Search review questions

Restoration failure rate · People with permanent or adult posterior teeth requiring restoration (parallel-group trials involved children aged 6… · Follow-up: 5 to 7 years

Quality of life · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Dentine-caries (D3) prevalence low <15% (non-CBCT)

Optical/esthetic improvement (visual-tactile assessment) · Patients with post-orthodontic white spot lesions (WSL) · 4 weeks to 6 months

Probing depth (PD) · Adults (general and hospital populations assessed in case-control studies) · Hospital/clinic-based case-control studies from Asia, America and Europe, Other/non-Asia (Da Silva 2019, Iordache 2019, Isola 2017, Pischon 2016)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces · in vivo

Diagnostic accuracy for proximal caries detection (dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Dentin detection level

Dental erosion prevalence · Preschool children (5-year-olds) in the United Arab Emirates (Sharjah) · Sharjah, UAE; kindergarten

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro

Dental caries prevalence · General population (children and adults) in East Africa · Community- and school-based populations, East Africa

Care index · Preschool children attending Al Ain pediatric dentistry department · Overall

Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring… · 6 months

Dental caries · Children · Community/population-based (multiple countries), Sample size: over 3,000

Harms (discomfort, pain intensity, analgesia use) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth · first week

Survival rate of restorations (6 months) · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction) · 6 months, Non-carious cervical lesions (composite restoration)

Sensitivity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or… · Up to 3 months between index test and reference standard (in vivo studies)

Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible;… · 1 year

Samples with fluoride concentration below the acceptable range · Brazilian cities in the Southeast region with artificially fluoridated public water supplies · 1995-2013, Brazilian Southeast, Southeast region

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report, Crude

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro) · In vitro (laboratory; extracted teeth); permanent posterior teeth, proximal surfaces, Caries detection level

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · In vivo (clinical); permanent posterior teeth, proximal surfaces, Dentin detection level

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies · Community-based and clinical cohorts worldwide (all continents); events ascertained from medical records, death certificates/registers, or self-report

Signs and symptoms of respiratory issues · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or…

Incidence of new white spot lesions by visual-tactile assessment · Patients receiving comprehensive fixed orthodontic treatment · 1 to 24 months, Fixed orthodontic treatment, Overall

Diagnostic accuracy for proximal caries detection (caries detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo) · In vivo (clinical); permanent posterior teeth, proximal surfaces, Caries detection level

Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation · Short term (0 to 24 hours)

Success rate at 1 year (root as unit, per-protocol analysis) · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible;… · 1 year, Root as unit of analysis (radiological), per-protocol (PP)

Dental caries prevalence · General Pakistani population (all ages and both sexes; predominantly children and adolescents) · Pakistan (school-, community-, and hospital/clinic-based cross-sectional surveys), Dentition: permanent

Effect of severity of PDC displacement towards the midline on the proportion of successful eruptions · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC) · 12 to 48 months, By baseline sector (severity of displacement)

Crossbite correction · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… · Children (7 to 11 years)

Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up, Caries risk: low

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies), Analogue

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · 18-24 months, Cavitated lesions, primary dentition

Dental caries susceptibility (risk of dental caries) · Children and adults (no age limit) assessed for dental caries susceptibility · Case-control studies of children and adults (China, India, Czech Republic, Turkey), Dentition: Permanent tooth caries

Crossbite correction · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… · Children

Water samples with fluoride concentration below the acceptable range · Artificially fluoridated public water supply in Brazilian cities (water samples under external control) · Public water supply / water treatment stations in Brazilian cities (external control of artificial fluoridation), Region: Northeast Brazil

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or… · 7 months after start of treatment

Dental caries prevalence · Ethiopia

Reported improvement in the position of the ectopic canine measured from radiographs · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

Quality of life · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or…

Amount of crowding (change in mandibular incisor crowding) at 6 months · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth · 6 months

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces · in vitro

Specificity for detection of enamel caries · Asymptomatic children or adults presenting for clinical examination (in vivo studies), or extracted teeth of children… · Up to 3 months between index test and reference standard (in vivo studies), Histology reference standard

Dental caries prevalence · School children aged 15-17 years in Dubai schools · Overall

Sensitivity · Adults (aged 16 years or over) presenting to primary or secondary care with clinically evident suspicious or innocuous…

Lactobacilli presence (CFU > 10^5) · Adults undergoing orthodontic treatment · 3 months, Adults

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious… · 12-18 months, Deep lesions, permanent dentition

Survival rate of restorations (18 months) · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction) · 18 months, Non-carious cervical lesions (composite restoration)

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted… · Up to 3 months between index test and reference standard (in vivo studies)