Non-Cochrane · intervention · PM41658988
Clinical stem cell therapy in oral and craniofacial bone regeneration: a systematic review and meta-analysis.
Hazrati Parham, Alanazi Abdulmohsen, Alrmali Abdusalam E, et al. · Frontiers in bioengineering and biotechnology · 2026 · PubMed · doi:10.3389/fbioe.2026.1677400
Findings
34 findings
| Population | ||||
|---|---|---|---|---|
| Patients with periodontal intrabony defects | Stem cell therapy (any stem cell type) | Control without stem cells (conventional regenerative treatment) | Periodontal clinical attachment level (CAL) gain 12 months · Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding Baba 2016; follow-up 12 months | MD 0.66 [-0.45, 1.76] GRADE not reported 3 studies · 65 participants |
| Patients with periodontal intrabony defects | Stem cell therapy (any stem cell type) | Control without stem cells (conventional regenerative treatment) | Periodontal clinical attachment level (CAL) gain 6 and 12 months combined · Oral and maxillofacial regenerative surgery | MD 1.17 [-0.11, 2.46] GRADE not reported 4 studies · 190 participants |
| Patients with periodontal intrabony defects | Stem cell therapy (any stem cell type) | Control without stem cells (conventional regenerative treatment) | Periodontal clinical attachment level (CAL) gain 6 and 12 months combined · Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding Baba 2016 | MD 0.34 [-0.70, 1.37] GRADE not reported 3 studies · 130 participants |
| Patients with periodontal intrabony defects | Stem cell therapy (any stem cell type) | Control without stem cells (conventional regenerative treatment) | Periodontal clinical attachment level (CAL) gain 6 months · Oral and maxillofacial regenerative surgery · Follow-up: 6 months | MD 0.85 [-1.25, 2.94] GRADE not reported 4 studies · 95 participants |
| Patients with periodontal intrabony defects | Stem cell therapy (any stem cell type) | Control without stem cells (conventional regenerative treatment) | Periodontal clinical attachment level (CAL) gain 6 months · Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding Baba 2016; follow-up 6 months | MD -0.00 [-1.89, 1.89] GRADE not reported 3 studies · 65 participants |
| Patients with periodontal intrabony defects | Stem cell therapy (any stem cell type) | Control without stem cells (conventional regenerative treatment) | Periodontal clinical attachment level (CAL) gain 12 months · Oral and maxillofacial regenerative surgery · Follow-up: 12 months | MD 1.49 [-0.25, 3.22] GRADE not reported 4 studies · 95 participants |
| Patients with periodontal intrabony defects | Bone marrow mesenchymal stem cells (BMMSC) | Control without stem cells (conventional regenerative treatment) | Periodontal clinical attachment level (CAL) gain 6 and 12 months combined · Oral and maxillofacial regenerative surgery · Stem cell type: BMMSC | MD 1.46 [-0.87, 3.80] GRADE not reported 2 studies · 94 participants |
| Patients with periodontal intrabony defects | Periodontal ligament stem cells (PDLSC) | Control without stem cells (conventional regenerative treatment) | Periodontal clinical attachment level (CAL) gain 6 and 12 months combined · Oral and maxillofacial regenerative surgery · Stem cell type: PDLSC | MD -0.14 [-1.74, 1.47] GRADE not reported 1 study · 38 participants |
| Patients with periodontal intrabony defects | Dental pulp stem cells (DPSC) | Control without stem cells (conventional regenerative treatment) | Periodontal clinical attachment level (CAL) gain 6 and 12 months combined · Oral and maxillofacial regenerative surgery · Stem cell type: DPSC | MD 1.73 [0.82, 2.63] GRADE not reported 1 study · 58 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone: horizontal (linear width) gain Oral and maxillofacial regenerative surgery · Dimension: horizontal gain | SMD 0.08 [-0.65, 0.81] GRADE not reported 6 studies · 78 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone: volumetric (3D) gain Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding studies at high overall risk of bias (Khojasteh 2017; Aloise 2018); volumetric gain | SMD 2.24 [0.00, 4.47] GRADE not reported 3 studies · 70 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone: vertical (linear height) gain Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding studies at high overall risk of bias (Khojasteh 2017; Aloise 2018); vertical gain | SMD 0.72 [-0.35, 1.79] GRADE not reported 3 studies · 38 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Histologic quality of regenerated bone Less than 6 months · Oral and maxillofacial regenerative surgery · Follow-up: less than 6 months | SMD 5.52 [-1.88, 12.92] GRADE not reported 6 studies · 116 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Histologic quality of regenerated bone Less than 6 months · Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding studies