Non-Cochrane · aetiology · PM40045256
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture.
Zhang Gongzi, Zheng Juan, Zhou Ying, et al. · BMC oral health · 2025 · PubMed · doi:10.1186/s12903-025-05735-7
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
83
current version
GRADE rated
0
No studies
0
Included studies
3
linked below
No studies 0 · 0%Ungraded 83 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | European-ancestry adults | European-ancestry adults (outcome GWAS up to n=490,889) |
| Intervention | Genetically predicted oral diseases: periodontitis (PD) and dental caries (DMFS index) | Periodontitis (7 SNPs; F=22.694; R2=0.298%) and DMFS (17 SNPs; F=22.397; R2=1.402%) |
| Comparison | Lower genetically predicted exposure (per 1-SD; MR contrast) | Lower genetically predicted exposure (per 1-SD) |
| Outcomes | Osteoporosis; bone mineral density (femoral neck, lumbar spine, forearm); osteoporotic fractures (osteoporosis with pathological fracture, postmenopausal osteoporosis with pathological fracture, fracture of femur, forearm, and lumbar spine and pelvis) | 9 outcomes analyzed: osteoporosis, FN-BMD, LS-BMD, FA-BMD, and 5 fracture outcomes |
| Study designs | Not specified | Not specified |
| Timing | Lifelong genetic liability | Lifelong genetic liability |
Search date: Not applicable (secondary analysis of published GWAS summary statistics). Databases: GWAS summary data: GLIDE consortium (exposures); GeFOS consortium (BMD); FinnGen (osteoporosis and fractures)
Questions and results
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS)
Population: European-ancestry adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Osteoporosis with pathological fracture Lifelong genetic liability · MVMR (IVW), adjusted for periodontitis In multivariable MR, genetically predicted dental caries (DMFS) had no significant causal effect on osteoporosis with pathological fracture (OR 1.279, not significant). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.279 [0.955, 1.713] | 376746 participants | Ungraded |
Osteoporosis with pathological fracture SVMR Weighted Median Population: European GWAS participants The SVMR Weighted Median interval included the null. Source: Fig. 4, Osteoporosis with pathological fracture, DMFS, SVMR Weighted Median · same question in other reviews | OR 1.181 [0.748, 1.866] | 376746 participants | Ungraded |
Fracture of lumbar spine and pelvis Lifelong genetic liability · MVMR (IVW), adjusted for periodontitis Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of lumbar spine and pelvis (multivariable MR, OR 0.968). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 0.968 [0.840, 1.114] | 490700 participants | Ungraded |
Lumbar spine and pelvis fracture SVMR Weighted Median Population: European GWAS participants The SVMR Weighted Median interval included the null. Source: Fig. 4, Lumbar spine and pelvis fracture, DMFS, SVMR Weighted Median · same question in other reviews | OR 0.867 [0.691, 1.087] | 490700 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture Lifelong genetic liability · MVMR (IVW), adjusted for periodontitis Population: Postmenopausal women (European ancestry) In multivariable MR (adjusted for periodontitis), genetically predicted dental caries (DMFS) causally increased postmenopausal osteoporosis with pathological fracture (OR 1.422, moderate evidence). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.422 [1.027, 1.969] | 281786 participants | Ungraded |
Osteoporosis SVMR Weighted Median Population: European GWAS participants The SVMR Weighted Median interval excluded the null. Source: Fig. 2, Osteoporosis, DMFS, SVMR Weighted Median · same question in other reviews | OR 1.260 [1.017, 1.560] | 483725 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture SVMR MR-Egger Population: European GWAS participants The SVMR MR-Egger interval included the null. Source: Fig. 4, Postmenopausal osteoporosis with pathological fracture, DMFS, SVMR MR-Egger · same question in other reviews | OR 1.355 [0.696, 2.635] | 281786 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture SVMR Weighted Median Population: European GWAS participants The SVMR Weighted Median interval included the null. Source: Fig. 4, Postmenopausal osteoporosis with pathological fracture, DMFS, SVMR Weighted Median · same question in other reviews | OR 1.214 [0.746, 1.977] | 281786 participants | Ungraded |
