Non-Cochrane · aetiology · PM33971854
Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies.
Zhang Suhan, Zhu Junfei, Zhu Yanshan, et al. · BMC oral health · 2021 · PubMed · doi:10.1186/s12903-021-01603-2
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
13
current version
GRADE rated
0
No studies
0
Included studies
12
linked below
No studies 0 · 0%Ungraded 13 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Any population (PECO framework: any population) | 11 case-control studies; adults with SSc vs SSc-free controls; studies from Asia (n=4), America (n=4), Europe (n=3) |
| Intervention | Exposure to systemic sclerosis (SSc) | Systemic sclerosis (SSc) |
| Comparison | Not exposed to SSc (SSc-free individuals) | SSc-free controls |
| Outcomes | Oral manifestations: probing depth, attachment loss, bleeding on probing, sites with PD >= 4 mm, prevalence of periodontitis, number of teeth, decayed teeth, missing teeth, filled teeth, DMFT index, interincisal distance | 11 pooled outcomes: interincisor distance (4 studies), periodontitis prevalence (3), PD (7), AL (4), sites PD>=4mm (3), BOP (5), decayed teeth (3), number of teeth (3), missing teeth (4), filled teeth (2), DMFT (3) |
| Study designs | Case-control studies | 11 case-control studies (NOS 4-8; 8 high quality, 3 moderate) |
| Timing | Not specified | Not specified (cross-sectional case-control) |
Search date: 2020-07. Databases: PubMed; Embase; Web of Science; Scopus
Questions and results
Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)
Population: Adults (general and hospital populations assessed in case-control studies)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Sites with probing depth >= 4 mm Sites with probing depth >= 4 mm are significantly more frequent in SSc patients (SMD 2.07); certainty ungraded. Source: Fig. 5b (forest plot); Results (Oral manifestations); Abstract · same question in other reviews | SMD 2.071 [0.267, 3.875] | 3 studies | Ungraded |
Probing depth (PD) Other/non-Asia (Da Silva 2019, Iordache 2019, Isola 2017, Pischon 2016) In the non-Asia subgroup, probing depth is significantly increased in SSc patients (SMD 4.86) with very high heterogeneity; certainty ungraded. Source: Fig. 4b (subgroup forest plot) · same question in other reviews | SMD 4.86 [1.61, 8.10] | 4 studies | Ungraded |
Probing depth (PD) Probing depth is significantly increased in systemic sclerosis patients (SMD 3.10) with very high heterogeneity; certainty ungraded. Source: Fig. 4a (forest plot); Results (Oral manifestations); Abstract · same question in other reviews | SMD 3.101 [1.374, 4.829] | 7 studies | Ungraded |
Probing depth (PD) Asia (Elimelech 2015, Leung 2011, Mayer 2013) In the Asia subgroup, probing depth is significantly increased in SSc patients (SMD 1.11) with no heterogeneity; certainty ungraded. Source: Fig. 4b (subgroup forest plot); Results (Oral manifestations) · same question in other reviews | SMD 1.113 [0.751, 1.476] | 3 studies | Ungraded |
Prevalence of periodontitis Periodontitis prevalence is significantly higher in systemic sclerosis patients than controls (OR 7.01); certainty ungraded. Source: Fig. 3 (forest plot); Results (Oral manifestations); Abstract · same question in other reviews | OR 7.007 [3.529, 13.915] | 3 studies | Ungraded |
Number of decayed teeth Systemic sclerosis patients have a significantly higher number of decayed teeth than controls (SMD 0.19); certainty ungraded. Source: Fig. 6a (forest plot); Results (Oral manifestations); Abstract · same question in other reviews | SMD 0.186 [0.007, 0.365] | 3 studies | Ungraded |
DMFT index No statistically significant difference in DMFT index between SSc patients and controls (SMD -0.03, CI includes 0); certainty ungraded. Source: Fig. 6e (forest plot); Results (Oral manifestations) · same question in other reviews | SMD -0.025 [-0.296, 0.247] | 3 studies | Ungraded |