at high overall risk of bias (Naujokat 2022; Aloise 2018); follow-up less than 6 months | SMD 5.52 [-1.88, 12.92] GRADE not reported 6 studies · 116 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone: volumetric (3D) gain Oral and maxillofacial regenerative surgery · Dimension: volumetric (3D) gain | SMD 1.99 [0.29, 3.68] GRADE not reported 4 studies · 76 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone (all dimensions) 6 months or more · Oral and maxillofacial regenerative surgery · Follow-up: 6 months or more | SMD 1.02 [-0.01, 2.06] GRADE not reported 8 studies · 137 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Histologic quality of regenerated bone 6 months · Oral and maxillofacial regenerative surgery · Follow-up: 6 months | SMD 1.03 [0.17, 1.89] GRADE not reported 5 studies · 78 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone (all dimensions) Less than 6 months · Oral and maxillofacial regenerative surgery · Follow-up: less than 6 months | SMD 0.37 [-0.66, 1.40] GRADE not reported 4 studies · 55 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone (all dimensions) Oral and maxillofacial regenerative surgery · Radiography | SMD 0.75 [0.02, 1.48] GRADE not reported 12 studies · 192 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone (all dimensions) 6 months or more · Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding studies at high overall risk of bias (Khojasteh 2017; Aloise 2018); follow-up 6 months or more | SMD 1.24 [-0.06, 2.55] GRADE not reported 6 studies · 115 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone (all dimensions) Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding studies at high overall risk of bias (Khojasteh 2017; Aloise 2018) | SMD 0.82 [-0.01, 1.65] GRADE not reported 10 studies · 170 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quality of regenerated bone Less than 6 months · Oral and maxillofacial regenerative surgery · Radiography; follow-up less than 6 months | SMD 5.29 [-3.92, 14.51] GRADE not reported 3 studies · 55 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Histologic quality of regenerated bone Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding studies at high overall risk of bias (Naujokat 2022; Aloise 2018) | SMD 3.40 [-0.66, 7.46] GRADE not reported 9 studies · 158 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quality of regenerated bone Oral and maxillofacial regenerative surgery · Radiography | SMD 3.18 [-0.71, 7.07] GRADE not reported 6 studies · 167 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Histologic quality of regenerated bone 6 months · Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding studies at high overall risk of bias (Naujokat 2022; Aloise 2018); follow-up 6 months | SMD 0.78 [-0.24, 1.80] GRADE not reported 3 studies · 42 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone: vertical (linear height) gain Oral and maxillofacial regenerative surgery · Dimension: vertical gain | SMD 0.72 [-0.35, 1.79] GRADE not reported 3 studies · 38 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone: horizontal (linear width) gain Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding studies at high overall risk of bias (Khojasteh 2017; Aloise 2018); horizontal (width) gain | SMD 0.14 [-0.74, 1.03] GRADE not reported 5 studies · 62 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quantity of regenerated bone (all dimensions) Less than 6 months · Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding studies at high overall risk of bias (Khojasteh 2017; Aloise 2018); follow-up less than 6 months | SMD 0.37 [-0.66, 1.40] GRADE not reported 4 studies · 55 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Histologic quality of regenerated bone Oral and maxillofacial regenerative surgery · Histology; alveolar ridge and sinus augmentation studies | SMD 2.57 [0.06, 5.08] GRADE not reported 11 studies · 194 participants |
| Patients with congenital or acquired maxillofacial skeletal defects (various regenerative procedures) | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Radiographic quality of regenerated bone 6 months · Oral and maxillofacial regenerative surgery · Radiography; follow-up 6 months | SMD 1.66 [0.07, 3.24] GRADE not reported 3 studies · 112 participants |
| Patients undergoing alveolar ridge augmentation | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Histologic quality of regenerated bone Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding studies at high overall risk of bias (Naujokat 2022; Aloise 2018) | SMD 2.99 [-2.37, 8.35] GRADE not reported 3 studies · 52 participants |
| Patients undergoing alveolar ridge augmentation | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Histologic quality of regenerated bone Oral and maxillofacial regenerative surgery · Procedure: alveolar ridge augmentation (histology) | SMD 2.35 [-0.63, 5.34] GRADE not reported 5 studies · 88 participants |
