Non-Cochrane · aetiology · PM34026863
Lower Number of Teeth Is Related to Higher Risks for ACVD and Death-Systematic Review and Meta-Analyses of Survival Data.
Beukers Nicky G F M, Su Naichuan, Loos Bruno G, et al. · Frontiers in cardiovascular medicine · 2021 · PubMed · doi:10.3389/fcvm.2021.621626
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
29
current version
GRADE rated
17
No studies
0
Included studies
140
linked below
No studies 0 · 0%Ungraded 12 · 41.4%Very low 0 · 0%Low 5 · 17.2%Moderate 5 · 17.2%High 7 · 24.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Study participants of any age with a known (categorical or linear-scaled) number of teeth at inclusion, followed longitudinally in prospective cohort studies | 3,857 records; 184 full texts read; 75 prospective cohort studies included (qualitative synthesis); 44 qualified for meta-analysis. Participants 173 to 4,440,970 (median 5,688, IQR 718 to 41,000); worldwide; max follow-up 1 to 57 years |
| Intervention | Lower number of remaining teeth / tooth loss (exposure) | Number of remaining teeth as categorical contrasts (categories 0, 1-19, 20-32; 0-10, 11-16, 17-24, 25-32; 0 vs 1-32) and as a continuous per-lost-tooth exposure |
| Comparison | Higher number of remaining teeth (reference categories) | Higher tooth-count reference groups (1-32, 20-32, or 25-32 remaining teeth) |
| Outcomes | ACVD-related events (morbidity or mortality) and all-cause mortality (ACM), as cumulative incidence and incidence density | ACVD-related events and all-cause mortality, pooled as cumulative incidence (risk ratio) and incidence density (hazard ratio; crude, age/sex-adjusted, and multivariable-adjusted). 29 pooled estimates in Figure 2 |
| Study designs | Prospective cohort studies (English language); cross-sectional, case-control, reviews, letters, opinions, book chapters, conference abstracts and patents excluded | Prospective observational cohort studies from all continents; 51 used clinical examination and the remainder self-report to count teeth; events from medical records, death certificates/registers, or self-report |
| Timing | Any follow-up time | Maximum follow-up 1 to 57 years |
Search date: Before 17 June 2020. Databases: Medline-PubMed (National Library of Medicine); EMBASE (Elsevier). No additional records identified through other sources.
Questions and results
Edentulous (0 remaining teeth) vs 1-32 remaining teeth
Population: Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All-cause mortality (ACM) In prospective cohorts, edentulous adults (0 teeth) had a higher cumulative incidence of all-cause mortality than adults with 1-32 teeth (RR 1.94, 95% CI 1.19 to 3.15; 14 cohort studies, I2=100%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2A; Results (Meta-Analyses; cumulative incidence, categorical data) · same question in other reviews | RR 1.94 [1.19, 3.15] | 14 studies · 4711667 participants | Low |
All-cause mortality (ACM) Multivariable-adjusted In prospective cohorts, the multivariable-adjusted HR for all-cause mortality in edentulous adults (0 teeth) vs adults with 1-32 teeth was 1.30 (95% CI 1.21 to 1.40; 7 studies, I2=20%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 1.30 [1.21, 1.40] | 7 studies · 102254 participants | Moderate |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) Multivariable-adjusted In prospective cohorts, the multivariable-adjusted HR for ACVD-related events in edentulous adults (0 teeth) vs adults with 1-32 teeth was 1.21 (95% CI 1.07 to 1.36; 5 studies, I2=35%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 1.21 [1.07, 1.36] | 5 studies · 101938 participants | Moderate |
All-cause mortality (ACM) Crude In prospective cohorts, the crude HR for all-cause mortality in edentulous adults (0 teeth) vs adults with 1-32 teeth was 1.73 (95% CI 1.41 to 2.13; 5 studies, I2=91%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 1.73 [1.41, 2.13] | 5 studies · 99303 participants | Ungraded |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) Crude In prospective cohorts, the crude HR for ACVD-related events in edentulous adults (0 teeth) vs adults with 1-32 teeth was 1.89 (95% CI 1.80 to 1.99; 3 studies, I2=0%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 1.89 [1.80, 1.99] | 3 studies · 98122 participants | Ungraded |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) In prospective cohorts, edentulous adults (0 teeth) had a higher cumulative incidence of ACVD-related events than adults with 1-32 teeth (RR 2.93, 95% CI 1.92 to 4.50; 10 cohort studies, I2=99%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2A; Results (Meta-Analyses; cumulative incidence, categorical data) · same question in other reviews | RR 2.93 [1.92, 4.50] | 10 studies · 4697021 participants | Moderate |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) Adjusted for age/sex In prospective cohorts, the age/sex-adjusted HR for ACVD-related events in edentulous adults (0 teeth) vs adults with 1-32 teeth was 1.49 (95% CI 1.39 to 1.58; 4 studies, I2=0%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 1.49 [1.39, 1.58] | 4 studies · 44937 participants | Ungraded |
