Non-Cochrane · intervention · PM41017258
Histological Outcomes of Root Coverage Procedures: A Systematic Review With Meta-Analysis.
Shanbhag Siddharth, Stødle Ida Haukåen, Lie Stein Atle, et al. · Journal of periodontal research · 2026 · PubMed · doi:10.1111/jre.70043
Findings
69 findings
| Population | ||||
|---|---|---|---|---|
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New connective tissue attachment length (CT1; new CT adjacent to new cementum), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 2.47 [1.53, 3.41] GRADE not reported 9 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | Soft-tissue thickness/width (ST), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 1.11 [0.80, 1.41] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New cementum length (CE), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 2.06 [1.22, 2.89] GRADE not reported 10 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New epithelium length (EP; junctional plus sulcular), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) 3.45 [1.68, 5.22] GRADE not reported 3 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New connective tissue attachment length (CT1; new CT adjacent to new cementum), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) 1.68 [0.99, 2.38] GRADE not reported 3 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New connective tissue attachment length (CT1; new CT adjacent to new cementum), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 2.79 [1.47, 4.11] GRADE not reported 6 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New epithelium length (EP; junctional plus sulcular), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 2.17 [1.80, 2.55] GRADE not reported 10 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New bone height (BO), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) -0.07 [-0.64, 0.51] GRADE not reported 3 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New cementum length (CE), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) 0.69 [-0.63, 2.01] GRADE not reported 2 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New bone height (BO), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 0.50 [0.13, 0.86] GRADE not reported 14 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New bone height (BO), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 0.66 [0.27, 1.05] GRADE not reported 11 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New cementum length (CE), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 1.83 [1.06, 2.60] GRADE not reported 12 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New connective tissue adhesion length (CT2; new CT not associated with new cementum), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 0.74 [0.50, 0.97] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New connective tissue adhesion length (CT2; new CT not associated with new cementum), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 0.74 [0.50, 0.97] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | New epithelium length (EP; junctional plus sulcular), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 2.47 [1.93, 3.02] GRADE not reported 13 studies |
| Dogs with experimentally created chronic recession-type defects | Coronally advanced flap (CAF) | None (single-arm pooled mean within the procedure) | Soft-tissue thickness/width (ST), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 1.11 [0.80, 1.41] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New cementum length (CE), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 2.87 [1.81, 3.92] GRADE not reported 4 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New bone height (BO), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) -0.37 [-1.06, 0.33] GRADE not reported 2 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New epithelium length (EP; junctional plus sulcular), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) 2.40 [1.85, 2.96] GRADE not reported 2 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New epithelium length (EP; junctional plus sulcular), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 2.72 [1.97, 3.47] GRADE not reported 6 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New bone height (BO), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 0.17 [-0.03, 0.36] GRADE not reported 6 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New cementum length (CE), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) 1.77 [0.69, 2.84] GRADE not reported 2 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New epithelium length (EP; junctional plus sulcular), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 2.58 [2.07, 3.09] GRADE not reported 8 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | Soft-tissue thickness/width (ST), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 1.45 [0.41, 2.49] GRADE not reported 3 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New bone height (BO), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 0.21 [0.01, 0.42] GRADE not reported 4 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New cementum length (CE), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 