Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by Emerging, personalized, and minimally invasive technologies for periodontal and peri-implant soft and hard tissue regenerative therapy.. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial. Ferrarotti 2018 · Ferrarotti Francesco, Romano Federica, et al. · Journal of clinical periodontology PMID:29779220 | 2018 | 5 | none stated | not extracted yet |
| Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A 12-month… Sanchez 2020 · Sánchez Nerea, Fierravanti Ludovica, et al. · Journal of clinical periodontology PMID:32946590 | 2020 | 4 | none stated | not extracted yet |
| Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial. Chen 2016 · Chen Fa-Ming, Gao Li-Na, et al. · Stem cell research & therapy PMID:26895633 | 2016 | 4 | none stated | not extracted yet |
| Volumetric assessment of volume stable collagen matrix in maxillary single implant site development: A randomized controlled clinical trial HamdyA 2024 · Hamdy Ahmed, Ibrahim Suzan Seif Allah, et al. · Clinical Implant Dentistry and Related Research DOI:10.1111/cid.13353 | 2024 | 3 | none stated | not extracted yet |
| Harvest graft substitute for soft tissue volume augmentation around existing implants: A randomized, controlled and blinded multicenter trial ClemDS 2024 · Clem Donald S., McClain Pamela K., et al. · Journal of Periodontology DOI:10.1002/jper.23-0305 | 2023 | 3 | 2 | not extracted yet |
| Histomorphometric Comparison of New Bone Formed After Maxillary Sinus Lift With Lateral and Crestal Approaches Using Periostal Mesenchymal Stem… Fatale 2022 · Fatale Valentina, Pagnoni Stefano, et al. · The Journal of craniofacial surgery PMID:36041126 | 2022 | 3 | none stated | not extracted yet |
| Comparison between a xenogeneic dermal matrix and connective tissue graft for the treatment of multiple adjacent gingival recessions: a randomized… Meza‐Mauricio 2021 · Meza-Mauricio Jonathan, Cortez-Gianezzi Jônatas, et al. · Clinical oral investigations PMID:34021404 | 2021 | 3 | none stated | not extracted yet |
| A comparative evaluation of bone regeneration using mesenchymal stem cells versus blood coagulum in sinus augmentation procedures. Gupta 2021 · Gupta Akash Sanjay, Aurora Jitender Kumar, et al. · National journal of maxillofacial surgery PMID:35153430 | 2021 | 3 | 2 | not extracted yet |
| Efficacy of stem cell allograft in maxillary sinus bone regeneration: a randomized controlled clinical and blinded histomorphometric study. Whitt 2020 · Whitt Josh, Al-Sabbagh Mohanad, et al. · International journal of implant dentistry PMID:32596764 | 2020 | 3 | none stated | not extracted yet |
| The use of collagen porcine dermal matrix and connective tissue graft with modified coronally advanced tunnel technique in the treatment of multiple… Rakasevic 2020 · Rakasevic Dragana L, Milinkovic Iva Z, et al. · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] PMID:32706184 | 2020 | 3 | none stated | not extracted yet |
| Clinical evaluation of Miller class I and II recessions treatment with the use of modified coronally advanced tunnel technique with either collagen… Pietruska 2019 · Pietruska Małgorzata, Skurska Anna, et al. · Journal of clinical periodontology PMID:30362599 | 2019 | 3 | none stated | not extracted yet |
| Buccal fat pad-derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: An exploratory… Khojasteh 2019 · Khojasteh Arash, Hosseinpour Sepanta, et al. · Clinical implant dentistry and related research PMID:30821120 | 2019 | 3 | none stated | not extracted yet |
| Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. Gjerde 2018 · Gjerde Cecilie, Mustafa Kamal, et al. · Stem cell research & therapy PMID:30092840 | 2018 | 3 | none stated | not extracted yet |
