Non-Cochrane · aetiology · PM33960841
Association Between the TaqI (rs731236 T>C) Gene Polymorphism and Dental Caries Risk: A Meta-analysis.
Lei Wei, Tian Haonan, Xia Yinlan · Genetic testing and molecular biomarkers · 2021 · PubMed · doi:10.1089/gtmb.2020.0263
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
30
current version
GRADE rated
0
No studies
0
Included studies
11
linked below
No studies 0 · 0%Ungraded 30 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Children and adults (no population/age limit); susceptibility to dental caries | 7 case-control studies; 1424 cases and 1046 controls; children and adults from China, India, Czech Republic and Turkey (n=7) |
| Intervention | TaqI (rs731236 T>C) polymorphism in the VDR gene | TaqI (rs731236 T>C) VDR polymorphism, genotyped by PCR-RFLP or TaqMan assays |
| Comparison | Genotype/allele contrasts across five genetic models: allele contrast (C vs T); dominant (CT/CC vs TT); recessive (CC vs TT/CT); homozygous (CC vs TT); heterozygous (CT vs TT) | All five genetic models analyzed (allele contrast, dominant, recessive, homozygous, heterozygous) |
| Outcomes | Susceptibility to dental caries (association quantified by odds ratio) | Dental caries susceptibility; significant overall association in the allele contrast (C vs T: OR 1.24, 95% CI 1.07 to 1.44) and recessive (CC vs TT/CT: OR 1.38, 95% CI 1.03 to 1.84) models; no significant overall association in the dominant, homozygous or heterozygous models |
| Study designs | Case-control studies with data available to calculate ORs, 95% CIs and p-values; case reports, editorials, reviews, non-case-control and duplicate studies excluded | 7 case-control studies; Newcastle-Ottawa Scale scores 5 to 8 (all >=5, rated high quality) |
| Timing | Not specified | Not specified |
Search date: Updated 31 August 2020. Databases: PubMed; Web of Science; Embase; SinoMed (Chinese biomedical literature service system); Wiley Online Library
Questions and results
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs C allele vs T allele (allele contrast model)
Population: Children and adults (no age limit) assessed for dental caries susceptibility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries susceptibility (risk of dental caries) Overall The TaqI (rs731236 T>C) C allele/variant genotype was associated with increased dental caries risk overall under the allele contrast (C vs T) model (OR 1.24, 95% CI 1.07 to 1.44); ungraded. Source: Table 4 (Total); Results (Quantitative data synthesis); Abstract · same question in other reviews | OR 1.24 [1.07, 1.44] | 7 studies · 2470 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Ethnicity: Caucasian No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Caucasians under the allele contrast (C vs T) model (OR 1.16, 95% CI 0.90 to 1.50); ungraded. Source: Table 4 (Ethnicity: Caucasian); Results (Quantitative data synthesis); Fig. 2 · same question in other reviews | OR 1.16 [0.90, 1.50] | 2 studies · 538 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Permanent tooth caries The TaqI (rs731236 T>C) C allele/variant genotype was associated with increased dental caries risk for permanent tooth caries under the allele contrast (C vs T) model (OR 1.40, 95% CI 1.11 to 1.77); ungraded. Source: Table 4 (Permanent tooth caries); Results (Quantitative data synthesis); Fig. 3; Abstract · same question in other reviews | OR 1.40 [1.11, 1.77] | 3 studies · 1271 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Deciduous tooth decay No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for deciduous tooth decay under the allele contrast (C vs T) model (OR 1.10, 95% CI 0.87 to 1.38); ungraded. Source: Table 4 (Deciduous decay); Results (Quantitative data synthesis); Fig. 3 · same question in other reviews | OR 1.10 [0.87, 1.38] | 2 studies · 929 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Mixed dentition caries No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for mixed dentition caries under the allele contrast (C vs T) model (OR 1.26, 95% CI 0.87 to 1.82); ungraded. Source: Table 4 (Mixed caries); Results (Quantitative data synthesis); Fig. 3 · same question in other reviews | OR 1.26 [0.87, 1.82] | 2 studies · 270 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Ethnicity: Asian The TaqI (rs731236 T>C) C allele/variant genotype was associated with increased dental caries risk in Asians under the allele contrast (C vs T) model (OR 1.28, 95% CI 1.06 to 1.54); ungraded. Source: Table 4 (Ethnicity: Asian); Results (Quantitative data synthesis); Fig. 2; Abstract · same question in other reviews | OR 1.28 [1.06, 1.54] | 5 studies · 1932 participants | Ungraded |
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT/CC genotype vs TT genotype (dominant model)
