Non-Cochrane · aetiology · PM38881267

Caries status in 12-year-old children, geographical location and socioeconomic conditions across European countries: A systematic review and meta-analysis.

Vukovic Ana, Schmutz Kian Alessandro, Borg-Bartolo Roberta, et al. · International journal of paediatric dentistry · 2025 · PubMed · doi:10.1111/ipd.13224

Oral HealthDental cariesAMSTAR 2: not applicable
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
23
current version
GRADE rated
0
No studies
0
Included studies
53
linked below
No studies 0 · 0%Ungraded 23 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Review question

ElementPlanned (methods)Found (results)
Population12-year-old children in the European region (UN M49); observational epidemiological studies, cross-sectional surveys and public-health datasets/registers, 2011-2022, reporting caries as DMFT (or from which D3MFT could be calculated)493,360 twelve-year-old children from 36 European countries, drawn from 61 scientific and public-health reports (sample sizes 22 in Belgium to 89,442 in the United Kingdom); 34 countries contributed to the GNI/geographical meta-analysis and 32 to the expenditure analysis
InterventionMacro-level socioeconomic exposures: gross national income (GNI), UN M49 geographical categorization, unemployment rate, Human Development Index (HDI), and per-capita expenditure on dental health careGNI (modified 3-category); UN M49 region (East/South/North/West Europe); unemployment rate (low/medium/high); HDI (high/very high); per-capita dental expenditure ($0-50/$51-100/>$100)
ComparisonContrasts across socioeconomic/geographical categories (higher vs lower income; Western/Northern vs Eastern/Southern Europe; lower vs higher unemployment; very-high vs high HDI; higher vs lower dental expenditure)Higher vs lower income; West/North vs East/South Europe; lower vs higher unemployment; very-high vs high HDI; higher vs lower dental expenditure
OutcomesCaries experience (DMFT index, and decayed/missing/filled components) in 12-year-oldsOverall pooled mean DMFT 2.10 (95% CI 1.63-2.57), I2=100%. Strong negative income-caries gradient (GNI ordinal OR 0.10, 95% CI 0.03-0.37, p<.01). Mean DMFT by GNI: middle 3.30, high 2.38, very-high 0.90. By region: East 2.76, South 2.61, North 1.34, West 0.88. By expenditure: $0-50 3.06, $51-100 2.14, >$100 0.96
Study designsObservational epidemiological studies, cross-sectional surveys and national statistical oral-health registers; excluded special-care-needs samples, non-European regions, pre-2011 data, unfit age groups, and studies not reporting DMFT/D3MFT61 cross-sectional/observational reports across 36 countries; study quality (NHLBI tool) mostly fair (32 fair, 17 poor, 2 good)
TimingSurvey data from 2011 to 2022Cross-sectional (2011-2022); meta-regression on year of publication plus geographical location explained 32% of between-study heterogeneity

Search date: June 2023. Databases: PubMed; Scopus; Embase; Google Scholar (plus hand search and Malmo University CAPP database)

Questions and results

All European countries pooled (overall) vs None (overall pooled prevalence)

Population: 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)
1 question
OutcomeEffectEvidenceStatus / GRADE
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · Overall
Across European countries the overall pooled mean DMFT in 12-year-olds was 2.10 (95% CI 1.63 to 2.57), with very high between-country heterogeneity (I2=100%); not GRADE-rated.
Source: Figures 2-4 (forest plots, overall green diamond); Results paragraph (overall pooled mean DMFT = 2.10) · same question in other reviews
MEAN 2.10 [1.63, 2.57]34 studies · 493360 participantsUngraded

Higher national income (GNI per capita) vs Lower national income (GNI categories: middle <=$15,000 / high $15,001-25,000 / very high >$25,000)