| Patients undergoing maxillary sinus augmentation | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Histologic quality of regenerated bone Oral and maxillofacial regenerative surgery · Procedure: sinus augmentation (histology) | SMD 4.30 [-2.86, 11.46] GRADE not reported 6 studies · 106 participants |
| Patients undergoing maxillary sinus augmentation | Stem cells or stem cell-containing autogenous biologics | Regenerative approaches not involving stem cells | Histologic quality of regenerated bone Oral and maxillofacial regenerative surgery · Sensitivity analysis excluding studies at high overall risk of bias (Naujokat 2022; Aloise 2018) | SMD 4.30 [-2.86, 11.46] GRADE not reported 6 studies · 106 participants |
Included primary studies 118
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Ferrarotti et al. 2018 Human intrabony defect regeneration with micrografts containing dental pulp stem cells: A randomized controlled clinical trial. PMID:29779220 | 2018 | 4 other reviews | not stated | not extracted yet |
| Chen 2016 matched by author and year (probable) | NR | 3 other reviews | not stated | not extracted yet |
| Chen et al. 2016 Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial. PMID:26895633 | 2016 | 3 other reviews | not stated | not extracted yet |
| Sanchez et al. 2020 Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A… PMID:32946590 | 2020 | 3 other reviews | not stated | not extracted yet |
| Apatzidou et al. 2021 A tissue-engineered biocomplex for periodontal reconstruction. A proof-of-principle randomized clinical study. PMID:33899259 | 2021 | 2 other reviews | not stated | not extracted yet |
| Bajestan et al. 2017 Stem cell therapy for reconstruction of alveolar cleft and trauma defects in adults: A randomized controlled, clinical trial. PMID:28656723 | 2017 | 2 other reviews | not stated | not extracted yet |
| Fatale et al. 2022 Histomorphometric Comparison of New Bone Formed After Maxillary Sinus Lift With Lateral and Crestal Approaches Using Periostal Mesenchymal… PMID:36041126 | 2022 | 2 other reviews | not stated | not extracted yet |
| Gjerde et al. 2018 Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. PMID:30092840 | 2018 | 2 other reviews | not stated | not extracted yet |
| Gupta et al. 2021 A comparative evaluation of bone regeneration using mesenchymal stem cells versus blood coagulum in sinus augmentation procedures. PMID:35153430 | 2021 | 2 other reviews | not stated | not extracted yet |
| Kaigler et al. 2013a Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial. PMID:22776413 | 2013 | 2 other reviews | not stated | not extracted yet |
| Kaigler et al. 2015 Bone Engineering of Maxillary Sinus Bone Deficiencies Using Enriched CD90+ Stem Cell Therapy: A Randomized Clinical Trial. PMID:25652112 | 2015 | 2 other reviews | not stated | not extracted yet |
| Khojasteh et al. 2019 Buccal fat pad-derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: An… PMID:30821120 | 2019 | 2 other reviews | not stated | not extracted yet |
| Payer et al. 2014 Effects of directly autotransplanted tibial bone marrow aspirates on bone regeneration and osseointegration of dental implants. PMID:23701676 | 2014 | 2 other reviews | not stated | not extracted yet |
| Whitt et al. 2020 Efficacy of stem cell allograft in maxillary sinus bone regeneration: a randomized controlled clinical and blinded histomorphometric study. PMID:32596764 | 2020 | 2 other reviews | not stated | not extracted yet |
| Aimetti et al. 2018 Regenerative Treatment of Periodontal Intrabony Defects Using Autologous Dental Pulp Stem Cells: A 1-Year Follow-Up Case Series. PMID:29240205 | 2018 | 1 other review | not stated | not extracted yet |
| Asahina et al. 2021 Clinical Outcome and 8-Year Follow-Up of Alveolar Bone Tissue Engineering for Severely Atrophic Alveolar Bone Using Autologous Bone Marrow… PMID:34830513 | 2021 | 1 other review | not stated | not extracted yet |
| Baba et al. 2016 Phase I/II Trial of Autologous Bone Marrow Stem Cell Transplantation with a Three-Dimensional Woven-Fabric Scaffold for Periodontitis. PMID:27990164 | 2016 | 1 other review | not stated | not extracted yet |
| De Riu et al. 2019 Bone marrow nucleated cell concentrate autograft in temporomandibular joint degenerative disorders: 1-year results of a randomized… PMID:31601466 | 2019 | 1 other review | not stated | not extracted yet |
| Fatale 2022 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Fayed 2024 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Feng 2021 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Feng et al. 2021 Small blood stem cells for enhancing early osseointegration formation on dental implants: a human phase I safety study. PMID:34215319 | 2021 | 1 other review | not stated | not extracted yet |