2.39 [1.57, 3.21] GRADE not reported 6 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | Soft-tissue thickness/width (ST), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 1.45 [0.41, 2.49] GRADE not reported 3 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New connective tissue adhesion length (CT2; new CT not associated with new cementum), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) 0.23 [0.09, 0.37] GRADE not reported 2 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New connective tissue adhesion length (CT2; new CT not associated with new cementum), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 0.59 [0.17, 1.01] GRADE not reported 6 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New connective tissue adhesion length (CT2; new CT not associated with new cementum), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 0.51 [0.17, 0.84] GRADE not reported 8 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New cementum length (CE), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) 1.10 [0.13, 2.07] GRADE not reported 2 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New connective tissue attachment length (CT1; new CT adjacent to new cementum), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 1.48 [0.23, 2.74] GRADE not reported 2 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New connective tissue attachment length (CT1; new CT adjacent to new cementum), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) 1.33 [0.36, 2.31] GRADE not reported 3 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New connective tissue attachment length (CT1; new CT adjacent to new cementum), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 1.31 [0.74, 1.87] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New connective tissue adhesion length (CT2; new CT not associated with new cementum), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 0.20 [-0.31, 0.71] GRADE not reported 2 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | Soft-tissue thickness/width (ST), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 1.54 [1.08, 2.00] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New cementum length (CE), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 0.97 [0.50, 1.44] GRADE not reported 8 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New bone height (BO), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) -0.02 [-0.57, 0.53] GRADE not reported 6 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New epithelium length (EP; junctional plus sulcular), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 2.75 [1.89, 3.60] GRADE not reported 7 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New epithelium length (EP; junctional plus sulcular), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) 2.96 [2.26, 3.65] GRADE not reported 10 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New epithelium length (EP; junctional plus sulcular), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) 3.60 [2.62, 4.57] GRADE not reported 3 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | Soft-tissue thickness/width (ST), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 1.54 [1.08, 2.00] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New connective tissue adhesion length (CT2; new CT not associated with new cementum), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 0.20 [-0.31, 0.71] GRADE not reported 2 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New bone height (BO), mm Early (<=6 weeks) · Preclinical, large-animal models | Pooled mean (mm) -0.12 [-0.48, 0.25] GRADE not reported 3 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New cementum length (CE), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 0.93 [0.34, 1.53] GRADE not reported 6 studies |
| Dogs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New bone height (BO), mm Overall (all observation times) · Preclinical, large-animal models | Pooled mean (mm) -0.10 [-0.43, 0.23] GRADE not reported 9 studies |
| Minipigs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New epithelium length (EP; junctional plus sulcular), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 2.69 [1.77, 3.60] GRADE not reported 3 studies |
| Minipigs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New bone height (BO), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) -0.10 [-0.50, 0.30] GRADE not reported 3 studies |
| Minipigs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New cementum length (CE), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 1.26 [0.27, 2.25] GRADE not reported 3 studies |
| Minipigs with experimentally created chronic recession-type defects | CAF plus connective tissue graft (CAF + CTG) | None (single-arm pooled mean within the procedure) | New connective tissue adhesion length (CT2; new CT not associated with new cementum), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 0.03 [0.00, 0.06] GRADE not reported 3 studies |
| Minipigs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New bone height (BO), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 0.71 [-0.32, 1.74] GRADE not reported 4 studies |
