2022 | this review only | not stated | not extracted yet |
| Neves 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Neves 2019 Randomized clinical trial evaluating single maxillary gingival recession treatment with connective tissue graft and tunnel or trapezoidal… PMID:31867724 | 2020 | this review only | not stated | not extracted yet |
| Oh 2020 Free gingival grafts for implants exhibiting a lack of keratinized mucosa: Extended follow‐up of a randomized controlled trial DOI:10.1111/jcpe.13272 | 2020 | this review only | not stated | not extracted yet |
| Oh 2020 Free gingival grafts for implants exhibiting a lack of keratinized mucosa: Extended follow-up of a randomized controlled trial. PMID:32096243 | 2020 | this review only | not stated | not extracted yet |
| Ozenci 2015 Tunnel technique <i>versus</i> coronally advanced flap with acellular dermal matrix graft in the treatment of multiple gingival recessions DOI:10.1111/jcpe.12477 | 2015 | this review only | not stated | not extracted yet |
| Ozenci 2015 Tunnel technique versus coronally advanced flap with acellular dermal matrix graft in the treatment of multiple gingival recessions. PMID:26507452 | 2015 | this review only | not stated | not extracted yet |
| Panwar 2022 DOI:10.1016/j.mjafi.2020.11.029pmc9485765 | NR | this review only | not stated | not extracted yet |
| Panwar 2022 Comparison of acellular dermal matrix allografts and connective tissue autografts in soft-tissue augmentation around immediate implants: A… PMID:36147428 | 2022 | this review only | not stated | not extracted yet |
| Paolantonio 2002 Treatment of Gingival Recessions by Combined Periodontal Regenerative Technique, Guided Tissue Regeneration, and Subpedicle Connective… DOI:10.1902/jop.2002.73.1.53 | 2002 | this review only | not stated | not extracted yet |
| Paolantonio 2002 Subpedicle Acellular Dermal Matrix Graft and Autogenous Connective Tissue Graft in the Treatment of Gingival Recessions: A Comparative… DOI:10.1902/jop.2002.73.11.1299 | 2002 | this review only | not stated | not extracted yet |
| Paolantonio 2002 Treatment of gingival recessions by combined periodontal regenerative technique, guided tissue regeneration, and subpedicle connective… PMID:11846201 | 2002 | this review only | not stated | not extracted yet |
| Paolantonio 2002 Subpedicle acellular dermal matrix graft and autogenous connective tissue graft in the treatment of gingival recessions: a comparative… PMID:12479634 | 2002 | this review only | not stated | not extracted yet |
| Pietruska 2019 Clinical evaluation of Miller class I and <scp>II</scp> recessions treatment with the use of modified coronally advanced tunnel technique… DOI:10.1111/jcpe.13031 | 2018 | this review only | not stated | not extracted yet |
| Puzio 2020 Soft tissue augmentation around dental implants with connective tissue graft (CTG) and xenogenic collagen matrix (XCM). 1-year randomized… DOI:10.1016/j.aanat.2020.151484 | 2020 | this review only | not stated | not extracted yet |
| Puzio 2020 Soft tissue augmentation around dental implants with connective tissue graft (CTG) and xenogenic collagen matrix (XCM). 1-year randomized… PMID:32205206 | 2020 | this review only | not stated | not extracted yet |
| Rakasevic 2020 The use of collagen porcine dermal matrix and connective tissue graft with modified coronally advanced tunnel technique in the treatment… DOI:10.1111/jerd.12624 | 2020 | this review only | not stated | not extracted yet |
| Rebele 2014 Tunnel technique with connective tissue graft <i>versus</i> coronally advanced flap with enamel matrix derivative for root coverage: a… DOI:10.1111/jcpe.12254 | 2014 | this review only | not stated | not extracted yet |
| Rebele 2014 Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivative for root coverage: a RCT using… PMID:24708338 | 2014 | this review only | not stated | not extracted yet |
| Rotundo 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Santamaria 2017 2‐Year Assessment of Tissue Biostimulation With Low‐Level Laser on the Outcomes of Connective Tissue Graft in the Treatment of Single… DOI:10.1902/jop.2016.160391 | 2017 | this review only | not stated | not extracted yet |
| Santamaria 2017 2-Year Assessment of Tissue Biostimulation With Low-Level Laser on the Outcomes of Connective Tissue Graft in the Treatment of Single… PMID:27834120 | 2017 | this review only | not stated | not extracted yet |