| Gjerde 2018 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Kaigler 2015 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Khojasteh and Sadeghi 2016 Application of buccal fat pad-derived stem cells in combination with autogenous iliac bone graft in the treatment of maxillomandibular… PMID:26846793 | 2016 | 1 other review | not stated | not extracted yet |
| Rickert 2014 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Rickert et al. 2011 Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective… PMID:20831758 | 2011 | 1 other review | not stated | not extracted yet |
| Rickert et al. 2014 Maxillary sinus floor elevation surgery with BioOss® mixed with a bone marrow concentrate or autogenous bone: test of principle on implant… PMID:24183511 | 2014 | 1 other review | not stated | not extracted yet |
| Sembronio et al. 2021 Temporomandibular Joint Arthrocentesis and Microfragmented Adipose Tissue Injection for the Treatment of Internal Derangement and… PMID:33675704 | 2021 | 1 other review | not stated | not extracted yet |
| Shabaan 2023 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Shabaan et al. 2023 Alveolar cleft reconstruction using bone marrow aspirate concentrate and iliac cancellous bone: A 12-month randomized clinical study. PMID:37794139 | 2023 | 1 other review | not stated | not extracted yet |
| Tzur 2021 matched by author and year (probable) | NR | 1 other review | not stated | not extracted yet |
| Tzur et al. 2021 Safety and Efficacy Results of BonoFill First-in-Human, Phase I/IIa Clinical Trial for the Maxillofacial Indication of Sinus Augmentation… PMID:33434518 | 2021 | 1 other review | not stated | not extracted yet |
| Wildburger et al. 2014 Impact of autogenous concentrated bone marrow aspirate on bone regeneration after sinus floor augmentation with a bovine bone… PMID:23875876 | 2014 | 1 other review | not stated | not extracted yet |
| Aimetti 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Akhlaghi 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Akhlaghi et al. 2019 Improved bone regeneration through amniotic membrane loaded with buccal fat pad-derived MSCs as an adjuvant in maxillomandibular… PMID:31337570 | 2019 | this review only | not stated | not extracted yet |
| Al-Ahmady 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Al-Ahmady et al. 2018 Combining autologous bone marrow mononuclear cells seeded on collagen sponge with Nano Hydroxyapatite, and platelet-rich fibrin: Reporting… PMID:30196860 | 2018 | this review only | not stated | not extracted yet |
| Aloise 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Aloise et al. 2018 Use of Bone Marrow Aspirate Concentrate (BMAC) Associated with Hyperbaric Oxygenation Therapy in Maxillary Appositional Bone… DOI:10.3390/sym10100533 | 2018 | this review only | not stated | not extracted yet |
| Apatzidou 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Asahina 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Baba 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bajestan 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bambuliak 2024 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bambuliak et al. 2024 Efficacy of the use of a therapeutic composition containing stem cells in the augmentation of the alveolar ridge according to the… DOI:10.37897/rjs.2024.1.8 | 2024 | this review only | not stated | not extracted yet |
| Barbier 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Barbier et al. 2018 Autologous dental pulp mesenchymal stem cells for inferior third molar post-extraction socket healing: A split-mouth randomised clinical… PMID:29924768 | 2018 | this review only | not stated | not extracted yet |
| Bertolai 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bertolai 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Bertolai et al. 2015 Bone graft and mesenchimal stem cells: clinical observations and histological analysis. PMID:26604947 | 2015 | this review only | not stated | not extracted yet |
| Bertolai et al. 2016 Mesenchymal stem cells in post-surgical cavities of large maxillary bone lesions. PMID:28228785 | 2016 | this review only | not stated | not extracted yet |
| Castillo-Cardiel 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Castillo-Cardiel et al. 2017 Bone regeneration in mandibular fractures after the application of autologous mesenchymal stem cells, a randomized clinical trial. PMID:27513920 | 2017 | this review only | not stated | not extracted yet |
| Cerruti 2007 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Cerruti et al. 2007 Allogenous bone grafts improved by bone marrow stem cells and platelet growth factors: clinical case reports. PMID:17437494 | 2007 | this review only | not stated | not extracted yet |