| Minipigs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New cementum length (CE), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 1.90 [1.05, 2.76] GRADE not reported 4 studies |
| Minipigs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | Soft-tissue thickness/width (ST), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 1.28 [1.00, 1.55] GRADE not reported 3 studies |
| Minipigs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New connective tissue adhesion length (CT2; new CT not associated with new cementum), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 0.16 [0.03, 0.30] GRADE not reported 4 studies |
| Minipigs with experimentally created chronic recession-type defects | CAF plus soft-tissue substitute (CAF + SUB) | None (single-arm pooled mean within the procedure) | New epithelium length (EP; junctional plus sulcular), mm Delayed (>=10 weeks) · Preclinical, large-animal models | Pooled mean (mm) 2.37 [1.50, 3.24] GRADE not reported 4 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive biologicals (EMD, FGF2, PRF or hyaluronic acid) | Same root coverage procedure without biologicals | New bone height (BO), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) 0.57 [0.20, 0.95] GRADE not reported 10 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive biologicals (EMD, FGF2, PRF or hyaluronic acid) | Same root coverage procedure without biologicals | New cementum length (CE), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) 0.92 [0.56, 1.29] GRADE not reported 10 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive biologicals (EMD, FGF2, PRF or hyaluronic acid) | Same root coverage procedure without biologicals | New connective tissue attachment length (CT1; new CT adjacent to new cementum), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) -0.16 [-0.54, 0.23] GRADE not reported 8 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive biologicals (EMD, FGF2, PRF or hyaluronic acid) | Same root coverage procedure without biologicals | New epithelium length (EP; junctional plus sulcular), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) -0.46 [-0.81, -0.10] GRADE not reported 10 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive biologicals (EMD, FGF2, PRF or hyaluronic acid) | Same root coverage procedure without biologicals | Soft-tissue thickness/width (ST), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) 0.54 [0.08, 1.00] GRADE not reported 7 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive enamel matrix derivative (EMD) | Same root coverage procedure without EMD | New cementum length (CE), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) 0.86 [0.36, 1.35] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive enamel matrix derivative (EMD) | Same root coverage procedure without EMD | New bone height (BO), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) 0.65 [0.05, 1.26] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive enamel matrix derivative (EMD) | Same root coverage procedure without EMD | New connective tissue attachment length (CT1; new CT adjacent to new cementum), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) -0.02 [-0.55, 0.51] GRADE not reported 4 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive enamel matrix derivative (EMD) | Same root coverage procedure without EMD | New epithelium length (EP; junctional plus sulcular), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) -0.63 [-1.18, -0.07] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive enamel matrix derivative (EMD) | Same root coverage procedure without EMD | Soft-tissue thickness/width (ST), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) 0.84 [-0.11, 1.78] GRADE not reported 3 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive membrane (guided tissue regeneration) | Same root coverage procedure without membrane | New connective tissue attachment length (CT1; new CT adjacent to new cementum), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) -0.12 [-1.08, 0.83] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive membrane (guided tissue regeneration) | Same root coverage procedure without membrane | New cementum length (CE), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) 0.87 [0.24, 1.50] GRADE not reported 4 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive membrane (guided tissue regeneration) | Same root coverage procedure without membrane | New bone height (BO), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) 0.20 [-0.29, 0.68] GRADE not reported 5 studies |
| Dogs with experimentally created chronic recession-type defects | Root coverage procedure with adjunctive membrane (guided tissue regeneration) | Same root coverage procedure without membrane | New epithelium length (EP; junctional plus sulcular), mm Various healing times (not stratified) · Preclinical, large-animal models | SMD (Hedges g) -0.70 [-1.42, 0.02] GRADE not reported 5 studies |
Included primary studies 85
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Skierska 2024 Tunnel technique and subepithelial connective tissue graft, with or without cross-linked hyaluronic acid, in the treatment of multiple… PMID:38808976 | 2024 | 1 other review | not stated | not extracted yet |