All-cause mortality (ACM) Adjusted for age/sex In prospective cohorts, the age/sex-adjusted HR for all-cause mortality in edentulous adults (0 teeth) vs adults with 1-32 teeth was 1.56 (95% CI 1.48 to 1.65; 3 studies, I2=0%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 1.56 [1.48, 1.65] | 3 studies · 43734 participants | Ungraded |
0-19 remaining teeth vs 20-32 remaining teeth
Population: Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All-cause mortality (ACM) Crude In prospective cohorts, the crude HR for all-cause mortality in adults with 0-19 teeth vs adults with 20-32 teeth was 2.47 (95% CI 2.40 to 2.54; 2 studies, I2=0%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 2.47 [2.40, 2.54] | 2 studies · 36379 participants | Ungraded |
All-cause mortality (ACM) In prospective cohorts, adults with 0-19 teeth had a higher cumulative incidence of all-cause mortality than adults with 20-32 teeth (RR 1.84, 95% CI 1.52 to 2.23; 11 cohort studies, I2=95%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2A; Results (Meta-Analyses; cumulative incidence, categorical data) · same question in other reviews | RR 1.84 [1.52, 2.23] | 11 studies · 267575 participants | Low |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) Crude In prospective cohorts, the crude HR for ACVD-related events in adults with 0-19 teeth vs adults with 20-32 teeth was 2.27 (95% CI 1.50 to 3.43; 1 study, I2 not applicable (single study)); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 2.27 [1.50, 3.43] | 1 study · 4380 participants | Ungraded |
All-cause mortality (ACM) Multivariable-adjusted In prospective cohorts, the multivariable-adjusted HR for all-cause mortality in adults with 0-19 teeth vs adults with 20-32 teeth was 1.29 (95% CI 1.21 to 1.37; 10 studies, I2=78%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 1.29 [1.21, 1.37] | 10 studies · 305970 participants | Low |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) Adjusted for age/sex In prospective cohorts, the age/sex-adjusted HR for ACVD-related events in adults with 0-19 teeth vs adults with 20-32 teeth was 1.29 (95% CI 1.08 to 1.53; 3 studies, I2=58%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 1.29 [1.08, 1.53] | 3 studies · 186749 participants | Ungraded |
All-cause mortality (ACM) Adjusted for age/sex In prospective cohorts, the age/sex-adjusted HR for all-cause mortality in adults with 0-19 teeth vs adults with 20-32 teeth was 1.42 (95% CI 1.15 to 1.75; 5 studies, I2=97%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 1.42 [1.15, 1.75] | 5 studies · 212657 participants | Ungraded |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) In prospective cohorts, adults with 0-19 teeth had a higher cumulative incidence of ACVD-related events than adults with 20-32 teeth (RR 1.98, 95% CI 1.86 to 2.10; 4 cohort studies, I2=0%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2A; Results (Meta-Analyses; cumulative incidence, categorical data) · same question in other reviews | RR 1.98 [1.86, 2.10] | 4 studies · 191129 participants | Moderate |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) Multivariable-adjusted In prospective cohorts, the multivariable-adjusted HR for ACVD-related events in adults with 0-19 teeth vs adults with 20-32 teeth was 1.19 (95% CI 1.13 to 1.26; 4 studies, I2=0%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2B; Results (Meta-Analyses; incidence density, categorical data) · same question in other reviews | HR 1.19 [1.13, 1.26] | 4 studies · 191129 participants | Moderate |
Edentulous (0 remaining teeth) vs 20-32 remaining teeth
Population: Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) In prospective cohorts, edentulous adults (0 teeth) had a higher cumulative incidence of ACVD-related events than adults with 20-32 teeth (RR 2.65, 95% CI 1.77 to 3.98; 2 cohort studies, I2=60%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2A; Results (Meta-Analyses; cumulative incidence, categorical data) · same question in other reviews | RR 2.65 [1.77, 3.98] | 2 studies · 130669 participants | High |
All-cause mortality (ACM) In prospective cohorts, edentulous adults (0 teeth) had a higher cumulative incidence of all-cause mortality than adults with 20-32 teeth (RR 2.27, 95% CI 1.82 to 2.83; 8 cohort studies, I2=94%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2A; Results (Meta-Analyses; cumulative incidence, categorical data) · same question in other reviews | RR 2.27 [1.82, 2.83] | 8 studies · 180222 participants | High |
1-19 remaining teeth vs 20-32 remaining teeth