Population: Children and adults (no age limit) assessed for dental caries susceptibility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries susceptibility (risk of dental caries) Dentition: Deciduous tooth decay No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for deciduous tooth decay under the dominant (CT/CC vs TT) model (OR 1.39, 95% CI 0.91 to 2.15); ungraded. Source: Table 4 (Deciduous decay); Results (Quantitative data synthesis) · same question in other reviews | OR 1.39 [0.91, 2.15] | 2 studies · 929 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Permanent tooth caries No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for permanent tooth caries under the dominant (CT/CC vs TT) model (OR 1.78, 95% CI 0.41 to 7.73); ungraded. Source: Table 4 (Permanent tooth caries); Results (Quantitative data synthesis) · same question in other reviews | OR 1.78 [0.41, 7.73] | 3 studies · 1271 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Ethnicity: Asian No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Asians under the dominant (CT/CC vs TT) model (OR 1.67, 95% CI 0.97 to 2.87); ungraded. Source: Table 4 (Ethnicity: Asian); Results (Quantitative data synthesis) · same question in other reviews | OR 1.67 [0.97, 2.87] | 5 studies · 1932 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Ethnicity: Caucasian No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Caucasians under the dominant (CT/CC vs TT) model (OR 1.05, 95% CI 0.65 to 1.71); ungraded. Source: Table 4 (Ethnicity: Caucasian); Results (Quantitative data synthesis) · same question in other reviews | OR 1.05 [0.65, 1.71] | 2 studies · 538 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Mixed dentition caries No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for mixed dentition caries under the dominant (CT/CC vs TT) model (OR 1.37, 95% CI 0.81 to 2.33); ungraded. Source: Table 4 (Mixed caries); Results (Quantitative data synthesis) · same question in other reviews | OR 1.37 [0.81, 2.33] | 2 studies · 270 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Overall No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries overall under the dominant (CT/CC vs TT) model (OR 1.45, 95% CI 0.96 to 2.19); ungraded. Source: Table 4 (Total); Results (Quantitative data synthesis) · same question in other reviews | OR 1.45 [0.96, 2.19] | 7 studies · 2470 participants | Ungraded |
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CC genotype vs CT/TT genotype (recessive model)
Population: Children and adults (no age limit) assessed for dental caries susceptibility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries susceptibility (risk of dental caries) Dentition: Mixed dentition caries No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for mixed dentition caries under the recessive (CC vs CT/TT) model (OR 1.23, 95% CI 0.66 to 2.29); ungraded. Source: Table 4 (Mixed caries); Results (Quantitative data synthesis) · same question in other reviews | OR 1.23 [0.66, 2.29] | 2 studies · 270 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Deciduous tooth decay No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for deciduous tooth decay under the recessive (CC vs CT/TT) model (OR 0.80, 95% CI 0.05 to 12.89); ungraded. Source: Table 4 (Deciduous decay); Results (Quantitative data synthesis) · same question in other reviews | OR 0.80 [0.05, 12.89] | 2 studies · 929 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Overall The TaqI (rs731236 T>C) C allele/variant genotype was associated with increased dental caries risk overall under the recessive (CC vs CT/TT) model (OR 1.38, 95% CI 1.03 to 1.84); ungraded. Source: Table 4 (Total); Results (Quantitative data synthesis); Abstract · same question in other reviews | OR 1.38 [1.03, 1.84] | 7 studies · 2470 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Ethnicity: Caucasian No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Caucasians under the recessive (CC vs CT/TT) model (OR 1.33, 95% CI 0.91 to 1.95); ungraded. Source: Table 4 (Ethnicity: Caucasian); Results (Quantitative data synthesis) · same question in other reviews | OR 1.33 [0.91, 1.95] | 2 studies · 538 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Permanent tooth caries The TaqI (rs731236 T>C) C allele/variant genotype was associated with increased dental caries risk for permanent tooth caries under the recessive (CC vs CT/TT) model (OR 1.44, 95% CI 1.03 to 2.00); ungraded. Source: Table 4 (Permanent tooth caries); Results (Quantitative data synthesis); Abstract · same question in other reviews | OR 1.44 [1.03, 2.00] | 3 studies · 1271 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Ethnicity: Asian No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Asians under the recessive (CC vs CT/TT) model (OR 1.45, 95% CI 0.93 to 2.26); ungraded. Source: Table 4 (Ethnicity: Asian); Results (Quantitative data synthesis) · same question in other reviews | OR 1.45 [0.93, 2.26] | 5 studies · 1932 participants | Ungraded |
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CC genotype vs TT genotype (homozygous model)
Population: Children and adults (no age limit) assessed for dental caries susceptibility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries susceptibility (risk of dental caries) Overall No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries overall under the homozygous (CC vs TT) model (OR 0.83, 95% CI 0.29 to 2.40); ungraded. Source: Table 4 (Total); Results (Quantitative data synthesis) · same question in other reviews | OR 0.83 [0.29, 2.40] | 7 studies · 2470 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Deciduous tooth decay No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for deciduous tooth decay under the homozygous (CC vs TT) model (OR 1.28, 95% CI 0.08 to 21.28); ungraded. Source: Table 4 (Deciduous decay); Results (Quantitative data synthesis) · same question in other reviews | OR 1.28 [0.08, 21.28] | 2 studies · 929 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Ethnicity: Caucasian No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Caucasians under the homozygous (CC vs TT) model (OR 0.62, 95% CI 0.13 to 3.09); ungraded. Source: Table 4 (Ethnicity: Caucasian); Results (Quantitative data synthesis) · same question in other reviews | OR 0.62 [0.13, 3.09] | 2 studies · 538 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Permanent