Non-Cochrane · aetiology · PM36815304
Associations of the activity and concentration of carbonic anhydrase VI with susceptibility to dental caries: A systematic review and meta-analysis.
Al-Mahdi Rania, Al-Sharani Hesham, Al-Haroni Mohammed, et al. · Clinical and experimental dental research · 2023 · PubMed · doi:10.1002/cre2.723
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
4
current version
GRADE rated
0
No studies
0
Included studies
10
linked below
No studies 0 · 0%Ungraded 4 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Individuals with dental caries and caries-free controls (any age), with quantitative salivary/plaque CA VI mean and SD | 477 participants across 9 studies (234 caries-active, 243 caries-free); mainly children aged 2-9 years, plus one study of adults aged 18-24 years (n=209) |
| Intervention | Dental caries (cases; dmft/DMFT > 0) | Dental caries (n=234) |
| Comparison | Caries-free controls (dmft/DMFT = 0) | Caries-free (n=243) |
| Outcomes | Salivary or plaque CA VI activity and/or concentration (reported as mean and SD) | CA VI activity (8 studies assessed, 7 pooled; 411 participants) and CA VI concentration (2 studies pooled; 141 participants) |
| Study designs | Cross-sectional and observational studies with a control group and quantitative CA VI data (case series, case reports, in vitro studies, and reviews excluded) | 9 cross-sectional/observational studies (7 low risk of bias, 2 moderate risk of bias by Newcastle-Ottawa Scale) |
| Timing | Not specified | Cross-sectional |
Search date: Inception to August 2022. Databases: PubMed, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), Cochrane Library
Questions and results
Dental caries (caries-active; dmft/DMFT > 0) vs Caries-free individuals (dmft/DMFT = 0)
Population: Children (age about 2-9 years) across the 7 meta-analyzed activity samples; excludes Kivela 1999 adults (18-24 years), qualitative only and not in the meta-analysis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Salivary/biofilm CA VI (carbonic anhydrase VI) activity Cross-sectional (single time point) Salivary/biofilm CA VI activity is significantly higher in individuals with dental caries than in caries-free individuals (SMD 0.894, 95% CI 0.386 to 1.392; not GRADE-rated). Source: Figure 2 (forest plot); Results - Meta-analysis results; Abstract; Table 2 · same question in other reviews | SMD 0.894 [0.386, 1.392] | 7 studies · 411 participants | Ungraded |
CA VI activity Population: Participants with dental caries and caries-free participants CA VI activity was higher in participants with caries (SMD 0.87, 95% CI 0.39 to 1.36; 7 studies, 411 participants); GRADE was not reported. Source: Figure 2; Results: Meta-analysis results · same question in other reviews | SMD 0.87 [0.39, 1.36] | 7 studies · 411 participants | Ungraded |
Salivary/biofilm CA VI (carbonic anhydrase VI) concentration Cross-sectional (single time point) Population: Individuals assessed for dental caries (mainly children aged 2-9 years; one study in adults aged 18-24 years) Salivary CA VI concentration is significantly lower in individuals with dental caries than in caries-free individuals (SMD -0.672, 95% CI -1.011 to -0.332; not GRADE-rated). Source: Figure 3 (forest plot); Results - Meta-analysis results; Abstract; Table 2 · same question in other reviews | SMD -0.672 [-1.011, -0.332] | 2 studies · 141 participants | Ungraded |
CA VI concentration Population: Participants with dental caries and caries-free participants CA VI concentration was lower in participants with caries (SMD -0.66, 95% CI -1.00 to -0.32; 2 studies, 141 participants); GRADE was not reported. Source: Figure 3; Results: Meta-analysis results · same question in other reviews | SMD -0.66 [-1.00, -0.32] | 2 studies · 141 participants | Ungraded |
Included primary studies 10
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Borghi et al., 2017 Relationship among α amylase and carbonic anhydrase VI in saliva, visible biofilm, and early childhood caries: a longitudinal study. PMID:27430359 | this review only | not stated | not extracted yet | not extracted yet |
| Cardoso et al., 2017 Influence of salivary parameters in the caries development in orthodontic patients-an observational clinical study. PMID:28247450 | this review only | not stated | not extracted yet | not extracted yet |
| de Sousa et al., 2021a Carbonic anhydrase VI activity in saliva and biofilm can predict early childhood caries: A preliminary study. PMID:32815217 | this review only | not stated | not extracted yet | not extracted yet |
| de Sousa et al., 2021b Combined effect of starch and sucrose on carbonic anhydrase VI activity in saliva and biofilm of children with early childhood caries.… PMID:32918121 | this review only | not stated | not extracted yet | not extracted yet |
| Frasseto et al., 2012 Relationship among salivary carbonic anhydrase VI activity and flow rate, biofilm pH and caries in primary dentition. PMID:22508543 | this review only | not stated | not extracted yet | not extracted yet |
| Kivelä et al., 1999 A low concentration of carbonic anhydrase isoenzyme VI in whole saliva is associated with caries prevalence. PMID:10207192 | this review only | not stated | not extracted yet | not extracted yet |
| Kormi et al. 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Kormi et al., 2020 (unpublished data) matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Picco et al., 2017 Children with a Higher Activity of Carbonic Anhydrase VI in Saliva Are More Likely to Develop Dental Caries. PMID:28633135 | this review only | not stated | not extracted yet | not extracted yet |
| Picco et al., 2019 Activity of Carbonic Anhydrase VI is Higher in Dental Biofilm of Children with Caries. PMID:31151296 | this review only | not stated | not extracted yet | not extracted yet |