Population: 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)
4 questions
OutcomeEffectEvidenceStatus / GRADE
Odds of higher caries (DMFT) category
Cross-sectional (survey data 2011-2022) · Higher vs lower income (ordinal logistic regression, adjusted)
Higher national income was strongly associated with lower odds of poor oral health (OR 0.10, 95% CI 0.03 to 0.37; about 90% lower odds); not GRADE-rated.
Source: Table 4 (ordinal logistic regression, GNI) · same question in other reviews
OR 0.10 [0.03, 0.37]NRUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · Very high income (GNI >$25,000)
Mean DMFT in 12-year-olds rises as national income falls: 0.90 (very high income), 2.38 (high income), 3.30 (middle income) (Figure 2); not GRADE-rated.
Source: Figure 2 (forest plot, pooled DMFT by GNI, GNI >$25000 subgroup diamond) · same question in other reviews
MEAN 0.90 [0.66, 1.15]14 studiesUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · High income (GNI $15,001-25,000)
Mean DMFT in 12-year-olds rises as national income falls: 0.90 (very high income), 2.38 (high income), 3.30 (middle income) (Figure 2); not GRADE-rated.
Source: Figure 2 (forest plot, pooled DMFT by GNI, GNI $15001-25000 subgroup diamond) · same question in other reviews
MEAN 2.38 [1.78, 2.97]8 studiesUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · Middle income (GNI <=$15,000)
Mean DMFT in 12-year-olds rises as national income falls: 0.90 (very high income), 2.38 (high income), 3.30 (middle income) (Figure 2); not GRADE-rated.
Source: Figure 2 (forest plot, pooled DMFT by GNI, GNI <=$15000 subgroup diamond) · same question in other reviews
MEAN 3.30 [2.57, 4.03]12 studiesUngraded

Western/Northern Europe (UN M49 region) vs Eastern/Southern Europe (UN M49 geographical categorization)

Population: 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)
5 questions
OutcomeEffectEvidenceStatus / GRADE
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · North Europe
Mean DMFT is lowest in West Europe (0.88) and North Europe (1.34) and highest in East Europe (2.76) and South Europe (2.61) (Figure 3); not GRADE-rated.
Source: Figure 3 (forest plot, pooled DMFT by geographical location, North Europe subgroup diamond) · same question in other reviews
MEAN 1.34 [0.62, 2.06]8 studiesUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · West Europe
Mean DMFT is lowest in West Europe (0.88) and North Europe (1.34) and highest in East Europe (2.76) and South Europe (2.61) (Figure 3); not GRADE-rated.
Source: Figure 3 (forest plot, pooled DMFT by geographical location, West Europe subgroup diamond) · same question in other reviews
MEAN 0.88 [0.54, 1.22]5 studiesUngraded
Odds of higher caries (DMFT) category
Cross-sectional (survey data 2011-2022) · Geographical location (ordinal logistic regression, adjusted)
In the adjusted ordinal model geographical location was not independently significant for DMFT category (OR 0.57, 95% CI 0.24 to 1.35); not GRADE-rated.
Source: Table 4 (ordinal logistic regression, geographical location) · same question in other reviews
OR 0.57 [0.24, 1.35]NRUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · South Europe
Mean DMFT is lowest in West Europe (0.88) and North Europe (1.34) and highest in East Europe (2.76) and South Europe (2.61) (Figure 3); not GRADE-rated.
Source: Figure 3 (forest plot, pooled DMFT by geographical location, South Europe subgroup diamond) · same question in other reviews
MEAN 2.61 [1.60, 3.62]12 studiesUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · East Europe
Mean DMFT is lowest in West Europe (0.88) and North Europe (1.34) and highest in East Europe (2.76) and South Europe (2.61) (Figure 3); not GRADE-rated.
Source: Figure 3 (forest plot, pooled DMFT by geographical location, East Europe subgroup diamond) · same question in other reviews
MEAN 2.76 [2.44, 3.08]9 studiesUngraded

All GNI strata vs No comparator (single-group pooled mean)