| Schulz 2023 Three-Dimensional Plotted Calcium Phosphate Scaffolds for Bone Defect Augmentation-A New Method for Regeneration. PMID:36983646 | 2023 | this review only | not stated | not extracted yet |
| Skierska 2024 Tunnel technique and subepithelial connective tissue graft, with or without cross‐linked hyaluronic acid, in the treatment of multiple… DOI:10.1002/jper.24-0093 | 2024 | this review only | not stated | not extracted yet |
| Stefanini 2016 Patient‐reported outcomes and aesthetic evaluation of root coverage procedures: a 12‐month follow‐up of a randomized controlled clinical… DOI:10.1111/jcpe.12626 | 2016 | this review only | not stated | not extracted yet |
| Stefanini 2016 Patient-reported outcomes and aesthetic evaluation of root coverage procedures: a 12-month follow-up of a randomized controlled clinical… PMID:27717210 | 2016 | this review only | not stated | not extracted yet |
| Surdiacourt 2025 A multi-centre randomized controlled trial comparing connective tissue graft with collagen matrix to increase soft tissue thickness at the… PMID:38485651 | 2025 | this review only | not stated | not extracted yet |
| Tavelli 2019 Acellular dermal matrix and coronally advanced flap or tunnel technique in the treatment of multiple adjacent gingival recessions. A… DOI:10.1111/jcpe.13163 | 2019 | this review only | not stated | not extracted yet |
| Tavelli 2019 Acellular dermal matrix and coronally advanced flap or tunnel technique in the treatment of multiple adjacent gingival recessions. A… PMID:31242333 | 2019 | this review only | not stated | not extracted yet |
| Tavelli 2022 DOI:10.1111/jcpe.13706pmc9796054 | NR | this review only | not stated | not extracted yet |
| Tavelli 2023 Coronally advanced flap versus tunnel technique for the treatment of peri-implant soft tissue dehiscences with the connective tissue… PMID:36935199 | 2023 | this review only | not stated | not extracted yet |
| Thoma 2020 Randomized controlled clinical trial comparing implant sites augmented with a volume‐stable collagen matrix or an autogenous connective… DOI:10.1111/jcpe.13271 | 2020 | this review only | not stated | not extracted yet |
| Thoma 2020 Randomized controlled clinical trial comparing implant sites augmented with a volume-stable collagen matrix or an autogenous connective… PMID:32096246 | 2020 | this review only | not stated | not extracted yet |
| Trivedi 2024 Comparative evaluation of pinhole surgical technique with and without<scp>A‐PRF</scp>in the treatment of multiple adjacent recession… DOI:10.1111/jerd.13076 | 2023 | this review only | not stated | not extracted yet |
| Uzun 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Uzun 2018 Effectiveness and predictability of titanium-prepared platelet-rich fibrin for the management of multiple gingival recessions. PMID:28990126 | 2018 | this review only | not stated | not extracted yet |
| Wang 2014 Comparison of Two Differently Processed Acellular Dermal Matrix Products for Root Coverage Procedures: A Prospective, Randomized… DOI:10.1902/jop.2014.140198 | 2014 | this review only | not stated | not extracted yet |
| Wang 2014 Comparison of two differently processed acellular dermal matrix products for root coverage procedures: a prospective, randomized… PMID:24965060 | 2014 | this review only | not stated | not extracted yet |
| Wang 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Wang 2015 Comparison of Freeze-Dried and Solvent-Dehydrated Acellular Dermal Matrix for Root Coverage: A Randomized Controlled Trial. PMID:26509984 | 2015 | this review only | not stated | not extracted yet |
| Wiesner 2010 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yavuz 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yavuz 2024 Treatment of multiple adjacent gingival recessions using leucocyte- and platelet-rich fibrin with coronally advanced flap: a 12-month… PMID:38691209 | 2024 | this review only | not stated | not extracted yet |
| Yilmaz 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Zafiropoulos 2017 Use of Collagen Matrix for Augmentation of the Peri-implant Soft Tissue at the Time of Immediate Implant Placement DOI:10.5005/jp-journals-10024-2052 | 2017 | this review only | not stated | not extracted yet |
| Zafiropoulos 2017 Use of Collagen Matrix for Augmentation of the Peri-implant Soft Tissue at the Time of Immediate Implant Placement. PMID:28512278 | 2017 | this review only | not stated | not extracted yet |