| Colangeli 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Colangeli et al. 2018 Jaw bones regeneration using mesenchymal stem cells. A single-center experience. PMID:29629885 | 2018 | this review only | not stated | not extracted yet |
| D'Aquino 2009 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| D'Aquino et al. 2009 Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. PMID:19908196 | 2009 | this review only | not stated | not extracted yet |
| De Riu 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Fayed et al. 2024 Bone marrow aspirate concentrate - A novel approach to alter the course of temporomandibular joint osteoarthritis (a clinical study). PMID:37748708 | 2024 | this review only | not stated | not extracted yet |
| Ferrarotti 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gali 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gali et al. 2018 Concentrated Bone Marrow Aspirate-Coated Hydroxyapatite for Reconstruction of Small-to-Moderate-Sized Mandibular Defects Caused by the… PMID:31772459 | 2018 | this review only | not stated | not extracted yet |
| Gimbel 2007 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Gimbel et al. 2007 Repair of alveolar cleft defects: reduced morbidity with bone marrow stem cells in a resorbable matrix. PMID:17667684 | 2007 | this review only | not stated | not extracted yet |
| Gupta 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Howlader 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Howlader et al. 2017 Hydroxyapatite collagen scaffold with autologous bone marrow aspirate for mandibular condylar reconstruction. PMID:28750725 | 2017 | this review only | not stated | not extracted yet |
| Jain 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Jain et al. 2016 Evaluation of two socket healing procedures with and without mesenchymal stem cells: A comparative study. PMID:28356687 | 2016 | this review only | not stated | not extracted yet |
| Kaigler 2013a matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kakabadze 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Kakabadze et al. 2017 Reconstruction of mandibular defects with autogenous bone and decellularized bovine bone grafts with freeze-dried bone marrow stem cell… PMID:28454328 | 2017 | this review only | not stated | not extracted yet |
| Katagiri 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Katagiri et al. 2017 Clinical Study of Bone Regeneration by Conditioned Medium From Mesenchymal Stem Cells After Maxillary Sinus Floor Elevation. PMID:28727618 | 2017 | this review only | not stated | not extracted yet |
| Khojasteh 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Khojasteh 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Khojasteh and Sadeghi 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Khojasteh et al. 2017 Lateral Ramus Cortical Bone Plate in Alveolar Cleft Osteoplasty with Concomitant Use of Buccal Fat Pad Derived Cells and Autogenous Bone:… PMID:29379800 | 2017 | this review only | not stated | not extracted yet |
| Mannelli 2017 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mannelli et al. 2017 The role of bone marrow aspirate cells in the management of atrophic mandibular fractures by mini-invasive surgical approach:… PMID:28259617 | 2017 | this review only | not stated | not extracted yet |
| Marx and Harrell 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Marx and Harrell 2014 Translational research: The CD34+ cell is crucial for large-volume bone regeneration from the milieu of bone marrow progenitor cells in… PMID:24683583 | 2014 | this review only | not stated | not extracted yet |
| Mazzetti 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mazzetti et al. 2018 Importance of Stem Cell Transplantation in Cleft Lip and Palate Surgical Treatment Protocol. PMID:30067525 | 2018 | this review only | not stated | not extracted yet |
| Mossaad 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mossaad 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Mossaad et al. 2019 Alveolar Cleft Reconstruction Using Different Grafting Techniques. PMID:31110587 | 2019 | this review only | not stated | not extracted yet |
| Mossaad et al. 2021 The Use of Dual Energy X-Ray Bone Density Scan in Assessment of Alveolar Cleft Grafting Using Bone Marrow Stem Cells… PMID:34727454 | 2021 | this review only | not stated | not extracted yet |
| Naujokat 2022 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Naujokat et al. 2022 Effect of enriched bone-marrow aspirates on the dimensional stability of cortico-cancellous iliac bone grafts in alveolar ridge… PMID:36063250 | 2022 | this review only | not stated | not extracted yet |
| Pasquali 2015 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pasquali 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pasquali et al. 2015 Maxillary Sinus Augmentation Combining Bio-Oss with the Bone Marrow Aspirate Concentrate: A Histomorphometric Study in Humans. PMID:26543482 | 2015 | this review only | not stated | not extracted yet |