Population: 12-year-old children in European countries
4 questions
OutcomeEffectEvidenceStatus / GRADE
DMFT caries experience
2011-2022 · Overall
The overall pooled mean DMFT was 2.10 across all GNI strata.
Source: Figure 2 · same question in other reviews
Mean DMFT 2.10 [1.63, 2.57]34 studiesUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · $0-50 per capita
Population: 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)
Countries with higher per-capita dental expenditure had lower mean DMFT (>$100: 0.96; $51-100: 2.14; $0-50: 3.06) (Figure 4); not GRADE-rated.
Source: Figure 4 (forest plot, pooled DMFT by per-capita dental expenditure, $0-50 per capita subgroup diamond) · same question in other reviews
MEAN 3.06 [2.32, 3.79]14 studiesUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · >$100 per capita
Population: 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)
Countries with higher per-capita dental expenditure had lower mean DMFT (>$100: 0.96; $51-100: 2.14; $0-50: 3.06) (Figure 4); not GRADE-rated.
Source: Figure 4 (forest plot, pooled DMFT by per-capita dental expenditure, >$100 per capita subgroup diamond) · same question in other reviews
MEAN 0.96 [0.64, 1.28]12 studiesUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · $51-100 per capita
Population: 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)
Countries with higher per-capita dental expenditure had lower mean DMFT (>$100: 0.96; $51-100: 2.14; $0-50: 3.06) (Figure 4); not GRADE-rated.
Source: Figure 4 (forest plot, pooled DMFT by per-capita dental expenditure, $51-100 per capita subgroup diamond) · same question in other reviews
MEAN 2.14 [1.40, 2.89]6 studiesUngraded

Lower unemployment rate vs Higher unemployment rate (low <=5% / medium >5-10% / high >10%)

Population: 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)
4 questions
OutcomeEffectEvidenceStatus / GRADE
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · Medium unemployment (>5-10%)
Mean DMFT tended to increase with unemployment rate (low 1.23, medium 2.08, high 2.38; ANOVA p<.05); descriptive country-level means only, not meta-analyzed or GRADE-rated.
Source: Table 3B (DMFT by unemployment rate; one-way ANOVA) · same question in other reviews
MEAN 2.08NRUngraded
Odds of higher caries (DMFT) category
Cross-sectional (survey data 2011-2022) · Unemployment rate (ordinal logistic regression, adjusted)
Unemployment rate was not independently associated with DMFT category in the adjusted model (OR 0.99, 95% CI 0.44 to 2.23); not GRADE-rated.
Source: Table 4 (ordinal logistic regression, unemployment rate) · same question in other reviews
OR 0.99 [0.44, 2.23]NRUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · Low unemployment (<=5%)
Mean DMFT tended to increase with unemployment rate (low 1.23, medium 2.08, high 2.38; ANOVA p<.05); descriptive country-level means only, not meta-analyzed or GRADE-rated.
Source: Table 3B (DMFT by unemployment rate; one-way ANOVA) · same question in other reviews
MEAN 1.23NRUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · High unemployment (>10%)
Mean DMFT tended to increase with unemployment rate (low 1.23, medium 2.08, high 2.38; ANOVA p<.05); descriptive country-level means only, not meta-analyzed or GRADE-rated.
Source: Table 3B (DMFT by unemployment rate; one-way ANOVA) · same question in other reviews
MEAN 2.38NRUngraded

Very high Human Development Index (HDI >=0.800) vs High Human Development Index (HDI 0.700-0.799)