| Xenogeneic collagen matrix versus connective tissue graft for buccal soft tissue augmentation at implant site. A randomized, controlled clinical trial CairoF 2017 · Cairo Francesco, Barbato Luigi, et al. · Journal of Clinical Periodontology DOI:10.1111/jcpe.12750 | 2017 | 3 | 2 | not extracted yet |
| Stem cell therapy for reconstruction of alveolar cleft and trauma defects in adults: A randomized controlled, clinical trial. Bajestan 2017 · Bajestan Mona N, Rajan Archana, et al. · Clinical implant dentistry and related research PMID:28656723 | 2017 | 3 | 2 | not extracted yet |
| Bone Engineering of Maxillary Sinus Bone Deficiencies Using Enriched CD90+ Stem Cell Therapy: A Randomized Clinical Trial. Kaigler 2015 · Kaigler Darnell, Avila-Ortiz Gustavo, et al. · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research PMID:25652112 | 2015 | 3 | none stated | not extracted yet |
| Effects of directly autotransplanted tibial bone marrow aspirates on bone regeneration and osseointegration of dental implants. Payer 2014 · Payer Michael, Lohberger Birgit, et al. · Clinical oral implants research PMID:23701676 | 2014 | 3 | 2 | not extracted yet |
| Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial. Kaigler 2013 · Kaigler Darnell, Pagni Giorgio, et al. · Cell transplantation PMID:22776413 | 2013 | 3 | none stated | not extracted yet |
| Treatment of multiple adjacent Miller class I and II gingival recessions with a Modified Coronally Advanced Tunnel (MCAT) technique and a collagen… Aroca 2013 · Aroca Sofia, Molnár Bálint, et al. · Journal of clinical periodontology PMID:23627374 | 2013 | 3 | none stated | not extracted yet |
| Bone Augmentation of Atrophic Alveolar Ridges Using a Synthetic Bone Substitute With Mesenchymal Stem Cells: A Randomized, Controlled Clinical Trial. Sanz 2025 · Sanz Mariano, Gjerde Cecilie, et al. · Clinical oral implants research PMID:40844304 | 2025 | 2 | none stated | not extracted yet |
| The Effect of Connective Tissue Graft Compared to Concentrated Growth Factor Graft on Buccal Peri-Implant Gingival Thickness: A 12-month Randomized… KassisJ 2024 · Kassis Joul, Aboud Magd Esber · Journal of Oral and Maxillofacial Surgery DOI:10.1016/j.joms.2024.02.005 | 2024 | 2 | none stated | not extracted yet |
| A multi‐centre randomized controlled trial comparing connective tissue graft with collagen matrix to increase soft tissue thickness at the buccal… SurdiacourtL 2025 · Surdiacourt Lenz, Christiaens Véronique, et al. · Journal of Clinical Periodontology DOI:10.1111/jcpe.13975 | 2024 | 2 | none stated | not extracted yet |
| Comparative evaluation of pinhole surgical technique with and without A-PRF in the treatment of multiple adjacent recession defects: A clinico… Trivedi 2024 · Trivedi Divya S, Kolte Abhay P, et al. · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] PMID:37466087 | 2024 | 2 | none stated | not extracted yet |
| Harvest graft substitute for soft tissue volume augmentation around existing implants: A randomized, controlled and blinded multicenter trial. Clem 2024 · Clem Donald S, McClain Pamela K, et al. · Journal of periodontology PMID:38071454 | 2024 | 2 | none stated | not extracted yet |
| Analysis of the treatment of RT2 recessions with a xenogeneic collagen matrix vs. connective tissue graft combined with a coronally advanced flap. A… Elena 2024 · Elena Ruiz-de-Gopegui-Palacios, Miren Vilor-Fernández, et al. · Clinical oral investigations PMID:38489063 | 2024 | 2 | none stated | not extracted yet |