Osteoporosis Lifelong genetic liability · MVMR (IVW), adjusted for periodontitis In multivariable MR (adjusted for periodontitis), higher genetically predicted dental caries (DMFS) causally increased osteoporosis risk (OR 1.165, moderate evidence). Source: Fig. 2; Results 'Causal effects of oral diseases on osteoporosis' · same question in other reviews | OR 1.165 [1.020, 1.331] | 483725 participants | Ungraded |
Osteoporosis with pathological fracture Lifelong genetic liability · SVMR (IVW), total causal effect In single-variable MR, genetically predicted dental caries (DMFS) had no significant causal effect on osteoporosis with pathological fracture (OR 1.261, not significant). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.261 [0.918, 1.732] | 376746 participants | Ungraded |
Lumbar spine bone mineral density SVMR IVW Population: European GWAS participants The SVMR IVW interval excluded zero. Source: Results, Causal effects of oral diseases on BMD · same question in other reviews | BETA 0.105 [0.006, 0.205] | 28498 participants | Ungraded |
Lumbar spine and pelvis fracture SVMR Maximum Likelihood Population: European GWAS participants The SVMR Maximum Likelihood interval included the null. Source: Fig. 4, Lumbar spine and pelvis fracture, DMFS, SVMR Maximum Likelihood · same question in other reviews | OR 0.950 [0.808, 1.117] | 490700 participants | Ungraded |
Forearm bone mineral density (FA-BMD) Lifelong genetic liability · SVMR and MVMR (IVW) Genetically predicted dental caries (DMFS) had no causal effect on forearm BMD. Source: Results 'Causal effects of oral diseases on BMD'; Fig. 3 · same question in other reviews | No causal effect of oral diseases on FA-BMD was found (SVMR and MVMR); no numeric estimate reported in text (see Fig. 3). | 8143 participants | Ungraded |
Femur fracture SVMR MR-Egger Population: European GWAS participants The SVMR MR-Egger interval included the null. Source: Fig. 4, Femur fracture, DMFS, SVMR MR-Egger · same question in other reviews | OR 0.893 [0.678, 1.175] | 489106 participants | Ungraded |
Femur fracture SVMR Maximum Likelihood Population: European GWAS participants The SVMR Maximum Likelihood interval included the null. Source: Fig. 4, Femur fracture, DMFS, SVMR Maximum Likelihood · same question in other reviews | OR 1.137 [0.976, 1.325] | 489106 participants | Ungraded |
Femoral neck bone mineral density (FN-BMD) Lifelong genetic liability · SVMR and MVMR (IVW) Genetically predicted dental caries (DMFS) had no causal effect on femoral neck BMD. Source: Results 'Causal effects of oral diseases on BMD'; Fig. 3 · same question in other reviews | No causal effect of oral diseases on FN-BMD was found (SVMR and MVMR); no numeric estimate reported in text (see Fig. 3). | 32735 participants | Ungraded |
Femur fracture SVMR Weighted Median Population: European GWAS participants The SVMR Weighted Median interval included the null. Source: Fig. 4, Femur fracture, DMFS, SVMR Weighted Median · same question in other reviews | OR 1.094 [0.884, 1.354] | 489106 participants | Ungraded |
Osteoporosis with pathological fracture SVMR MR-Egger Population: European GWAS participants The SVMR MR-Egger interval included the null. Source: Fig. 4, Osteoporosis with pathological fracture, DMFS, SVMR MR-Egger · same question in other reviews | OR 1.097 [0.598, 2.011] | 376746 participants | Ungraded |
Fracture of forearm Lifelong genetic liability · MVMR (IVW), adjusted for periodontitis Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of forearm (multivariable MR, OR 0.973). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 0.973 [0.891, 1.063] | 490889 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture SVMR Maximum Likelihood Population: European GWAS participants The SVMR Maximum Likelihood interval included the null. Source: Fig. 4, Postmenopausal osteoporosis with pathological fracture, DMFS, SVMR Maximum Likelihood · same question in other reviews | OR 1.363 [0.955, 1.947] | 281786 participants | Ungraded |
Lumbar spine and pelvis fracture SVMR MR-Egger Population: European GWAS participants The SVMR MR-Egger interval included the null. Source: Fig. 4, Lumbar spine and pelvis fracture, DMFS, SVMR MR-Egger · same question in other reviews | OR 0.994 [0.729, 1.355] | 490700 participants | Ungraded |
Fracture of femur Lifelong genetic liability · MVMR (IVW), adjusted for periodontitis Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of femur (multivariable MR, OR 1.069). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.069 [0.923, 1.239] | 489106 participants | Ungraded |