Population: Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All-cause mortality (ACM) In prospective cohorts, adults with 1-19 teeth had a higher cumulative incidence of all-cause mortality than adults with 20-32 teeth (RR 1.76, 95% CI 1.41 to 2.19; 8 cohort studies, I2=94%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2A; Results (Meta-Analyses; cumulative incidence, categorical data) · same question in other reviews | RR 1.76 [1.41, 2.19] | 8 studies · 222572 participants | High |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) In prospective cohorts, adults with 1-19 teeth had a higher cumulative incidence of ACVD-related events than adults with 20-32 teeth (RR 1.69, 95% CI 1.13 to 2.53; 2 cohort studies, I2=60%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2A; Results (Meta-Analyses; cumulative incidence, categorical data) · same question in other reviews | RR 1.69 [1.13, 2.53] | 2 studies · 165066 participants | High |
0-10 remaining teeth vs 25-32 remaining teeth
Population: Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) In prospective cohorts, adults with 0-10 teeth had a higher cumulative incidence of ACVD-related events than adults with 25-32 teeth (RR 2.65, 95% CI 1.84 to 3.81; 4 cohort studies, I2=87%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2A; Results (Meta-Analyses; cumulative incidence, categorical data) · same question in other reviews | RR 2.65 [1.84, 3.81] | 4 studies · 193546 participants | High |
11-16 remaining teeth vs 25-32 remaining teeth
Population: Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) In prospective cohorts, adults with 11-16 teeth had a higher cumulative incidence of ACVD-related events than adults with 25-32 teeth (RR 2.27, 95% CI 1.55 to 3.32; 4 cohort studies, I2=87%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2A; Results (Meta-Analyses; cumulative incidence, categorical data) · same question in other reviews | RR 2.27 [1.55, 3.32] | 4 studies · 189120 participants | High |
17-24 remaining teeth vs 25-32 remaining teeth
Population: Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) In prospective cohorts, adults with 17-24 teeth had a higher cumulative incidence of ACVD-related events than adults with 25-32 teeth (RR 1.73, 95% CI 1.22 to 2.45; 4 cohort studies, I2=87%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2A; Results (Meta-Analyses; cumulative incidence, categorical data) · same question in other reviews | RR 1.73 [1.22, 2.45] | 4 studies · 213202 participants | High |
Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment)
Population: Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All-cause mortality (ACM) Crude Each additional lost tooth was associated with a crude HR of 1.01 (95% CI 1.00 to 1.03) for all-cause mortality (3 studies, I2=80%), not statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2C; Results (Meta-Analyses; incidence density, continuous data) · same question in other reviews | HR 1.01 [1.00, 1.03] | 3 studies · 2219 participants | Ungraded |
All-cause mortality (ACM) Multivariable-adjusted Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for all-cause mortality (11 studies, I2=89%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2C; Results (Meta-Analyses; incidence density, continuous data) · same question in other reviews | HR 1.02 [1.01, 1.03] | 11 studies · 4467321 participants | Low |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) Multivariable-adjusted Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for ACVD-related events (13 studies, I2=75%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2C; Results (Meta-Analyses; incidence density, continuous data) · same question in other reviews | HR 1.02 [1.01, 1.03] | 13 studies · 4639644 participants | Low |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) Crude Each additional lost tooth was associated with a crude HR of 1.01 (95% CI 0.99 to 1.03) for ACVD-related events (1 study, I2 not applicable (single study)), not statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2C; Results (Meta-Analyses; incidence density, continuous data) · same question in other reviews | HR 1.01 [0.99, 1.03] | 1 study · 1385 participants | Ungraded |
All-cause mortality (ACM) Adjusted for age/sex Each additional lost tooth was associated with a age/sex-adjusted HR of 1.02 (95% CI 1.01 to 1.04) for all-cause mortality (5 studies, I2=93%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2C; Results (Meta-Analyses; incidence density, continuous data) · same question in other reviews | HR 1.02 [1.01, 1.04] | 5 studies · 4421245 participants | Ungraded |
Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) Adjusted for age/sex Each additional lost tooth was associated with a age/sex-adjusted HR of 1.01 (95% CI 1.00 to 1.03) for ACVD-related events (7 studies, I2=79%), not statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources). Source: Figure 2C; Results (Meta-Analyses; incidence density, continuous data) · same question in other reviews | HR 1.01 [1.00, 1.03] | 7 studies · 4546574 participants | Ungraded |