Population: 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)
3 questions
OutcomeEffectEvidenceStatus / GRADE
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · High HDI (0.700-0.799)
Mean DMFT was higher in high-HDI (3.41) than very-high-HDI (1.73) countries (ANOVA p<.01); descriptive country-level means only, not meta-analyzed or GRADE-rated.
Source: Table 3C (DMFT by Human Development Index; one-way ANOVA) · same question in other reviews
MEAN 3.41NRUngraded
Odds of higher caries (DMFT) category
Cross-sectional (survey data 2011-2022) · Human Development Index (ordinal logistic regression, adjusted)
HDI was not independently associated with DMFT category in the adjusted model (OR 1.82, 95% CI 0.32 to 10.47); not GRADE-rated.
Source: Table 4 (ordinal logistic regression, Human Development Index) · same question in other reviews
OR 1.82 [0.32, 10.47]NRUngraded
Caries experience (mean DMFT)
Cross-sectional (survey data 2011-2022) · Very high HDI (>=0.800)
Mean DMFT was higher in high-HDI (3.41) than very-high-HDI (1.73) countries (ANOVA p<.01); descriptive country-level means only, not meta-analyzed or GRADE-rated.
Source: Table 3C (DMFT by Human Development Index; one-way ANOVA) · same question in other reviews
MEAN 1.73NRUngraded

All M49 regions vs No comparator (single-group pooled mean)

Population: 12-year-old children in European countries
1 question
OutcomeEffectEvidenceStatus / GRADE
DMFT caries experience
2011-2022 · Overall
The overall pooled mean DMFT was 2.10 across all M49 regions.
Source: Figure 3 · same question in other reviews
Mean DMFT 2.10 [1.63, 2.57]34 studiesUngraded

All dental health care expenditure strata vs No comparator (single-group pooled mean)

Population: 12-year-old children in European countries
1 question
OutcomeEffectEvidenceStatus / GRADE
DMFT caries experience
2011-2022 · Overall
The overall pooled mean DMFT was 2.10 across all dental health care expenditure strata.
Source: Figure 4 · same question in other reviews
Mean DMFT 2.10 [1.61, 2.59]32 studiesUngraded