tooth caries Under the homozygous (CC vs TT) model, the TaqI (rs731236 T>C) CC genotype was associated with lower dental caries risk for permanent tooth caries (OR 0.29, 95% CI 0.16 to 0.53); this isolated estimate should be interpreted cautiously; ungraded. Source: Table 4 (Permanent tooth caries); Results (Quantitative data synthesis) · same question in other reviews | OR 0.29 [0.16, 0.53] | 3 studies · 1271 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Ethnicity: Asian No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Asians under the homozygous (CC vs TT) model (OR 1.38, 95% CI 0.55 to 3.50); ungraded. Source: Table 4 (Ethnicity: Asian); Results (Quantitative data synthesis) · same question in other reviews | OR 1.38 [0.55, 3.50] | 5 studies · 1932 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Mixed dentition caries No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for mixed dentition caries under the homozygous (CC vs TT) model (OR 1.44, 95% CI 0.72 to 2.85); ungraded. Source: Table 4 (Mixed caries); Results (Quantitative data synthesis) · same question in other reviews | OR 1.44 [0.72, 2.85] | 2 studies · 270 participants | Ungraded |
TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT genotype vs TT genotype (heterozygous model)
Population: Children and adults (no age limit) assessed for dental caries susceptibility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Dental caries susceptibility (risk of dental caries) Dentition: Deciduous tooth decay No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for deciduous tooth decay under the heterozygous (CT vs TT) model (OR 1.40, 95% CI 0.91 to 2.15); ungraded. Source: Table 4 (Deciduous decay); Results (Quantitative data synthesis) · same question in other reviews | OR 1.40 [0.91, 2.15] | 2 studies · 929 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Permanent tooth caries No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for permanent tooth caries under the heterozygous (CT vs TT) model (OR 1.65, 95% CI 0.33 to 8.35); ungraded. Source: Table 4 (Permanent tooth caries); Results (Quantitative data synthesis) · same question in other reviews | OR 1.65 [0.33, 8.35] | 3 studies · 1271 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Ethnicity: Caucasian No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Caucasians under the heterozygous (CT vs TT) model (OR 0.93, 95% CI 0.56 to 1.56); ungraded. Source: Table 4 (Ethnicity: Caucasian); Results (Quantitative data synthesis) · same question in other reviews | OR 0.93 [0.56, 1.56] | 2 studies · 538 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Ethnicity: Asian No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Asians under the heterozygous (CT vs TT) model (OR 1.67, 95% CI 0.96 to 2.90); ungraded. Source: Table 4 (Ethnicity: Asian); Results (Quantitative data synthesis) · same question in other reviews | OR 1.67 [0.96, 2.90] | 5 studies · 1932 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Overall No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries overall under the heterozygous (CT vs TT) model (OR 1.41, 95% CI 0.89 to 2.22); ungraded. Source: Table 4 (Total); Results (Quantitative data synthesis) · same question in other reviews | OR 1.41 [0.89, 2.22] | 7 studies · 2470 participants | Ungraded |
Dental caries susceptibility (risk of dental caries) Dentition: Mixed dentition caries No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for mixed dentition caries under the heterozygous (CT vs TT) model (OR 1.34, 95% CI 0.75 to 2.40); ungraded. Source: Table 4 (Mixed caries); Results (Quantitative data synthesis) · same question in other reviews | OR 1.34 [0.75, 2.40] | 2 studies · 270 participants | Ungraded |
Included primary studies 11
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Aribam 2020 Single-nucleotide polymorphism in Vitamin D receptor gene and its association with dental caries in children. PMID:32174623 | 1 other review | not stated | not extracted yet | not extracted yet |
| Cogulu 2016 The Role of Vitamin D Receptor Polymorphisms on Dental Caries. PMID:27472568 | 1 other review | not stated | not extracted yet | not extracted yet |
| Izakovicova Holla 2017 Vitamin D Receptor TaqI Gene Polymorphism and Dental Caries in Czech Children. PMID:27889775 | 1 other review | not stated | not extracted yet | not extracted yet |
| Kong 2017 matched by author and year (probable) | 1 other review | not stated | not extracted yet | not extracted yet |
| Kong 2017 The relationship between vitamin D receptor gene polymorphism and deciduous tooth decay in Chinese children. PMID:28697775 | 1 other review | not stated | not extracted yet | not extracted yet |
| Qin 2019 Investigation of Interaction between Vitamin D Receptor Gene Polymorphisms and Environmental Factors in Early Childhood Caries in Chinese… PMID:31930121 | 1 other review | not stated | not extracted yet | not extracted yet |
| Yu 2017 Association between Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Polymorphisms and Permanent Tooth Caries Susceptibility to… PMID:29259981 | 1 other review | not stated | not extracted yet | not extracted yet |
| Aribam 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Cogulu 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Hu 2015 Analysis of the association between polymorphisms in the vitamin D receptor (VDR) gene and dental caries in a Chinese population. PMID:26436404 | this review only | not stated | not extracted yet | not extracted yet |
| Izakovicova Holla 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match).