| Tunnel technique and subepithelial connective tissue graft, with or without cross-linked hyaluronic acid, in the treatment of multiple gingival… Skierska 2024 · Skierska Izabela, Górski Bartłomiej, et al. · Journal of periodontology PMID:38808976 | 2024 | 2 | none stated | not extracted yet |
| Volumetric assessment of volume stable collagen matrix in maxillary single implant site development: A randomized controlled clinical trial. Hamdy 2024 · Hamdy Ahmed, Ibrahim Suzan Seif Allah, et al. · Clinical implant dentistry and related research PMID:38938060 | 2024 | 2 | none stated | not extracted yet |
| Efficacy of xenogeneic collagen matrix in the treatment of gingival recessions: a controlled clinical trial. Menezes 2024 · Menezes Karyna de Melo, Borges Samuel Batista, et al. · Brazilian oral research PMID:39536202 | 2024 | 2 | none stated | not extracted yet |
| Coronally advanced flap versus tunnel technique for the treatment of peri‐implant soft tissue dehiscences with the connective tissue graft: A… TavelliL 2023 · Tavelli Lorenzo, Majzoub Jad, et al. · Journal of Clinical Periodontology DOI:10.1111/jcpe.13806 | 2023 | 2 | none stated | not extracted yet |
| Clinical efficacy of soft‐tissue augmentation on tissue preservation at immediate implant sites: A randomized controlled trial LeeCT 2023 · Lee Chun‐Teh, Tran Duong, et al. · Journal of Clinical Periodontology DOI:10.1111/jcpe.13816 | 2023 | 2 | none stated | not extracted yet |
| Does vestibular incision improve the outcomes of vestibular incision subperiosteal tunnel technique: A randomized clinical trial for treatment of… Chen 2023 · Chen Ziyuan, Zhong Jinsheng, et al. · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] PMID:37078417 | 2023 | 2 | none stated | not extracted yet |
| Root coverage with platelet-rich fibrin or connective tissue graft: a split-mouth randomized trial. Carrera 2023 · Carrera Thaisa Macedo Iunes, Machado Laryssa Moraes, et al. · Brazilian oral research PMID:37672418 | 2023 | 2 | none stated | not extracted yet |
| Alveolar cleft reconstruction using bone marrow aspirate concentrate and iliac cancellous bone: A 12-month randomized clinical study. Shabaan 2023 · Shabaan Alshaimaa Ahmed, Salahuddin Ahmad, et al. · Clinical oral investigations PMID:37794139 | 2023 | 2 | none stated | not extracted yet |
| Soft tissue esthetics around immediately provisionalized delayed implants with and without connective tissue graft: A randomized clinical trial… AbdelwahabD 2023 · Abdelwahab Dina, Ezz AlArab Azza, et al. · Clinical Implant Dentistry and Related Research DOI:10.1111/cid.13168 | 2022 | 2 | none stated | not extracted yet |
| Effect of 24% EDTA root conditioning on the outcome of modified coronally advanced tunnel technique with subepithelial connective tissue graft for… Górski 2022 · Górski Bartłomiej, Szerszeń Marcin, et al. · Clinical oral investigations PMID:34431001 | 2022 | 2 | none stated | not extracted yet |
| Single implant placement in the maxillary aesthetic area with or without connective tissue grafting: A 1-year follow-up randomised clinical trial. Lazzari 2022 · Lazzari Thiago Rodrigues, Jardini Maria Aparecida Neves, et al. · International journal of oral implantology (Berlin, Germany) PMID:35266669 | 2022 | 2 | none stated | not extracted yet |
| Modified coronally advanced tunnel versus epithelialized free gingival graft technique in gingival phenotype modification: a comparative randomized… Yilmaz 2022 · Yilmaz Birtan Tolga, Comerdov Elnur, et al. · Clinical oral investigations PMID:35708779 | 2022 | 2 | none stated | not extracted yet |
| Recombinant human platelet-derived growth factor improves root coverage of a collagen matrix for multiple adjacent gingival recessions: A… Tavelli 2022 · Tavelli Lorenzo, Barootchi Shayan, et al. · Journal of clinical periodontology PMID:35871600 | 2022 | 2 | none stated | not extracted yet |