Included primary studies 53

Open as a trial list
StudyAlso included byOutcomes it informs hereTrial PICOResults
Almerich-Silla et al. 2014
Caries prevalence in children from Valencia (Spain) using ICDAS II criteria, 2010.
PMID:25350591
1 other reviewnot statednot extracted yetnot extracted yet
Campus et al. 2020
Caries severity and socioeconomic inequalities in a nationwide setting: data from the Italian National pathfinder in 12-years children.
PMID:32973175
1 other reviewnot statednot extracted yetnot extracted yet
Maldupa et al. 2021
Caries Prevalence and Severity for 12-Year-Old Children in Latvia.
PMID:34024331
1 other reviewnot statednot extracted yetnot extracted yet
Vernazza et al. 2016
Caries experience, the caries burden and associated factors in children in England, Wales and Northern Ireland 2013.
PMID:27659635
1 other reviewnot statednot extracted yetnot extracted yet
Wang et al. 2021
Dental caries thresholds among adolescents in England, Wales, and Northern Ireland, 2013 at 12, and 15 years: implications for…
PMID:33740952
1 other reviewnot statednot extracted yetnot extracted yet
Baker et al. 2018
Structural Determinants and Children's Oral Health: A Cross-National Study.
PMID:29608864
this review onlynot statednot extracted yetnot extracted yet
Bilder et al. 2018
The pathfinder study among schoolchildren in the Republic of Moldova: dental caries experience.
PMID:29696641
this review onlynot statednot extracted yetnot extracted yet
Bravo et al. 2020
matched by author and year (probable)
this review onlynot statednot extracted yetnot extracted yet
Calado et al. 2017
Caries prevalence and treatment needs in young people in Portugal: the third national study.
PMID:28573842
this review onlynot statednot extracted yetnot extracted yet
Davies et al. 2012
The caries experience of 11 to 12 year-old children in Scotland and Wales and 12 year-olds in England in 2008-2009: reports of…
PMID:22482242
this review onlynot statednot extracted yetnot extracted yet
Diamanti et al. 2021
Caries prevalence and caries experience (ICDAS II criteria) of 5-, 12- and 15-year-old Greek children in relation to socio-demographic…
PMID:33423209
this review onlynot statednot extracted yetnot extracted yet
Dianiskova et al. 2016
matched by author and year (probable)
this review onlynot statednot extracted yetnot extracted yet
Ekstrand & Abreu-Placeres 2020
The impact of a national caries strategy in Greenland 10 years after implementation. A failure or a success?
PMID:32799764
this review onlynot statednot extracted yetnot extracted yet
Ferizi et al. 2020
Oral Health Status Among 12-Year-Old Schoolchildren in Kosovo
DOI:10.1590/pboci.2020.082
this review onlynot statednot extracted yetnot extracted yet
Gaszynska et al. 2014
Thirty years of evolution of oral health behaviours and dental caries in urban and rural areas in Poland.
PMID:25292128
this review onlynot statednot extracted yetnot extracted yet
Gorbatova et al. 2012
Dental caries experience among 12-year-old children in Northwest Russia.
PMID:22482244
this review onlynot statednot extracted yetnot extracted yet
Gudkina et al. 2016
Factors influencing the caries experience of 6 and 12 year old children in Riga, Latvia.
PMID:27649612
this review onlynot statednot extracted yetnot extracted yet
Hysi et al. 2014
Caries experience and treatment needs among Albanian 12-year-olds.
PMID:25300147
this review onlynot statednot extracted yetnot extracted yet
Jipa & Amariei 2012
Oral health status of children aged 6-12 years from the Danube Delta Biosphere Reserve.
PMID:22488031
this review onlynot statednot extracted yetnot extracted yet
Jordan et al. 2014
The Fifth German Oral Health Study (Fünfte Deutsche Mundgesundheitsstudie, DMS V) - rationale, design, and methods.
PMID:25547464
this review onlynot statednot extracted yetnot extracted yet
Kramer et al. 2016
Demographic factors and dental health of Swedish children and adolescents.
PMID:26133545
this review onlynot statednot extracted yetnot extracted yet
Kuzmina et al. 2015
matched by author and year (probable)
this review onlynot statednot extracted yetnot extracted yet
Leous 2016
[The feasibility of descriptive epidemiology in assessments of dental caries disease in children in Russia and Belarus].
PMID:27636756
this review onlynot statednot extracted yetnot extracted yet
Leous et al. 2020
[Longitudinal study of the primary prevention effect on dental caries].
PMID:32441072
this review onlynot statednot extracted yetnot extracted yet
Lesic et al. 2019
Caries prevalence among schoolchildren in urban and rural Croatia.
PMID:31580564
this review onlynot statednot extracted yetnot extracted yet
Malmo University 2024
matched by author and year (probable)
this review onlynot statednot extracted yetnot extracted yet
Markovic & Arslanagic Muratbegovic 2014
matched by author and year (probable)
this review onlynot statednot extracted yetnot extracted yet
Markovic 2014
matched by author and year (probable)
this review onlynot statednot extracted yetnot extracted yet
Mensah et al. 2021