| Al Hezaimi 2014 The feasibility of using coronally advanced flap with an extracellular matrix membrane for treating gingival recession defects: a… PMID:24804288 | 2014 | this review only | not stated | not extracted yet |
| Al‐Hezaimi 2013 Efficacy of acellular dermal matrix and coronally advanced flaps for the treatment of induced gingival recession defects: a… PMID:23088530 | 2013 | this review only | not stated | not extracted yet |
| Bokan 1997 Potential of gingival connective tissue to induce keratinization of an alveolar mucosal flap: a long-term histologic and clinical… PMID:9573863 | 1997 | this review only | not stated | not extracted yet |
| Bruno 2000 Histology of a human biopsy section following the placement of a subepithelial connective tissue graft. PMID:11203564 | 2000 | this review only | not stated | not extracted yet |
| Caffesse 1984 Revascularization following the lateral sliding flap procedure. PMID:6588192 | 1984 | this review only | not stated | not extracted yet |
| Camelo 2012 Treatment of gingival recession defects with xenogenic collagen matrix: a histologic report. PMID:22292146 | 2012 | this review only | not stated | not extracted yet |
| Carnio 2002 Histological evaluation of 4 cases of root coverage following a connective tissue graft combined with an enamel matrix derivative… PMID:12546106 | 2002 | this review only | not stated | not extracted yet |
| Carnio 2003 Root resorption associated with a subepithelial connective tissue graft for root coverage: clinical and histologic report of a case. PMID:12956483 | 2003 | this review only | not stated | not extracted yet |
| Carnio 2014 Mineral trioxide aggregate and subepithelial connective tissue graft for treatment of iatrogenic gingival recession: long-term results. PMID:24396836 | 2014 | this review only | not stated | not extracted yet |
| Casati 2000 Guided tissue regeneration with a bioabsorbable polylactic acid membrane in gingival recessions. A histometric study in dogs. PMID:10711614 | 2000 | this review only | not stated | not extracted yet |
| Castellanos 2006 Enamel matrix derivative and coronal flaps to cover marginal tissue recessions. PMID:16579697 | 2006 | this review only | not stated | not extracted yet |
| Cha 2017 Root coverage using porcine collagen matrix with fibroblast growth factor-2: a pilot study in dogs. PMID:27790732 | 2017 | this review only | not stated | not extracted yet |
| Chackartchi 2023 Histological evaluation following treatment of recession-type defects with coronally advanced flap and a novel human recombinant amelogenin. PMID:37421492 | 2023 | this review only | not stated | not extracted yet |
| Chambrone 2015 Wound Healing of the Laterally Positioned Flap: A Histomorphometric Assessment. PMID:26509981 | 2015 | this review only | not stated | not extracted yet |
| Common 1983 The effects of citric acid on attachment of laterally positioned flaps. PMID:6572256 | 1983 | this review only | not stated | not extracted yet |
| Comuzzi 2014 Human histologic evaluation of root coverage obtained with connective tissue graft over a compomer restoration. PMID:24396839 | 2014 | this review only | not stated | not extracted yet |
| Cortellini 1991 Guided tissue regeneration procedure using a fibrin-fibronectin system in surgically induced recession in dogs. PMID:1938186 | 1991 | this review only | not stated | not extracted yet |
| Cortellini 1993 Histologic assessment of new attachment following the treatment of a human buccal recession by means of a guided tissue regeneration… PMID:8515369 | 1993 | this review only | not stated | not extracted yet |
| Cummings 2005 Histologic evaluation of autogenous connective tissue and acellular dermal matrix grafts in humans. PMID:15974840 | 2005 | this review only | not stated | not extracted yet |
| de Oliveira 2005 Acellular dermal matrix allograft used alone and in combination with enamel matrix protein in gingival recession: histologic study in dogs. PMID:16353534 | 2005 | this review only | not stated | not extracted yet |
| Di Domenico 2023 Multiple coronally advanced flap with a selective use of connective tissue graft: A 3-year prospective clinical and histological study. PMID:37036093 | 2023 | this review only | not stated | not extracted yet |
| Dragan 2022 Evaluation of Omega-3 piscine acellular dermal matrix membrane as a soft tissue alternative for the treatment of mucogingival defects. PMID:35661039 | 2022 | this review only | not stated | not extracted yet |
| Eren 2016 Vascularization after treatment of gingival recession defects with platelet-rich fibrin or connective tissue graft. PMID:26696115 | 2016 | this review only | not stated | not extracted yet |
| Fickl 2015 Porcine dermal matrix in the treatment of dehiscence-type defects--an experimental split-mouth animal trial. PMID:24547948 | 2015 | this review only | not stated | not extracted yet |
| Franca‐Grohmann 2020 Treatment of dehiscence-type defects with collagen matrix and/or enamel matrix derivative: Histomorphometric study in minipigs. PMID:31833570 | 2020 | this review only | not stated | not extracted yet |