Included primary studies 140
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Abnet 2005 Tooth loss is associated with increased risk of total death and death from upper gastrointestinal cancer, heart disease, and stroke in a… DOI:10.1093/ije/dyh375 | this review only | not stated | not extracted yet | not extracted yet |
| Abnet 2005 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Adolph 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Adolph 2017 Oral health in relation to all-cause mortality: the IPC cohort study. PMID:28294149 | this review only | not stated | not extracted yet | not extracted yet |
| Aida 2011 Oral Health and Cancer, Cardiovascular, and Respiratory Mortality of Japanese DOI:10.1177/0022034511414423 | this review only | not stated | not extracted yet | not extracted yet |
| Aida 2011 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Ajwani 2003 Oral health status, C‐reactive protein and mortality – a 10 year follow‐up study DOI:10.1111/j.1741-2358.2003.00032.x | this review only | not stated | not extracted yet | not extracted yet |
| Ajwani 2003 Periodontal disease and mortality in an aged population DOI:10.1111/j.1754-4505.2003.tb00297.x | this review only | not stated | not extracted yet | not extracted yet |
| Ajwani 2003 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Ando 2014 Associations of number of teeth with risks for all‐cause mortality and cause‐specific mortality in middle‐aged and elderly men in the… DOI:10.1111/cdoe.12095 | this review only | not stated | not extracted yet | not extracted yet |
| Ando 2014 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Ansai 2010 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Ansai 2010 Relationship between tooth loss and mortality in 80-year-old Japanese community-dwelling subjects. PMID:20594306 | this review only | not stated | not extracted yet | not extracted yet |
| Batty 2018 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Batty 2018 Oral health and later coronary heart disease: Cohort study of one million people. PMID:29461088 | this review only | not stated | not extracted yet | not extracted yet |
| Brown 2009 Complete Edentulism Prior to the Age of 65 Years is Associated with All‐Cause Mortality DOI:10.1111/j.1752-7325.2009.00132.x | this review only | not stated | not extracted yet | not extracted yet |
| Brown 2009 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Cabrera 2005 Can the relation between tooth loss and chronic disease be explained by socio-economic status? A 24-year follow-up from the Population… DOI:10.1007/s10654-004-5961-5 | this review only | not stated | not extracted yet | not extracted yet |
| Cabrera 2005 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Caplan 2017 Dental status as a predictor of mortality among nursing facility residents in eastern Iowa DOI:10.1111/ger.12260 | this review only | not stated | not extracted yet | not extracted yet |
| Caplan 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Chang 2020 Better oral hygiene is associated with lower risk of stroke DOI:10.1002/jper.20-0053 | this review only | not stated | not extracted yet | not extracted yet |
| Chang 2020 Improved oral hygiene care is associated with decreased risk of occurrence for atrial fibrillation and heart failure: A nationwide… DOI:10.1177/2047487319886018 | this review only | not stated | not extracted yet | not extracted yet |
| Chang 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Choe 2009 Tooth loss, hypertension and risk for stroke in a Korean population DOI:10.1016/j.atherosclerosis.2008.07.017 | this review only | not stated | not extracted yet | not extracted yet |
| Choe 2009 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Darnaud 2020 Masticatory Capacity and Mortality: The Preventive and Clinical Investigation Center (IPC) Cohort Study DOI:10.1177/0022034519889021 | this review only | not stated | not extracted yet | not extracted yet |
| Darnaud 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Del Brutto 2017 Severe edentulism is a major risk factor influencing stroke incidence in rural Ecuador (The Atahualpa Project) DOI:10.1177/1747493016676621 | this review only | not stated | not extracted yet | not extracted yet |
| Del Brutto 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Dewake 2020 Posterior occluding pairs of teeth or dentures and 1‐year mortality in nursing home residents in Japan DOI:10.1111/joor.12883 | this review only | not stated | not extracted yet | not extracted yet |
| Dewake 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Dietrich 2008 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Dietrich 2008 Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. PMID:18362228 | this review only | not stated | not extracted yet | not extracted yet |
| Fukai 2008 Mortality rates of community‐residing adults with and without dentures DOI:10.1111/j.1447-0594.2008.00464.x | this review only | not stated | not extracted yet | not extracted yet |