Swedish quality registry for caries and periodontal diseases (SKaPa): validation of data on dental caries in 6- and 12-year-old children.
PMID:34301237
this review onlynot statednot extracted yetnot extracted yet
Narbutaite et al. 2016
Variation in fluorosis and caries experience among Lithuanian 12 year olds exposed to more than 1 ppm F in tap water.
PMID:25448884
this review onlynot statednot extracted yetnot extracted yet
Nonkulovski et al. 2022
Dental caries experience of 12 year old children from Resen municipality
DOI:10.17352/2394-8418.000108
this review onlynot statednot extracted yetnot extracted yet
Obregon-Rodriguez et al. 2019
Prevalence and caries-related risk factors in schoolchildren of 12- and 15-year-old: a cross-sectional study.
PMID:31215489
this review onlynot statednot extracted yetnot extracted yet
Olczak-Kowalczyk et al. 2016
Dental Caries Level and Sugar Consumption in 12-Year-Old Children from Poland.
PMID:27629744
this review onlynot statednot extracted yetnot extracted yet
Ondine Lucaciu et al. 2020
A WHO Pathfinder Survey of Dental Caries in 6 and 12-Year Old Transylvanian Children and the Possible Correlation with Their Family…
PMID:32545394
this review onlynot statednot extracted yetnot extracted yet
Onov & Beltcheva 2020
Caries Prevalence in 12-year-old Children from Plovdiv - a Multifactorial Regression Analysis.
PMID:32337903
this review onlynot statednot extracted yetnot extracted yet
Oulis et al. 2012
Caries prevalence of 5, 12 and 15-year-old Greek children: a national pathfinder survey.
PMID:22482246
this review onlynot statednot extracted yetnot extracted yet
Panagidis & Schulte 2012
Caries prevalence in 12-year-old Cypriot children.
PMID:23488213
this review onlynot statednot extracted yetnot extracted yet
Peric et al. 2022
Oral Health in 12- and 15-Year-Old Children in Serbia: A National Pathfinder Study.
PMID:36231568
this review onlynot statednot extracted yetnot extracted yet
Pieper et al. 2013
Caries prevalence in 12-year-old children from Germany: results of the 2009 national survey.
PMID:24151786
this review onlynot statednot extracted yetnot extracted yet
Pilat et al. 2020
Oral health status of 6- and 12-year-old children of Roma origin from Eastern Slovakia: a pilot study.
PMID:33338365
this review onlynot statednot extracted yetnot extracted yet
Rodakowska et al. 2013
Epidemiological analysis of dental caries in 12-year-old children residing in urban and rural settings in the Podlaskie region of…
PMID:23772585
this review onlynot statednot extracted yetnot extracted yet
Sarakinova et al. 2013
National strategy for prevention of oral diseases in children from 0 to 14 years old age in the Republic of Macedonia for the period…
PMID:24280788
this review onlynot statednot extracted yetnot extracted yet
Sava-Rosianu et al. 2021
Caries Prevalence Associated with Oral Health-Related Behaviors among Romanian Schoolchildren.
PMID:34204253
this review onlynot statednot extracted yetnot extracted yet
Sgan-Cohen et al. 2014
Dental caries among children in Georgia by age, gender, residence location and ethnic group.
PMID:25300151
this review onlynot statednot extracted yetnot extracted yet
Smolyar & Chuhray 2015
[The study of caries incidence in children according to WHO Significant Index of Caries].
PMID:27002702
this review onlynot statednot extracted yetnot extracted yet
Splieth et al. 2019
40-Year Longitudinal Caries Development in German Adolescents in the Light of New Caries Measures.
PMID:31352461
this review onlynot statednot extracted yetnot extracted yet
Statistics Norway 2024
matched by author and year (probable)
this review onlynot statednot extracted yetnot extracted yet
Steiner et al. 2011
Changes in dental caries in Zurich school-children over a period of 45 years.
PMID:21243546
this review onlynot statednot extracted yetnot extracted yet
Sulo et al. 2022
Regional variations in caries experience, predictors, and follow-up among children and adolescents in Western Norway.
PMID:34818125
this review onlynot statednot extracted yetnot extracted yet
Szoke & Petersen 2020
Changing Levels of Dental Caries over 30 Years among Children in a Country of Central and Eastern Europe - The Case of Hungary.
PMID:32238990
this review onlynot statednot extracted yetnot extracted yet
Trufanova et al. 2018
Characteristics of epidemiology of dental caries in children from regions with high and optimum fluorine content in drinking water.
PMID:29786582
this review onlynot statednot extracted yetnot extracted yet
Vrbic et al. 2020
Epidemiology of Dental Caries and Disease Prevention Among 12-Year-Olds in Slovenia Over Thirty Years (1987-2017).
PMID:32238991
this review onlynot statednot extracted yetnot extracted yet
Waltimo et al. 2015
Caries experience in 7-, 12-, and 15-year-old schoolchildren in the canton of Basel-Landschaft, Switzerland, from 1992 to 2011.
PMID:26709202
this review onlynot statednot extracted yetnot extracted yet

Overlap with other reviews

Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match).