Fracture of lumbar spine and pelvis Lifelong genetic liability · SVMR (IVW), total causal effect Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of lumbar spine and pelvis (single-variable MR, OR 0.950). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 0.950 [0.810, 1.113] | 490700 participants | Ungraded |
Fracture of forearm Lifelong genetic liability · SVMR (IVW), total causal effect Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of forearm (single-variable MR, OR 0.921). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 0.921 [0.838, 1.012] | 490889 participants | Ungraded |
Osteoporosis SVMR Maximum Likelihood Population: European GWAS participants The SVMR Maximum Likelihood interval included the null. Source: Fig. 2, Osteoporosis, DMFS, SVMR Maximum Likelihood · same question in other reviews | OR 1.162 [0.998, 1.353] | 483725 participants | Ungraded |
Forearm fracture SVMR Weighted Median Population: European GWAS participants The SVMR Weighted Median interval included the null. Source: Fig. 4, Forearm fracture, DMFS, SVMR Weighted Median · same question in other reviews | OR 0.914 [0.799, 1.046] | 490889 participants | Ungraded |
Fracture of femur Lifelong genetic liability · SVMR (IVW), total causal effect Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of femur (single-variable MR, OR 1.126). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.126 [0.975, 1.300] | 489106 participants | Ungraded |
Osteoporosis Lifelong genetic liability · SVMR (IVW), total causal effect In single-variable MR, higher genetically predicted dental caries (DMFS) showed no significant causal effect on osteoporosis (OR 1.156, not significant). Source: Fig. 2; Results 'Causal effects of oral diseases on osteoporosis' · same question in other reviews | OR 1.156 [0.994, 1.343] | 483725 participants | Ungraded |
Osteoporosis SVMR MR-Egger Population: European GWAS participants The SVMR MR-Egger interval included the null. Source: Fig. 2, Osteoporosis, DMFS, SVMR MR-Egger · same question in other reviews | OR 1.329 [0.991, 1.782] | 483725 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture Lifelong genetic liability · SVMR (IVW), total causal effect Population: Postmenopausal women (European ancestry) In single-variable MR, genetically predicted dental caries (DMFS) had no significant causal effect on postmenopausal osteoporosis with pathological fracture (OR 1.343, not significant). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.343 [0.948, 1.901] | 281786 participants | Ungraded |
Osteoporosis with pathological fracture SVMR Maximum Likelihood Population: European GWAS participants The SVMR Maximum Likelihood interval included the null. Source: Fig. 4, Osteoporosis with pathological fracture, DMFS, SVMR Maximum Likelihood · same question in other reviews | OR 1.278 [0.921, 1.773] | 376746 participants | Ungraded |
Forearm fracture SVMR MR-Egger Population: European GWAS participants The SVMR MR-Egger interval included the null. Source: Fig. 4, Forearm fracture, DMFS, SVMR MR-Egger · same question in other reviews | OR 0.883 [0.738, 1.057] | 490889 participants | Ungraded |
Forearm fracture SVMR Maximum Likelihood Population: European GWAS participants The SVMR Maximum Likelihood interval included the null. Source: Fig. 4, Forearm fracture, DMFS, SVMR Maximum Likelihood · same question in other reviews | OR 0.920 [0.836, 1.011] | 490889 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability
Population: European GWAS participants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Osteoporosis with pathological fracture SVMR Weighted Median The SVMR Weighted Median interval included the null. Source: Fig. 4, Osteoporosis with pathological fracture, PD, SVMR Weighted Median · same question in other reviews | OR 0.985 [0.846, 1.146] | 376746 participants | Ungraded |
Forearm fracture SVMR Weighted Median The SVMR Weighted Median interval included the null. Source: Fig. 4, Forearm fracture, PD, SVMR Weighted Median · same question in other reviews | OR 0.992 [0.945, 1.042] | 490889 participants | Ungraded |
Osteoporosis Lifelong genetic liability · MVMR (IVW), adjusted for DMFS Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on osteoporosis (multivariable MR, OR 1.000). Source: Fig. 2; Results 'Causal effects of oral diseases on osteoporosis' · same question in other reviews | OR 1.000 [0.937, 1.067] | 483725 participants | Ungraded |
Fracture of lumbar spine and pelvis Lifelong genetic liability · SVMR (IVW), total causal effect Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on fracture of lumbar spine and pelvis (single-variable MR, OR 1.055). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.055 [0.984, 1.130] | 490700 participants | Ungraded |