| Garcia‐De‐la‐Fuente 2017 Histologic and Clinical Study of Gingival Recession Treated with Subepithelial Connective Tissue Graft: A Case Report. PMID:27977823 | 2017 | this review only | not stated | not extracted yet |
| Ghanaati 2011 Evaluation of the tissue reaction to a new bilayered collagen matrix in vivo and its translation to the clinic. PMID:21239849 | 2011 | this review only | not stated | not extracted yet |
| Goldstein 2001 Human histology of new attachment after root coverage using subepithelial connective tissue graft. PMID:11422587 | 2001 | this review only | not stated | not extracted yet |
| Gomaa 2022 Healing of experimental gingival recession defects treated with amnion allograft: Histologic and histometric analysis in dogs. PMID:35077863 | 2022 | this review only | not stated | not extracted yet |
| Gottlow 1986 Treatment of localized gingival recessions with coronally displaced flaps and citric acid. An experimental study in the dog. PMID:3455937 | 1986 | this review only | not stated | not extracted yet |
| Gottlow 1990 Guided tissue regeneration following treatment of recession-type defects in the monkey. PMID:2254834 | 1990 | this review only | not stated | not extracted yet |
| Guiha 2001 Histological evaluation of healing and revascularization of the subepithelial connective tissue graft. PMID:11338299 | 2001 | this review only | not stated | not extracted yet |
| Harris 1998 Root coverage with a connective tissue with partial thickness double pedicle graft and an acellular dermal matrix graft: a clinical and… PMID:9848542 | 1998 | this review only | not stated | not extracted yet |
| Harris 1999 Human histologic evaluation of root coverage obtained with a connective tissue with partial thickness double pedicle graft. A case report. PMID:10440645 | 1999 | this review only | not stated | not extracted yet |
| Harris 1999 Successful root coverage: a human histologic evaluation of a case. PMID:10709509 | 1999 | this review only | not stated | not extracted yet |
| Harris 2001 Histologic evaluation of root coverage obtained with GTR in humans: a case report. PMID:11490401 | 2001 | this review only | not stated | not extracted yet |
| Iglhaut 1987 Apical migration of oral epithelium in experimental dehiscence wounds. PMID:3479454 | 1987 | this review only | not stated | not extracted yet |
| Jung 2008 Histologic observation of soft tissue acquired from maxillary tuberosity area for root coverage. PMID:18454674 | 2008 | this review only | not stated | not extracted yet |
| Lafzi 2007 Enamel matrix derivative Emdogain as an adjuvant for a laterally-positioned flap in the treatment of gingival recession: an electron… PMID:17594666 | 2007 | this review only | not stated | not extracted yet |
| Lee 2002 Comparative histologic analysis of coronally advanced flap with and without collagen membrane for root coverage. PMID:12146538 | 2002 | this review only | not stated | not extracted yet |
| Lim 2023 Effect of polydeoxyribonucleotide with xenogeneic collagen matrix on gingival phenotype modification: a pilot preclinical study. PMID:37681354 | 2023 | this review only | not stated | not extracted yet |
| Luczyszyn 2007 Histologic analysis of the acellular dermal matrix graft incorporation process: a pilot study in dogs. PMID:17726990 | 2007 | this review only | not stated | not extracted yet |
| Majzoub 2001 Histology of connective tissue graft. A case report. PMID:11759874 | 2001 | this review only | not stated | not extracted yet |
| Manhal 2021 Poor Biointegration of Porcine Acellular Dermal Matrix Associated with Unfavorable Gingival Healing: A Report of Three Cases. PMID:34753851 | 2021 | this review only | not stated | not extracted yet |
| Martins 2011 Recession defects associated with scraped roots treated with subepithelial connective tissue graft. PMID:22067857 | 2011 | this review only | not stated | not extracted yet |
| McGuire 2003 Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative or connective tissue. Part… PMID:14514225 | 2003 | this review only | not stated | not extracted yet |
| McGuire 2009 Evaluation of human recession defects treated with coronally advanced flaps and either purified recombinant human platelet-derived growth… PMID:19244878 | 2009 | this review only | not stated | not extracted yet |
| McGuire 2009 Growth factor-mediated treatment of recession defects: a randomized controlled trial and histologic and microcomputed tomography… PMID:19335074 | 2009 | this review only | not stated | not extracted yet |
| McGuire 2016 A Prospective, Case-Controlled Study Evaluating the Use of Enamel Matrix Derivative on Human Buccal Recession Defects: A Human Histologic… PMID:26832834 | 2016 | this review only | not stated | not extracted yet |
| Nishimura 1981 Histologic evaluation of free gingival graft especially about the attachment between the graft and the exposed root. PMID:6956703 | 1981 | this review only | not stated | not extracted yet |
| Nunez 2009 Clinical and histological evaluation of an acellular dermal matrix allograft in combination with the coronally advanced flap in the… PMID:19508251 | 2009 | this review only | not stated | not extracted yet |