Maximum interincisor distance (mouth opening) Systemic sclerosis patients have significantly reduced mouth opening compared with controls (SMD -1.06); certainty ungraded. Source: Fig. 2 (forest plot); Results (Oral manifestations); Abstract · same question in other reviews | SMD -1.061 [-1.546, -0.576] | 4 studies | Ungraded |
Number of teeth No statistically significant difference in number of teeth between SSc patients and controls (SMD -0.95, CI includes 0); certainty ungraded. Source: Fig. 6b (forest plot); Results (Oral manifestations) · same question in other reviews | SMD -0.947 [-2.131, 0.237] | 3 studies | Ungraded |
Number of missing teeth No statistically significant difference in number of missing teeth between SSc patients and controls (SMD 0.55, CI includes 0); certainty ungraded. Source: Fig. 6c (forest plot); Results (Oral manifestations) · same question in other reviews | SMD 0.546 [-0.148, 1.241] | 4 studies | Ungraded |
Bleeding on probing (BOP) No statistically significant difference in bleeding on probing between SSc patients and controls (SMD 1.05, CI includes 0); certainty ungraded. Source: Fig. 5c (forest plot); Results (Oral manifestations) · same question in other reviews | SMD 1.054 [-0.973, 3.081] | 5 studies | Ungraded |
Attachment loss (AL) Attachment loss is significantly increased in systemic sclerosis patients (SMD 2.58) with very high heterogeneity; certainty ungraded. Source: Fig. 5a (forest plot); Results (Oral manifestations); Abstract · same question in other reviews | SMD 2.584 [0.321, 4.846] | 4 studies | Ungraded |
Number of filled teeth No statistically significant difference in number of filled teeth between SSc patients and controls (SMD -0.12, CI includes 0); certainty ungraded. Source: Fig. 6d (forest plot); Results (Oral manifestations) · same question in other reviews | SMD -0.119 [-0.302, 0.063] | 2 studies | Ungraded |
Included primary studies 12
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Baron 2014 The Canadian systemic sclerosis oral health study: orofacial manifestations and oral health-related quality of life in systemic sclerosis… PMID:24464709 | this review only | not stated | not extracted yet | not extracted yet |
| Chu 2011 Oral health of Chinese people with systemic sclerosis. PMID:20938795 | this review only | not stated | not extracted yet | not extracted yet |
| da Silva 2019 Oral features of systemic sclerosis: A case–control study DOI:10.1111/odi.13174 | this review only | not stated | not extracted yet | not extracted yet |
| Elimelech 2015 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Iordache 2019 Sensorineural hearing loss and the Marinesco-Sjögren syndrome. PMID:2019810 | this review only | not stated | not extracted yet | not extracted yet |
| Iordache, 2019 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Isola 2017 Risk association between scleroderma disease characteristics, periodontitis, and tooth loss DOI:10.1007/s10067-017-3861-9 | this review only | not stated | not extracted yet | not extracted yet |
| Leung 2011 Periodontal Status of Adults With Systemic Sclerosis: Case‐Control Study DOI:10.1902/jop.2010.100593 | this review only | not stated | not extracted yet | not extracted yet |
| Marcucci 2009 Clinical and radiographic study of orofacial alterations in patients with systemic sclerosis DOI:10.1590/s1806-83242009000100014 | this review only | not stated | not extracted yet | not extracted yet |
| Mayer 2013 Periodontal Condition of Patients With Autoimmune Diseases and the Effect of Anti‐Tumor Necrosis Factor‐α Therapy DOI:10.1902/jop.2012.120009 | this review only | not stated | not extracted yet | not extracted yet |
| Pischon 2016 Increased Periodontal Attachment Loss in Patients With Systemic Sclerosis DOI:10.1902/jop.2016.150475 | this review only | not stated | not extracted yet | not extracted yet |
| Wood 1988 Analysis of the oral manifestations of systemic sclerosis (scleroderma) DOI:10.1016/0030-4220(88)90161-2 | this review only | not stated | not extracted yet | not extracted yet |