| Fukai 2008 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Furuta 2018 Tooth loss, swallowing dysfunction and mortality in Japanese older adults receiving home care services DOI:10.1111/ggi.13271 | this review only | not stated | not extracted yet | not extracted yet |
| Furuta 2018 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Garcia 1998 Periodontal Disease and Mortality From All Causes in the VA Dental Longitudinal Study DOI:10.1902/annals.1998.3.1.339 | this review only | not stated | not extracted yet | not extracted yet |
| Garcia 1998 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Goto 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Goto 2020 Number of Teeth and All-Cause and Cancer Mortality in a Japanese Community: The Takayama Study. PMID:31006716 | this review only | not stated | not extracted yet | not extracted yet |
| Hamalainen 2003 Relationship between dental health and 10‐year mortality in a cohort of community‐dwelling elderly people DOI:10.1034/j.1600-0722.2003.00055.x | this review only | not stated | not extracted yet | not extracted yet |
| Hamalainen 2003 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Hayasaka 2013 Tooth Loss and Mortality in Elderly Japanese Adults: Effect of Oral Care DOI:10.1111/jgs.12225 | this review only | not stated | not extracted yet | not extracted yet |
| Hayasaka 2013 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Heitmann 2008 Remaining teeth, cardiovascular morbidity and death among adult Danes DOI:10.1016/j.ypmed.2008.04.007 | this review only | not stated | not extracted yet | not extracted yet |
| Heitmann 2008 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Hiratsuka 2020 Contribution of systemic inflammation and nutritional status to the relationship between tooth loss and mortality in a community-dwelling… DOI:10.1007/s00784-019-03072-y | this review only | not stated | not extracted yet | not extracted yet |
| Hiratsuka 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Hirotomi 2015 Number of teeth and 5‐year mortality in an elderly population DOI:10.1111/cdoe.12146 | this review only | not stated | not extracted yet | not extracted yet |
| Hirotomi 2015 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Hoke 2011 The impact of dental disease on mortality in patients with asymptomatic carotid atherosclerosis DOI:10.4414/smw.2011.13236 | this review only | not stated | not extracted yet | not extracted yet |
| Hoke 2011 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Holm-Pedersen 2008 Tooth Loss and Subsequent Disability and Mortality in Old Age DOI:10.1111/j.1532-5415.2007.01602.x | this review only | not stated | not extracted yet | not extracted yet |
| Holm-Pedersen 2008 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Holmlund 2010 Number of Teeth as a Predictor of Cardiovascular Mortality in a Cohort of 7,674 Subjects Followed for 12 Years DOI:10.1902/jop.2010.090680 | this review only | not stated | not extracted yet | not extracted yet |
| Holmlund 2010 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Holmlund 2017 Oral health and cardiovascular disease risk in a cohort of periodontitis patients DOI:10.1016/j.atherosclerosis.2017.05.009 | this review only | not stated | not extracted yet | not extracted yet |
| Holmlund 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Hu 2015 Association Between Tooth Loss, Body Mass Index, and All-Cause Mortality Among Elderly Patients in Taiwan. PMID:26426618 | this review only | not stated | not extracted yet | not extracted yet |
| Hung 2003 Oral Health and Peripheral Arterial Disease DOI:10.1161/01.cir.0000051456.68470.c8 | this review only | not stated | not extracted yet | not extracted yet |
| Hung 2003 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Hung 2004 The Association Between Tooth Loss and Coronary Heart Disease in Men and Women DOI:10.1111/j.1752-7325.2004.tb02755.x | this review only | not stated | not extracted yet | not extracted yet |
| Hung 2004 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Iwasaki 2017 Association between tooth loss and medical costs related to stroke in healthy older adults aged over 75 years in <scp>J</scp>apan DOI:10.1111/ggi.12687 | this review only | not stated | not extracted yet | not extracted yet |
| Iwasaki 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Janket 2013 Removable dental prostheses and cardiovascular survival: A 15-year follow-up study DOI:10.1016/j.jdent.2013.05.009 | this review only | not stated | not extracted yet | not extracted yet |
| Janket 2013 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Janket 2014 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Janket 2014 Number of teeth, C-reactive protein, fibrinogen and cardiovascular mortality: a 15-year follow-up study in a Finnish cohort. PMID:24354534 | this review only | not stated | not extracted yet | not extracted yet |
