Cochrane · intervention · CD009434
Laser therapy for dentinal hypersensitivity
Mahdian, M, Behboodi, S, Ogata, Y, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Full textEvery question was extracted from the full review (methods and results), not only its Summary of Findings table.
Questions
35
current version
GRADE rated
8
No studies
3
Included studies
23
as reported
No studies 3 · 8.6%Ungraded 24 · 68.6%Very low 4 · 11.4%Low 4 · 11.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Patients aged above 12 years presenting with self-reported tooth hypersensitivity confirmed in clinical evaluation | 936 participants (2296 teeth) with dentinal hypersensitivity across 23 RCTs; age range 12 to 69 years; most studies showed higher female preponderance |
| Intervention | Any type of in-office laser with different radiation parameters: Nd:YAG; Er:YAG; diode of different wavelengths (visible red 630-700 nm, near infrared 700-850 nm, near infrared 2 850-980 nm); Er,Cr:YSGG; CO2 laser | Diode laser at varying wavelengths 655-980 nm (n=20); Er,Cr:YSGG laser (n=4); Nd:YAG laser (n=2) |
| Comparison | Placebo lasers; Placebo agents; No treatment | Placebo laser (n=18); Placebo agents e.g. toothpaste/distilled water/saline (n=5); No treatment (n=2) |
| Outcomes | Changes in intensity of pain (VAS) tested through air blast stimulus at short (0 to 24 hours), medium (24 hours to 2 months) and long term (more than 2 months); changes in intensity of pain (VAS) tested through tactile stimulus at short, medium and long term; adverse outcomes; patient-reported quality of life | Changes in intensity of pain via air blast stimuli (n=22); changes in intensity of pain via tactile stimuli (n=12); adverse events (n=15); patient-reported quality of life (n=0) |
| Study designs | Randomised controlled trials (RCTs), including split-mouth design | RCT (n=23; 13 split-mouth, 10 parallel-group) |
| Timing | Short term (0 to 24 hours); medium term (24 hours to 2 months); long term (more than 2 months) | Short term (0 to 24 hours); medium term (24 hours to 2 months); long term (more than 2 months); follow-up up to 6 months |
Search date: 2020-10. Databases: Cochrane Oral Health's Trials Register; Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE Ovid; Embase Ovid; CINAHL EBSCO; LILACS BIREME Virtual Health Library; ISI Web of Science; ZETOC; OpenGrey; ClinicalTrials.gov; WHO International Clinical Trials Registry Platform
Questions and results
Show all 2 versionsIn-office laser therapy (all types combined) vs Placebo (placebo laser or placebo agent) or no treatment
Population: Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Short term (0 to 24 hours) | MD -2.24 [-3.55, -0.93] -2.24 [-3.55, -0.93] VAS points (0 to 10) | 13 studies · 978 participants | Low Downgraded: inconsistency |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Medium term (24 hours to 2 months) | MD -1.73 [-3.17, -0.30] -1.73 [-3.17, -0.30] VAS points (0 to 10) | 9 studies · 591 participants | Very low Downgraded: risk of bias, inconsistency |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Long term (more than 2 months) | MD -2.60 [-4.47, -0.73] -2.60 [-4.47, -0.73] VAS points (0 to 10) | 5 studies · 564 participants | Very low Downgraded: imprecision, inconsistency |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Long term (more than 2 months) | MD -3.52 [-10.37, 3.33] -3.52 [-10.37, 3.33] VAS points (0 to 10) | 2 studies · 184 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Medium term (24 hours to 2 months) | MD -2.46 [-3.57, -1.35] -2.46 [-3.57, -1.35] VAS points (0 to 10) | 11 studies · 1007 participants | Very low Downgraded: risk of bias, inconsistency |
Adverse events Air blast stimuli studies (SoF 1) | No adverse event was noted in the experimental and control groups | 11 studies · 954 participants | Low Downgraded: risk of bias, imprecision |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Short term (0 to 24 hours) | MD -0.67 [-1.31, -0.03] -0.67 [-1.31, -0.03] VAS points (0 to 10) | 8 studies · 506 participants | Low Downgraded: risk of bias, inconsistency |
Patient-reported quality of life | Outcome not measured in any of the included studies | 0 studies | No studies |
Adverse events Tactile stimuli studies (SoF 2) | No adverse event was noted in the experimental and control groups | 5 studies · 386 participants | Low Downgraded: risk of bias, imprecision |
