aetiology :: Exposure: genetic -> Caries (unspecified)

Dental caries (self-reported history) · Japanese adults (present-study direct-to-consumer genetic testing cohort); self-reported disease cases vs controls · Lifelong (germline genotype), MAGMA gene-based test (present study)

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), PCR-RFLP genotyping

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Caucasian ethnicity

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Primary dentition

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TG+GG)

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), PCR-RFLP genotyping

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (G vs A)

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (CC vs CA+AA)

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs G)

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Permanent dentition

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (C vs T)

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (CC+CT vs TT)

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (AA vs AG+GG)

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Permanent dentition

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Real-time quantitative PCR genotyping

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), PCR-RFLP genotyping

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (AA+AG vs GG)

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (CC+CA vs AA)

Dental caries · Children (<18 years) with vs without dental caries · Not meta-analyzed (single study)

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C)

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TG vs GG)

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Asian ethnicity

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Mixed dentition

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Real-time quantitative PCR genotyping

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (GG vs GA+AA), Zhang 2006 removed, Sensitivity analysis (Zhang 2006 excluded)

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (AA+GG vs GA), Zhang 2006 removed, Sensitivity analysis (Zhang 2006 excluded)

Dental caries - genome-wide-significant loci · Japanese adults (present-study cohort: 30,859 dental caries cases / 14,666 controls) · Lifelong (germline genotype), Present-study GWAS (Japanese)

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC)

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Primary dentition

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Asian ethnicity

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Asian ethnicity

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+GG vs TG)

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (CC vs CT+TT)

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (CC+AA vs CA)

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (GG vs GA+AA)

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), PCR-RFLP genotyping

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Caucasian ethnicity

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Primary dentition

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Real-time quantitative PCR genotyping

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Permanent dentition

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Real-time quantitative PCR genotyping

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC)

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC)

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (AA+GG vs AG)

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Mixed dentition

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Mixed dentition

Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Asian ethnicity

Dental caries · Children (<18 years) with vs without dental caries · Allelic model (C vs A)

Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (AA+GG vs GA)

Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Mixed dentition