| Okubo 2013 Coverage of gingival recession defects using acellular dermal matrix allograft with or without beta-tricalcium phosphate. PMID:21862508 | 2013 | this review only | not stated | not extracted yet |
| Ouhayoun 1993 Chemically separated connective tissue grafts: clinical application and histological evaluation. PMID:7692034 | 1993 | this review only | not stated | not extracted yet |
| Owens 2017 Histologic Evaluation of Acellular Dermal Matrix Allografts in Humans. PMID:32689743 | 2017 | this review only | not stated | not extracted yet |
| Papageorgiou 2009 Treatment outcomes of ligature-induced recession in the dog model using guided tissue regeneration or coronally positioned flap procedures. PMID:19431957 | 2009 | this review only | not stated | not extracted yet |
| Pasquinelli 1995 The histology of new attachment utilizing a thick autogenous soft tissue graft in an area of deep recession: a case report. PMID:7558658 | 1995 | this review only | not stated | not extracted yet |
| Perotto 2017 Vascularization and Innervation of Connective Tissue Grafts in the Treatment of Gingival Recessions: A Histologic and Immunohistochemical… PMID:28609502 | 2017 | this review only | not stated | not extracted yet |
| Pfeifer 1971 Histologic evaluation of full and partial thickness lateral repositioned flaps: a pilot study. PMID:5282573 | 1971 | this review only | not stated | not extracted yet |
| Rasperini 2000 Clinical and histologic evaluation of human gingival recession treated with a subepithelial connective tissue graft and enamel matrix… PMID:11203568 | 2000 | this review only | not stated | not extracted yet |
| Reddy 2024 Histological and whole-genome sequencing analysis of coronally advanced flap with connective tissue graft for the treatment of gingival… PMID:37987219 | 2024 | this review only | not stated | not extracted yet |
| Roman 2010 Subepithelial connective tissue graft for root coverage: clinical case reports and histologic evaluation. PMID:21103645 | 2010 | this review only | not stated | not extracted yet |
| Romano 2017 Epithelial Inclusions Following a Bilaminar Root Coverage Procedure with a Subepithelial Connective Tissue Graft: A Histologic and… PMID:28817128 | 2017 | this review only | not stated | not extracted yet |
| Rosetti 2009 Treatment of gingival recession with collagen membrane and DFDBA: a histometric study in dogs. PMID:19893967 | 2009 | this review only | not stated | not extracted yet |
| Sallum 2003 Coronally positioned flap with or without enamel matrix protein derivative for the treatment of gingival recessions. PMID:14677605 | 2003 | this review only | not stated | not extracted yet |
| Sallum 2006 Coronally positioned flap with or without acellular dermal matrix graft in gingival recessions: a histometric study. PMID:16764138 | 2006 | this review only | not stated | not extracted yet |
| Sanchez 2022 Cell Therapy Based on Gingiva-Derived Mesenchymal Stem Cells Seeded in a Xenogeneic Collagen Matrix for Root Coverage of RT1 Gingival… DOI:10.3390/ijms23063248 | 2022 | this review only | not stated | not extracted yet |
| Sanchez 2022 Cell Therapy Based on Gingiva-Derived Mesenchymal Stem Cells Seeded in a Xenogeneic Collagen Matrix for Root Coverage of RT1 Gingival… PMID:35328670 | 2022 | this review only | not stated | not extracted yet |
| Sculean 2015 Healing of localized gingival recessions treated with coronally advanced flap alone or combined with either a resorbable collagen matrix… PMID:25081389 | 2015 | this review only | not stated | not extracted yet |
| Sheinberg 2024 Preclinical evaluation of mucogingival defect treatment using piscine membranes: An in vivo assessment of wound healing. PMID:39148256 | 2024 | this review only | not stated | not extracted yet |
| Shirakata 2016 Healing of localized gingival recessions treated with a coronally advanced flap alone or combined with an enamel matrix derivative and a… PMID:26612398 | 2016 | this review only | not stated | not extracted yet |
| Shirakata 2019 Split-mouth evaluation of connective tissue graft with or without enamel matrix derivative for the treatment of isolated gingival… PMID:30506228 | 2019 | this review only | not stated | not extracted yet |
| Shirakata 2021 Healing of buccal gingival recessions following treatment with coronally advanced flap alone or combined with a cross-linked hyaluronic… PMID:33513277 | 2021 | this review only | not stated | not extracted yet |
| Shirakata 2021 Histological Evaluation of Gingival and Intrabony Periodontal Defects Treated with Platelet-rich Fibrin Using Different Protocols: A… PMID:34673845 | 2021 | this review only | not stated | not extracted yet |
| Shujaa Addin 2017 Biodegradable gelatin/beta-tricalcium phosphate sponges incorporating recombinant human fibroblast growth factor-2 for treatment of… PMID:28345758 | 2017 | this review only | not stated | not extracted yet |
| Stahli 2023 The effect of connective tissue graft or a collagen matrix on epithelial differentiation around teeth and implants: a preclinical study in… PMID:37300738 | 2023 | this review only | not stated | not extracted yet |