Er,Cr:YSGG laser (erbium,chromium:yttrium-scandium-gallium-garnet) vs Placebo (placebo laser or placebo agent) or no treatment
Population: Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Long term (more than 2 months) | MD -5.19 [-5.50, -4.89] | 2 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Short term (0 to 24 hours) | MD -4.61 [-4.83, -4.39] | 3 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Medium term (24 hours to 2 months) | MD 0.38 [-0.13, 0.89] | 1 study | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Medium term (24 hours to 2 months) | MD -4.90 [-5.21, -4.59] | 2 studies | Ungraded |
Nd:YAG laser (neodymium-doped:yttrium-aluminum-garnet) vs Placebo (placebo laser or placebo agent) or no treatment
Population: Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Short term (0 to 24 hours) | MD -0.25 [-0.91, 0.41] | 1 study | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Long term (more than 2 months) | MD 0.18 [-0.84, 1.20] | 1 study | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Short term (0 to 24 hours) | MD 0.22 [-0.55, 0.99] | 2 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Medium term (24 hours to 2 months) | MD -1.06 [-2.15, 0.03] | 2 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Medium term (24 hours to 2 months) | MD 0.42 [-0.97, 1.82] | 2 studies | Ungraded |
Diode laser, visible red (630 nm to 700 nm) vs Placebo (placebo laser or placebo agent) or no treatment
Population: Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Short term (0 to 24 hours) | MD -1.95 [-3.14, -0.76] | 4 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Long term (more than 2 months) | MD 0.81 [-0.78, 2.40] | 1 study | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Medium term (24 hours to 2 months) | MD -2.95 [-5.14, -0.75] | 4 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Long term (more than 2 months) | MD -4.67 [-5.38, -3.96] | 2 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Short term (0 to 24 hours) | MD -0.81 [-1.16, -0.45] | 4 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Medium term (24 hours to 2 months) | MD -1.45 [-4.35, 1.44] | 4 studies | Ungraded |
Diode laser, near infrared (700 nm to 850 nm) vs Placebo (placebo laser or placebo agent) or no treatment
Population: Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Medium term (24 hours to 2 months) | MD -3.22 [-4.88, -1.56] | 4 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Short term (0 to 24 hours) | MD -2.62 [-5.61, 0.38] | 4 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Medium term (24 hours to 2 months) | MD -0.68 [-3.57, 2.21] | 2 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Short term (0 to 24 hours) | MD 0.27 [-0.60, 1.14] | 2 studies | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Long term (more than 2 months) | MD -3.83 [-6.90, -0.77] | 2 studies | Ungraded |
Diode laser, near infrared (850 nm to 980 nm) vs Placebo (placebo laser or placebo agent) or no treatment
Population: Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Short term (0 to 24 hours) | MD -1.90 [-2.49, -1.31] | 1 study | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Medium term (24 hours to 2 months) | MD -1.83 [-2.36, -1.30] | 1 study | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through air blast stimuli Medium term (24 hours to 2 months) | MD -2.30 [-2.86, -1.74] | 1 study | Ungraded |
Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli Short term (0 to 24 hours) | MD -2.17 [-2.80, -1.54] | 1 study | Ungraded |
Er:YAG laser (erbium-doped:yttrium-aluminum-garnet) vs Placebo (placebo laser or placebo agent) or no treatment
Population: Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcome NR | We did not find any eligible study to evaluate erbium:yttrium-aluminum-garnet (Er:YAG) or carbon dioxide (CO2) laser compared with placebo/no treatment. | 0 studies | No studies |
CO2 laser (carbon dioxide) vs Placebo (placebo laser or placebo agent) or no treatment
Population: Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcome NR | We did not find any eligible study to evaluate erbium:yttrium-aluminum-garnet (Er:YAG) or carbon dioxide (CO2) laser compared with placebo/no treatment. | 0 studies | No studies |