CA VI concentration · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
CA VI concentration was lower in participants with caries (SMD -0.66, 95% CI -1.00 to -0.32; 2 studies, 141 participants); GRADE was not reported.
1 finding from 1 review
Pulp necrosis · Vital teeth
One study reported a 1.1% incidence with zinc polycarboxylate permanent cement.
1 finding from 1 review
Proportion 1.1
1 study
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Self-assembling peptide P11-4 did not differ significantly from fluoride varnish (SMD -0.31, 95% CI -0.71 to 0.09); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Dental caries · Children (mixed dentition; baseline about 8 years)
In children with mixed dentition, vitamin D deficiency was associated with an 8% higher caries risk (RR 1.08; ungraded).
1 finding from 1 review
RR 1.08 [1.04, 1.12]
4 studies
GRADE not reported
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Self-assembling peptide P11-4 did not differ significantly from CPP-ACP (SMD -0.38, 95% CI -0.87 to 0.11; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Dental caries estimates · People receiving or providing primary care; all ages, ability types, and locations
Seven studies measured change in dental caries estimates.
1 finding from 1 review
Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment
It is very uncertain whether fibre-reinforced composite fixed (bonded) retainer changes stability: Little's Irregularity Index (lower arch) compared with multistrand / spiral wire fixed (bonded) retainer (very low certainty).
1 finding from 1 review
MMP-9 location/depth · Human ex vivo carious dentin
No clear direction of MMP-9 expression by lesion depth/location was found; the evidence is very uncertain (very low certainty).
1 finding from 1 review
Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment
It is very uncertain whether CAD/CAM nitinol fixed (bonded) retainer changes stability: Little's Irregularity Index (lower arch) compared with conventional/analogue multistrand fixed (bonded) retainer (very low certainty).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
CPP-ACP did not differ significantly from CPP-ACFP (SMD 0.25, 95% CI -0.24 to 0.73); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
Toothache/dental pain is associated with worse OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Root caries (presence of root caries) · Adults (mean age ~53 years)
Adults with periodontal disease had significantly higher odds of root caries than those without (pooled OR 1.38, 95% CI 1.25 to 1.53; 2 observational studies; low certainty).
1 finding from 1 review
new carious lesions or fillings · Children with dental caries in permanent (first) molars
The review reported no significant result for SDF; no effect estimate or GRADE rating was reported.
1 finding from 1 review
Overall treatment time wearing orthodontic appliances · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
Light vibrational forces (LVF) showed no clear difference in duration of orthodontic treatment compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
Access to dental care is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Recurrence · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes
The review found no eligible studies for this question.
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported that traumatic dental injury treatment reduces negative oral health-related quality-of-life impact, based on parental perception.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Secondary caries · Patients requiring dental restoration; permanent teeth
Over 2 or more years in permanent teeth, GIC probably reduces secondary caries versus resin composite (RR 0.50, 95% CI 0.28-0.91; moderate certainty).
2 findings from 1 review
Total number of orthodontic appliance adjustment appointments during treatment · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances
Light vibrational forces (LVF) showed no clear difference in total number of orthodontic appliance adjustment appointments during… compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).
1 finding from 1 review
Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment
It is very uncertain whether full-time wear of removable retainer (any type) changes stability: Little's Irregularity Index (lower arch) compared with part-time wear of removable retainer (any type) (very low certainty).
1 finding from 1 review