Fracture of forearm Lifelong genetic liability · MVMR (IVW), adjusted for DMFS Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on fracture of forearm (multivariable MR, OR 0.995). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 0.995 [0.953, 1.039] | 490889 participants | Ungraded |
Fracture of femur Lifelong genetic liability · SVMR (IVW), total causal effect Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on fracture of femur (single-variable MR, OR 1.044). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.044 [0.982, 1.110] | 489106 participants | Ungraded |
Lumbar spine and pelvis fracture SVMR MR-Egger The SVMR MR-Egger interval included the null. Source: Fig. 4, Lumbar spine and pelvis fracture, PD, SVMR MR-Egger · same question in other reviews | OR 1.036 [0.956, 1.122] | 490700 participants | Ungraded |
Forearm bone mineral density (FA-BMD) Lifelong genetic liability · SVMR and MVMR (IVW) Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on forearm BMD. Source: Results 'Causal effects of oral diseases on BMD'; Fig. 3 · same question in other reviews | No causal effect of oral diseases on FA-BMD was found (SVMR and MVMR); no numeric estimate reported in text (see Fig. 3). | 8143 participants | Ungraded |
Femoral neck bone mineral density (FN-BMD) Lifelong genetic liability · SVMR and MVMR (IVW) Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on femoral neck BMD. Source: Results 'Causal effects of oral diseases on BMD'; Fig. 3 · same question in other reviews | No causal effect of oral diseases on FN-BMD was found (SVMR and MVMR); no numeric estimate reported in text (see Fig. 3). | 32735 participants | Ungraded |
Fracture of femur Lifelong genetic liability · MVMR (IVW), adjusted for DMFS Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on fracture of femur (multivariable MR, OR 1.034). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.034 [0.963, 1.109] | 489106 participants | Ungraded |
Lumbar spine bone mineral density SVMR IVW The SVMR IVW interval excluded zero. Source: Results, Causal effects of oral diseases on BMD · same question in other reviews | BETA 0.055 [0.008, 0.102] | 28498 participants | Ungraded |
Osteoporosis SVMR MR-Egger The SVMR MR-Egger interval included the null. Source: Fig. 2, Osteoporosis, PD, SVMR MR-Egger · same question in other reviews | OR 1.001 [0.918, 1.093] | 483725 participants | Ungraded |
Fracture of lumbar spine and pelvis Lifelong genetic liability · MVMR (IVW), adjusted for DMFS Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on fracture of lumbar spine and pelvis (multivariable MR, OR 1.060). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.060 [0.989, 1.135] | 490700 participants | Ungraded |
Osteoporosis with pathological fracture SVMR Maximum Likelihood The SVMR Maximum Likelihood interval included the null. Source: Fig. 4, Osteoporosis with pathological fracture, PD, SVMR Maximum Likelihood · same question in other reviews | OR 1.003 [0.874, 1.151] | 376746 participants | Ungraded |
Osteoporosis with pathological fracture Lifelong genetic liability · SVMR (IVW), total causal effect Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on osteoporosis with pathological fracture (single-variable MR, OR 1.003). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.003 [0.875, 1.150] | 376746 participants | Ungraded |
Lumbar spine and pelvis fracture SVMR Weighted Median The SVMR Weighted Median interval included the null. Source: Fig. 4, Lumbar spine and pelvis fracture, PD, SVMR Weighted Median · same question in other reviews | OR 1.058 [0.966, 1.158] | 490700 participants | Ungraded |
Osteoporosis with pathological fracture Lifelong genetic liability · MVMR (IVW), adjusted for DMFS Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on osteoporosis with pathological fracture (multivariable MR, OR 1.003). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.003 [0.546, 1.842] | 376746 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture SVMR Weighted Median The SVMR Weighted Median interval included the null. Source: Fig. 4, Postmenopausal osteoporosis with pathological fracture, PD, SVMR Weighted Median · same question in other reviews | OR 0.979 [0.826, 1.159] | 281786 participants | Ungraded |
Forearm fracture SVMR MR-Egger The SVMR MR-Egger interval included the null. Source: Fig. 4, Forearm fracture, PD, SVMR MR-Egger · same question in other reviews | OR 0.994 [0.948, 1.042] | 490889 participants | Ungraded |