| Pasquali et al. 2021 Clinical, Histological, and Scintigraphic Comparative Study of the Use of Mandibular Bone Marrow and Peripheral Blood in Bone Neoformation. PMID:35003261 | 2021 | this review only | not stated | not extracted yet |
| Payer 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pelegrine 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Pelegrine et al. 2016 Can bone marrow aspirate concentrate change the mineralization pattern of the anterior maxilla treated with xenografts? A preliminary study. PMID:27041895 | 2016 | this review only | not stated | not extracted yet |
| Prins 2016 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Prins et al. 2016 Bone Regeneration Using the Freshly Isolated Autologous Stromal Vascular Fraction of Adipose Tissue in Combination With Calcium Phosphate… PMID:27388241 | 2016 | this review only | not stated | not extracted yet |
| Rickert 2011 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Sanchez 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Sandor 2012 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Sandor 2012 Tissue engineering of bone: Clinical observations with adipose-derived stem cells, resorbable scaffolds, and growth factors. PMID:23483030 | 2012 | this review only | not stated | not extracted yet |
| Sembronio 2021 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Shayesteh 2008 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Shayesteh et al. 2008 Sinus augmentation using human mesenchymal stem cells loaded into a beta-tricalcium phosphate/hydroxyapatite scaffold. PMID:18424115 | 2008 | this review only | not stated | not extracted yet |
| Talaat 2018 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Talaat et al. 2018 Autologous Bone Marrow Concentrates and Concentrated Growth Factors Accelerate Bone Regeneration After Enucleation of Mandibular… PMID:29481504 | 2018 | this review only | not stated | not extracted yet |
| Vignesh 2019 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Vignesh et al. 2019 Bone Marrow Aspirate in Cystic Maxillofacial Bony Defects. PMID:30845084 | 2019 | this review only | not stated | not extracted yet |
| Whitt 2020 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Wildburger 2014 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yamada 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Yamada et al. 2013 Osteotome technique with injectable tissue-engineered bone and simultaneous implant placement by cell therapy. PMID:22150696 | 2013 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Humans with congenital or acquired skeletal defect or deficiency in the maxilla or mandible | Patients with alveolar ridge defects (n=16 studies), sinus augmentation (n=16), alveolar cleft (n=8), pathologic defects (n=8), periodontal intrabony defects (n=6), TMD (n=4), mandibular fracture (n=2) |
| Intervention | Application of stem cells or autogenous biologics containing stem cells in surgical regenerative approaches | Stem cells: bone marrow aspirate and/or MSCs (over three quarters of studies), alone or with scaffolds; also adipose, dental pulp, PDL, buccal fat pad, hematopoietic and mononuclear cells |
| Comparison | Other regenerative approaches not involving stem cell therapy, or none | Conventional grafting or regenerative materials without stem cells in RCTs and CCTs; single-arm studies had no control |
| Outcomes | Primary: quantity or quality of regenerated bone; secondary: patient reported outcomes and periodontal CAL gain | Meta-analysed: periodontal CAL gain (n=4 studies), histologic bone quality (n=11), radiographic bone quality (n=6), radiographic bone quantity (n=12) overall and by vertical, horizontal and volumetric dimension |
| Study designs | Prospective RCTs, controlled clinical trials and single-arm pre-post studies with at least 5 patients | 59 studies: 31 RCTs, 11 CCTs, 16 single-arm per Results text (32 RCTs and 27 NRSIs per Discussion) |
| Timing | Any publication date; no follow-up restriction specified | Follow-up from 3 months to 94 months; subgroups less than 6 months, 6 months, 12 months |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | Yes | No | no |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | Yes | Yes | yes |
| 8Included studies described in detail | Partial Yes | Partial Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: Yes | RCT: Yes · NRSI: Yes | yes |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: No · NRSI: No | RCT: No · NRSI: No | yes |
| 12Impact of risk of bias on the pooled results | Yes | Yes | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | No | No | yes |
| 16Conflicts of interest reported | Yes | Yes | yes |
| Overall | Critically Low | Critically Low | yes |