| Joshipura 1996 Poor Oral Health and Coronary Heart Disease DOI:10.1177/00220345960750090301 | this review only | not stated | not extracted yet | not extracted yet |
| Joshipura 1996 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Joshipura 2003 Periodontal Disease, Tooth Loss, and Incidence of Ischemic Stroke DOI:10.1161/01.str.0000052974.79428.0c | this review only | not stated | not extracted yet | not extracted yet |
| Joshipura 2003 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Joshy 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Joshy 2016 Is poor oral health a risk marker for incident cardiovascular disease hospitalisation and all-cause mortality? Findings from 172 630… PMID:27577588 | this review only | not stated | not extracted yet | not extracted yet |
| Kebede 2017 Association of Periodontal Destruction and Diabetes with Mortality DOI:10.1177/0022034516668839 | this review only | not stated | not extracted yet | not extracted yet |
| Kebede 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Kim 2013 Oral health problems and mortality. PMID:24416472 | this review only | not stated | not extracted yet | not extracted yet |
| LaMonte 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| LaMonte 2017 History of Periodontitis Diagnosis and Edentulism as Predictors of Cardiovascular Disease, Stroke, and Mortality in Postmenopausal Women. PMID:28356279 | this review only | not stated | not extracted yet | not extracted yet |
| Lee 2019 Tooth Loss Predicts Myocardial Infarction, Heart Failure, Stroke, and Death DOI:10.1177/0022034518814829 | this review only | not stated | not extracted yet | not extracted yet |
| Li 2010 Oral disease and subsequent cardiovascular disease in people with type 2 diabetes: a prospective cohort study based on the Action in… PMID:20700576 | this review only | not stated | not extracted yet | not extracted yet |
| Liljestrand 2015 Missing Teeth Predict Incident Cardiovascular Events, Diabetes, and Death DOI:10.1177/0022034515586352 | this review only | not stated | not extracted yet | not extracted yet |
| Liljestrand 2015 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Matsuyama 2017 Dental Status and Compression of Life Expectancy with Disability DOI:10.1177/0022034517713166 | this review only | not stated | not extracted yet | not extracted yet |
| Matsuyama 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Morita 2006 Relationship between survival rates and numbers of natural teeth in an elderly Japanese population DOI:10.1111/j.1741-2358.2006.00134.x | this review only | not stated | not extracted yet | not extracted yet |
| Morita 2006 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Morrison 1999 Periodontal Disease and Risk of Fatal Coronary Heart and Cerebrovascular Diseases DOI:10.1177/204748739900600102 | this review only | not stated | not extracted yet | not extracted yet |
| Morrison 1999 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Mucci 2009 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Mucci 2009 Do genetic factors explain the association between poor oral health and cardiovascular disease? A prospective study among Swedish twins. PMID:19648170 | this review only | not stated | not extracted yet | not extracted yet |
| Munoz-Torres 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Munoz-Torres 2017 Relationship between tooth loss and peripheral arterial disease among women. PMID:28766735 | this review only | not stated | not extracted yet | not extracted yet |
| Noguchi 2015 Five-year follow-up study of the association between periodontal disease and myocardial infarction among Japanese male workers: MY Health… DOI:10.1093/pubmed/fdu076 | this review only | not stated | not extracted yet | not extracted yet |
| Noguchi 2015 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Nomura 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Nomura 2020 Effects of self-assessed chewing ability, tooth loss and serum albumin on mortality in 80-year-old individuals: a 20-year follow-up study. PMID:32316955 | this review only | not stated | not extracted yet | not extracted yet |
| Oluwagbemigun 2015 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Oluwagbemigun 2015 Association between Number of Teeth and Chronic Systemic Diseases: A Cohort Study Followed for 13 Years. PMID:25945503 | this review only | not stated | not extracted yet | not extracted yet |
| Osterberg 2007 Number of teeth – a predictor of mortality in the elderly? A population study in three Nordic localities DOI:10.1080/00016350701739519 | this review only | not stated | not extracted yet | not extracted yet |
| Osterberg 2007 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Osterberg 2008 Number of teeth – a predictor of mortality in 70‐year‐old subjects DOI:10.1111/j.1600-0528.2007.00413.x | this review only | not stated | not extracted yet | not extracted yet |