| Zucchelli 2010 Patient morbidity and root coverage outcome after subepithelial connective tissue and de‐epithelialized grafts: a comparative… DOI:10.1111/j.1600-051x.2010.01550.x | 2010 | this review only | not stated | not extracted yet |
| Zucchelli 2012 Root coverage in molar teeth: a comparative controlled randomized clinical trial DOI:10.1111/jcpe.12002 | 2012 | this review only | not stated | not extracted yet |
| Zucchelli 2012 Root coverage in molar teeth: a comparative controlled randomized clinical trial. PMID:22943446 | 2012 | this review only | not stated | not extracted yet |
| Zucchelli 2014 Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial DOI:10.1111/jcpe.12256 | 2014 | this review only | not stated | not extracted yet |
| Zucchelli 2014 Coronally advanced flap + connective tissue graft techniques for the treatment of deep gingival recession in the lower incisors. A… DOI:10.1111/jcpe.12269 | 2014 | this review only | not stated | not extracted yet |
| Zucchelli 2014 Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial. PMID:24708394 | 2014 | this review only | not stated | not extracted yet |
| Zucchelli 2014 Coronally advanced flap + connective tissue graft techniques for the treatment of deep gingival recession in the lower incisors. A… PMID:24802283 | 2014 | this review only | not stated | not extracted yet |
| Zuhr 2014 Tunnel technique with connective tissue graft <i>versus</i> coronally advanced flap with enamel matrix derivative for root coverage: a… DOI:10.1111/jcpe.12178 | 2013 | this review only | not stated | not extracted yet |
| Zuhr 2014 Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivative for root coverage: a RCT using… PMID:24117676 | 2014 | this review only | not stated | not extracted yet |
| Zuhr 2021 Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivate for root coverage: 5‐year results… DOI:10.1111/jcpe.13470 | 2021 | this review only | not stated | not extracted yet |
| Zuhr 2021 Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivate for root coverage: 5-year results… PMID:33847022 | 2021 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Human adults with at least one natural tooth or dental implant with a soft or hard tissue defect requiring augmentation | Adults with gingival thickness deficiency at teeth (54 RCTs, 2952 teeth) and mucosal thickness deficiency at implants (24 RCTs, 851 implants) |
| Intervention | Professionally administered emerging technologies and personalized strategies for regeneration of periodontal or peri-implant soft or hard tissue | Bilaminar soft tissue grafting: CTG, hADM, pADM, CMX, VCMX; qualitative review of stem cell, 3D-printed scaffold, secretome and AI approaches for bone |
| Comparison | All suitable comparisons among included interventions; flap therapy alone or no augmentation as control for soft tissue | Flap therapy alone or no soft tissue augmentation; CTG as reference |
| Outcomes | Buccal soft tissue thickness (GT around teeth, MT around implants) as primary; pain, satisfaction, quality of life, treatment time | Gingival thickness (teeth); mucosal thickness (implants); association with recession, PI, PD, BOP |
| Study designs | Prospective controlled RCTs (min 10 patients) for the soft tissue NMA; any prospective interventional human study for hard tissue | 78 RCTs in the NMA; non-randomized prospective studies and case reports in the qualitative bone section |
| Timing | At least 12 months follow-up for teeth and 6 months for implants (soft tissue) | 6 to 144 months for teeth (data beyond 72 months not analyzed); 6 to 48 months for implants |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | Yes | No | no |
| 4Comprehensive literature searchcritical | Yes | Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | Yes | Yes | yes |
| 8Included studies described in detail | Yes | Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: No | RCT: Yes · NRSI: N/A | no |
| 10Funding of included studies reported | Yes | Yes | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes · NRSI: N/A | RCT: Yes · NRSI: N/A | yes |
| 12Impact of risk of bias on the pooled results | No | Yes | no |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | No | Yes | no |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Low | no |