Search review questions

Negative oral-health impact on daily performance measured by Child-OIDP · Adolescents aged 10 to 19 years · Cross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months, Instrument subgroup: Child-OIDP

Restoration longevity · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible… · >=12 months

Early childhood caries (presence/prevalence/severity by dmft/dmfs) · Healthy children under 6 years of age (6 months to 6 years); preschool children · Leave-one-out sensitivity analysis (Alhabdan 2018 outlier excluded, k=7)

OHRQoL sum score transformed to 0-100 · Community-dwelling adults aged 60 years or older · Baseline for longitudinal studies, Low edentulism prevalence

Femur fracture · European GWAS participants · MVMR MR-Egger

Composite: Preference for replacement over repair - Scenario 8: disruption of occlusal integrity · HDI: Low

Oral hygiene improvement · Gamified group (reminder sticker book, rewards and visual aids)

Early childhood caries (ECC) - incidence/risk · Children up to 71 months (early childhood; primary dentition) · Up to 71 months of age (study follow-up 1-9 years), More than 24 months

Treatment failure (time-to-failure, 7 years) · Resin infiltration 1.3% vs standard of care 7.8% (Paris 2020, Kaplan-Meier)

Composite: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · Continent: South America

Radiographic progression of proximal caries lesions · Children with non-cavitated proximal caries lesions in primary teeth (ages 5-8) · 1 year, Glass ionomer vs non-invasive (Fig. 5, subgroup 2.1.3)

Amalgam: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · HDI: Medium

Lumbar spine and pelvis fracture · European GWAS participants · SVMR Weighted Median

Interleukin-8 (IL-8) · Humans who use e-cigarettes (mostly adults, often with periodontal disease) assessed for oral proinflammatory markers · Cross-sectional (single time point) for most; a few 6-month prospective, Overall (saliva + GCF)

Dental caries experience (DMFT/DMFS index) · Humans who use e-cigarettes (adolescents to adults) assessed for dental caries · Cross-sectional to 6 months

Prevalence of early childhood caries · Children up to 71 months · More than 12 months

Caries experience (mean DMFT) · 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022) · Cross-sectional (survey data 2011-2022), Low unemployment (<=5%)

Forearm fracture · European GWAS participants · MVMR MR-Egger

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD

Osteoporosis · European GWAS participants · SVMR MR-Egger

Dental caries discrimination (area under the curve) · Children and adolescents (≤18 years) · Validation assessment; prediction horizon not reported

Dental caries (presence/absence) · Children and adolescents under 18 years with HIV · Prospective follow-up, Cohort studies

Occlusion · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities) · 2 years

Occlusal caries detection: specificity · Patients (in vivo); permanent and primary teeth, occlusal surfaces · Permanent dentition

Amalgam: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration · HDI: Low

Future caries · Children without a previous history of caries

Amalgam: Preference for replacement over repair - Scenario 8: disruption of occlusal integrity · Dentists managing a defective direct amalgam restoration (posterior occlusal Class I; standardized vignette of a… · Not applicable (single time-point survey, June to October 2023), Overall (all 21 countries pooled)

OHRQoL sum score transformed to 0-100 · Community-dwelling adults aged 60 years or older · Baseline for longitudinal studies, High edentulism prevalence

Osteoporosis with pathological fracture · European GWAS participants · SVMR Weighted Median

Patient- and clinical-reported outcomes (tooth survival, clinical/radiographic success, pain) · Asymptomatic permanent teeth with deep caries (no symptoms)

Willingness-to-pay (WTP) for dental treatment · (Potential) patients with freedom of choice regarding dental treatments, including parents and caregivers deciding for…

Amalgam: Preference for replacement over repair - Scenario 4: marginal discoloration · Coverage: Covering cost of minimally invasive treatment

Engagement / adherence to oral hygiene routines · Children and adolescents aged <=18 years · Post-intervention (predominantly short-term; long-term follow-up in a minority of studies)

TNF-α level · People who use electronic cigarettes · Saliva

Risk of fractures (any site) · General population (both sexes, all ages) · Long-term / lifetime fluoride exposure, Drinking-water fluoride 1.2 mg/L vs null

Factors of choice influencing dental treatment decisions (overall) · (Potential) patients with freedom of choice regarding dental treatments, including parents and caregivers deciding for…

Radiographic progression of proximal caries lesions · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages… · Final follow-up (1 to 3.5 years), Sealant vs non-invasive (Fig. 5, subgroup 2.1.2)

Oral health-related quality of life (OHRQoL sum score, transformed 0-100) · Overall (pooled across all studies)

Pain as a factor of choice · Potential patients in dental care, including parents or caregivers making treatment decisions; excludes patients with…

Bleeding on probing (BOP) · Patients with anorexia nervosa aged >=12 years (mean age ~18.4; entirely female in reported data), general…

Oral candidiasis / Candida spp. prevalence · Adult e-cigarette (ENDS) users (general oral health; predominantly natural dentition)

Osteoporosis with pathological fracture · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for periodontitis

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Self-Etch + chemical ACAD

Clinical and radiographic success rate · Full meta-regression: preoperative diagnosis

Postmenopausal osteoporosis with pathological fracture · European GWAS participants · SVMR Maximum Likelihood

Composite: Preference for replacement over repair - Scenario 6: superficial discoloration · HDI: High

Out-of-pocket payment / cost as a factor of choice · (Potential) patients with freedom of choice regarding dental treatments, including parents and caregivers deciding for…

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro) · 24 h (immediate), Etch-and-Rinse + biological ACAD

Composite: Preference for replacement over repair - Scenario 7: non-stable (mobile) restoration · HDI: Medium

Amalgam: Preference for replacement over repair - Scenario 3: secondary caries · Coverage: Covering cost of minimally invasive treatment