| Small blood stem cells for enhancing early osseointegration formation on dental implants: a human phase I safety study. Feng 2021 · Feng Sheng-Wei, Su Yi-Han, et al. · Stem cell research & therapy PMID:34215319 | 2021 | 2 | none stated | not extracted yet |
| Clinical Outcome and 8-Year Follow-Up of Alveolar Bone Tissue Engineering for Severely Atrophic Alveolar Bone Using Autologous Bone Marrow Stromal… Asahina 2021 · Asahina Izumi, Kagami Hideaki, et al. · Journal of clinical medicine PMID:34830513 | 2021 | 2 | none stated | not extracted yet |
| Adjunctive benefit of a xenogenic collagen matrix associated with coronally advanced flap for the treatment of multiple gingival recessions: A… Rotundo 2019 · Rotundo Roberto, Genzano Luigi, et al. · Journal of clinical periodontology PMID:31292987 | 2019 | 2 | none stated | not extracted yet |
| Coronally advanced flap and envelope type of flap plus acellular dermal matrix graft for the treatment of thin phenotype multiple recession defects.… Ahmedbeyli 2019 · Ahmedbeyli Cavid, Dirikan Ipçi Sebnem, et al. · Journal of clinical periodontology PMID:31350924 | 2019 | 2 | none stated | not extracted yet |
| Ultrasound assessment of soft tissue augmentation around implants in the aesthetic zone using a connective tissue graft and xenogeneic collagen… Puzio 2018 · Puzio Monika, Błaszczyszyn Artur, et al. · Annals of Anatomy - Anatomischer Anzeiger DOI:10.1016/j.aanat.2017.11.003 | 2018 | 2 | 2 | not extracted yet |
| Clinical evaluation of coronally advanced flap with or without platelet-rich fibrin for the treatment of multiple gingival recessions. Kuka 2018 · Kuka Samed, Ipci Sebnem Dirikan, et al. · Clinical oral investigations PMID:29058084 | 2018 | 2 | none stated | not extracted yet |
| Regenerative Treatment of Periodontal Intrabony Defects Using Autologous Dental Pulp Stem Cells: A 1-Year Follow-Up Case Series. Aimetti 2018 · Aimetti Mario, Ferrarotti Francesco, et al. · The International journal of periodontics & restorative dentistry PMID:29240205 | 2018 | 2 | none stated | not extracted yet |
| Ultrasound assessment of soft tissue augmentation around implants in the aesthetic zone using a connective tissue graft and xenogeneic collagen… Puzio 2018 · Puzio Monika, Błaszczyszyn Artur, et al. · Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft PMID:29248711 | 2018 | 2 | none stated | not extracted yet |
| Peri-implant Soft Tissue Stability After Single Implant Restorations Using Either Guided Bone Regeneration or a Connective Tissue Graft: A… D'EliaC 2017 · D’Elia Chiara, Baldini Nicola, et al. · The International Journal of Periodontics & Restorative Dentistry DOI:10.11607/prd.2747 | 2017 | 2 | none stated | not extracted yet |
| Xenogeneic collagen matrix versus connective tissue graft for buccal soft tissue augmentation at implant site. A randomized, controlled clinical… Cairo 2017 · Cairo Francesco, Barbato Luigi, et al. · Journal of clinical periodontology PMID:28548210 | 2017 | 2 | none stated | not extracted yet |
| Clinical efficacy of coronally advanced flap with or without connective tissue graft for the treatment of multiple adjacent gingival recessions in… Cairo 2016 · Cairo Francesco, Cortellini Pierpaolo, et al. · Journal of clinical periodontology PMID:27329829 | 2016 | 2 | none stated | not extracted yet |
| Phase I/II Trial of Autologous Bone Marrow Stem Cell Transplantation with a Three-Dimensional Woven-Fabric Scaffold for Periodontitis. Baba 2016 · Baba Shunsuke, Yamada Yoichi, et al. · Stem cells international PMID:27990164 | 2016 | 2 | none stated | not extracted yet |