| Suaid 2008 Platelet-rich plasma and connective tissue grafts in the treatment of gingival recessions: a histometric study in dogs. PMID:18454668 | 2008 | this review only | not stated | not extracted yet |
| Suarez‐Lopez Del Amo 2019 Comparison of two soft tissue substitutes for the treatment of gingival recession defects: an animal histological study. PMID:31596366 | 2019 | this review only | not stated | not extracted yet |
| Sugarman 1969 A clinical and histological study of the attachment of grafted tissue to bone and teeth. PMID:5257236 | 1969 | this review only | not stated | not extracted yet |
| Vignoletti 2011 Clinical and histological healing of a new collagen matrix in combination with the coronally advanced flap for the treatment of Miller… PMID:21770997 | 2011 | this review only | not stated | not extracted yet |
| Vincenzi 1998 Guided tissue regeneration using a resorbable membrane in gingival recession-type defects: a histologic case report in humans. PMID:9558554 | 1998 | this review only | not stated | not extracted yet |
| Weng 1998 Healing patterns in recession defects treated with ePTFE membranes and with free connective tissue grafts. A histologic and histometric… PMID:9580329 | 1998 | this review only | not stated | not extracted yet |
| Wilderman 1965 REPAIR OF A DENTOGINGIVAL DEFECT WITH A PEDICLE FLAP. PMID:14296932 | 1965 | this review only | not stated | not extracted yet |
| Woodyard 1984 A histometric evaluation of the effect of citric acid preparation upon healing of coronally positioned flaps in nonhuman primates. PMID:6585538 | 1984 | this review only | not stated | not extracted yet |
| Żurek 2016 Multiple gingival recession coverage with an allogeneic biostatic fascia lata graft using the tunnel technique--A histological assessment. PMID:26617158 | 2016 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Emerging, personalized, and minimally invasive technologies for periodontal and peri-implant soft and hard tissue regenerative therapy. (2026) | 1 | 0.00 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Large-animal models (canine, porcine, primate) or human subjects with recession defects, no age or gender restriction; small-animal models excluded | 41 preclinical studies (32 canine, 5 porcine, 4 primate models) with artificial recession-type defects; 43 clinical studies (27 block biopsy, 16 soft-tissue biopsy; mostly case reports/series) |
| Intervention | Root coverage procedures (RCPs) using any surgical technique (flaps, grafts, soft-tissue substitutes) with or without adjunctive biologicals or membranes | CAF with or without CTG or soft-tissue substitutes most frequent; adjunctive EMD, other biologicals and membranes; LSF, FGG, tunneling |
| Comparison | Different RCPs; RCPs with versus without adjunctive biologicals or membranes | Meta-analysed in canine models of chronic defects: RCP with versus without biologicals (n=10), with versus without EMD (n=5), with versus without membrane (n=5); pooled means for CAF, CAF + CTG, CAF + SUB |
| Outcomes | Qualitative or quantitative histological evaluation of autopsy (animals) or biopsy (humans) specimens: new epithelium, connective tissue, cementum, bone, periodontal ligament, soft-tissue thickness; periodontal regeneration | Pooled means and Hedges g for epithelium, CT attachment/adhesion, cementum, bone and soft-tissue thickness; descriptive histology for human biopsies |
| Study designs | Preclinical and clinical studies of any design; in vitro studies and reviews excluded | Preclinical studies (ex vivo autopsy) and clinical studies, mostly case reports and case series (one RCT) |
| Timing | Not specified (observation time subgroups early <=6 weeks and delayed >=10 weeks defined for meta-analysis) | Early (<=6 weeks) and delayed (>=10 weeks) healing in canine/minipig models; human healing times up to 3 years |
AMSTAR 2 items
Two independent extractors rated each item. Their ratings are shown side by side because they have not been reconciled yet. The overall rating follows Shea et al. 2017: one critical flaw gives Low, more than one gives Critically Low.
| Item | Extractor A | Extractor B | Agree |
|---|---|---|---|
| 1Research question includes PICO components | Yes | Yes | yes |
| 2Protocol established before the reviewcritical | Partial Yes | Partial Yes | yes |
| 3Choice of study designs explained | Yes | No | no |
| 4Comprehensive literature searchcritical | Partial Yes | Partial Yes | yes |
| 5Study selection in duplicate | Yes | Yes | yes |
| 6Data extraction in duplicate | Yes | Yes | yes |
| 7List of excluded studies with reasonscritical | Yes | Yes | yes |
| 8Included studies described in detail | Yes | Yes | yes |
| 9Risk of bias assessed satisfactorilycritical | RCT: Yes · NRSI: Partial Yes | NRSI: No · RCT: Yes | no |
| 10Funding of included studies reported | No | No | yes |
| 11Appropriate meta-analysis methodscritical | RCT: Yes · NRSI: N/A | NRSI: N/A · RCT: Partial Yes | no |
| 12Impact of risk of bias on the pooled results | No | No | yes |
| 13Risk of bias accounted for in interpretationcritical | Yes | Yes | yes |
| 14Heterogeneity explained | Yes | Yes | yes |
| 15Publication bias investigatedcritical | Yes | Yes | yes |
| 16Conflicts of interest reported | No | No | yes |
| Overall | Moderate | Low | no |