Femur fracture SVMR Weighted Median The SVMR Weighted Median interval included the null. Source: Fig. 4, Femur fracture, PD, SVMR Weighted Median · same question in other reviews | OR 1.055 [0.979, 1.136] | 489106 participants | Ungraded |
Femur fracture SVMR Maximum Likelihood The SVMR Maximum Likelihood interval included the null. Source: Fig. 4, Femur fracture, PD, SVMR Maximum Likelihood · same question in other reviews | OR 1.044 [0.983, 1.109] | 489106 participants | Ungraded |
Femur fracture SVMR MR-Egger The SVMR MR-Egger interval included the null. Source: Fig. 4, Femur fracture, PD, SVMR MR-Egger · same question in other reviews | OR 1.063 [0.991, 1.140] | 489106 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture Lifelong genetic liability · SVMR (IVW), total causal effect Population: Postmenopausal women (European ancestry) Genetically predicted periodontitis had no causal effect on postmenopausal osteoporosis with pathological fracture (single-variable MR, OR 1.014). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.014 [0.857, 1.199] | 281786 participants | Ungraded |
Osteoporosis with pathological fracture SVMR MR-Egger The SVMR MR-Egger interval included the null. Source: Fig. 4, Osteoporosis with pathological fracture, PD, SVMR MR-Egger · same question in other reviews | OR 0.953 [0.813, 1.117] | 376746 participants | Ungraded |
Forearm fracture SVMR Maximum Likelihood The SVMR Maximum Likelihood interval included the null. Source: Fig. 4, Forearm fracture, PD, SVMR Maximum Likelihood · same question in other reviews | OR 0.990 [0.950, 1.032] | 490889 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture SVMR Maximum Likelihood The SVMR Maximum Likelihood interval included the null. Source: Fig. 4, Postmenopausal osteoporosis with pathological fracture, PD, SVMR Maximum Likelihood · same question in other reviews | OR 1.014 [0.872, 1.179] | 281786 participants | Ungraded |
Osteoporosis SVMR Maximum Likelihood The SVMR Maximum Likelihood interval included the null. Source: Fig. 2, Osteoporosis, PD, SVMR Maximum Likelihood · same question in other reviews | OR 0.998 [0.934, 1.067] | 483725 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture Lifelong genetic liability · MVMR (IVW), adjusted for DMFS Population: Postmenopausal women (European ancestry) Genetically predicted periodontitis had no causal effect on postmenopausal osteoporosis with pathological fracture (multivariable MR, OR 1.016). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 1.016 [0.867, 1.191] | 281786 participants | Ungraded |
Osteoporosis SVMR Weighted Median The SVMR Weighted Median interval included the null. Source: Fig. 2, Osteoporosis, PD, SVMR Weighted Median · same question in other reviews | OR 1.002 [0.925, 1.086] | 483725 participants | Ungraded |
Osteoporosis Lifelong genetic liability · SVMR (IVW), total causal effect Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on osteoporosis (single-variable MR, OR 0.998). Source: Fig. 2; Results 'Causal effects of oral diseases on osteoporosis' · same question in other reviews | OR 0.998 [0.933, 1.067] | 483725 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture SVMR MR-Egger The SVMR MR-Egger interval included the null. Source: Fig. 4, Postmenopausal osteoporosis with pathological fracture, PD, SVMR MR-Egger · same question in other reviews | OR 0.934 [0.786, 1.111] | 281786 participants | Ungraded |
Fracture of forearm Lifelong genetic liability · SVMR (IVW), total causal effect Population: European-ancestry adults Genetically predicted periodontitis had no causal effect on fracture of forearm (single-variable MR, OR 0.990). Source: Fig. 4; Results 'Causal effects of oral diseases on fractures' · same question in other reviews | OR 0.990 [0.951, 1.031] | 490889 participants | Ungraded |
Osteoporosis SVMR IVW The SVMR IVW interval included the null. Source: Fig. 2, Osteoporosis, PD, SVMR IVW · same question in other reviews | OR 0.998 [0.933, 1.067] | 483725 participants | Ungraded |
Lumbar spine and pelvis fracture SVMR Maximum Likelihood The SVMR Maximum Likelihood interval included the null. Source: Fig. 4, Lumbar spine and pelvis fracture, PD, SVMR Maximum Likelihood · same question in other reviews | OR 1.055 [0.983, 1.132] | 490700 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis
Population: European GWAS participants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Forearm fracture MVMR MR-Egger The MVMR MR-Egger interval included the null. Source: Fig. 4, Forearm fracture, DMFS, MVMR MR-Egger · same question in other reviews | OR 0.901 [0.751, 1.081] | 490889 participants | Ungraded |
Osteoporosis MVMR MR-Egger The MVMR MR-Egger interval excluded the null. Source: Fig. 2, Osteoporosis, DMFS, MVMR MR-Egger · same question in other reviews | OR 1.343 [1.015, 1.778] | 483725 participants | Ungraded |
Femur fracture MVMR MR-Egger The MVMR MR-Egger interval included the null. Source: Fig. 4, Femur fracture, DMFS, MVMR MR-Egger · same question in other reviews | OR 0.820 [0.618, 1.087] | 489106 participants | Ungraded |
Lumbar spine and pelvis fracture MVMR MR-Egger The MVMR MR-Egger interval included the null. Source: Fig. 4, Lumbar spine and pelvis fracture, DMFS, MVMR MR-Egger · same question in other reviews | OR 1.034 [0.769, 1.390] | 490700 participants | Ungraded |
Lumbar spine bone mineral density MVMR IVW The MVMR IVW interval excluded zero. Source: Results, Causal effects of oral diseases on BMD · same question in other reviews | BETA 0.105 [0.011, 0.199] | 28498 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture MVMR MR-Egger The MVMR MR-Egger interval included the null. Source: Fig. 4, Postmenopausal osteoporosis with pathological fracture, DMFS, MVMR MR-Egger · same question in other reviews | OR 1.281 [0.640, 2.565] | 281786 participants | Ungraded |
Osteoporosis with pathological fracture MVMR MR-Egger The MVMR MR-Egger interval included the null. Source: Fig. 4, Osteoporosis with pathological fracture, DMFS, MVMR MR-Egger · same question in other reviews | OR 1.011 [0.876, 1.167] | 376746 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS
Population: European GWAS participants
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Femur fracture MVMR MR-Egger The MVMR MR-Egger interval included the null. Source: Fig. 4, Femur fracture, PD, MVMR MR-Egger · same question in other reviews | OR 1.024 [0.960, 1.093] | 489106 participants | Ungraded |
Postmenopausal osteoporosis with pathological fracture MVMR MR-Egger The MVMR MR-Egger interval included the null. Source: Fig. 4, Postmenopausal osteoporosis with pathological fracture, PD, MVMR MR-Egger · same question in other reviews | OR 1.012 [0.858, 1.193] | 281786 participants | Ungraded |
Lumbar spine and pelvis fracture MVMR MR-Egger The MVMR MR-Egger interval included the null. Source: Fig. 4, Lumbar spine and pelvis fracture, PD, MVMR MR-Egger · same question in other reviews | OR 1.062 [0.991, 1.137] | 490700 participants | Ungraded |
Osteoporosis with pathological fracture MVMR MR-Egger The MVMR MR-Egger interval included the null. Source: Fig. 4, Osteoporosis with pathological fracture, PD, MVMR MR-Egger · same question in other reviews | OR 1.002 [0.867, 1.158] | 376746 participants | Ungraded |
Forearm fracture MVMR MR-Egger The MVMR MR-Egger interval included the null. Source: Fig. 4, Forearm fracture, PD, MVMR MR-Egger · same question in other reviews | OR 0.992 [0.950, 1.036] | 490889 participants | Ungraded |
Lumbar spine bone mineral density MVMR IVW The MVMR IVW interval included zero. Source: Results, Causal effects of oral diseases on BMD · same question in other reviews | BETA 0.047 [-0.002, 0.096] | 28498 participants | Ungraded |
Osteoporosis MVMR MR-Egger The MVMR MR-Egger interval included the null. Source: Fig. 2, Osteoporosis, PD, MVMR MR-Egger · same question in other reviews | OR 1.005 [0.940, 1.074] | 483725 participants | Ungraded |
Comparison
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postmenopausal osteoporosis with pathological fracture DMFS, bias-corrected (MR-RAPS/Debiased IVW) | OR 1.401 [1.040, 1.887] | NR | Ungraded |
Osteoporosis DMFS, bias-corrected (MR-RAPS/Debiased IVW) | OR 1.171 [1.051, 1.304] | NR | Ungraded |
Included primary studies 3
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Shungin et al. 2019 Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data. PMID:31235808 | 1 other review | not stated | not extracted yet | not extracted yet |
| Kurki et al. 2023 FinnGen provides genetic insights from a well-phenotyped isolated population. PMID:36653562 | this review only | not stated | not extracted yet | not extracted yet |
| Morris et al. 2019 An atlas of genetic influences on osteoporosis in humans and mice. PMID:30598549 | this review only | not stated | not extracted yet | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match).
| Review | Shared studies | Jaccard |
|---|---|---|
| Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024) | 1 | 0.33 |