Primary study · included by 2 reviews

Impact of autogenous concentrated bone marrow aspirate on bone regeneration after sinus floor augmentation with a bovine bone substitute--a split-mouth pilot study.

Wildburger 2014 · Wildburger Angelika, Payer Michael, Jakse Norbert, et al. · Clinical oral implants research · 2014

Included by

Can Mesenchymal Stem Cells Improve Bone Regeneration in Maxillary Sinus Augmentation? A Systematic Review and Meta-Analysis.
Non-Cochrane · intervention · 2026 · cited as Wildburger 2014 · Table 1; References 49-54
Outcome this study informsPooled effectEvidenceCertainty
Bone regeneration success (presence or absence of new bone formation, dichotomous)
Mesenchymal stem cell (MSC)-based bone regeneration (MSC with biomaterial or cellular allograft) vs Bone regeneration without stem cells (e.g., biomaterial or autograft alone, blood clot, particulate allograft)
RR 1.16 [0.70, 1.93]2 studiesGRADE not reported
Implant success rate
Mesenchymal stem cell (MSC)-based bone regeneration (MSC with biomaterial or cellular allograft) vs Bone regeneration without stem cells (e.g., biomaterial or autograft alone, blood clot, particulate allograft)
log RR -0.03 [-0.09, 0.04]4 studiesGRADE not reported
Bone regeneration success (presence or absence of new bone formation, dichotomous)
Mesenchymal stem cell (MSC)-based bone regeneration (MSC with biomaterial or cellular allograft) vs Bone regeneration without stem cells (e.g., biomaterial or autograft alone, blood clot, particulate allograft)
RR 1.22 [0.73, 2.04]2 studiesGRADE not reported
Implant success rate
Mesenchymal stem cell (MSC)-based bone regeneration (MSC with biomaterial or cellular allograft) vs Bone regeneration without stem cells (e.g., biomaterial or autograft alone, blood clot, particulate allograft)
log RR -0.03 [-0.10, 0.04]4 studiesGRADE not reported
Implant success rate
Mesenchymal stem cell (MSC)-based bone regeneration (MSC with biomaterial or cellular allograft) vs Bone regeneration without stem cells (e.g., biomaterial or autograft alone, blood clot, particulate allograft) · Follow-up 3 to 12 months
RR 0.98 [0.94, 1.03]5 studies · 222 implants participantsModerate
Implant success rate
Mesenchymal stem cell (MSC)-based bone regeneration (MSC with biomaterial or cellular allograft) vs Bone regeneration without stem cells (e.g., biomaterial or autograft alone, blood clot, particulate allograft)
log RR -0.01 [-0.06, 0.03]4 studiesGRADE not reported
Implant success rate
Mesenchymal stem cell (MSC)-based bone regeneration (MSC with biomaterial or cellular allograft) vs Bone regeneration without stem cells (e.g., biomaterial or autograft alone, blood clot, particulate allograft)
log RR -0.03 [-0.10, 0.04]4 studiesGRADE not reported
Bone regeneration success (presence or absence of new bone formation, dichotomous)
Mesenchymal stem cell (MSC)-based bone regeneration (MSC with biomaterial or cellular allograft) vs Bone regeneration without stem cells (e.g., biomaterial or autograft alone, blood clot, particulate allograft)
RR 1.03 [0.63, 1.69]2 studiesGRADE not reported
Implant success rate
Mesenchymal stem cell (MSC)-based bone regeneration (MSC with biomaterial or cellular allograft) vs Bone regeneration without stem cells (e.g., biomaterial or autograft alone, blood clot, particulate allograft)
log RR -0.00 [-0.05, 0.04]4 studiesGRADE not reported
Bone regeneration success (presence or absence of new bone formation, dichotomous)
Mesenchymal stem cell (MSC)-based bone regeneration (MSC with biomaterial or cellular allograft) vs Bone regeneration without stem cells (e.g., biomaterial or autograft alone, blood clot, particulate allograft)
RR 1.11 [0.73, 1.67]3 studiesHigh
Clinical stem cell therapy in oral and craniofacial bone regeneration: a systematic review and meta-analysis.
Non-Cochrane · intervention · 2026 · cited as Wildburger et al. 2014 · Table 3

The review does not say which of its outcomes this study informs.

2 including reviews in total.