| Osterberg 2008 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Padilha 2008 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Padilha 2008 Number of teeth and mortality risk in the Baltimore Longitudinal Study of Aging. PMID:18693229 | this review only | not stated | not extracted yet | not extracted yet |
| Paganini-Hill 2011 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Paganini-Hill 2011 Dental health behaviors, dentition, and mortality in the elderly: the leisure world cohort study. PMID:21748004 | this review only | not stated | not extracted yet | not extracted yet |
| Park 2019 Improved oral hygiene care attenuates the cardiovascular risk of oral health disease: a population-based study from Korea DOI:10.1093/eurheartj/ehy836 | this review only | not stated | not extracted yet | not extracted yet |
| Park 2019 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Qi 2020 Association between periodontal disease and tooth loss and mortality in an elderly Chinese population DOI:10.1007/s40520-019-01446-6 | this review only | not stated | not extracted yet | not extracted yet |
| Ragnarsson 2004 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Reichert 2015 Use of floss/interdental brushes is associated with lower risk for new cardiovascular events among patients with coronary heart disease DOI:10.1111/jre.12191 | this review only | not stated | not extracted yet | not extracted yet |
| Reichert 2015 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Reichert 2016 Periodontal conditions and incidence of new cardiovascular events among patients with coronary vascular disease DOI:10.1111/jcpe.12611 | this review only | not stated | not extracted yet | not extracted yet |
| Reichert 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Saito 2019 Associations of number of teeth with medical costs and hospitalization duration in an older Japanese population DOI:10.1111/ggi.13622 | this review only | not stated | not extracted yet | not extracted yet |
| Saito 2019 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Schwahn 2013 Missing, unreplaced teeth and risk of all-cause and cardiovascular mortality DOI:10.1016/j.ijcard.2012.04.061 | this review only | not stated | not extracted yet | not extracted yet |
| Schwahn 2013 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Shimazaki 2001 Influence of Dentition Status on Physical Disability, Mental Impairment, and Mortality in Institutionalized Elderly People DOI:10.1177/00220345010800010801 | this review only | not stated | not extracted yet | not extracted yet |
| Shimazaki 2001 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Soikkonen 2000 Radiographic periodontal attachment loss as an indicator of death risk in the elderly DOI:10.1034/j.1600-051x.2000.027002087.x | this review only | not stated | not extracted yet | not extracted yet |
| Soikkonen 2000 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Tu 2007 Associations between tooth loss and mortality patterns in the Glasgow Alumni Cohort. PMID:17164486 | this review only | not stated | not extracted yet | not extracted yet |
| Tuominen 2003 Oral Health Indicators Poorly Predict Coronary Heart Disease Deaths DOI:10.1177/154405910308200911 | this review only | not stated | not extracted yet | not extracted yet |
| Tuominen 2003 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Vedin 2016 Tooth loss is independently associated with poor outcomes in stable coronary heart disease DOI:10.1177/2047487315621978 | this review only | not stated | not extracted yet | not extracted yet |
| Vedin 2016 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Vedin 2017 Associations between tooth loss and prognostic biomarkers and the risk for cardiovascular events in patients with stable coronary heart… DOI:10.1016/j.ijcard.2017.07.036 | this review only | not stated | not extracted yet | not extracted yet |
| Vedin 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Vogtmann 2017 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Vogtmann 2017 Oral health and mortality in the Golestan Cohort Study. PMID:28449082 | this review only | not stated | not extracted yet | not extracted yet |
| Watt 2012 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Watt 2012 Tooth loss and cardiovascular disease mortality risk--results from the Scottish Health Survey. PMID:22363491 | this review only | not stated | not extracted yet | not extracted yet |
| Wu 2000 Periodontal Disease and Risk of Cerebrovascular Disease DOI:10.1001/archinte.160.18.2749 | this review only | not stated | not extracted yet | not extracted yet |
| Yuan 2020 matched by author and year (probable) | this review only | not stated | not extracted yet | not extracted yet |
| Yuan 2020 Number of natural teeth, denture use and mortality in Chinese elderly: a population-based prospective cohort study. PMID:32276615 | this review only | not stated | not extracted yet | not extracted yet |